Result of FASTA (omim) for
pF1KE2633
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2633, 862 aa
1>>>pF1KE2633 862 - 862 aa - 862 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.9704+/-0.000665; mu= -31.6619+/- 0.041
mean_var=619.2008+/-127.140, 0's: 0 Z-trim(116.0): 86 B-trim: 209 in 1/54
Lambda= 0.051542
statistics sampled from 26819 (26891) to 26819 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.315), width: 16
Scan time: 10.360
The best scores are: opt bits E(85289)
NP_004694 (OMIM: 603616) rab GTPase-binding effect ( 862) 5422 419.5 3.3e-116
NP_001278510 (OMIM: 603616) rab GTPase-binding eff ( 819) 5079 394.0 1.5e-108
NP_001077054 (OMIM: 603616) rab GTPase-binding eff ( 829) 4835 375.8 4.4e-103
XP_016880784 (OMIM: 603616) PREDICTED: rab GTPase- ( 552) 3378 267.4 1.3e-70
XP_011522362 (OMIM: 603616) PREDICTED: rab GTPase- ( 884) 3178 252.6 5.7e-66
XP_016880783 (OMIM: 603616) PREDICTED: rab GTPase- ( 574) 3123 248.4 6.8e-65
NP_001278511 (OMIM: 603616) rab GTPase-binding eff ( 190) 1135 100.3 8.7e-21
NP_079092 (OMIM: 611869) rab GTPase-binding effect ( 569) 397 45.7 0.00071
XP_011537117 (OMIM: 605070) PREDICTED: early endos (1365) 387 45.2 0.0024
NP_003557 (OMIM: 605070) early endosome antigen 1 (1411) 387 45.2 0.0025
XP_016875507 (OMIM: 605070) PREDICTED: early endos (1417) 387 45.2 0.0025
XP_011537116 (OMIM: 605070) PREDICTED: early endos (1453) 387 45.2 0.0026
>>NP_004694 (OMIM: 603616) rab GTPase-binding effector p (862 aa)
initn: 5422 init1: 5422 opt: 5422 Z-score: 2207.3 bits: 419.5 E(85289): 3.3e-116
Smith-Waterman score: 5422; 100.0% identity (100.0% similar) in 862 aa overlap (1-862:1-862)
10 20 30 40 50 60
pF1KE2 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
790 800 810 820 830 840
850 860
pF1KE2 LERIRAILNDTKLTDINQLPET
::::::::::::::::::::::
NP_004 LERIRAILNDTKLTDINQLPET
850 860
>>NP_001278510 (OMIM: 603616) rab GTPase-binding effecto (819 aa)
initn: 5079 init1: 5079 opt: 5079 Z-score: 2069.8 bits: 394.0 E(85289): 1.5e-108
Smith-Waterman score: 5079; 99.9% identity (100.0% similar) in 809 aa overlap (54-862:11-819)
30 40 50 60 70 80
pF1KE2 INAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQA
.:::::::::::::::::::::::::::::
NP_001 MAQPGPASQPDEDLKRQNAVLQAAQDDLGHLRTQLWEAQA
10 20 30 40
90 100 110 120 130 140
pF1KE2 EMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQW
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE2 AQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLT
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE2 EAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE2 HLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQED
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE2 DEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE2 LPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE2 GADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVS
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE2 PSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLM
470 480 490 500 510 520
570 580 590 600 610 620
pF1KE2 LRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRD
530 540 550 560 570 580
630 640 650 660 670 680
pF1KE2 VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLK
590 600 610 620 630 640
690 700 710 720 730 740
pF1KE2 YREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISS
650 660 670 680 690 700
750 760 770 780 790 800
pF1KE2 LKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNK
710 720 730 740 750 760
810 820 830 840 850 860
pF1KE2 AQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
770 780 790 800 810
>>NP_001077054 (OMIM: 603616) rab GTPase-binding effecto (829 aa)
initn: 4846 init1: 4797 opt: 4835 Z-score: 1971.6 bits: 375.8 E(85289): 4.4e-103
Smith-Waterman score: 5159; 96.2% identity (96.2% similar) in 862 aa overlap (1-862:1-829)
10 20 30 40 50 60
pF1KE2 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE
:::::::::::::::::::::::::::::::::::::
NP_001 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ-----------------------
730 740 750
790 800 810 820 830 840
pF1KE2 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
760 770 780 790 800
850 860
pF1KE2 LERIRAILNDTKLTDINQLPET
::::::::::::::::::::::
NP_001 LERIRAILNDTKLTDINQLPET
810 820
>>XP_016880784 (OMIM: 603616) PREDICTED: rab GTPase-bind (552 aa)
initn: 3378 init1: 3378 opt: 3378 Z-score: 1388.7 bits: 267.4 E(85289): 1.3e-70
Smith-Waterman score: 3378; 99.8% identity (100.0% similar) in 542 aa overlap (321-862:11-552)
300 310 320 330 340 350
pF1KE2 QRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVC
.:::::::::::::::::::::::::::::
XP_016 MLRNCGKNCMKEDDEQQRLNKRKDHKKADVEEEIKIPVVC
10 20 30 40
360 370 380 390 400 410
pF1KE2 ALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDS
50 60 70 80 90 100
420 430 440 450 460 470
pF1KE2 LGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK
110 120 130 140 150 160
480 490 500 510 520 530
pF1KE2 DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG
170 180 190 200 210 220
540 550 560 570 580 590
pF1KE2 RRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE
230 240 250 260 270 280
600 610 620 630 640 650
pF1KE2 DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND
290 300 310 320 330 340
660 670 680 690 700 710
pF1KE2 SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK
350 360 370 380 390 400
720 730 740 750 760 770
pF1KE2 EQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLE
410 420 430 440 450 460
780 790 800 810 820 830
pF1KE2 SLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQV
470 480 490 500 510 520
840 850 860
pF1KE2 QLERIRQADSLERIRAILNDTKLTDINQLPET
::::::::::::::::::::::::::::::::
XP_016 QLERIRQADSLERIRAILNDTKLTDINQLPET
530 540 550
>>XP_011522362 (OMIM: 603616) PREDICTED: rab GTPase-bind (884 aa)
initn: 3098 init1: 3098 opt: 3178 Z-score: 1305.3 bits: 252.6 E(85289): 5.7e-66
Smith-Waterman score: 5368; 97.5% identity (97.5% similar) in 884 aa overlap (1-862:1-884)
10 20 30 40 50 60
pF1KE2 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
310 320 330 340 350 360
370 380 390
pF1KE2 LSNEE----------------------EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMF
::::: :::::::::::::::::::::::::::::::::
XP_011 LSNEEKTPFKIKITDRSSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMF
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 KDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLG
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 SLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLL
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 QKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDK
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 QELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 ESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQ
790 800 810 820 830 840
820 830 840 850 860
pF1KE2 RDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
850 860 870 880
>>XP_016880783 (OMIM: 603616) PREDICTED: rab GTPase-bind (574 aa)
initn: 3098 init1: 3098 opt: 3123 Z-score: 1286.0 bits: 248.4 E(85289): 6.8e-65
Smith-Waterman score: 3324; 95.9% identity (96.1% similar) in 564 aa overlap (321-862:11-574)
300 310 320 330 340 350
pF1KE2 QRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVC
.:::::::::::::::::::::::::::::
XP_016 MLRNCGKNCMKEDDEQQRLNKRKDHKKADVEEEIKIPVVC
10 20 30 40
360 370 380
pF1KE2 ALTQEESSAQLSNEE----------------------EHLDSTRGSVHSLDAGLLLPSGD
::::::::::::::: :::::::::::::::::::::::
XP_016 ALTQEESSAQLSNEEKTPFKIKITDRSSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGD
50 60 70 80 90 100
390 400 410 420 430 440
pF1KE2 PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSV
110 120 130 140 150 160
450 460 470 480 490 500
pF1KE2 SENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR
170 180 190 200 210 220
510 520 530 540 550 560
pF1KE2 LVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAN
230 240 250 260 270 280
570 580 590 600 610 620
pF1KE2 DQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQM
290 300 310 320 330 340
630 640 650 660 670 680
pF1KE2 AVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDI
350 360 370 380 390 400
690 700 710 720 730 740
pF1KE2 INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL
410 420 430 440 450 460
750 760 770 780 790 800
pF1KE2 ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQ
470 480 490 500 510 520
810 820 830 840 850 860
pF1KE2 TELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
530 540 550 560 570
>>NP_001278511 (OMIM: 603616) rab GTPase-binding effecto (190 aa)
initn: 1128 init1: 1128 opt: 1135 Z-score: 494.2 bits: 100.3 E(85289): 8.7e-21
Smith-Waterman score: 1135; 94.7% identity (95.8% similar) in 190 aa overlap (1-190:1-190)
10 20 30 40 50 60
pF1KE2 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: .
NP_001 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKDPIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
:. :: :
NP_001 DTILHLVVSP
190
>>NP_079092 (OMIM: 611869) rab GTPase-binding effector p (569 aa)
initn: 691 init1: 267 opt: 397 Z-score: 190.6 bits: 45.7 E(85289): 0.00071
Smith-Waterman score: 704; 28.9% identity (51.3% similar) in 816 aa overlap (52-862:21-569)
30 40 50 60 70 80
pF1KE2 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA
: :.. ....: .: . .:..::..: :
NP_079 MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGA
10 20 30 40 50
90 100 110 120 130 140
pF1KE2 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT
::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.:::
NP_079 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ
60 70 80 90 100
150 160 170 180 190 200
pF1KE2 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK
: : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: :
NP_079 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE2 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE
: .::. :.:.
NP_079 LLRAEELIQEI-------------------------------------------------
170 180
270 280 290 300 310 320
pF1KE2 VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQ
:.: .: : .. ..: : :: : :. .:::
NP_079 ------QRRPRHAPSLH----GSTELLP----LSRD--------PSPPLEPLEEL-----
190 200 210
330 340 350 360 370 380
pF1KE2 EDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAG
: :.:
NP_079 -------------------------------------------------------SGDGG
390 400 410 420 430 440
pF1KE2 LLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGP
:... :... .: :.:..: .:: .:
NP_079 ---PAAEAFAHNCDD-----------------SASISSFSLG-------GG---------
220 230 240
450 460 470 480 490 500
pF1KE2 LVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAY
::..: ..: : : ....:::::::::.:. : :. :
NP_079 -VGSSS-------------SLP--------QSR--QGLSPEQEETASLVSTGTLVPEGIY
250 260 270
510 520 530 540 550 560
pF1KE2 VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ
. : ::.:: .:.:. :: : :: ::: .:
NP_079 LPPPGYQLVPDTQWEQLQTE--------GR----------QLQ---------KD------
280 290 300
570 580 590 600 610 620
pF1KE2 LMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAK
::.. ....::.. ...:.:: ..:...:. ..: :: ::. :: .:::.
NP_079 ---------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQ
310 320 330 340 350
630 640 650 660 670
pF1KE2 RDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAEDFILPDTTEA
. :: ::: :. ... . .:. ::...:..:.... . : :.:. ::...
NP_079 ERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPE
360 370 380 390 400 410
680 690 700 710 720 730
pF1KE2 LRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKE
:..:. :.. : .: :.:. ::. :.: .. : . .:: :... :. .
NP_079 LQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEV
420 430 440 450 460 470
740 750 760 770 780 790
pF1KE2 EIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQL
::. ::..:.::.. :. .:: . .:
NP_079 LEASLCSLRTEMERVQQEQ---------------------------------SKAQLPDL
480 490 500
800 810 820 830 840 850
pF1KE2 MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDI
. :.. :. :::.::..:::::::::.:::.:::.:::::::..::..:.:.... :::.
NP_079 LSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDV
510 520 530 540 550 560
860
pF1KE2 NQLPET
.. .:
NP_079 RDIKDT
>>XP_011537117 (OMIM: 605070) PREDICTED: early endosome (1365 aa)
initn: 158 init1: 73 opt: 387 Z-score: 180.9 bits: 45.2 E(85289): 0.0024
Smith-Waterman score: 428; 22.7% identity (57.0% similar) in 904 aa overlap (12-833:319-1177)
10 20 30 40
pF1KE2 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQ
: :... .:.. :. ...: ....
XP_011 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL----SEVETKYQH
290 300 310 320 330 340
50 60 70 80 90
pF1KE2 KRAKFKELYLAKEEDLKRQNAV-LQAAQDDLGH--LRT--QLWEAQAEMENIKAIATVSE
.:.::.: .:: :.:... ::. ..: :.: :: ::...... . ... .
XP_011 LKAEFKQLQQQREE--KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL
350 360 370 380 390 400
100 110 120 130 140
pF1KE2 NTKQEAIDEVK-------RQWREEVAS---LQAVMKETVRDYEHQFHLRLEQERTQWAQY
:.. . ... .: .:.:.. :: . .: . .:: . :.: : :.
XP_011 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ--QHQEQQALQQSTT--AKL
410 420 430 440 450
150 160 170 180 190
pF1KE2 RESAEREIADLRRRLSE-GQEEENLENEMKKAQEDA-------EKLRSVVMPMEKEIAAL
:: :. .. .. :.... :. .::: ..:..:. : : . .. : : :.:
XP_011 RE-AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL
460 470 480 490 500 510
200 210 220 230 240 250
pF1KE2 KDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKE
..: : . ..: .. ...:.. :..:. . .:. : ... . :. . .:.
XP_011 -NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS
520 530 540 550 560 570
260 270 280 290 300 310
pF1KE2 LHEVCHLLEQERQQHNQLKHTWQKANDQFL---ESQRLLMR-DMQ-RMEIVLTSEQLRQV
..:. :.. ... .:: ::. ..: :. . .: :.: ... . .. : .:
XP_011 VNELNSQLNESKEKVSQLD-IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ
580 590 600 610 620 630
320 330 340 350 360 370
pF1KE2 EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRG
: : : :. .:. ...: ...: ..: .:. .: .. :.:. :
XP_011 ELNKITTQLDQVTAKLQDKQEHC-SQLESHLK-------EYKEKYLSLEQKTEELE---G
640 650 660 670 680
380 390 400 410 420 430
pF1KE2 SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN
....:.: : . : .. ..: .. : . .: .. :: : .. . :.
XP_011 QIKKLEADSL-----EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR
690 700 710 720 730
440 450 460 470
pF1KE2 LD--------ESDFGPLVGADS----VSENFDTAS----LGSLQMPSGFMLTKDQERAIK
:: :: :. . ....:.: : . .. . .. : . . .:
XP_011 LDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK
740 750 760 770 780 790
480 490 500 510 520 530
pF1KE2 ----AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC
:. : . . ::.:....... ... :.: .. ..: .
XP_011 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM
800 810 820 830 840 850
540 550 560 570 580
pF1KE2 DMCSNYEKQLQGIQIQEAETRDQVK----KLQLMLRQANDQLEKTMKDKQELE---DFIK
. . .:.:. .: :. :.: ..: .: ::.. :... :..:.:. . .:
XP_011 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK
860 870 880 890 900 910
590 600 610 620 630
pF1KE2 QSSEDSSHQISAL-----VLRAQASEILLEELQQGLSQAKRDV---QEQMAVLMQSREQV
::::....:: :: . : .: : ..::: :.:: ... .:...::... :.
XP_011 QSSEQKKKQIEALQGELKIAVLQKTE-LENKLQQQLTQAAQELAAEKEKISVLQNNYEKS
920 930 940 950 960 970
640 650 660 670 680 690
pF1KE2 SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADH-
.: . .::.: . :..: .. .: : . ..: : .::.:. :. .
XP_011 QETFKQLQSD---FYGRESELLATRQ-------DLKSVEEKLSLA-QEDLISNRNQIGNQ
980 990 1000 1010 1020
700 710 720 730 740 750
pF1KE2 ---VEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC-KE-EIASISSLKAELERIK
..: :. . ... . :: :.: . ... :. :: :... .: ::.:.::
XP_011 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK
1030 1040 1050 1060 1070 1080
760 770 780 790 800
pF1KE2 VEKGQLESTLRE--KSQQLESLQEI-------KISLEEQLK---KETAAKATVEQLMFEE
.. . . : : ::..:::..:: .. ....:. : . ::.::: :
XP_011 CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ----E
1090 1100 1110 1120 1130 1140
810 820 830 840 850
pF1KE2 KNKAQRLQTELDVSEQ-VQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQL
: . : :. .. :. ....:.. :. ...
XP_011 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN
1150 1160 1170 1180 1190 1200
860
pF1KE2 PET
XP_011 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL
1210 1220 1230 1240 1250 1260
>>NP_003557 (OMIM: 605070) early endosome antigen 1 [Hom (1411 aa)
initn: 158 init1: 73 opt: 387 Z-score: 180.7 bits: 45.2 E(85289): 0.0025
Smith-Waterman score: 428; 22.7% identity (57.0% similar) in 904 aa overlap (12-833:365-1223)
10 20 30 40
pF1KE2 MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQ
: :... .:.. :. ...: ....
NP_003 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL----SEVETKYQH
340 350 360 370 380 390
50 60 70 80 90
pF1KE2 KRAKFKELYLAKEEDLKRQNAV-LQAAQDDLGH--LRT--QLWEAQAEMENIKAIATVSE
.:.::.: .:: :.:... ::. ..: :.: :: ::...... . ... .
NP_003 LKAEFKQLQQQREE--KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL
400 410 420 430 440
100 110 120 130 140
pF1KE2 NTKQEAIDEVK-------RQWREEVAS---LQAVMKETVRDYEHQFHLRLEQERTQWAQY
:.. . ... .: .:.:.. :: . .: . .:: . :.: : :.
NP_003 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ--QHQEQQALQQSTT--AKL
450 460 470 480 490 500
150 160 170 180 190
pF1KE2 RESAEREIADLRRRLSE-GQEEENLENEMKKAQEDA-------EKLRSVVMPMEKEIAAL
:: :. .. .. :.... :. .::: ..:..:. : : . .. : : :.:
NP_003 RE-AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL
510 520 530 540 550 560
200 210 220 230 240 250
pF1KE2 KDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKE
..: : . ..: .. ...:.. :..:. . .:. : ... . :. . .:.
NP_003 -NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS
570 580 590 600 610 620
260 270 280 290 300 310
pF1KE2 LHEVCHLLEQERQQHNQLKHTWQKANDQFL---ESQRLLMR-DMQ-RMEIVLTSEQLRQV
..:. :.. ... .:: ::. ..: :. . .: :.: ... . .. : .:
NP_003 VNELNSQLNESKEKVSQLD-IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ
630 640 650 660 670 680
320 330 340 350 360 370
pF1KE2 EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRG
: : : :. .:. ...: ...: ..: .:. .: .. :.:. :
NP_003 ELNKITTQLDQVTAKLQDKQEHC-SQLESHLK-------EYKEKYLSLEQKTEELE---G
690 700 710 720 730
380 390 400 410 420 430
pF1KE2 SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN
....:.: : . : .. ..: .. : . .: .. :: : .. . :.
NP_003 QIKKLEADSL-----EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR
740 750 760 770 780
440 450 460 470
pF1KE2 LD--------ESDFGPLVGADS----VSENFDTAS----LGSLQMPSGFMLTKDQERAIK
:: :: :. . ....:.: : . .. . .. : . . .:
NP_003 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK
790 800 810 820 830 840
480 490 500 510 520 530
pF1KE2 ----AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC
:. : . . ::.:....... ... :.: .. ..: .
NP_003 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM
850 860 870 880 890 900
540 550 560 570 580
pF1KE2 DMCSNYEKQLQGIQIQEAETRDQVK----KLQLMLRQANDQLEKTMKDKQELE---DFIK
. . .:.:. .: :. :.: ..: .: ::.. :... :..:.:. . .:
NP_003 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK
910 920 930 940 950 960
590 600 610 620 630
pF1KE2 QSSEDSSHQISAL-----VLRAQASEILLEELQQGLSQAKRDV---QEQMAVLMQSREQV
::::....:: :: . : .: : ..::: :.:: ... .:...::... :.
NP_003 QSSEQKKKQIEALQGELKIAVLQKTE-LENKLQQQLTQAAQELAAEKEKISVLQNNYEKS
970 980 990 1000 1010 1020
640 650 660 670 680 690
pF1KE2 SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADH-
.: . .::.: . :..: .. .: : . ..: : .::.:. :. .
NP_003 QETFKQLQSD---FYGRESELLATRQ-------DLKSVEEKLSLA-QEDLISNRNQIGNQ
1030 1040 1050 1060 1070
700 710 720 730 740 750
pF1KE2 ---VEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC-KE-EIASISSLKAELERIK
..: :. . ... . :: :.: . ... :. :: :... .: ::.:.::
NP_003 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK
1080 1090 1100 1110 1120 1130
760 770 780 790 800
pF1KE2 VEKGQLESTLRE--KSQQLESLQEI-------KISLEEQLK---KETAAKATVEQLMFEE
.. . . : : ::..:::..:: .. ....:. : . ::.::: :
NP_003 CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ----E
1140 1150 1160 1170 1180
810 820 830 840 850
pF1KE2 KNKAQRLQTELDVSEQ-VQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQL
: . : :. .. :. ....:.. :. ...
NP_003 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN
1190 1200 1210 1220 1230 1240
860
pF1KE2 PET
NP_003 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL
1250 1260 1270 1280 1290 1300
862 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:38:15 2016 done: Tue Nov 8 16:38:16 2016
Total Scan time: 10.360 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]