Result of FASTA (omim) for
pF1KE4276
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4276, 1261 aa
1>>>pF1KE4276 1261 - 1261 aa - 1261 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6989+/-0.000471; mu= 1.7475+/- 0.029
mean_var=274.2762+/-57.871, 0's: 0 Z-trim(116.6): 227 B-trim: 36 in 1/54
Lambda= 0.077443
statistics sampled from 28587 (28851) to 28587 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.314), width: 16
Scan time: 8.000
The best scores are: opt bits E(91774)
NP_001315593 (OMIM: 610496) rho GTPase-activating (1261) 8250 936.9 0
XP_011540741 (OMIM: 610496) rho GTPase-activating (1261) 8250 936.9 0
NP_004806 (OMIM: 610496) rho GTPase-activating pro (1261) 8250 936.9 0
NP_001315594 (OMIM: 610496) rho GTPase-activating (1197) 7821 889.0 0
NP_001315596 (OMIM: 610496) rho GTPase-activating (1197) 7821 889.0 0
NP_001315595 (OMIM: 610496) rho GTPase-activating (1252) 5552 635.5 7.3e-181
XP_016882351 (OMIM: 609694) GEM-interacting protei ( 835) 1170 145.7 1.3e-33
XP_011526350 (OMIM: 609694) GEM-interacting protei ( 849) 1170 145.7 1.3e-33
XP_016882350 (OMIM: 609694) GEM-interacting protei ( 884) 1170 145.8 1.4e-33
NP_057657 (OMIM: 609694) GEM-interacting protein i ( 970) 1170 145.8 1.4e-33
NP_001269263 (OMIM: 601155) rho GTPase-activating ( 771) 1059 133.3 6.6e-30
XP_024307203 (OMIM: 601155) rho GTPase-activating ( 821) 1054 132.8 1e-29
XP_005259984 (OMIM: 609694) GEM-interacting protei ( 967) 1048 132.2 1.8e-29
NP_036424 (OMIM: 601155) rho GTPase-activating pro (1136) 1024 129.5 1.3e-28
NP_001308161 (OMIM: 601155) rho GTPase-activating (1140) 1024 129.5 1.3e-28
NP_001245257 (OMIM: 601155) rho GTPase-activating (1152) 1024 129.5 1.3e-28
NP_001269264 (OMIM: 601155) rho GTPase-activating (1019) 986 125.3 2.3e-27
XP_006722776 (OMIM: 601155) rho GTPase-activating (1164) 975 124.1 6e-27
XP_011526160 (OMIM: 601155) rho GTPase-activating (1168) 975 124.1 6e-27
NP_001275927 (OMIM: 609694) GEM-interacting protei ( 941) 675 90.5 6.3e-17
NP_001275928 (OMIM: 609694) GEM-interacting protei ( 944) 671 90.0 8.6e-17
XP_011519925 (OMIM: 604875,618198) unconventional (1737) 276 46.1 0.0026
XP_016877719 (OMIM: 604875,618198) unconventional (2547) 276 46.3 0.0035
NP_008832 (OMIM: 604875,618198) unconventional myo (2548) 276 46.3 0.0035
XP_016877718 (OMIM: 604875,618198) unconventional (2566) 276 46.3 0.0035
XP_011519924 (OMIM: 604875,618198) unconventional (2566) 276 46.3 0.0035
XP_011519923 (OMIM: 604875,618198) unconventional (2598) 276 46.3 0.0036
XP_011519922 (OMIM: 604875,618198) unconventional (2618) 276 46.3 0.0036
XP_011519921 (OMIM: 604875,618198) unconventional (2619) 276 46.3 0.0036
XP_006720602 (OMIM: 604875,618198) unconventional (2619) 276 46.3 0.0036
XP_011519920 (OMIM: 604875,618198) unconventional (2620) 276 46.3 0.0036
XP_011519919 (OMIM: 604875,618198) unconventional (2637) 276 46.3 0.0036
XP_011519918 (OMIM: 604875,618198) unconventional (2638) 276 46.3 0.0036
XP_011519915 (OMIM: 604875,618198) unconventional (2638) 276 46.3 0.0036
XP_011519917 (OMIM: 604875,618198) unconventional (2638) 276 46.3 0.0036
XP_011519916 (OMIM: 604875,618198) unconventional (2638) 276 46.3 0.0036
NP_001306780 (OMIM: 610576) rho GTPase-activating ( 420) 250 42.7 0.0068
NP_001354352 (OMIM: 610576) rho GTPase-activating ( 516) 250 42.8 0.0079
XP_005269142 (OMIM: 610576) rho GTPase-activating ( 535) 250 42.8 0.0081
XP_005269141 (OMIM: 610576) rho GTPase-activating ( 535) 250 42.8 0.0081
NP_001073625 (OMIM: 610576) rho GTPase-activating ( 547) 250 42.8 0.0083
NP_001354355 (OMIM: 610576) rho GTPase-activating ( 547) 250 42.8 0.0083
NP_001306781 (OMIM: 610576) rho GTPase-activating ( 566) 250 42.8 0.0085
XP_016875289 (OMIM: 610576) rho GTPase-activating ( 566) 250 42.8 0.0085
XP_005269140 (OMIM: 610576) rho GTPase-activating ( 566) 250 42.8 0.0085
XP_016880032 (OMIM: 600365) active breakpoint clus ( 660) 250 42.9 0.0095
XP_016880031 (OMIM: 600365) active breakpoint clus ( 663) 250 42.9 0.0095
XP_011536960 (OMIM: 610576) rho GTPase-activating ( 700) 250 42.9 0.0099
>>NP_001315593 (OMIM: 610496) rho GTPase-activating prot (1261 aa)
initn: 8250 init1: 8250 opt: 8250 Z-score: 4997.7 bits: 936.9 E(91774): 0
Smith-Waterman score: 8250; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)
10 20 30 40 50 60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
1210 1220 1230 1240 1250 1260
pF1KE4 V
:
NP_001 V
>>XP_011540741 (OMIM: 610496) rho GTPase-activating prot (1261 aa)
initn: 8250 init1: 8250 opt: 8250 Z-score: 4997.7 bits: 936.9 E(91774): 0
Smith-Waterman score: 8250; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)
10 20 30 40 50 60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
1210 1220 1230 1240 1250 1260
pF1KE4 V
:
XP_011 V
>>NP_004806 (OMIM: 610496) rho GTPase-activating protein (1261 aa)
initn: 8250 init1: 8250 opt: 8250 Z-score: 4997.7 bits: 936.9 E(91774): 0
Smith-Waterman score: 8250; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)
10 20 30 40 50 60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
1210 1220 1230 1240 1250 1260
pF1KE4 V
:
NP_004 V
>>NP_001315594 (OMIM: 610496) rho GTPase-activating prot (1197 aa)
initn: 7821 init1: 7821 opt: 7821 Z-score: 4738.9 bits: 889.0 E(91774): 0
Smith-Waterman score: 7821; 100.0% identity (100.0% similar) in 1193 aa overlap (69-1261:5-1197)
40 50 60 70 80 90
pF1KE4 IFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
::::::::::::::::::::::::::::::
NP_001 MERRDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
10 20 30
100 110 120 130 140 150
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE4 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE4 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE4 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE4 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE4 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE4 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
460 470 480 490 500 510
580 590 600 610 620 630
pF1KE4 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
520 530 540 550 560 570
640 650 660 670 680 690
pF1KE4 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
580 590 600 610 620 630
700 710 720 730 740 750
pF1KE4 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
640 650 660 670 680 690
760 770 780 790 800 810
pF1KE4 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
700 710 720 730 740 750
820 830 840 850 860 870
pF1KE4 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
760 770 780 790 800 810
880 890 900 910 920 930
pF1KE4 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
820 830 840 850 860 870
940 950 960 970 980 990
pF1KE4 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
880 890 900 910 920 930
1000 1010 1020 1030 1040 1050
pF1KE4 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
940 950 960 970 980 990
1060 1070 1080 1090 1100 1110
pF1KE4 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
1000 1010 1020 1030 1040 1050
1120 1130 1140 1150 1160 1170
pF1KE4 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
1060 1070 1080 1090 1100 1110
1180 1190 1200 1210 1220 1230
pF1KE4 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
1120 1130 1140 1150 1160 1170
1240 1250 1260
pF1KE4 CQRPRLKRMQQFEDLEGEIPQFV
:::::::::::::::::::::::
NP_001 CQRPRLKRMQQFEDLEGEIPQFV
1180 1190
>>NP_001315596 (OMIM: 610496) rho GTPase-activating prot (1197 aa)
initn: 7821 init1: 7821 opt: 7821 Z-score: 4738.9 bits: 889.0 E(91774): 0
Smith-Waterman score: 7821; 100.0% identity (100.0% similar) in 1193 aa overlap (69-1261:5-1197)
40 50 60 70 80 90
pF1KE4 IFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
::::::::::::::::::::::::::::::
NP_001 MERRDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
10 20 30
100 110 120 130 140 150
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE4 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE4 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE4 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE4 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE4 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE4 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
460 470 480 490 500 510
580 590 600 610 620 630
pF1KE4 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
520 530 540 550 560 570
640 650 660 670 680 690
pF1KE4 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
580 590 600 610 620 630
700 710 720 730 740 750
pF1KE4 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
640 650 660 670 680 690
760 770 780 790 800 810
pF1KE4 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
700 710 720 730 740 750
820 830 840 850 860 870
pF1KE4 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
760 770 780 790 800 810
880 890 900 910 920 930
pF1KE4 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
820 830 840 850 860 870
940 950 960 970 980 990
pF1KE4 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
880 890 900 910 920 930
1000 1010 1020 1030 1040 1050
pF1KE4 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
940 950 960 970 980 990
1060 1070 1080 1090 1100 1110
pF1KE4 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
1000 1010 1020 1030 1040 1050
1120 1130 1140 1150 1160 1170
pF1KE4 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
1060 1070 1080 1090 1100 1110
1180 1190 1200 1210 1220 1230
pF1KE4 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
1120 1130 1140 1150 1160 1170
1240 1250 1260
pF1KE4 CQRPRLKRMQQFEDLEGEIPQFV
:::::::::::::::::::::::
NP_001 CQRPRLKRMQQFEDLEGEIPQFV
1180 1190
>>NP_001315595 (OMIM: 610496) rho GTPase-activating prot (1252 aa)
initn: 8177 init1: 5524 opt: 5552 Z-score: 3368.6 bits: 635.5 E(91774): 7.3e-181
Smith-Waterman score: 8163; 99.3% identity (99.3% similar) in 1261 aa overlap (1-1261:1-1252)
10 20 30 40 50 60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDLTLKA---------HLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
430 440 450 460 470
490 500 510 520 530 540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
1200 1210 1220 1230 1240 1250
pF1KE4 V
:
NP_001 V
>>XP_016882351 (OMIM: 609694) GEM-interacting protein is (835 aa)
initn: 1596 init1: 527 opt: 1170 Z-score: 725.0 bits: 145.7 E(91774): 1.3e-33
Smith-Waterman score: 1664; 38.8% identity (67.7% similar) in 778 aa overlap (129-893:18-764)
100 110 120 130 140 150
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
....: :...: ...::. ..: ::
XP_016 MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGD---P
10 20 30 40
160 170 180 190 200 210
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPL---ELDNVLLKNTDSIELALSYAKTW
: . : .: . .. : :. . :: ::: :... ... :: :::::
XP_016 LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTW
50 60 70 80 90 100
220 230 240 250 260 270
pF1KE4 SKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSH
:.:.:....:.::. . ::: ... .:.::: ...: : :::: ..: : .:. .
XP_016 SRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGT
110 120 130 140 150 160
280 290 300 310 320 330
pF1KE4 LLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQR
: ..:.: : . ::: ....:.:: :::.:: : .::..: :: .::..:.: .::
XP_016 LAMETVAQ-QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQR
170 180 190 200 210 220
340 350 360 370 380 390
pF1KE4 QDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTN
... .:.:. . .: : .:: :..:: .::: :..::. ::..:: .
XP_016 SEDL-RARSQGSPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVRE
230 240 250 260 270
400 410 420 430 440 450
pF1KE4 VEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAK
.. :..::: .:..:....: :::: : .:. ::..:: .. :: .. .: .
XP_016 ANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCA
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE4 LYDPGQEYSEFVKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKI
..:::.:.:::.: . .. : : . : . ..: :: ..
XP_016 PFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RL
340 350 360 370 380 390
520 530 540 550 560
pF1KE4 EEDRCSNSADITGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPR
.:. .. . :. : : : :: .:.::.:::::::: . ::: :.: .
XP_016 DENS-AEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVK
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE4 TPSSGTMSSADDLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCE
. :.:: :: ::..::.: . .. :.::. : : .:.:: ::..:.::.:.:::.::
XP_016 ASSTGTESS-DDFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECE
460 470 480 490 500
630 640 650 660 670 680
pF1KE4 GIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFIL
...: .:.:::::.:.::..:::.:.:.:::..::.. :::..: :. . :. .::..
XP_016 AFMV-SGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVV
510 520 530 540 550 560
690 700 710 720 730 740
pF1KE4 KICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLR
:..:::.::: .:::::: :.....:.::::.::: ::..: : ::. .::: .:.
XP_016 TKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQ
570 580 590 600 610 620
750 760 770 780 790 800
pF1KE4 QLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLR
.: :: : :.:: ::.::: . :.. .: :. :. : : : ::
XP_016 ELTEPVIPFHLYDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLV
630 640 650 660 670
810 820 830 840 850 860
pF1KE4 QLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSL
::: ::.:.:. :..:: ::. . ::::...:::..:::.:.:: : .: : .. :
XP_016 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCL
680 690 700 710 720 730
870 880 890 900 910 920
pF1KE4 AEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKS
. ..::.::::::.. ..:: . ::
XP_016 LDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDPDSQ
740 750 760 770 780 790
>>XP_011526350 (OMIM: 609694) GEM-interacting protein is (849 aa)
initn: 1377 init1: 527 opt: 1170 Z-score: 724.9 bits: 145.7 E(91774): 1.3e-33
Smith-Waterman score: 1461; 37.0% identity (63.3% similar) in 792 aa overlap (257-1029:25-770)
230 240 250 260 270 280
pF1KE4 EKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQA
:::: ..: : .:. . : ..:.: :
XP_011 MPRPGAAMPRNCLPGLKREPAMSHMPLQYIYTLFLEHDLSLGTLAMETVAQ-QK
10 20 30 40 50
290 300 310 320 330 340
pF1KE4 NKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSM
. ::: ....:.:: :::.:: : .::..: :: .::..:.: .::... .:.:.
XP_011 RDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDL-RARSQG
60 70 80 90 100 110
350 360 370 380 390 400
pF1KE4 FRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENT
. .: : .:: :..:: .::: :..::. ::..:: ... :..::: .
XP_011 SPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIA
120 130 140 150 160
410 420 430 440 450 460
pF1KE4 KREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEF
:..:....: :::: : .:. ::..:: .. :: .. .: . ..:::.:.::
XP_011 KQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEF
170 180 190 200 210 220
470 480 490 500 510 520
pF1KE4 VKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADI
:.: . .. : : . : . ..: :: ...:. .. .
XP_011 VRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RLDENS-AEPGPW
230 240 250 260 270 280
530 540 550 560 570 580
pF1KE4 TGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSAD
:. : : : :: .:.::.:::::::: . ::: :.: .. :.:: :: :
XP_011 EDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESS-D
290 300 310 320 330 340
590 600 610 620 630
pF1KE4 DLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECE
:..::.: . .. :.::. : : .:.:: ::..:.::.:.:::.::...: .:.:::
XP_011 DFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMV-SGTECE
350 360 370 380 390
640 650 660 670 680 690
pF1KE4 ECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRA
::.:.::..:::.:.:.:::..::.. :::..: :. . :. .::.. :..:::.::
XP_011 ECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRA
400 410 420 430 440 450
700 710 720 730 740 750
pF1KE4 LCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRL
: .:::::: :.....:.::::.::: ::..: : ::. .::: .:..: :: : :.:
XP_011 LDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHL
460 470 480 490 500 510
760 770 780 790 800 810
pF1KE4 YKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLH
: ::.::: . :.. .: :. :. : : : :: ::: ::.:.:.
XP_011 YDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLVQLPDSNYNTLR
520 530 540 550 560
820 830 840 850 860 870
pF1KE4 FLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSLAEYSNQARLVE
:..:: ::. . ::::...:::..:::.:.:: : .: : .. : . ..::.:::
XP_011 HLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGHQAQLVE
570 580 590 600 610 620
880 890 900 910 920 930
pF1KE4 FLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLS-----PEERDIERSMKSLFFSSK
:::.. ..:: . :: . :.. : :: . : . : . . : .
XP_011 FLIVHYEQIFGMDELPQAT--EPPPQDSSPAPGPLTTSSQPPPPHLDPDSQPPVLASDPG
630 640 650 660 670 680
940 950 960 970 980 990
pF1KE4 EDI-HTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGK
: : : :.. : . . : : :. : .: .:: ::
XP_011 PDPQHHSTLEQHPTATPTEIPTPQSDQRE---------DVAEDTKDGGGEVSSQGPED--
690 700 710 720 730
1000 1010 1020 1030 1040
pF1KE4 TPKPLSLKSDRSTNNVERHT---PRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKF
:: . .: .. :. :: .:::. .. : :..
XP_011 -----SLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEETPITSVPRGSLR
740 750 760 770 780
1050 1060 1070 1080 1090 1100
pF1KE4 CKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGV
XP_011 GRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPDVQPEEAEDH
790 800 810 820 830 840
>>XP_016882350 (OMIM: 609694) GEM-interacting protein is (884 aa)
initn: 1596 init1: 527 opt: 1170 Z-score: 724.7 bits: 145.8 E(91774): 1.4e-33
Smith-Waterman score: 1664; 38.8% identity (67.7% similar) in 778 aa overlap (129-893:18-764)
100 110 120 130 140 150
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
....: :...: ...::. ..: ::
XP_016 MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGD---P
10 20 30 40
160 170 180 190 200 210
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPL---ELDNVLLKNTDSIELALSYAKTW
: . : .: . .. : :. . :: ::: :... ... :: :::::
XP_016 LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTW
50 60 70 80 90 100
220 230 240 250 260 270
pF1KE4 SKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSH
:.:.:....:.::. . ::: ... .:.::: ...: : :::: ..: : .:. .
XP_016 SRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGT
110 120 130 140 150 160
280 290 300 310 320 330
pF1KE4 LLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQR
: ..:.: : . ::: ....:.:: :::.:: : .::..: :: .::..:.: .::
XP_016 LAMETVAQ-QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQR
170 180 190 200 210 220
340 350 360 370 380 390
pF1KE4 QDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTN
... .:.:. . .: : .:: :..:: .::: :..::. ::..:: .
XP_016 SEDL-RARSQGSPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVRE
230 240 250 260 270
400 410 420 430 440 450
pF1KE4 VEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAK
.. :..::: .:..:....: :::: : .:. ::..:: .. :: .. .: .
XP_016 ANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCA
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE4 LYDPGQEYSEFVKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKI
..:::.:.:::.: . .. : : . : . ..: :: ..
XP_016 PFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RL
340 350 360 370 380 390
520 530 540 550 560
pF1KE4 EEDRCSNSADITGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPR
.:. .. . :. : : : :: .:.::.:::::::: . ::: :.: .
XP_016 DENS-AEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVK
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE4 TPSSGTMSSADDLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCE
. :.:: :: ::..::.: . .. :.::. : : .:.:: ::..:.::.:.:::.::
XP_016 ASSTGTESS-DDFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECE
460 470 480 490 500
630 640 650 660 670 680
pF1KE4 GIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFIL
...: .:.:::::.:.::..:::.:.:.:::..::.. :::..: :. . :. .::..
XP_016 AFMV-SGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVV
510 520 530 540 550 560
690 700 710 720 730 740
pF1KE4 KICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLR
:..:::.::: .:::::: :.....:.::::.::: ::..: : ::. .::: .:.
XP_016 TKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQ
570 580 590 600 610 620
750 760 770 780 790 800
pF1KE4 QLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLR
.: :: : :.:: ::.::: . :.. .: :. :. : : : ::
XP_016 ELTEPVIPFHLYDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLV
630 640 650 660 670
810 820 830 840 850 860
pF1KE4 QLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSL
::: ::.:.:. :..:: ::. . ::::...:::..:::.:.:: : .: : .. :
XP_016 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCL
680 690 700 710 720 730
870 880 890 900 910 920
pF1KE4 AEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKS
. ..::.::::::.. ..:: . ::
XP_016 LDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDPDSQ
740 750 760 770 780 790
>>NP_057657 (OMIM: 609694) GEM-interacting protein isofo (970 aa)
initn: 1596 init1: 527 opt: 1170 Z-score: 724.2 bits: 145.8 E(91774): 1.4e-33
Smith-Waterman score: 1676; 36.2% identity (63.4% similar) in 923 aa overlap (129-1029:18-891)
100 110 120 130 140 150
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
....: :...: ...::. ..: ::
NP_057 MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGD---P
10 20 30 40
160 170 180 190 200 210
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPL---ELDNVLLKNTDSIELALSYAKTW
: . : .: . .. : :. . :: ::: :... ... :: :::::
NP_057 LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTW
50 60 70 80 90 100
220 230 240 250 260 270
pF1KE4 SKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSH
:.:.:....:.::. . ::: ... .:.::: ...: : :::: ..: : .:. .
NP_057 SRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGT
110 120 130 140 150 160
280 290 300 310 320 330
pF1KE4 LLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQR
: ..:.: : . ::: ....:.:: :::.:: : .::..: :: .::..:.: .::
NP_057 LAMETVAQ-QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQR
170 180 190 200 210 220
340 350 360 370 380 390
pF1KE4 QDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTN
... .:.:. . .: : .:: :..:: .::: :..::. ::..:: .
NP_057 SEDL-RARSQGSPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVRE
230 240 250 260 270
400 410 420 430 440 450
pF1KE4 VEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAK
.. :..::: .:..:....: :::: : .:. ::..:: .. :: .. .: .
NP_057 ANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCA
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE4 LYDPGQEYSEFVKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKI
..:::.:.:::.: . .. : : . : . ..: :: ..
NP_057 PFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RL
340 350 360 370 380 390
520 530 540 550 560
pF1KE4 EEDRCSNSADITGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPR
.:. .. . :. : : : :: .:.::.:::::::: . ::: :.: .
NP_057 DENS-AEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVK
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE4 TPSSGTMSSADDLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCE
. :.:: :: ::..::.: . .. :.::. : : .:.:: ::..:.::.:.:::.::
NP_057 ASSTGTESS-DDFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECE
460 470 480 490 500
630 640 650 660 670 680
pF1KE4 GIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFIL
...: .:.:::::.:.::..:::.:.:.:::..::.. :::..: :. . :. .::..
NP_057 AFMV-SGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVV
510 520 530 540 550 560
690 700 710 720 730 740
pF1KE4 KICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLR
:..:::.::: .:::::: :.....:.::::.::: ::..: : ::. .::: .:.
NP_057 TKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQ
570 580 590 600 610 620
750 760 770 780 790 800
pF1KE4 QLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLR
.: :: : :.:: ::.::: . :.. .: :. :. : : : ::
NP_057 ELTEPVIPFHLYDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLV
630 640 650 660 670
810 820 830 840 850 860
pF1KE4 QLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSL
::: ::.:.:. :..:: ::. . ::::...:::..:::.:.:: : .: : .. :
NP_057 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCL
680 690 700 710 720 730
870 880 890 900 910 920
pF1KE4 AEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLS-----PEERDIE
. ..::.::::::.. ..:: . :: . :.. : :: . : . : .
NP_057 LDSGHQAQLVEFLIVHYEQIFGMDELPQAT--EPPPQDSSPAPGPLTTSSQPPPPHLDPD
740 750 760 770 780 790
930 940 950 960 970
pF1KE4 RSMKSLFFSSKEDI-HTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEA
. : . : : : :.. : . . : : :. : .
NP_057 SQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQRE---------DVAEDTKDGGG
800 810 820 830 840
980 990 1000 1010 1020 1030
pF1KE4 ESASQKIEDGKTPKPLSLKSDRSTNNVERHT---PRTKIRPVSLPVDRLLLASPPNERNG
: .:: :: :: . .: .. :. :: .:::. .. : :..
NP_057 EVSSQGPED-------SLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEET
850 860 870 880 890
1040 1050 1060 1070 1080 1090
pF1KE4 RNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTM
NP_057 PITSVPRGSLRGRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCC
900 910 920 930 940 950
1261 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:57:33 2019 done: Tue Jul 16 15:57:34 2019
Total Scan time: 8.000 Total Display time: 0.320
Function used was FASTA [36.3.4 Apr, 2011]