Result of FASTA (omim) for
pF1KE3557
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3557, 548 aa
1>>>pF1KE3557 548 - 548 aa - 548 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4467+/-0.000328; mu= 5.2232+/- 0.021
mean_var=193.0917+/-39.611, 0's: 0 Z-trim(121.6): 455 B-trim: 256 in 2/57
Lambda= 0.092298
statistics sampled from 39402 (39883) to 39402 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.432), width: 16
Scan time: 5.530
The best scores are: opt bits E(92320)
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 3738 510.2 7.2e-144
XP_016879801 (OMIM: 610591) rho GTPase-activating ( 689) 3738 510.3 8.6e-144
NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 3738 510.3 1.1e-143
XP_006721808 (OMIM: 610591) rho GTPase-activating ( 889) 3738 510.3 1.1e-143
XP_005257185 (OMIM: 610591) rho GTPase-activating ( 667) 2674 368.6 3.8e-101
XP_006721810 (OMIM: 610591) rho GTPase-activating ( 867) 2674 368.7 4.6e-101
XP_011522771 (OMIM: 610591) rho GTPase-activating ( 900) 1913 267.3 1.5e-70
XP_011522776 (OMIM: 610591) rho GTPase-activating ( 581) 1888 263.9 1.1e-69
XP_016879802 (OMIM: 610591) rho GTPase-activating ( 629) 1888 263.9 1.2e-69
XP_006721813 (OMIM: 610591) rho GTPase-activating ( 615) 1887 263.8 1.2e-69
XP_011522774 (OMIM: 610591) rho GTPase-activating ( 722) 1888 263.9 1.3e-69
XP_011522772 (OMIM: 610591) rho GTPase-activating ( 870) 1888 264.0 1.5e-69
XP_011522770 (OMIM: 610591) rho GTPase-activating ( 922) 1888 264.0 1.6e-69
XP_016879800 (OMIM: 610591) rho GTPase-activating ( 922) 1888 264.0 1.6e-69
XP_011522773 (OMIM: 610591) rho GTPase-activating ( 865) 1884 263.5 2.1e-69
XP_011522775 (OMIM: 610591) rho GTPase-activating ( 587) 1678 235.9 2.9e-61
NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 1431 203.1 3e-51
XP_005252701 (OMIM: 610577) rho GTPase-activating ( 794) 1376 195.8 4.6e-49
NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 1376 195.8 4.6e-49
XP_016872443 (OMIM: 610577) rho GTPase-activating ( 742) 1332 189.9 2.5e-47
NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 1325 189.0 5e-47
XP_011518063 (OMIM: 610577) rho GTPase-activating ( 772) 1296 185.1 7.3e-46
NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 1296 185.1 7.5e-46
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 1296 185.2 7.8e-46
NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 1293 184.8 1e-45
XP_016859989 (OMIM: 610578) rho GTPase-activating ( 432) 1218 174.6 6.2e-43
NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 1218 174.6 6.7e-43
XP_011509781 (OMIM: 610578) rho GTPase-activating ( 475) 1218 174.6 6.7e-43
XP_016859988 (OMIM: 610578) rho GTPase-activating ( 475) 1218 174.6 6.7e-43
XP_011509785 (OMIM: 610578) rho GTPase-activating ( 397) 1089 157.4 8.6e-38
XP_011509783 (OMIM: 610578) rho GTPase-activating ( 435) 1054 152.7 2.3e-36
XP_011509784 (OMIM: 610578) rho GTPase-activating ( 416) 1038 150.6 9.9e-36
XP_024308768 (OMIM: 610578) rho GTPase-activating ( 241) 944 137.9 3.8e-32
XP_024308769 (OMIM: 610578) rho GTPase-activating ( 241) 944 137.9 3.8e-32
NP_001073626 (OMIM: 610576) rho GTPase-activating ( 640) 710 107.0 1.9e-22
XP_011536961 (OMIM: 610576) rho GTPase-activating ( 640) 710 107.0 1.9e-22
NP_001354353 (OMIM: 610576) rho GTPase-activating ( 456) 697 105.2 4.9e-22
NP_001354354 (OMIM: 610576) rho GTPase-activating ( 425) 696 105.0 5.1e-22
XP_011509786 (OMIM: 610578) rho GTPase-activating ( 342) 672 101.8 4e-21
XP_016859990 (OMIM: 610578) rho GTPase-activating ( 341) 544 84.7 5.3e-16
NP_001166101 (OMIM: 614902) rho GTPase-activating (1123) 486 77.4 2.9e-13
NP_443180 (OMIM: 614902) rho GTPase-activating pro (1126) 486 77.4 2.9e-13
XP_011524718 (OMIM: 614902) rho GTPase-activating (1161) 486 77.4 2.9e-13
NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 474 75.4 3.2e-13
NP_001353107 (OMIM: 614902) rho GTPase-activating (1287) 486 77.4 3.2e-13
XP_011524723 (OMIM: 614902) rho GTPase-activating ( 703) 479 76.3 3.8e-13
XP_016881727 (OMIM: 614902) rho GTPase-activating ( 711) 479 76.3 3.8e-13
XP_011524720 (OMIM: 614902) rho GTPase-activating (1134) 479 76.5 5.5e-13
XP_011524719 (OMIM: 614902) rho GTPase-activating (1152) 479 76.5 5.6e-13
NP_001269078 (OMIM: 600365) active breakpoint clus ( 641) 474 75.6 5.6e-13
>>NP_954976 (OMIM: 610591) rho GTPase-activating protein (548 aa)
initn: 3738 init1: 3738 opt: 3738 Z-score: 2704.5 bits: 510.2 E(92320): 7.2e-144
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:1-548)
10 20 30 40 50 60
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
490 500 510 520 530 540
pF1KE3 CADIFPPH
::::::::
NP_954 CADIFPPH
>>XP_016879801 (OMIM: 610591) rho GTPase-activating prot (689 aa)
initn: 3738 init1: 3738 opt: 3738 Z-score: 2703.1 bits: 510.3 E(92320): 8.6e-144
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:142-689)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_016 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
180 190 200 210 220 230
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
240 250 260 270 280 290
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
300 310 320 330 340 350
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
360 370 380 390 400 410
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
420 430 440 450 460 470
340 350 360 370 380 390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
480 490 500 510 520 530
400 410 420 430 440 450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
540 550 560 570 580 590
460 470 480 490 500 510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
600 610 620 630 640 650
520 530 540
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
::::::::::::::::::::::::::::::::::::::
XP_016 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
660 670 680
>>NP_001269219 (OMIM: 610591) rho GTPase-activating prot (889 aa)
initn: 3738 init1: 3738 opt: 3738 Z-score: 2701.5 bits: 510.3 E(92320): 1.1e-143
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:342-889)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
NP_001 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
320 330 340 350 360 370
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
440 450 460 470 480 490
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
500 510 520 530 540 550
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
560 570 580 590 600 610
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
620 630 640 650 660 670
340 350 360 370 380 390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
680 690 700 710 720 730
400 410 420 430 440 450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
740 750 760 770 780 790
460 470 480 490 500 510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
800 810 820 830 840 850
520 530 540
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
::::::::::::::::::::::::::::::::::::::
NP_001 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
860 870 880
>>XP_006721808 (OMIM: 610591) rho GTPase-activating prot (889 aa)
initn: 3738 init1: 3738 opt: 3738 Z-score: 2701.5 bits: 510.3 E(92320): 1.1e-143
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:342-889)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_006 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
320 330 340 350 360 370
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
440 450 460 470 480 490
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
500 510 520 530 540 550
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
560 570 580 590 600 610
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
620 630 640 650 660 670
340 350 360 370 380 390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
680 690 700 710 720 730
400 410 420 430 440 450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
740 750 760 770 780 790
460 470 480 490 500 510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
800 810 820 830 840 850
520 530 540
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
::::::::::::::::::::::::::::::::::::::
XP_006 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
860 870 880
>>XP_005257185 (OMIM: 610591) rho GTPase-activating prot (667 aa)
initn: 2702 init1: 2641 opt: 2674 Z-score: 1937.6 bits: 368.6 E(92320): 3.8e-101
Smith-Waterman score: 3542; 96.0% identity (96.0% similar) in 548 aa overlap (1-548:142-667)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_005 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
180 190 200 210 220 230
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::
XP_005 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEK--------------------
240 250 260 270
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 --TKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
280 290 300 310 320
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
330 340 350 360 370 380
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
390 400 410 420 430 440
340 350 360 370 380 390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
450 460 470 480 490 500
400 410 420 430 440 450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
510 520 530 540 550 560
460 470 480 490 500 510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
570 580 590 600 610 620
520 530 540
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
::::::::::::::::::::::::::::::::::::::
XP_005 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
630 640 650 660
>>XP_006721810 (OMIM: 610591) rho GTPase-activating prot (867 aa)
initn: 2711 init1: 2641 opt: 2674 Z-score: 1936.0 bits: 368.7 E(92320): 4.6e-101
Smith-Waterman score: 3542; 96.0% identity (96.0% similar) in 548 aa overlap (1-548:342-867)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_006 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
320 330 340 350 360 370
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::
XP_006 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEK--------------------
440 450 460 470
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 --TKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
480 490 500 510 520
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
530 540 550 560 570 580
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
590 600 610 620 630 640
340 350 360 370 380 390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
650 660 670 680 690 700
400 410 420 430 440 450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
710 720 730 740 750 760
460 470 480 490 500 510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
770 780 790 800 810 820
520 530 540
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
::::::::::::::::::::::::::::::::::::::
XP_006 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
830 840 850 860
>>XP_011522771 (OMIM: 610591) rho GTPase-activating prot (900 aa)
initn: 2795 init1: 1851 opt: 1913 Z-score: 1388.1 bits: 267.3 E(92320): 1.5e-70
Smith-Waterman score: 3466; 90.5% identity (90.5% similar) in 581 aa overlap (1-548:342-900)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_011 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
320 330 340 350 360 370
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::
XP_011 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEK--------------------
440 450 460 470
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 --TKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
480 490 500 510 520
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
530 540 550 560 570 580
280 290
pF1KE3 QEL---------------------------------SAELPPEESESSRVDFGSSERLGS
::: ::::::::::::::::::::::::
XP_011 QELGSMQLREVNVLRLTGGGPAAGSRPRLSEAMGIQSAELPPEESESSRVDFGSSERLGS
590 600 610 620 630 640
300 310 320 330 340 350
pF1KE3 WQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCA
650 660 670 680 690 700
360 370 380 390 400 410
pF1KE3 LAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDD
710 720 730 740 750 760
420 430 440 450 460 470
pF1KE3 GRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPN
770 780 790 800 810 820
480 490 500 510 520 530
pF1KE3 HDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELI
830 840 850 860 870 880
540
pF1KE3 LQQCADIFPPH
:::::::::::
XP_011 LQQCADIFPPH
890 900
>>XP_011522776 (OMIM: 610591) rho GTPase-activating prot (581 aa)
initn: 1888 init1: 1888 opt: 1888 Z-score: 1372.8 bits: 263.9 E(92320): 1.1e-69
Smith-Waterman score: 3662; 94.3% identity (94.3% similar) in 581 aa overlap (1-548:1-581)
10 20 30 40 50 60
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
190 200 210 220 230 240
250 260 270
pF1KE3 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQEL---------------------------
:::::::::::::::::::::::::::::::::
XP_011 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELGSMQLREVNVLRLTGGGPAAGSRPRLS
250 260 270 280 290 300
280 290 300 310 320
pF1KE3 ------SAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAMGIQSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE3 HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE3 DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE3 RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI
490 500 510 520 530 540
510 520 530 540
pF1KE3 VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
:::::::::::::::::::::::::::::::::::::::::
XP_011 VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
550 560 570 580
>>XP_016879802 (OMIM: 610591) rho GTPase-activating prot (629 aa)
initn: 1958 init1: 1888 opt: 1888 Z-score: 1372.3 bits: 263.9 E(92320): 1.2e-69
Smith-Waterman score: 1888; 99.6% identity (100.0% similar) in 274 aa overlap (1-274:342-615)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_016 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
320 330 340 350 360 370
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
440 450 460 470 480 490
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
500 510 520 530 540 550
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
560 570 580 590 600 610
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
:::.
XP_016 QELAHWWRTRSWLKAPPL
620
>>XP_006721813 (OMIM: 610591) rho GTPase-activating prot (615 aa)
initn: 1887 init1: 1887 opt: 1887 Z-score: 1371.7 bits: 263.8 E(92320): 1.2e-69
Smith-Waterman score: 1887; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:342-614)
10 20 30
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYP
::::::::::::::::::::::::::::::
XP_006 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
320 330 340 350 360 370
40 50 60 70 80 90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
440 450 460 470 480 490
160 170 180 190 200 210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
500 510 520 530 540 550
220 230 240 250 260 270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
560 570 580 590 600 610
280 290 300 310 320 330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
:::
XP_006 QELR
548 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:33:16 2019 done: Thu Oct 24 21:33:17 2019
Total Scan time: 5.530 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]