Result of FASTA (omim) for
pF1KE2494
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2494, 390 aa
1>>>pF1KE2494 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3320+/-0.000361; mu= 11.8658+/- 0.023
mean_var=90.3001+/-18.604, 0's: 0 Z-trim(114.7): 22 B-trim: 185 in 1/52
Lambda= 0.134968
statistics sampled from 24643 (24661) to 24643 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.289), width: 16
Scan time: 8.650
The best scores are: opt bits E(85289)
NP_001222 (OMIM: 114250,616231) calsequestrin-1 pr ( 396) 2577 512.0 1e-144
NP_001223 (OMIM: 114251,604772,611938) calsequestr ( 399) 1797 360.1 5.3e-99
NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406) 208 50.7 7.5e-06
NP_061895 (OMIM: 616102) protein disulfide-isomera ( 454) 166 42.5 0.0024
NP_000909 (OMIM: 112240,176790) protein disulfide- ( 508) 162 41.8 0.0045
XP_011524337 (OMIM: 616102) PREDICTED: protein dis ( 229) 152 39.7 0.0088
>>NP_001222 (OMIM: 114250,616231) calsequestrin-1 precur (396 aa)
initn: 2577 init1: 2577 opt: 2577 Z-score: 2719.2 bits: 512.0 E(85289): 1e-144
Smith-Waterman score: 2577; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:7-396)
10 20 30 40 50
pF1KE2 MGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSATDRMGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 LGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 KLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 TIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 ETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWME
310 320 330 340 350 360
360 370 380 390
pF1KE2 MDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
::::::::::::::::::::::::::::::::::::
NP_001 MDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
370 380 390
>>NP_001223 (OMIM: 114251,604772,611938) calsequestrin-2 (399 aa)
initn: 1797 init1: 1797 opt: 1797 Z-score: 1898.3 bits: 360.1 E(85289): 5.3e-99
Smith-Waterman score: 1797; 68.4% identity (91.3% similar) in 367 aa overlap (24-390:15-381)
10 20 30 40 50 60
pF1KE2 MGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNVFKKYEV
:. ...:::.:: ::: :::.... ::.:.:.:::..
NP_001 MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDL
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 LALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEV
: : :::: .::..:.::...:..:::.::::: :..:: .::..:.: .:::::. :
NP_001 LCLYYHEPVSSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 DSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYF
:.:..:::..::.::::.::..::::::..:::::.: .. :.:::: ::: :::::.:
NP_001 GSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFF
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 KSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKP
::.:::.:::::.:::.:.::: ::::::. :::::.::.::.:::: ::.::..::.::
NP_001 KSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKP
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 NSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFLETLKAV
.:::.:.::.::.: :::.:.:: :.::::::..:::::::::..::::.:::: :: :
NP_001 YTEEELVEFVKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 AQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWMEMDDEED
:.:::.::::::.::::::::::: :::::: ::: :::::::::::::::::. :..:
NP_001 ARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDD
300 310 320 330 340 350
370 380 390
pF1KE2 LPSAEELEDWLEDVLEGEINTEDDDDDDDD
::.:::::::.:::: :.:::::::.::::
NP_001 LPTAEELEDWIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE
360 370 380 390
>>NP_055866 (OMIM: 609170) endoplasmic reticulum residen (406 aa)
initn: 115 init1: 87 opt: 208 Z-score: 226.1 bits: 50.7 E(85289): 7.5e-06
Smith-Waterman score: 216; 20.8% identity (56.0% similar) in 384 aa overlap (5-382:8-359)
10 20 30 40 50
pF1KE2 MGPRAVPGLRLALLLLLV-LGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNVFK
..: :: .::::.. . :: . .:: ...:...: : .
NP_055 MHPAVFLSLPDLRCSLLLLVTWVFTPVT--TEITSLD---TENIDEILNNADVALVNFYA
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLG
. .. . : : ..:: ..: : . ... : :. :: .. . .:..
NP_055 DWCRFSQMLH--PIFEEAS-------DVIKE---EFPNENQVVFARVDCDQHSDIAQRYR
60 70 80 90 100
120 130 140 150 160 170
pF1KE2 LTEVDSMYVFKGDEVI--EYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEI
... .. .:.. .. :: :. :. ...... . ::.. :. :. ... . .:
NP_055 ISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNI
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE2 KLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPV
::::..:::..:..:: .:. .: :...: . :.: . ..: . :
NP_055 --IGYFEQKDSDNYRVFERVANILHDDCAFLSAFGD-VSKPERYSGDNIIYKPPGHSAPD
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 TIPDKPNSEEEIV-NFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEF
. .. ... :..... .:.. :. : :. . .. : . : ...:.
NP_055 MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLP--FLILFHMKEDTESLEI
230 240 250 260 270
300 310 320 330 340 350
pF1KE2 LETLKAVAQDNTENPDLSIIWIDPDDF--PLLVPYWEKTFDIDLSAPQIGVVNVTDADSV
... ... : .:. .... : : : ::: . .:: . : :.. :.
NP_055 FQN-EVARQLISEKGTINFLHADCDKFRHPLL--HIQKT---PADCPVIAI----DSFRH
280 290 300 310 320
360 370 380 390
pF1KE2 WMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
. . : .:. .:.... :. :... :
NP_055 MYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQ
330 340 350 360 370 380
NP_055 KLAPSEYRYTLLRDRDEL
390 400
>>NP_061895 (OMIM: 616102) protein disulfide-isomerase T (454 aa)
initn: 121 init1: 72 opt: 166 Z-score: 181.1 bits: 42.5 E(85289): 0.0024
Smith-Waterman score: 189; 20.2% identity (55.3% similar) in 302 aa overlap (93-385:68-350)
70 80 90 100 110
pF1KE2 LLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVG----FGLVDSEKDAAVAKKLGLT
:: :..: : .:. . ...:...:.
NP_061 NRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVR
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE2 EVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIG
.. ..::: . .: : . : :.:: : ::. : ::... . ...
NP_061 GYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRV---SGALIRPLPSQQMFEHMQKRHRVFF
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 YFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPD
. . .: . . ::: :. : ::.. . : . .::: :. .: .: . :
NP_061 VYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLK--EMPAVLVFKDETYFVYD
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 KPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADP--DGFEFLET
. . .. ......: .. . .:: : . .: .: . . ..
NP_061 E-YEDGDLSSWINRERFQNYLAMDGFLLYEL--GDTGKLVALAVIDEKNTSVEHTRLKSI
220 230 240 250 260
300 310 320 330 340 350
pF1KE2 LKAVAQDNTE--NPDLSIIWIDPDDFPLLVPYWEKTFDID-LSAPQIGVVNVTDADSVWM
.. ::.: . . :... .: .:. .:. .: :..: . :.:... . .
NP_061 IQEVARDYRDLFHRDFQFGHMDGNDYI-------NTLLMDELTVPTVVVLNTSNQQYFLL
270 280 290 300 310 320
360 370 380 390
pF1KE2 EMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
.... ..:.. ......:.: .... :
NP_061 ----DRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMG
330 340 350 360 370
NP_061 CFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQEQIEESKEQQEPSSGGSV
380 390 400 410 420 430
>>NP_000909 (OMIM: 112240,176790) protein disulfide-isom (508 aa)
initn: 104 init1: 70 opt: 162 Z-score: 176.2 bits: 41.8 E(85289): 0.0045
Smith-Waterman score: 169; 22.4% identity (50.8% similar) in 398 aa overlap (9-383:2-379)
10 20 30 40 50 60
pF1KE2 MGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNVFKKYEV
:: ::: : : . .. : :: . :.:. . .:. ... ..
NP_000 MLRRALLCLAVAALVRA--------DAPEEE--DHVLVLRKSNFAEALAAHKY
10 20 30 40
70 80 90 100 110 120
pF1KE2 LALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEV
: . .. : . :. . .: : : . . .. ::. ... .:.. :.
NP_000 LLVEFYAPWCGHCKALAP-EYAKAAGKLKA---EGSEIRLAKVDATEESDLAQQYGVRGY
50 60 70 80 90
130 140 150 160 170
pF1KE2 DSMYVFK-GDEVI--EYDGEFSADTIVEFLLDVL-EDPVELIEGERELQAFENIEDEIKL
.. :. :: . :: . :: ::..: . : .: . :. .:. .
NP_000 PTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVES--SEVAV
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 IGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTI
::.::. .:. : : .::: . ::: : .: : .: : . . ... : .: .
NP_000 IGFFKDVESDSAKQFLQAAEAIDD-IPFGITSNSDVFSKYQLDKDGVVLFKKF-DEGRNN
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 PDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEA--DPDG----
. ..:....:..... . .. .. . . .. ::. : .. : ::
NP_000 FEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIK-THILLFLPKSVSDYDGKLSN
220 230 240 250 260 270
300 310 320 330 340
pF1KE2 FEFL-ETLKA------VAQDNTENPD-LSIIWIDPDDFPL--LVPYWEKTFDIDLSAPQI
:. :..:. . .:.:.: : .. . .. : :. :. . ..
NP_000 FKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEEL
280 290 300 310 320 330
350 360 370 380 390
pF1KE2 GVVNVTDADSVWMEMDDEEDLPSAEELEDWLED---VLEGEINTEDDDDDDDD
. .:. ..: . : : : ::: .. :: :. : ::
NP_000 TAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGK-NFEDVAFDEKKNVFVEFY
340 350 360 370 380 390
NP_000 APWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRT
400 410 420 430 440 450
>>XP_011524337 (OMIM: 616102) PREDICTED: protein disulfi (229 aa)
initn: 121 init1: 72 opt: 152 Z-score: 170.9 bits: 39.7 E(85289): 0.0088
Smith-Waterman score: 152; 26.1% identity (54.2% similar) in 153 aa overlap (93-241:68-215)
70 80 90 100 110
pF1KE2 LLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVG----FGLVDSEKDAAVAKKLGLT
:: :..: : .:. . ...:...:.
XP_011 NRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVR
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE2 EVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIG
.. ..::: . .: : . : :.:: : ::. : ::... . ...
XP_011 GYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRV---SGALIRPLPSQQMFEHMQKRHRVFF
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 YFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPD
. . .: . . ::: :. : ::.. . : . .::: :. .: .: . :
XP_011 VYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLK--EMPAVLVFKDETYFVYD
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 KPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFLETLK
:
XP_011 DNNYTLMLSYKRYYLHT
220
390 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:57:10 2016 done: Mon Nov 7 20:57:11 2016
Total Scan time: 8.650 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]