Result of FASTA (omim) for
pF1KE2689
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2689, 562 aa
1>>>pF1KE2689 562 - 562 aa - 562 aa
Library: /omim/omim.rfq.tfa
62035967 residues in 87258 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0491+/-0.000285; mu= 15.3118+/- 0.018
mean_var=78.5742+/-15.337, 0's: 0 Z-trim(118.9): 45 B-trim: 33 in 1/53
Lambda= 0.144689
statistics sampled from 32619 (32664) to 32619 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.374), width: 16
Scan time: 9.640
The best scores are: opt bits E(87258)
NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 3917 827.0 0
NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 2522 535.8 1.4e-151
XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 2510 533.3 7.7e-151
XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 2380 506.1 1.2e-142
XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 2368 503.6 6.8e-142
NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 1872 400.1 1e-110
NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 1761 376.9 9.5e-104
NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 1757 376.1 1.6e-103
NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 1727 369.9 1.5e-101
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 1245 269.1 1.5e-71
NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 1019 222.0 3.8e-57
NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 1019 222.0 3.9e-57
NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 1019 222.0 3.9e-57
NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 753 166.5 1.9e-40
NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 583 131.0 1.1e-29
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 479 109.3 2.9e-23
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 273 66.3 3.4e-10
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 251 61.8 8.4e-09
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 251 61.8 8.7e-09
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 251 61.8 9.1e-09
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 210 53.2 3e-06
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 208 52.8 4.1e-06
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 208 52.8 4.1e-06
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 208 52.8 4.1e-06
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 208 52.8 4.2e-06
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 165 43.8 0.0021
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 165 43.8 0.0021
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 165 43.8 0.0022
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 165 43.8 0.0022
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 165 43.8 0.0023
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 165 43.8 0.0023
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 165 43.8 0.0024
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 165 43.8 0.0024
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 165 43.8 0.0024
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 165 43.8 0.0024
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 165 43.8 0.0025
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 165 43.8 0.0025
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 165 43.8 0.0025
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 165 43.8 0.0025
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 165 43.8 0.0026
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 165 43.8 0.0026
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 165 43.8 0.0026
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 165 43.8 0.0027
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 165 43.9 0.0028
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 165 43.9 0.0028
>>NP_001243759 (OMIM: 602866) acid-sensing ion channel 1 (562 aa)
initn: 3917 init1: 3917 opt: 3917 Z-score: 4416.1 bits: 827.0 E(87258): 0
Smith-Waterman score: 3917; 100.0% identity (100.0% similar) in 562 aa overlap (1-562:1-562)
10 20 30 40 50 60
pF1KE2 MPIQIFCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPIQIFCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 TLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 PGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 MVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKAS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAG
490 500 510 520 530 540
550 560
pF1KE2 MTYAANILPHHPARGTFEDFTC
::::::::::::::::::::::
NP_001 MTYAANILPHHPARGTFEDFTC
550 560
>>NP_001086 (OMIM: 602866) acid-sensing ion channel 1 is (528 aa)
initn: 2814 init1: 2515 opt: 2522 Z-score: 2842.8 bits: 535.8 E(87258): 1.4e-151
Smith-Waterman score: 2794; 78.9% identity (88.7% similar) in 522 aa overlap (53-562:7-528)
30 40 50 60 70 80
pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE
.: : .:... :::.: :::: :::
NP_001 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY
10 20 30
90 100 110 120 130 140
pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN
. ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: :
NP_001 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN
40 50 60 70 80 90
150 160 170 180 190
pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR
:.::.: :: . . .:.: .. . : . .: ..:. .:::...
NP_001 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
::.:. : ..:::: : ..: :. ..:.:::::::::::::::::::::::::::::::
NP_001 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE2 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE2 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE2 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE2 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH
460 470 480 490 500 510
560
pF1KE2 HPARGTFEDFTC
::::::::::::
NP_001 HPARGTFEDFTC
520
>>XP_011536654 (OMIM: 602866) PREDICTED: acid-sensing io (529 aa)
initn: 2018 init1: 1733 opt: 2510 Z-score: 2829.2 bits: 533.3 E(87258): 7.7e-151
Smith-Waterman score: 2782; 78.8% identity (88.5% similar) in 523 aa overlap (53-562:7-529)
30 40 50 60 70 80
pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE
.: : .:... :::.: :::: :::
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY
10 20 30
90 100 110 120 130 140
pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN
. ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: :
XP_011 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN
40 50 60 70 80 90
150 160 170 180 190
pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR
:.::.: :: . . .:.: .. . : . .: ..:. .:::...
XP_011 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
::.:. : ..:::: : ..: :. ..:.:::::::::::::::::::::::::::::::
XP_011 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
220 230 240 250 260 270
320 330 340 350 360
pF1KE2 EQR-LIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAP
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQRQLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAP
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 YCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFN
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 KSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFD
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 YAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILP
460 470 480 490 500 510
550 560
pF1KE2 HHPARGTFEDFTC
:::::::::::::
XP_011 HHPARGTFEDFTC
520
>>XP_011536653 (OMIM: 602866) PREDICTED: acid-sensing io (559 aa)
initn: 2771 init1: 2377 opt: 2380 Z-score: 2682.2 bits: 506.1 E(87258): 1.2e-142
Smith-Waterman score: 2722; 74.5% identity (83.7% similar) in 553 aa overlap (53-562:7-559)
30 40 50 60 70 80
pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE
.: : .:... :::.: :::: :::
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY
10 20 30
90 100 110 120 130 140
pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN
. ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: :
XP_011 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN
40 50 60 70 80 90
150 160 170 180 190
pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR
:.::.: :: . . .:.: .. . : . .: ..:. .:::...
XP_011 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE
100 110 120 130 140 150
200 210 220
pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSV------------------------------
::.:. : ..:::: : ..: :. ..:.:
XP_011 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEK
160 170 180 190 200 210
230 240 250 260 270
pF1KE2 -VFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE2 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSY
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE2 SITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEM
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 PCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKA
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE2 YEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVA
460 470 480 490 500 510
520 530 540 550 560
pF1KE2 LSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
:::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
520 530 540 550
>>XP_011536652 (OMIM: 602866) PREDICTED: acid-sensing io (560 aa)
initn: 2127 init1: 1733 opt: 2368 Z-score: 2668.6 bits: 503.6 E(87258): 6.8e-142
Smith-Waterman score: 2710; 74.4% identity (83.6% similar) in 554 aa overlap (53-562:7-560)
30 40 50 60 70 80
pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE
.: : .:... :::.: :::: :::
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY
10 20 30
90 100 110 120 130 140
pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN
. ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: :
XP_011 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN
40 50 60 70 80 90
150 160 170 180 190
pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR
:.::.: :: . . .:.: .. . : . .: ..:. .:::...
XP_011 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE
100 110 120 130 140 150
200 210 220
pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSV------------------------------
::.:. : ..:::: : ..: :. ..:.:
XP_011 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEK
160 170 180 190 200 210
230 240 250 260 270
pF1KE2 -VFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE2 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQR-LIYLPPPWGTCKAVTMDSDLDFFDS
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_011 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRQLIYLPPPWGTCKAVTMDSDLDFFDS
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE2 YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCE
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 MPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKK
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE2 AYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGV
460 470 480 490 500 510
520 530 540 550 560
pF1KE2 ALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
520 530 540 550 560
>>NP_064423 (OMIM: 602866) acid-sensing ion channel 1 is (574 aa)
initn: 2142 init1: 1857 opt: 1872 Z-score: 2108.9 bits: 400.1 E(87258): 1e-110
Smith-Waterman score: 2579; 71.8% identity (81.0% similar) in 554 aa overlap (53-548:7-560)
30 40 50 60 70 80
pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE
.: : .:... :::.: :::: :::
NP_064 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY
10 20 30
90 100 110 120 130 140
pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN
. ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: :
NP_064 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN
40 50 60 70 80 90
150 160 170 180 190
pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR
:.::.: :: . . .:.: .. . : . .: ..:. .:::...
NP_064 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
::.:. : ..:::: : ..: :. ..:.:::::::::::::::::::::::::::::::
NP_064 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE2 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE2 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK
340 350 360 370 380 390
440 450 460
pF1KE2 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLG-----------------------
:::::::::::::::::::::::::::::::::::::
NP_064 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKA
400 410 420 430 440 450
470 480 490 500
pF1KE2 -----------------------DIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGK
:::::::::::::::::::::::::::::::::::::
NP_064 GCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGK
460 470 480 490 500 510
510 520 530 540 550 560
pF1KE2 CQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
::::::::::::::::::::::::::::::::::::::::::::
NP_064 CQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
520 530 540 550 560 570
>>NP_899233 (OMIM: 601784) acid-sensing ion channel 2 is (563 aa)
initn: 1178 init1: 979 opt: 1761 Z-score: 1983.8 bits: 376.9 E(87258): 9.5e-104
Smith-Waterman score: 1964; 59.5% identity (76.6% similar) in 516 aa overlap (73-562:66-563)
50 60 70 80 90
pF1KE2 EEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFV----EGGPGPRQVLWAVAFVL
::: :. . :: :..::..::
NP_899 GQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCT
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE2 ALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLA
..: .: ..:. :.::.: : ... . .: :::::.::.: .:. .:: :: : .
NP_899 SFGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAG
100 110 120 130 140 150
160 170 180 190
pF1KE2 PMLGLDESDDPGVPLAPPGPEAFSG-EP----------FNL-----H------RFYNRSC
::: . . ::. : . : :: : : : :..:
NP_899 HWLGLLLPNRTARPLVS---ELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLG
160 170 180 190 200 210
200 210 220 230 240 250
pF1KE2 HRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIML
:.:::::: :.:.: ::::::: :::.::::: ::::.::.: : :.::::::::::::
NP_899 HQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIML
220 230 240 250 260 270
260 270 280 290 300 310
pF1KE2 DIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIY
:::::::::.::::.::.::::.:::::::.:::::..:::::::::::::: ::::: :
NP_899 DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE2 LPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQY
:::::: :.. : :::: ::::::::::::::.::::::::::::::::.:::::.
NP_899 LPPPWGECRSSEMG--LDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQH
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE2 KECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIG
::::.::: .:.:::..::.:. :::::::.:::::::::::.::::: :::::::.::.
NP_899 KECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE2 ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIK
:::::::::::.:::::::::::::.:.:::::::::::::::::::.:::::: ::.::
NP_899 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE2 HKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGT
.:: :: ..: :..:. :... .: .....:. : . . ::
NP_899 EKLL--DLLGKEEDEGSHDENVST----------CDTMPNHSETISHTVNV-PLQTTLGT
520 530 540 550
560
pF1KE2 FEDFTC
.:...:
NP_899 LEEIAC
560
>>NP_001085 (OMIM: 601784) acid-sensing ion channel 2 is (512 aa)
initn: 1291 init1: 979 opt: 1757 Z-score: 1979.9 bits: 376.1 E(87258): 1.6e-103
Smith-Waterman score: 2088; 60.6% identity (79.8% similar) in 525 aa overlap (51-562:3-512)
30 40 50 60 70
pF1KE2 LGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGH-SPMDLVAFANSCTLHGTNHI
... ::: .: .. :::. :::: ::
NP_001 MDLKESPSEGSLQPSSIQIFANTSTLHGIRHI
10 20 30
80 90 100 110 120 130
pF1KE2 FVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLC
:: : :.:::::::: .:: .: . ..::.::.:: ::: ..::.. :.:::::::
NP_001 FVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLC
40 50 60 70 80 90
140 150 160 170 180
pF1KE2 NTNAVRLSQLSYPDLLYLAPMLGLDESDD--PGVPLAPPGP-EA---------FSGEPFN
: :. :.:.:. :: . . .:.: . . : :: :. :: .. . :.
NP_001 NLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGG
. .: .: : :.::.:::...: :: ..:..:::.::::: ::::.::.: : :.:::
NP_001 MLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 TGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFV
::::::::::::::::::.::::.::.::::.:::::::.:::::..:::::::::::::
NP_001 TGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFV
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 ACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGD
: ::::: ::::::: :.. : :::: ::::::::::::::.::::::::::::::
NP_001 ATQEQRLTYLPPPWGECRSSEMG--LDFFPVYSITACRIDCETRYIVENCNCRMVHMPGD
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 APYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKK
::.:::::.::::.::: .:.:::..::.:. :::::::.:::::::::::.::::: ::
NP_001 APFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKK
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 FNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL
:::::.::.:::::::::::.:::::::::::::.:.:::::::::::::::::::.:::
NP_001 FNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILEL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 FDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANI
::: ::.::.:: :: ..: :..:. :... .: .....:.
NP_001 FDYIYELIKEKLL--DLLGKEEDEGSHDENVST----------CDTMPNHSETISHTVNV
460 470 480 490
550 560
pF1KE2 LPHHPARGTFEDFTC
: . . ::.:...:
NP_001 -PLQTTLGTLEEIAC
500 510
>>NP_061144 (OMIM: 606715) acid-sensing ion channel 4 is (666 aa)
initn: 1208 init1: 848 opt: 1727 Z-score: 1944.3 bits: 369.9 E(87258): 1.5e-101
Smith-Waterman score: 1727; 49.8% identity (72.5% similar) in 546 aa overlap (36-562:136-666)
10 20 30 40 50 60
pF1KE2 FCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEA-----SEGHS
:. .::. . ::::: ... . : .
NP_061 PGLLAREGQGREALASPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAA
110 120 130 140 150 160
70 80 90 100 110
pF1KE2 PMDLVAFANSCTLHGTNHIFVEGGPGP---RQVLWAVAFVLALGAFLCQVGDRVAYYLSY
: ::..::.. :::: .. :::: :..:::.:.. .:.::: :.. . ::.
NP_061 PRDLATFASTSTLHGLGRAC---GPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTR
170 180 190 200 210 220
120 130 140 150 160 170
pF1KE2 PHVTLLNEVATTELA-FPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPG---VPL
::.. .. .: . .: :::::::: : : : :: :...:: . :: .: : . :
NP_061 PHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGL
230 240 250 260 270 280
180 190 200 210 220 230
pF1KE2 APPGPEAFSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNS
: :. . . ::. :.: ::: :...: :. :::::.::::::::::.
NP_061 RYPEPDMVD--------ILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA
290 300 310 320 330
240 250 260 270 280 290
pF1KE2 GRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFID
: : : . :: :.::::::::::.::::.: ::.::::::::.::::::.:::.:
NP_061 --DPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIH
340 350 360 370 380 390
300 310 320 330 340 350
pF1KE2 QLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTM--DSDLDFFDSYSITACRIDCETR
::::::.:::::::.:::::: ::: :::.:.: . . .:. ...::..:::. :: .
NP_061 QLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKE
400 410 420 430 440 450
360 370 380 390 400 410
pF1KE2 YLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELS
... :.::::::::. : :. : :::: .:: : . : : ::::::::::.:
NP_061 AVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGKEIS
460 470 480 490 500 510
420 430 440 450 460 470
pF1KE2 MVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGG
::.::...::.:::.:.:..: :: ::.::::.:::.:. :..::. :: ...::::.::
NP_061 MVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGG
520 530 540 550 560 570
480 490 500 510 520 530
pF1KE2 QMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPC
::::::::::::.::..:: ::: .: : . : :.:. .:.:...:...::
NP_061 QMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPC
580 590 600 610 620 630
540 550 560
pF1KE2 ESLRGHPAGMTYAANILPHH-----PARGTFEDFTC
: ::. : ....::.: : : ::::.:
NP_061 PS-RGRVEG-GGVSSLLPNHHHPHGPPGGLFEDFAC
640 650 660
>>XP_016859928 (OMIM: 606715) PREDICTED: acid-sensing io (320 aa)
initn: 1257 init1: 739 opt: 1245 Z-score: 1405.5 bits: 269.1 E(87258): 1.5e-71
Smith-Waterman score: 1245; 56.4% identity (79.1% similar) in 321 aa overlap (249-562:2-320)
220 230 240 250 260 270
pF1KE2 SVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAG
:.::::::::::.::::.: ::.:::::::
XP_016 MGSGLEIMLDIQQEEYLPIWRETNETSFEAG
10 20 30
280 290 300 310 320 330
pF1KE2 IKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTM--DSDLDFF
:.::::::.:::.: ::::::.:::::::.:::::: ::: :::.:.: . . .:. .
XP_016 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY
40 50 60 70 80 90
340 350 360 370 380 390
pF1KE2 DSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCV
..::..:::. :: . ... :.::::::::. : :. : :::: .:: : . :
XP_016 SAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCF
100 110 120 130 140 150
400 410 420 430 440 450
pF1KE2 CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ
: ::::::::::.:::.::...::.:::.:.:..: :: ::.::::.:::.:. :..::
XP_016 CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQ
160 170 180 190 200 210
460 470 480 490 500 510
pF1KE2 KKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADK
. :: ...::::.::::::::::::::.::..:: ::: .: : . : :.:.
XP_016 RAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGG
220 230 240 250 260 270
520 530 540 550 560
pF1KE2 GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHH-----PARGTFEDFTC
.:.:...:...:: : ::. : ....::.: : : ::::.:
XP_016 ISTLGLQELKEQSPCPS-RGRVEGGG-VSSLLPNHHHPHGPPGGLFEDFAC
280 290 300 310 320
562 residues in 1 query sequences
62035967 residues in 87258 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Jun 2 11:44:49 2017 done: Fri Jun 2 11:44:51 2017
Total Scan time: 9.640 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]