Result of FASTA (omim) for
pF1KE2589
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2589, 972 aa
1>>>pF1KE2589 972 - 972 aa - 972 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4304+/-0.000405; mu= 1.6751+/- 0.025
mean_var=203.3310+/-41.534, 0's: 0 Z-trim(118.4): 29 B-trim: 1527 in 1/52
Lambda= 0.089944
statistics sampled from 31326 (31355) to 31326 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.368), width: 16
Scan time: 10.490
The best scores are: opt bits E(85289)
NP_055502 (OMIM: 613516,615705) run domain Beclin- ( 972) 6528 860.6 0
XP_006713891 (OMIM: 613516,615705) PREDICTED: run ( 997) 3939 524.6 9.7e-148
XP_016863033 (OMIM: 613516,615705) PREDICTED: run ( 820) 3773 503.0 2.5e-141
XP_016863034 (OMIM: 613516,615705) PREDICTED: run ( 820) 3773 503.0 2.5e-141
NP_001139114 (OMIM: 613516,615705) run domain Becl ( 927) 3773 503.1 2.8e-141
XP_005269431 (OMIM: 613516,615705) PREDICTED: run ( 987) 3773 503.1 2.9e-141
XP_016863032 (OMIM: 613516,615705) PREDICTED: run ( 830) 2792 375.8 5.3e-103
XP_006713890 (OMIM: 613516,615705) PREDICTED: run (1012) 2782 374.5 1.5e-102
XP_006713893 (OMIM: 613516,615705) PREDICTED: run ( 845) 2605 351.5 1.1e-95
XP_006713894 (OMIM: 613516,615705) PREDICTED: run ( 845) 2605 351.5 1.1e-95
XP_006713892 (OMIM: 613516,615705) PREDICTED: run ( 952) 2605 351.5 1.2e-95
XP_016880943 (OMIM: 611466,611497) PREDICTED: plec ( 531) 485 76.3 4.8e-13
XP_011523830 (OMIM: 611466,611497) PREDICTED: plec ( 535) 485 76.3 4.8e-13
XP_006722264 (OMIM: 611466,611497) PREDICTED: plec ( 926) 485 76.4 7.6e-13
XP_016880942 (OMIM: 611466,611497) PREDICTED: plec ( 926) 485 76.4 7.6e-13
XP_016880941 (OMIM: 611466,611497) PREDICTED: plec ( 967) 485 76.4 7.9e-13
XP_011523828 (OMIM: 611466,611497) PREDICTED: plec ( 989) 485 76.4 8.1e-13
XP_011523827 (OMIM: 611466,611497) PREDICTED: plec (1005) 485 76.4 8.2e-13
NP_055613 (OMIM: 611466,611497) pleckstrin homolog (1056) 485 76.4 8.5e-13
XP_011523825 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 76.4 8.5e-13
XP_011523826 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 76.4 8.5e-13
XP_016880940 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 76.4 8.5e-13
>>NP_055502 (OMIM: 613516,615705) run domain Beclin-1-in (972 aa)
initn: 6528 init1: 6528 opt: 6528 Z-score: 4589.2 bits: 860.6 E(85289): 0
Smith-Waterman score: 6528; 100.0% identity (100.0% similar) in 972 aa overlap (1-972:1-972)
10 20 30 40 50 60
pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 CAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 LIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 GHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAE
910 920 930 940 950 960
970
pF1KE2 ALALEAAVLEAT
::::::::::::
NP_055 ALALEAAVLEAT
970
>>XP_006713891 (OMIM: 613516,615705) PREDICTED: run doma (997 aa)
initn: 3939 init1: 3939 opt: 3939 Z-score: 2773.3 bits: 524.6 E(85289): 9.7e-148
Smith-Waterman score: 6468; 97.5% identity (97.5% similar) in 997 aa overlap (1-972:1-997)
10 20 30 40 50 60
pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR
490 500 510 520 530 540
550 560 570 580 590
pF1KE2 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEG
550 560 570 580 590 600
600 610 620 630
pF1KE2 ---------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLK
:::::::::::::::::::::::::::::::::::::::
XP_006 SNLTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLK
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 QFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAP
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 PRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQ
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 MAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQ
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 LCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGA
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE2 THVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 THVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERL
910 920 930 940 950 960
940 950 960 970
pF1KE2 QARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::::
XP_006 QARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
970 980 990
>>XP_016863033 (OMIM: 613516,615705) PREDICTED: run doma (820 aa)
initn: 5367 init1: 3746 opt: 3773 Z-score: 2658.2 bits: 503.0 E(85289): 2.5e-141
Smith-Waterman score: 5341; 98.2% identity (98.2% similar) in 820 aa overlap (168-972:1-820)
140 150 160 170 180 190
pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
200 210 220 230 240 250
pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
380 390 400 410 420
pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES
::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE2 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE2 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
520 530 540 550 560 570
730 740 750 760 770 780
pF1KE2 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
580 590 600 610 620 630
790 800 810 820 830 840
pF1KE2 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
640 650 660 670 680 690
850 860 870 880 890 900
pF1KE2 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
700 710 720 730 740 750
910 920 930 940 950 960
pF1KE2 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
760 770 780 790 800 810
970
pF1KE2 ALEAAVLEAT
::::::::::
XP_016 ALEAAVLEAT
820
>>XP_016863034 (OMIM: 613516,615705) PREDICTED: run doma (820 aa)
initn: 5367 init1: 3746 opt: 3773 Z-score: 2658.2 bits: 503.0 E(85289): 2.5e-141
Smith-Waterman score: 5341; 98.2% identity (98.2% similar) in 820 aa overlap (168-972:1-820)
140 150 160 170 180 190
pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
200 210 220 230 240 250
pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
380 390 400 410 420
pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES
::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE2 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE2 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
520 530 540 550 560 570
730 740 750 760 770 780
pF1KE2 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
580 590 600 610 620 630
790 800 810 820 830 840
pF1KE2 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
640 650 660 670 680 690
850 860 870 880 890 900
pF1KE2 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
700 710 720 730 740 750
910 920 930 940 950 960
pF1KE2 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
760 770 780 790 800 810
970
pF1KE2 ALEAAVLEAT
::::::::::
XP_016 ALEAAVLEAT
820
>>NP_001139114 (OMIM: 613516,615705) run domain Beclin-1 (927 aa)
initn: 6098 init1: 3746 opt: 3773 Z-score: 2657.4 bits: 503.1 E(85289): 2.8e-141
Smith-Waterman score: 6072; 98.4% identity (98.4% similar) in 927 aa overlap (61-972:1-927)
40 50 60 70 80 90
pF1KE2 NLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRW
::::::::::::::::::::::::::::::
NP_001 MQSILYHGLIRDQACRRQTDYWQFVKDIRW
10 20 30
100 110 120 130 140 150
pF1KE2 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE2 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE2 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE2 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE2 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
280 290 300 310 320 330
400 410 420 430
pF1KE2 EGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ESCNDKAKLRGPLPY
:::::::::::::::::::::::::::::: :::::::::::::::
NP_001 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE2 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE2 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE2 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE2 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE2 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE2 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE2 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL
760 770 780 790 800 810
860 870 880 890 900 910
pF1KE2 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC
820 830 840 850 860 870
920 930 940 950 960 970
pF1KE2 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
880 890 900 910 920
>>XP_005269431 (OMIM: 613516,615705) PREDICTED: run doma (987 aa)
initn: 6514 init1: 3746 opt: 3773 Z-score: 2657.0 bits: 503.1 E(85289): 2.9e-141
Smith-Waterman score: 6488; 98.5% identity (98.5% similar) in 987 aa overlap (1-972:1-987)
10 20 30 40 50 60
pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
370 380 390 400 410 420
430 440 450 460
pF1KE2 ---------------ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE2 ADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAA
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE2 SELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVH
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 PAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRK
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 WDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKT
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE2 CRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQ
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE2 AKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQ
910 920 930 940 950 960
950 960 970
pF1KE2 SLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::
XP_005 SLESYLSDYEEEPAEALALEAAVLEAT
970 980
>>XP_016863032 (OMIM: 613516,615705) PREDICTED: run doma (830 aa)
initn: 2792 init1: 2792 opt: 2792 Z-score: 1970.2 bits: 375.8 E(85289): 5.3e-103
Smith-Waterman score: 5321; 97.0% identity (97.0% similar) in 830 aa overlap (168-972:1-830)
140 150 160 170 180 190
pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
200 210 220 230 240 250
pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSG
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE2 QSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFS
280 290 300 310 320 330
500 510 520 530 540 550
pF1KE2 ISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQE
340 350 360 370 380 390
560 570 580 590
pF1KE2 AEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD---------------------
:::::::::::::::::::::::::::::::::::::::
XP_016 AEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSNLTHISKNGLSVSLAS
400 410 420 430 440 450
600 610 620 630 640 650
pF1KE2 ----ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
460 470 480 490 500 510
660 670 680 690 700 710
pF1KE2 PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKI
520 530 540 550 560 570
720 730 740 750 760 770
pF1KE2 AVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYY
580 590 600 610 620 630
780 790 800 810 820 830
pF1KE2 VSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL
640 650 660 670 680 690
840 850 860 870 880 890
pF1KE2 LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICE
700 710 720 730 740 750
900 910 920 930 940 950
pF1KE2 FCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLS
760 770 780 790 800 810
960 970
pF1KE2 DYEEEPAEALALEAAVLEAT
::::::::::::::::::::
XP_016 DYEEEPAEALALEAAVLEAT
820 830
>>XP_006713890 (OMIM: 613516,615705) PREDICTED: run doma (1012 aa)
initn: 5373 init1: 2782 opt: 2782 Z-score: 1961.9 bits: 374.5 E(85289): 1.5e-102
Smith-Waterman score: 6386; 96.0% identity (96.0% similar) in 1004 aa overlap (1-964:1-1004)
10 20 30 40 50 60
pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
370 380 390 400 410 420
430 440 450 460
pF1KE2 ---------------ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
:::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
550 560 570 580 590 600
590 600 610 620
pF1KE2 ADEVDEFEIQD-------------------------ADIRRNTASSSKSFVSSQSFSHCF
::::::::::: ::::::::::::::::::::::::
XP_006 ADEVDEFEIQDGSEGSNLTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCF
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 LHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADI
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCE
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 YLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALY
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 RKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRK
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 GELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYH
910 920 930 940 950 960
930 940 950 960 970
pF1KE2 KACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
::::::::::::::::::::::::::::::::::::::::::::
XP_006 KACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
970 980 990 1000 1010
>>XP_006713893 (OMIM: 613516,615705) PREDICTED: run doma (845 aa)
initn: 4226 init1: 2605 opt: 2605 Z-score: 1838.9 bits: 351.5 E(85289): 1.1e-95
Smith-Waterman score: 5281; 95.3% identity (95.3% similar) in 845 aa overlap (168-972:1-845)
140 150 160 170 180 190
pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_006 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
200 210 220 230 240 250
pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
380 390 400 410 420
pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES
::::::::::::::::::::::::::::::::::::::::::: ::
XP_006 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
550 560 570 580 590
pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN
400 410 420 430 440 450
600 610 620 630
pF1KE2 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
:::::::::::::::::::::::::::::::::::::::::
XP_006 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE2 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE2 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE2 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE2 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
700 710 720 730 740 750
880 890 900 910 920 930
pF1KE2 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
760 770 780 790 800 810
940 950 960 970
pF1KE2 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::
XP_006 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
820 830 840
>>XP_006713894 (OMIM: 613516,615705) PREDICTED: run doma (845 aa)
initn: 4226 init1: 2605 opt: 2605 Z-score: 1838.9 bits: 351.5 E(85289): 1.1e-95
Smith-Waterman score: 5281; 95.3% identity (95.3% similar) in 845 aa overlap (168-972:1-845)
140 150 160 170 180 190
pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_006 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
200 210 220 230 240 250
pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
380 390 400 410 420
pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES
::::::::::::::::::::::::::::::::::::::::::: ::
XP_006 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
550 560 570 580 590
pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN
400 410 420 430 440 450
600 610 620 630
pF1KE2 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
:::::::::::::::::::::::::::::::::::::::::
XP_006 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE2 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE2 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE2 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE2 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
700 710 720 730 740 750
880 890 900 910 920 930
pF1KE2 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
760 770 780 790 800 810
940 950 960 970
pF1KE2 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::
XP_006 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
820 830 840
972 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:44:02 2016 done: Tue Nov 8 16:44:04 2016
Total Scan time: 10.490 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]