Result of FASTA (omim) for
pF1KE2527
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2527, 1870 aa
1>>>pF1KE2527 1870 - 1870 aa - 1870 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 19.2527+/-0.000751; mu= -43.5729+/- 0.046
mean_var=864.6833+/-180.727, 0's: 0 Z-trim(115.8): 725 B-trim: 0 in 0/56
Lambda= 0.043616
statistics sampled from 26763 (27483) to 26763 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.596), E-opt: 0.2 (0.299), width: 16
Scan time: 10.950
The best scores are: opt bits E(91774)
NP_001129069 (OMIM: 609736,617507) girdin isoform (1870) 11711 754.8 1.9e-216
NP_001352409 (OMIM: 609736,617507) girdin isoform (1871) 11699 754.1 3.2e-216
XP_011531268 (OMIM: 609736,617507) girdin isoform (1871) 11699 754.1 3.2e-216
XP_016859965 (OMIM: 609736,617507) girdin isoform (2026) 11584 746.9 5.2e-214
XP_005264475 (OMIM: 609736,617507) girdin isoform (2027) 11572 746.1 8.7e-214
NP_001241872 (OMIM: 609736,617507) girdin isoform (1796) 10850 700.6 3.7e-200
XP_016859970 (OMIM: 609736,617507) girdin isoform (1797) 10838 699.9 6.3e-200
XP_011531270 (OMIM: 609736,617507) girdin isoform (1797) 10838 699.9 6.3e-200
XP_016859969 (OMIM: 609736,617507) girdin isoform (1952) 10220 661.0 3.4e-188
XP_005264478 (OMIM: 609736,617507) girdin isoform (1844) 9879 639.6 9.5e-182
XP_016859966 (OMIM: 609736,617507) girdin isoform (2000) 9879 639.6 1e-181
XP_011531269 (OMIM: 609736,617507) girdin isoform (1843) 9088 589.8 9.1e-167
NP_060554 (OMIM: 609736,617507) girdin isoform 2 [ (1843) 9088 589.8 9.1e-167
XP_016859968 (OMIM: 609736,617507) girdin isoform (1972) 9088 589.8 9.6e-167
XP_016859967 (OMIM: 609736,617507) girdin isoform (1999) 9088 589.8 9.7e-167
XP_005264483 (OMIM: 609736,617507) girdin isoform (1311) 8113 528.3 2e-148
XP_005267748 (OMIM: 236600,611204,616053) protein (1535) 4059 273.3 1.4e-71
XP_016876824 (OMIM: 236600,611204,616053) protein (1577) 4059 273.3 1.5e-71
NP_001073883 (OMIM: 236600,611204,616053) protein (2028) 4059 273.4 1.8e-71
XP_011535098 (OMIM: 236600,611204,616053) protein (1992) 3930 265.2 4.9e-69
XP_016876826 (OMIM: 236600,611204,616053) protein ( 921) 3428 233.5 8.3e-60
XP_016876825 (OMIM: 236600,611204,616053) protein (1055) 1511 112.9 1.9e-23
NP_115627 (OMIM: 611205) coiled-coil domain-contai (1476) 856 71.7 6.5e-11
XP_024304219 (OMIM: 611205) coiled-coil domain-con (1529) 856 71.7 6.6e-11
XP_011543262 (OMIM: 611205) coiled-coil domain-con (1528) 841 70.8 1.3e-10
XP_006718582 (OMIM: 611205) coiled-coil domain-con (1560) 832 70.2 1.9e-10
XP_016873090 (OMIM: 611205) coiled-coil domain-con ( 959) 821 69.4 2.1e-10
XP_011543261 (OMIM: 611205) coiled-coil domain-con (1555) 688 61.2 1e-07
XP_024304218 (OMIM: 611205) coiled-coil domain-con (1608) 688 61.2 1.1e-07
XP_011543259 (OMIM: 611205) coiled-coil domain-con (1639) 664 59.7 3.1e-07
XP_011537117 (OMIM: 605070) early endosome antigen (1365) 647 58.6 5.5e-07
NP_003557 (OMIM: 605070) early endosome antigen 1 (1411) 647 58.6 5.7e-07
XP_011537116 (OMIM: 605070) early endosome antigen (1453) 647 58.6 5.8e-07
XP_016863148 (OMIM: 117143,616051) centromere-asso (2551) 618 56.9 3.3e-06
XP_011529850 (OMIM: 117143,616051) centromere-asso (2604) 587 54.9 1.3e-05
NP_001273663 (OMIM: 117143,616051) centromere-asso (2580) 583 54.7 1.5e-05
XP_011529849 (OMIM: 117143,616051) centromere-asso (2605) 583 54.7 1.5e-05
XP_016883107 (OMIM: 609689,618358) centrosome-asso (2198) 571 53.9 2.3e-05
XP_011526821 (OMIM: 609689,618358) centrosome-asso (2240) 571 53.9 2.3e-05
XP_011526820 (OMIM: 609689,618358) centrosome-asso (2319) 571 53.9 2.4e-05
XP_016883106 (OMIM: 609689,618358) centrosome-asso (2332) 571 53.9 2.4e-05
XP_011526819 (OMIM: 609689,618358) centrosome-asso (2355) 571 53.9 2.4e-05
XP_005260320 (OMIM: 609689,618358) centrosome-asso (2370) 571 53.9 2.4e-05
NP_115786 (OMIM: 607825) protein Hook homolog 3 [H ( 718) 548 52.2 2.4e-05
XP_006723757 (OMIM: 609689,618358) centrosome-asso (2404) 571 53.9 2.4e-05
XP_005260319 (OMIM: 609689,618358) centrosome-asso (2442) 571 53.9 2.5e-05
NP_009117 (OMIM: 609689,618358) centrosome-associa (2442) 571 53.9 2.5e-05
XP_006723753 (OMIM: 609689,618358) centrosome-asso (2442) 571 53.9 2.5e-05
XP_006723755 (OMIM: 609689,618358) centrosome-asso (2442) 571 53.9 2.5e-05
XP_006723756 (OMIM: 609689,618358) centrosome-asso (2442) 571 53.9 2.5e-05
>>NP_001129069 (OMIM: 609736,617507) girdin isoform 1 [H (1870 aa)
initn: 11711 init1: 11711 opt: 11711 Z-score: 4007.5 bits: 754.8 E(91774): 1.9e-216
Smith-Waterman score: 11711; 99.9% identity (100.0% similar) in 1870 aa overlap (1-1870:1-1870)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_001 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS
1810 1820 1830 1840 1850 1860
1870
pF1KE2 KSRSREQQSS
::::::::::
NP_001 KSRSREQQSS
1870
>>NP_001352409 (OMIM: 609736,617507) girdin isoform 4 [H (1871 aa)
initn: 5914 init1: 5914 opt: 11699 Z-score: 4003.4 bits: 754.1 E(91774): 3.2e-216
Smith-Waterman score: 11699; 99.9% identity (99.9% similar) in 1871 aa overlap (1-1870:1-1871)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_001 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
NP_001 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
1810 1820 1830 1840 1850 1860
1860 1870
pF1KE2 SKSRSREQQSS
:::::::::::
NP_001 SKSRSREQQSS
1870
>>XP_011531268 (OMIM: 609736,617507) girdin isoform X7 [ (1871 aa)
initn: 5914 init1: 5914 opt: 11699 Z-score: 4003.4 bits: 754.1 E(91774): 3.2e-216
Smith-Waterman score: 11699; 99.9% identity (99.9% similar) in 1871 aa overlap (1-1870:1-1871)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
1810 1820 1830 1840 1850 1860
1860 1870
pF1KE2 SKSRSREQQSS
:::::::::::
XP_011 SKSRSREQQSS
1870
>>XP_016859965 (OMIM: 609736,617507) girdin isoform X2 [ (2026 aa)
initn: 12005 init1: 11584 opt: 11584 Z-score: 3963.8 bits: 746.9 E(91774): 5.2e-214
Smith-Waterman score: 11584; 99.9% identity (100.0% similar) in 1850 aa overlap (1-1850:1-1850)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_016 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS
:::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASSEYHLHQWSSH
1810 1820 1830 1840 1850 1860
1870
pF1KE2 KSRSREQQSS
XP_016 ILDIPTHTIGSCAQNDLAIDMPEPLYAQARNSRTGRSHFLNQTFATIRMPSDAFGMLAKD
1870 1880 1890 1900 1910 1920
>>XP_005264475 (OMIM: 609736,617507) girdin isoform X1 [ (2027 aa)
initn: 11570 init1: 5914 opt: 11572 Z-score: 3959.7 bits: 746.1 E(91774): 8.7e-214
Smith-Waterman score: 11572; 99.8% identity (99.9% similar) in 1851 aa overlap (1-1850:1-1851)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_005 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_005 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASSEYHLHQWSS
1810 1820 1830 1840 1850 1860
1860 1870
pF1KE2 SKSRSREQQSS
XP_005 HILDIPTHTIGSCAQNDLAIDMPEPLYAQARNSRTGRSHFLNQTFATIRMPSDAFGMLAK
1870 1880 1890 1900 1910 1920
>>NP_001241872 (OMIM: 609736,617507) girdin isoform 3 [H (1796 aa)
initn: 11253 init1: 10832 opt: 10850 Z-score: 3714.9 bits: 700.6 E(91774): 3.7e-200
Smith-Waterman score: 11064; 96.0% identity (96.0% similar) in 1870 aa overlap (1-1870:1-1796)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_001 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA---------
1690 1700 1710 1720 1730
1750 1760 1770 1780 1790 1800
pF1KE2 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT
NP_001 ------------------------------------------------------------
1810 1820 1830 1840 1850 1860
pF1KE2 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----SVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS
1740 1750 1760 1770 1780
1870
pF1KE2 KSRSREQQSS
::::::::::
NP_001 KSRSREQQSS
1790
>>XP_016859970 (OMIM: 609736,617507) girdin isoform X10 (1797 aa)
initn: 10818 init1: 5914 opt: 10838 Z-score: 3710.9 bits: 699.9 E(91774): 6.3e-200
Smith-Waterman score: 11052; 95.9% identity (96.0% similar) in 1871 aa overlap (1-1870:1-1797)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_016 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_016 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA--------
1690 1700 1710 1720 1730
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
XP_016 ------------------------------------------------------------
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ------SVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
1740 1750 1760 1770 1780
1860 1870
pF1KE2 SKSRSREQQSS
:::::::::::
XP_016 SKSRSREQQSS
1790
>>XP_011531270 (OMIM: 609736,617507) girdin isoform X10 (1797 aa)
initn: 10818 init1: 5914 opt: 10838 Z-score: 3710.9 bits: 699.9 E(91774): 6.3e-200
Smith-Waterman score: 11052; 95.9% identity (96.0% similar) in 1871 aa overlap (1-1870:1-1797)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA--------
1690 1700 1710 1720 1730
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
XP_011 ------------------------------------------------------------
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ------SVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
1740 1750 1760 1770 1780
1860 1870
pF1KE2 SKSRSREQQSS
:::::::::::
XP_011 SKSRSREQQSS
1790
>>XP_016859969 (OMIM: 609736,617507) girdin isoform X6 [ (1952 aa)
initn: 10218 init1: 5670 opt: 10220 Z-score: 3500.2 bits: 661.0 E(91774): 3.4e-188
Smith-Waterman score: 10915; 95.8% identity (95.9% similar) in 1851 aa overlap (1-1850:1-1776)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::
XP_016 VKKLLLLLLGCAVQ----------------------------------------------
130
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
:::::::::::::::::::::::::::::::
XP_016 -----------------------------TIIELSEERDGLHFLPHASSSAQSPCGSPGM
140 150 160
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_016 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
350 360 370 380 390 400
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
410 420 430 440 450 460
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
470 480 490 500 510 520
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
530 540 550 560 570 580
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
590 600 610 620 630 640
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
650 660 670 680 690 700
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
710 720 730 740 750 760
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
770 780 790 800 810 820
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_016 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
830 840 850 860 870 880
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
890 900 910 920 930 940
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
950 960 970 980 990 1000
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1010 1020 1030 1040 1050 1060
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1070 1080 1090 1100 1110 1120
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1130 1140 1150 1160 1170 1180
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1190 1200 1210 1220 1230 1240
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1250 1260 1270 1280 1290 1300
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1310 1320 1330 1340 1350 1360
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1370 1380 1390 1400 1410 1420
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1430 1440 1450 1460 1470 1480
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
1490 1500 1510 1520 1530 1540
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1550 1560 1570 1580 1590 1600
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
1610 1620 1630 1640 1650 1660
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
1670 1680 1690 1700 1710 1720
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASSEYHLHQWSS
1730 1740 1750 1760 1770 1780
1860 1870
pF1KE2 SKSRSREQQSS
XP_016 HILDIPTHTIGSCAQNDLAIDMPEPLYAQARNSRTGRSHFLNQTFATIRMPSDAFGMLAK
1790 1800 1810 1820 1830 1840
>>XP_005264478 (OMIM: 609736,617507) girdin isoform X8 [ (1844 aa)
initn: 7582 init1: 5914 opt: 9879 Z-score: 3384.6 bits: 639.6 E(91774): 9.5e-182
Smith-Waterman score: 11470; 98.5% identity (98.5% similar) in 1871 aa overlap (1-1870:1-1844)
10 20 30 40 50 60
pF1KE2 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DARSARMYRDELDALREKAVRVNKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_005 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
850 860 870 880 890 900
910 920 930 940 950
pF1KE2 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_005 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
:::::::::::::::::::::: :::::::::::
XP_005 SFEDISPQGVSDDSSTGSRVHA---------------------------GAVNNQSRPQS
1570 1580 1590
1620 1630 1640 1650 1660 1670
pF1KE2 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
1600 1610 1620 1630 1640 1650
1680 1690 1700 1710 1720 1730
pF1KE2 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
1660 1670 1680 1690 1700 1710
1740 1750 1760 1770 1780 1790
pF1KE2 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
1720 1730 1740 1750 1760 1770
1800 1810 1820 1830 1840 1850
pF1KE2 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
1780 1790 1800 1810 1820 1830
1860 1870
pF1KE2 SKSRSREQQSS
:::::::::::
XP_005 SKSRSREQQSS
1840
1870 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 16:03:40 2019 done: Tue Jul 16 16:03:42 2019
Total Scan time: 10.950 Total Display time: 0.780
Function used was FASTA [36.3.4 Apr, 2011]