Result of FASTA (omim) for
pF1KE3526
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3526, 1036 aa
1>>>pF1KE3526 1036 - 1036 aa - 1036 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.0915+/-0.000454; mu= -23.8096+/- 0.028
mean_var=502.5339+/-104.573, 0's: 0 Z-trim(122.8): 57 B-trim: 1985 in 1/57
Lambda= 0.057213
statistics sampled from 43101 (43158) to 43101 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.47), width: 16
Scan time: 8.510
The best scores are: opt bits E(91774)
NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 6851 580.8 1.6e-164
XP_011516568 (OMIM: 609205) disabled homolog 2-int (1153) 6851 580.8 1.6e-164
XP_011516572 (OMIM: 609205) disabled homolog 2-int (1065) 6829 578.9 5.3e-164
NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 6829 578.9 5.3e-164
XP_016869789 (OMIM: 609205) disabled homolog 2-int (1065) 6829 578.9 5.3e-164
XP_011516573 (OMIM: 609205) disabled homolog 2-int (1065) 6829 578.9 5.3e-164
XP_024303186 (OMIM: 609205) disabled homolog 2-int (1125) 6829 579.0 5.6e-164
XP_024303185 (OMIM: 609205) disabled homolog 2-int (1128) 6829 579.0 5.6e-164
XP_016869788 (OMIM: 609205) disabled homolog 2-int (1141) 6829 579.0 5.6e-164
XP_005251778 (OMIM: 609205) disabled homolog 2-int (1161) 6829 579.0 5.7e-164
XP_016869787 (OMIM: 609205) disabled homolog 2-int (1164) 6829 579.0 5.7e-164
XP_011516566 (OMIM: 609205) disabled homolog 2-int (1182) 6829 579.0 5.8e-164
XP_005251776 (OMIM: 609205) disabled homolog 2-int (1189) 6829 579.0 5.8e-164
XP_011516567 (OMIM: 609205) disabled homolog 2-int (1160) 3805 329.4 7.9e-89
XP_011516569 (OMIM: 609205) disabled homolog 2-int (1131) 3800 328.9 1e-88
NP_004832 (OMIM: 606136) ras GTPase-activating pro (1139) 3742 324.2 2.8e-87
XP_011508469 (OMIM: 606136) ras GTPase-activating (1287) 3742 324.2 3.2e-87
XP_016858339 (OMIM: 606136) ras GTPase-activating (1416) 3742 324.2 3.4e-87
XP_005245679 (OMIM: 606136) ras GTPase-activating (1142) 3628 314.7 1.9e-84
XP_016858343 (OMIM: 606136) ras GTPase-activating (1145) 3628 314.7 1.9e-84
XP_016858342 (OMIM: 606136) ras GTPase-activating (1234) 3628 314.8 2.1e-84
XP_011508468 (OMIM: 606136) ras GTPase-activating (1290) 3628 314.8 2.2e-84
XP_016858338 (OMIM: 606136) ras GTPase-activating (1419) 3628 314.8 2.3e-84
NP_733793 (OMIM: 606136) ras GTPase-activating pro (1280) 3110 272.0 1.6e-71
XP_016858341 (OMIM: 606136) ras GTPase-activating (1409) 3110 272.0 1.7e-71
XP_016858344 (OMIM: 606136) ras GTPase-activating (1138) 3100 271.2 2.5e-71
XP_016858340 (OMIM: 606136) ras GTPase-activating (1412) 3100 271.2 3.1e-71
NP_001123538 (OMIM: 603384,612621) ras/Rap GTPase- (1292) 1765 161.0 4.2e-38
NP_006763 (OMIM: 603384,612621) ras/Rap GTPase-act (1343) 1727 157.9 3.8e-37
XP_024307424 (OMIM: 616561) RAS protein activator (1005) 1510 139.9 7.3e-32
NP_075055 (OMIM: 616561) RAS protein activator lik (1011) 1506 139.6 9.3e-32
XP_011526488 (OMIM: 616561) RAS protein activator (1008) 1472 136.8 6.5e-31
XP_011526489 (OMIM: 616561) RAS protein activator ( 949) 1468 136.4 7.7e-31
XP_011526487 (OMIM: 616561) RAS protein activator (1014) 1468 136.4 8.2e-31
NP_001334957 (OMIM: 616561) RAS protein activator ( 568) 1008 98.4 1.3e-19
NP_001334956 (OMIM: 616561) RAS protein activator ( 574) 1004 98.0 1.7e-19
NP_072179 (OMIM: 139150,605462,608354) ras GTPase- ( 870) 635 67.7 3.6e-10
NP_002881 (OMIM: 139150,605462,608354) ras GTPase- (1047) 635 67.7 4.2e-10
NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 435 51.1 3.1e-05
XP_011533144 (OMIM: 605182) ras GTPase-activating ( 802) 435 51.1 3.1e-05
XP_011533143 (OMIM: 605182) ras GTPase-activating ( 802) 435 51.1 3.1e-05
NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 435 51.1 3.2e-05
XP_016862459 (OMIM: 601589) ras GTPase-activating ( 707) 398 48.0 0.00023
XP_024309459 (OMIM: 601589) ras GTPase-activating ( 792) 398 48.1 0.00025
NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 398 48.1 0.00027
NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 398 48.1 0.00027
XP_011511361 (OMIM: 601589) ras GTPase-activating ( 853) 398 48.1 0.00027
NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 398 48.1 0.00027
XP_016862458 (OMIM: 601589) ras GTPase-activating ( 871) 398 48.1 0.00028
XP_016862457 (OMIM: 601589) ras GTPase-activating ( 872) 398 48.1 0.00028
>>NP_115941 (OMIM: 609205) disabled homolog 2-interactin (1132 aa)
initn: 6851 init1: 6851 opt: 6851 Z-score: 3075.3 bits: 580.8 E(91774): 1.6e-164
Smith-Waterman score: 6851; 100.0% identity (100.0% similar) in 1036 aa overlap (1-1036:97-1132)
10 20 30
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEE
::::::::::::::::::::::::::::::
NP_115 KLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEE
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE3 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE3 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE3 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE3 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE3 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE3 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE3 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE3 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE3 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE3 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE3 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
730 740 750 760 770 780
700 710 720 730 740 750
pF1KE3 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
790 800 810 820 830 840
760 770 780 790 800 810
pF1KE3 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
850 860 870 880 890 900
820 830 840 850 860 870
pF1KE3 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
910 920 930 940 950 960
880 890 900 910 920 930
pF1KE3 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
970 980 990 1000 1010 1020
940 950 960 970 980 990
pF1KE3 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
1030 1040 1050 1060 1070 1080
1000 1010 1020 1030
pF1KE3 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
1090 1100 1110 1120 1130
>>XP_011516568 (OMIM: 609205) disabled homolog 2-interac (1153 aa)
initn: 6851 init1: 6851 opt: 6851 Z-score: 3075.2 bits: 580.8 E(91774): 1.6e-164
Smith-Waterman score: 6851; 100.0% identity (100.0% similar) in 1036 aa overlap (1-1036:118-1153)
10 20 30
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEE
::::::::::::::::::::::::::::::
XP_011 KLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEE
90 100 110 120 130 140
40 50 60 70 80 90
pF1KE3 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
150 160 170 180 190 200
100 110 120 130 140 150
pF1KE3 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
210 220 230 240 250 260
160 170 180 190 200 210
pF1KE3 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
270 280 290 300 310 320
220 230 240 250 260 270
pF1KE3 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
330 340 350 360 370 380
280 290 300 310 320 330
pF1KE3 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
390 400 410 420 430 440
340 350 360 370 380 390
pF1KE3 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
450 460 470 480 490 500
400 410 420 430 440 450
pF1KE3 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
510 520 530 540 550 560
460 470 480 490 500 510
pF1KE3 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
570 580 590 600 610 620
520 530 540 550 560 570
pF1KE3 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
630 640 650 660 670 680
580 590 600 610 620 630
pF1KE3 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
690 700 710 720 730 740
640 650 660 670 680 690
pF1KE3 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
750 760 770 780 790 800
700 710 720 730 740 750
pF1KE3 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
810 820 830 840 850 860
760 770 780 790 800 810
pF1KE3 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
870 880 890 900 910 920
820 830 840 850 860 870
pF1KE3 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
930 940 950 960 970 980
880 890 900 910 920 930
pF1KE3 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
990 1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KE3 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030
pF1KE3 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
1110 1120 1130 1140 1150
>>XP_011516572 (OMIM: 609205) disabled homolog 2-interac (1065 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.9 bits: 578.9 E(91774): 5.3e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:1-1033)
10 20 30 40 50 60
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
970 980 990 1000 1010 1020
1030
pF1KE3 NARLMSALTQLKESMH
:::::::::::::
XP_011 NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC
1030 1040 1050 1060
>>NP_619723 (OMIM: 609205) disabled homolog 2-interactin (1065 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.9 bits: 578.9 E(91774): 5.3e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:1-1033)
10 20 30 40 50 60
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
970 980 990 1000 1010 1020
1030
pF1KE3 NARLMSALTQLKESMH
:::::::::::::
NP_619 NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC
1030 1040 1050 1060
>>XP_016869789 (OMIM: 609205) disabled homolog 2-interac (1065 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.9 bits: 578.9 E(91774): 5.3e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:1-1033)
10 20 30 40 50 60
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
970 980 990 1000 1010 1020
1030
pF1KE3 NARLMSALTQLKESMH
:::::::::::::
XP_016 NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC
1030 1040 1050 1060
>>XP_011516573 (OMIM: 609205) disabled homolog 2-interac (1065 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.9 bits: 578.9 E(91774): 5.3e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:1-1033)
10 20 30 40 50 60
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
970 980 990 1000 1010 1020
1030
pF1KE3 NARLMSALTQLKESMH
:::::::::::::
XP_011 NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC
1030 1040 1050 1060
>>XP_024303186 (OMIM: 609205) disabled homolog 2-interac (1125 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.5 bits: 579.0 E(91774): 5.6e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:61-1093)
10 20 30
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEE
::::::::::::::::::::::::::::::
XP_024 KLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEE
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE3 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE3 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE3 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE3 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE3 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE3 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE3 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE3 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE3 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE3 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE3 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
700 710 720 730 740 750
700 710 720 730 740 750
pF1KE3 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
760 770 780 790 800 810
760 770 780 790 800 810
pF1KE3 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
820 830 840 850 860 870
820 830 840 850 860 870
pF1KE3 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
880 890 900 910 920 930
880 890 900 910 920 930
pF1KE3 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
940 950 960 970 980 990
940 950 960 970 980 990
pF1KE3 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
1000 1010 1020 1030 1040 1050
1000 1010 1020 1030
pF1KE3 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
:::::::::::::::::::::::::::::::::::::::::::
XP_024 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK
1060 1070 1080 1090 1100 1110
XP_024 LQITENGEFRNSSNC
1120
>>XP_024303185 (OMIM: 609205) disabled homolog 2-interac (1128 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.5 bits: 579.0 E(91774): 5.6e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:64-1096)
10 20 30
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEE
::::::::::::::::::::::::::::::
XP_024 PDLAPEPRGLQVPRTRSAERPALPPQRSHLMPRLKESRSHESLLSPSSAVEALDLSMEEE
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE3 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE3 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE3 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE3 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE3 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE3 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE3 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE3 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE3 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE3 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE3 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
700 710 720 730 740 750
700 710 720 730 740 750
pF1KE3 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
760 770 780 790 800 810
760 770 780 790 800 810
pF1KE3 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
820 830 840 850 860 870
820 830 840 850 860 870
pF1KE3 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
880 890 900 910 920 930
880 890 900 910 920 930
pF1KE3 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
940 950 960 970 980 990
940 950 960 970 980 990
pF1KE3 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
1000 1010 1020 1030 1040 1050
1000 1010 1020 1030
pF1KE3 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
:::::::::::::::::::::::::::::::::::::::::::
XP_024 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK
1060 1070 1080 1090 1100 1110
XP_024 LQITENGEFRNSSNC
1120
>>XP_016869788 (OMIM: 609205) disabled homolog 2-interac (1141 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.4 bits: 579.0 E(91774): 5.6e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:77-1109)
10 20 30
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEE
::::::::::::::::::::::::::::::
XP_016 VFPRNMPFSALSLAGVRTLCTRMRGLVSHLMPRLKESRSHESLLSPSSAVEALDLSMEEE
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE3 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
110 120 130 140 150 160
100 110 120 130 140 150
pF1KE3 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
170 180 190 200 210 220
160 170 180 190 200 210
pF1KE3 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
230 240 250 260 270 280
220 230 240 250 260 270
pF1KE3 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
290 300 310 320 330 340
280 290 300 310 320 330
pF1KE3 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
350 360 370 380 390 400
340 350 360 370 380 390
pF1KE3 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
410 420 430 440 450 460
400 410 420 430 440 450
pF1KE3 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
470 480 490 500 510 520
460 470 480 490 500 510
pF1KE3 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
530 540 550 560 570 580
520 530 540 550 560 570
pF1KE3 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
590 600 610 620 630 640
580 590 600 610 620 630
pF1KE3 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
650 660 670 680 690 700
640 650 660 670 680 690
pF1KE3 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
710 720 730 740 750 760
700 710 720 730 740 750
pF1KE3 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
770 780 790 800 810 820
760 770 780 790 800 810
pF1KE3 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
830 840 850 860 870 880
820 830 840 850 860 870
pF1KE3 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
890 900 910 920 930 940
880 890 900 910 920 930
pF1KE3 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
950 960 970 980 990 1000
940 950 960 970 980 990
pF1KE3 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
1010 1020 1030 1040 1050 1060
1000 1010 1020 1030
pF1KE3 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
:::::::::::::::::::::::::::::::::::::::::::
XP_016 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK
1070 1080 1090 1100 1110 1120
XP_016 LQITENGEFRNSSNC
1130 1140
>>XP_005251778 (OMIM: 609205) disabled homolog 2-interac (1161 aa)
initn: 6829 init1: 6829 opt: 6829 Z-score: 3065.3 bits: 579.0 E(91774): 5.7e-164
Smith-Waterman score: 6829; 100.0% identity (100.0% similar) in 1033 aa overlap (1-1033:97-1129)
10 20 30
pF1KE3 MPRLKESRSHESLLSPSSAVEALDLSMEEE
::::::::::::::::::::::::::::::
XP_005 KLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEE
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE3 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHI
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE3 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVH
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE3 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE3 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLT
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE3 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE3 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISE
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE3 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE3 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQS
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE3 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGL
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE3 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDA
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE3 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSE
730 740 750 760 770 780
700 710 720 730 740 750
pF1KE3 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGS
790 800 810 820 830 840
760 770 780 790 800 810
pF1KE3 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGR
850 860 870 880 890 900
820 830 840 850 860 870
pF1KE3 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPV
910 920 930 940 950 960
880 890 900 910 920 930
pF1KE3 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTK
970 980 990 1000 1010 1020
940 950 960 970 980 990
pF1KE3 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK
1030 1040 1050 1060 1070 1080
1000 1010 1020 1030
pF1KE3 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
:::::::::::::::::::::::::::::::::::::::::::
XP_005 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK
1090 1100 1110 1120 1130 1140
XP_005 LQITENGEFRNSSNC
1150 1160
1036 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:39:59 2019 done: Tue Jul 16 15:40:01 2019
Total Scan time: 8.510 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]