Result of FASTA (omim) for
pF1KE2492
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2492, 1788 aa
1>>>pF1KE2492 1788 - 1788 aa - 1788 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.3657+/-0.000549; mu= 14.8890+/- 0.034
mean_var=163.6956+/-34.522, 0's: 0 Z-trim(111.5): 149 B-trim: 675 in 1/56
Lambda= 0.100243
statistics sampled from 20029 (20177) to 20029 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.237), width: 16
Scan time: 12.940
The best scores are: opt bits E(85289)
NP_003165 (OMIM: 604126) supervillin isoform 1 [Ho (1788) 11832 1725.5 0
XP_016872071 (OMIM: 604126) PREDICTED: supervillin (1873) 11832 1725.6 0
XP_011517935 (OMIM: 604126) PREDICTED: supervillin (2267) 10042 1466.8 0
NP_001310529 (OMIM: 604126) supervillin isoform 4 (1820) 9584 1400.4 0
XP_016872070 (OMIM: 604126) PREDICTED: supervillin (1905) 9584 1400.5 0
NP_001310528 (OMIM: 604126) supervillin isoform 3 (1904) 9557 1396.6 0
XP_016872068 (OMIM: 604126) PREDICTED: supervillin (1989) 9557 1396.6 0
NP_068506 (OMIM: 604126) supervillin isoform 2 [Ho (2214) 9557 1396.6 0
XP_016872066 (OMIM: 604126) PREDICTED: supervillin (2299) 9557 1396.6 0
XP_011517932 (OMIM: 604126) PREDICTED: supervillin (2315) 7024 1030.3 0
XP_016872069 (OMIM: 604126) PREDICTED: supervillin (1974) 7020 1029.7 0
XP_011517940 (OMIM: 604126) PREDICTED: supervillin (1915) 7019 1029.5 0
XP_011517939 (OMIM: 604126) PREDICTED: supervillin (1947) 7019 1029.5 0
XP_016872067 (OMIM: 604126) PREDICTED: supervillin (1999) 7019 1029.5 0
XP_011517938 (OMIM: 604126) PREDICTED: supervillin (2031) 7019 1029.5 0
XP_005252630 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0
XP_011517937 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0
XP_005252628 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0
XP_011517936 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0
XP_005252627 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0
XP_011517934 (OMIM: 604126) PREDICTED: supervillin (2284) 7019 1029.6 0
XP_011517933 (OMIM: 604126) PREDICTED: supervillin (2309) 7019 1029.6 0
XP_016872065 (OMIM: 604126) PREDICTED: supervillin (2314) 7019 1029.6 0
XP_016872064 (OMIM: 604126) PREDICTED: supervillin (2341) 7019 1029.6 0
XP_016872072 (OMIM: 604126) PREDICTED: supervillin (1274) 2545 382.3 1.6e-104
NP_009058 (OMIM: 193040) villin-1 [Homo sapiens] ( 827) 251 50.4 8.5e-05
NP_001738 (OMIM: 153615) macrophage-capping protei ( 348) 235 47.8 0.00022
XP_011531425 (OMIM: 153615) PREDICTED: macrophage- ( 348) 235 47.8 0.00022
NP_001243068 (OMIM: 153615) macrophage-capping pro ( 348) 235 47.8 0.00022
NP_001307661 (OMIM: 153615) macrophage-capping pro ( 348) 235 47.8 0.00022
NP_001307662 (OMIM: 153615) macrophage-capping pro ( 348) 235 47.8 0.00022
XP_011531424 (OMIM: 153615) PREDICTED: macrophage- ( 348) 235 47.8 0.00022
NP_001106177 (OMIM: 613416) adseverin isoform 1 [H ( 715) 234 47.9 0.00042
XP_016861969 (OMIM: 161565) PREDICTED: NK-tumor re (1094) 216 45.4 0.0035
XP_016861968 (OMIM: 161565) PREDICTED: NK-tumor re (1095) 216 45.4 0.0035
XP_016861967 (OMIM: 161565) PREDICTED: NK-tumor re (1095) 216 45.4 0.0035
XP_016861966 (OMIM: 161565) PREDICTED: NK-tumor re (1163) 216 45.5 0.0036
XP_016861965 (OMIM: 161565) PREDICTED: NK-tumor re (1163) 216 45.5 0.0036
XP_011532052 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 216 45.5 0.0038
XP_016861964 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 216 45.5 0.0038
XP_011532049 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 216 45.5 0.0038
XP_006713236 (OMIM: 161565) PREDICTED: NK-tumor re (1353) 216 45.5 0.0041
NP_005376 (OMIM: 161565) NK-tumor recognition prot (1462) 216 45.6 0.0043
XP_005265230 (OMIM: 161565) PREDICTED: NK-tumor re (1463) 216 45.6 0.0043
>>NP_003165 (OMIM: 604126) supervillin isoform 1 [Homo s (1788 aa)
initn: 11832 init1: 11832 opt: 11832 Z-score: 9254.3 bits: 1725.5 E(85289): 0
Smith-Waterman score: 11832; 100.0% identity (100.0% similar) in 1788 aa overlap (1-1788:1-1788)
10 20 30 40 50 60
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATLQASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATLQASA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 HQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 NARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 NDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEM
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 DEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 FMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 RELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIY
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 RLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 WNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELK
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 FEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAA
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 GKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVH
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 SGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWH
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 GCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 YDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPAL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 FLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 HAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARP
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780
pF1KE2 LPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
1750 1760 1770 1780
>>XP_016872071 (OMIM: 604126) PREDICTED: supervillin iso (1873 aa)
initn: 11832 init1: 11832 opt: 11832 Z-score: 9254.0 bits: 1725.6 E(85289): 0
Smith-Waterman score: 11832; 100.0% identity (100.0% similar) in 1788 aa overlap (1-1788:86-1873)
10 20 30
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV
::::::::::::::::::::::::::::::
XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE2 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN
480 490 500 510 520 530
460 470 480 490 500 510
pF1KE2 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE
540 550 560 570 580 590
520 530 540 550 560 570
pF1KE2 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP
600 610 620 630 640 650
580 590 600 610 620 630
pF1KE2 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA
660 670 680 690 700 710
640 650 660 670 680 690
pF1KE2 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG
720 730 740 750 760 770
700 710 720 730 740 750
pF1KE2 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE
780 790 800 810 820 830
760 770 780 790 800 810
pF1KE2 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI
840 850 860 870 880 890
820 830 840 850 860 870
pF1KE2 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV
900 910 920 930 940 950
880 890 900 910 920 930
pF1KE2 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR
960 970 980 990 1000 1010
940 950 960 970 980 990
pF1KE2 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE
1020 1030 1040 1050 1060 1070
1000 1010 1020 1030 1040 1050
pF1KE2 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS
1080 1090 1100 1110 1120 1130
1060 1070 1080 1090 1100 1110
pF1KE2 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL
1140 1150 1160 1170 1180 1190
1120 1130 1140 1150 1160 1170
pF1KE2 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV
1200 1210 1220 1230 1240 1250
1180 1190 1200 1210 1220 1230
pF1KE2 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG
1260 1270 1280 1290 1300 1310
1240 1250 1260 1270 1280 1290
pF1KE2 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV
1320 1330 1340 1350 1360 1370
1300 1310 1320 1330 1340 1350
pF1KE2 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH
1380 1390 1400 1410 1420 1430
1360 1370 1380 1390 1400 1410
pF1KE2 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL
1440 1450 1460 1470 1480 1490
1420 1430 1440 1450 1460 1470
pF1KE2 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL
1500 1510 1520 1530 1540 1550
1480 1490 1500 1510 1520 1530
pF1KE2 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH
1560 1570 1580 1590 1600 1610
1540 1550 1560 1570 1580 1590
pF1KE2 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT
1620 1630 1640 1650 1660 1670
1600 1610 1620 1630 1640 1650
pF1KE2 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW
1680 1690 1700 1710 1720 1730
1660 1670 1680 1690 1700 1710
pF1KE2 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT
1740 1750 1760 1770 1780 1790
1720 1730 1740 1750 1760 1770
pF1KE2 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY
1800 1810 1820 1830 1840 1850
1780
pF1KE2 NALPAWKQVNLKKAKGLF
::::::::::::::::::
XP_016 NALPAWKQVNLKKAKGLF
1860 1870
>>XP_011517935 (OMIM: 604126) PREDICTED: supervillin iso (2267 aa)
initn: 10036 init1: 10036 opt: 10042 Z-score: 7853.9 bits: 1466.8 E(85289): 0
Smith-Waterman score: 10042; 98.3% identity (98.8% similar) in 1548 aa overlap (244-1788:722-2267)
220 230 240 250 260 270
pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE
:.:.. : . .. . : : .: : :
XP_011 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE
700 710 720 730 740
280 290 300 310 320 330
pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
. :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
750 760 770 780 790 800
340 350 360 370 380 390
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
810 820 830 840 850 860
400 410 420 430 440 450
pF1KE2 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN
870 880 890 900 910 920
460 470 480 490 500 510
pF1KE2 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE
930 940 950 960 970 980
520 530 540 550 560 570
pF1KE2 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP
990 1000 1010 1020 1030 1040
580 590 600 610 620 630
pF1KE2 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA
1050 1060 1070 1080 1090 1100
640 650 660 670 680 690
pF1KE2 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG
1110 1120 1130 1140 1150 1160
700 710 720 730 740 750
pF1KE2 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE
1170 1180 1190 1200 1210 1220
760 770 780 790 800 810
pF1KE2 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI
1230 1240 1250 1260 1270 1280
820 830 840 850 860 870
pF1KE2 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV
1290 1300 1310 1320 1330 1340
880 890 900 910 920 930
pF1KE2 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR
1350 1360 1370 1380 1390 1400
940 950 960 970 980 990
pF1KE2 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE
1410 1420 1430 1440 1450 1460
1000 1010 1020 1030 1040 1050
pF1KE2 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS
1470 1480 1490 1500 1510 1520
1060 1070 1080 1090 1100 1110
pF1KE2 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL
1530 1540 1550 1560 1570 1580
1120 1130 1140 1150 1160 1170
pF1KE2 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV
1590 1600 1610 1620 1630 1640
1180 1190 1200 1210 1220 1230
pF1KE2 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG
1650 1660 1670 1680 1690 1700
1240 1250 1260 1270 1280 1290
pF1KE2 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV
1710 1720 1730 1740 1750 1760
1300 1310 1320 1330 1340 1350
pF1KE2 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH
1770 1780 1790 1800 1810 1820
1360 1370 1380 1390 1400 1410
pF1KE2 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL
1830 1840 1850 1860 1870 1880
1420 1430 1440 1450 1460 1470
pF1KE2 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL
1890 1900 1910 1920 1930 1940
1480 1490 1500 1510 1520 1530
pF1KE2 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH
1950 1960 1970 1980 1990 2000
1540 1550 1560 1570 1580 1590
pF1KE2 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT
2010 2020 2030 2040 2050 2060
1600 1610 1620 1630 1640 1650
pF1KE2 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW
2070 2080 2090 2100 2110 2120
1660 1670 1680 1690 1700 1710
pF1KE2 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT
2130 2140 2150 2160 2170 2180
1720 1730 1740 1750 1760 1770
pF1KE2 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY
2190 2200 2210 2220 2230 2240
1780
pF1KE2 NALPAWKQVNLKKAKGLF
::::::::::::::::::
XP_011 NALPAWKQVNLKKAKGLF
2250 2260
>--
initn: 1828 init1: 1798 opt: 1802 Z-score: 1413.6 bits: 275.1 E(85289): 5.4e-72
Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:86-415)
10 20 30
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV
::::::::::::::::::::::::::::::
XP_011 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
::::: . .. .. . . : . .. .. . ... : . .: :. :.. :
XP_011 PEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASES--VT
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
::
XP_011 QRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENA
420 430 440 450 460 470
>>NP_001310529 (OMIM: 604126) supervillin isoform 4 [Hom (1820 aa)
initn: 9553 init1: 9553 opt: 9584 Z-score: 7497.2 bits: 1400.4 E(85289): 0
Smith-Waterman score: 11758; 98.2% identity (98.2% similar) in 1820 aa overlap (1-1788:1-1820)
10 20 30 40 50 60
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV
250 260 270 280 290 300
310 320 330 340 350
pF1KE2 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAAT-----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATEPIPA
310 320 330 340 350 360
360 370 380
pF1KE2 ---------------------------LQASAHQKALAKDQTNEGKELAEQGEPDSSTLS
:::::::::::::::::::::::::::::::::
NP_001 SCSGGTHPVMARLPSPTVARSAVQPARLQASAHQKALAKDQTNEGKELAEQGEPDSSTLS
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE2 LAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPA
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE2 VNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPL
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE2 VEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYA
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 VPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLR
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 AAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 EGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRV
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 TESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVAS
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 PICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGK
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE2 SVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRP
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE2 KRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLAS
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE2 KENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLL
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE2 LSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFW
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE2 KLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEV
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE2 LVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKG
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE2 QGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTR
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE2 MVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQ
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE2 FHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTV
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KE2 ELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEG
1450 1460 1470 1480 1490 1500
1470 1480 1490 1500 1510 1520
pF1KE2 NLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAG
1510 1520 1530 1540 1550 1560
1530 1540 1550 1560 1570 1580
pF1KE2 LHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFA
1570 1580 1590 1600 1610 1620
1590 1600 1610 1620 1630 1640
pF1KE2 ATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARI
1630 1640 1650 1660 1670 1680
1650 1660 1670 1680 1690 1700
pF1KE2 RWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEM
1690 1700 1710 1720 1730 1740
1710 1720 1730 1740 1750 1760
pF1KE2 DTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRD
1750 1760 1770 1780 1790 1800
1770 1780
pF1KE2 EYNALPAWKQVNLKKAKGLF
::::::::::::::::::::
NP_001 EYNALPAWKQVNLKKAKGLF
1810 1820
>>XP_016872070 (OMIM: 604126) PREDICTED: supervillin iso (1905 aa)
initn: 9553 init1: 9553 opt: 9584 Z-score: 7496.9 bits: 1400.5 E(85289): 0
Smith-Waterman score: 11758; 98.2% identity (98.2% similar) in 1820 aa overlap (1-1788:86-1905)
10 20 30
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV
::::::::::::::::::::::::::::::
XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
360 370 380 390 400 410
340 350
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA
::::::::::::::::::::::::: :::
XP_016 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
720 730 740 750 760 770
660 670 680 690 700 710
pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
780 790 800 810 820 830
720 730 740 750 760 770
pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
840 850 860 870 880 890
780 790 800 810 820 830
pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
900 910 920 930 940 950
840 850 860 870 880 890
pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
960 970 980 990 1000 1010
900 910 920 930 940 950
pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
1020 1030 1040 1050 1060 1070
960 970 980 990 1000 1010
pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
1080 1090 1100 1110 1120 1130
1020 1030 1040 1050 1060 1070
pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
1140 1150 1160 1170 1180 1190
1080 1090 1100 1110 1120 1130
pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
1200 1210 1220 1230 1240 1250
1140 1150 1160 1170 1180 1190
pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
1260 1270 1280 1290 1300 1310
1200 1210 1220 1230 1240 1250
pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
1320 1330 1340 1350 1360 1370
1260 1270 1280 1290 1300 1310
pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
1380 1390 1400 1410 1420 1430
1320 1330 1340 1350 1360 1370
pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
1440 1450 1460 1470 1480 1490
1380 1390 1400 1410 1420 1430
pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
1500 1510 1520 1530 1540 1550
1440 1450 1460 1470 1480 1490
pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
1560 1570 1580 1590 1600 1610
1500 1510 1520 1530 1540 1550
pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
1620 1630 1640 1650 1660 1670
1560 1570 1580 1590 1600 1610
pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
1680 1690 1700 1710 1720 1730
1620 1630 1640 1650 1660 1670
pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
1740 1750 1760 1770 1780 1790
1680 1690 1700 1710 1720 1730
pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
1800 1810 1820 1830 1840 1850
1740 1750 1760 1770 1780
pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
1860 1870 1880 1890 1900
>>NP_001310528 (OMIM: 604126) supervillin isoform 3 [Hom (1904 aa)
initn: 9553 init1: 9553 opt: 9557 Z-score: 7475.8 bits: 1396.6 E(85289): 0
Smith-Waterman score: 11029; 93.6% identity (93.6% similar) in 1820 aa overlap (85-1788:85-1904)
60 70 80 90 100 110
pF1KE2 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR
::::::::::::::::::::::::::::::
NP_001 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG
180 190 200 210 220 230
240 250 260 270
pF1KE2 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARP-------------------
:::::::::::::::::::::::::::::::::::::::::
NP_001 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDT
240 250 260 270 280 290
pF1KE2 ------------------------------------------------------------
NP_001 PSLINWPSSKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 -----RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
360 370 380 390 400 410
340 350
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA
::::::::::::::::::::::::: :::
NP_001 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
720 730 740 750 760 770
660 670 680 690 700 710
pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
780 790 800 810 820 830
720 730 740 750 760 770
pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
840 850 860 870 880 890
780 790 800 810 820 830
pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
900 910 920 930 940 950
840 850 860 870 880 890
pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
960 970 980 990 1000 1010
900 910 920 930 940 950
pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
1020 1030 1040 1050 1060 1070
960 970 980 990 1000 1010
pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
1080 1090 1100 1110 1120 1130
1020 1030 1040 1050 1060 1070
pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
1140 1150 1160 1170 1180 1190
1080 1090 1100 1110 1120 1130
pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
1200 1210 1220 1230 1240 1250
1140 1150 1160 1170 1180 1190
pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
1260 1270 1280 1290 1300 1310
1200 1210 1220 1230 1240 1250
pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
1320 1330 1340 1350 1360 1370
1260 1270 1280 1290 1300 1310
pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
1380 1390 1400 1410 1420 1430
1320 1330 1340 1350 1360 1370
pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
1440 1450 1460 1470 1480 1490
1380 1390 1400 1410 1420 1430
pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
1500 1510 1520 1530 1540 1550
1440 1450 1460 1470 1480 1490
pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
1560 1570 1580 1590 1600 1610
1500 1510 1520 1530 1540 1550
pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
1620 1630 1640 1650 1660 1670
1560 1570 1580 1590 1600 1610
pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
1680 1690 1700 1710 1720 1730
1620 1630 1640 1650 1660 1670
pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
1740 1750 1760 1770 1780 1790
1680 1690 1700 1710 1720 1730
pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
1800 1810 1820 1830 1840 1850
1740 1750 1760 1770 1780
pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
1860 1870 1880 1890 1900
>--
initn: 551 init1: 551 opt: 551 Z-score: 436.8 bits: 94.1 E(85289): 1.4e-17
Smith-Waterman score: 551; 100.0% identity (100.0% similar) in 84 aa overlap (1-84:1-84)
10 20 30 40 50 60
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
::::::::::::::::::::::::
NP_001 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
70 80 90 100 110 120
>>XP_016872068 (OMIM: 604126) PREDICTED: supervillin iso (1989 aa)
initn: 9553 init1: 9553 opt: 9557 Z-score: 7475.6 bits: 1396.6 E(85289): 0
Smith-Waterman score: 11029; 93.6% identity (93.6% similar) in 1820 aa overlap (85-1788:170-1989)
60 70 80 90 100 110
pF1KE2 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR
::::::::::::::::::::::::::::::
XP_016 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR
140 150 160 170 180 190
120 130 140 150 160 170
pF1KE2 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE2 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG
260 270 280 290 300 310
240 250 260 270
pF1KE2 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARP-------------------
:::::::::::::::::::::::::::::::::::::::::
XP_016 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDT
320 330 340 350 360 370
pF1KE2 ------------------------------------------------------------
XP_016 PSLINWPSSKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAE
380 390 400 410 420 430
280 290 300 310 320 330
pF1KE2 -----RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
440 450 460 470 480 490
340 350
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA
::::::::::::::::::::::::: :::
XP_016 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA
500 510 520 530 540 550
360 370 380 390 400 410
pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
560 570 580 590 600 610
420 430 440 450 460 470
pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
620 630 640 650 660 670
480 490 500 510 520 530
pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
680 690 700 710 720 730
540 550 560 570 580 590
pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
740 750 760 770 780 790
600 610 620 630 640 650
pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
800 810 820 830 840 850
660 670 680 690 700 710
pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
860 870 880 890 900 910
720 730 740 750 760 770
pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
920 930 940 950 960 970
780 790 800 810 820 830
pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
980 990 1000 1010 1020 1030
840 850 860 870 880 890
pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
1040 1050 1060 1070 1080 1090
900 910 920 930 940 950
pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
1100 1110 1120 1130 1140 1150
960 970 980 990 1000 1010
pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
1160 1170 1180 1190 1200 1210
1020 1030 1040 1050 1060 1070
pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
1220 1230 1240 1250 1260 1270
1080 1090 1100 1110 1120 1130
pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
1280 1290 1300 1310 1320 1330
1140 1150 1160 1170 1180 1190
pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
1340 1350 1360 1370 1380 1390
1200 1210 1220 1230 1240 1250
pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
1400 1410 1420 1430 1440 1450
1260 1270 1280 1290 1300 1310
pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
1460 1470 1480 1490 1500 1510
1320 1330 1340 1350 1360 1370
pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
1520 1530 1540 1550 1560 1570
1380 1390 1400 1410 1420 1430
pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
1580 1590 1600 1610 1620 1630
1440 1450 1460 1470 1480 1490
pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
1640 1650 1660 1670 1680 1690
1500 1510 1520 1530 1540 1550
pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
1700 1710 1720 1730 1740 1750
1560 1570 1580 1590 1600 1610
pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
1760 1770 1780 1790 1800 1810
1620 1630 1640 1650 1660 1670
pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
1820 1830 1840 1850 1860 1870
1680 1690 1700 1710 1720 1730
pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
1880 1890 1900 1910 1920 1930
1740 1750 1760 1770 1780
pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
1940 1950 1960 1970 1980
>--
initn: 551 init1: 551 opt: 551 Z-score: 436.5 bits: 94.1 E(85289): 1.4e-17
Smith-Waterman score: 551; 100.0% identity (100.0% similar) in 84 aa overlap (1-84:86-169)
10 20 30
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV
::::::::::::::::::::::::::::::
XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
180 190 200 210 220 230
>>NP_068506 (OMIM: 604126) supervillin isoform 2 [Homo s (2214 aa)
initn: 11337 init1: 9553 opt: 9557 Z-score: 7475.0 bits: 1396.6 E(85289): 0
Smith-Waterman score: 9968; 96.3% identity (96.8% similar) in 1580 aa overlap (244-1788:637-2214)
220 230 240 250 260 270
pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE
:.:.. : . .. . : : .: : :
NP_068 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE
610 620 630 640 650 660
280 290 300 310 320 330
pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
. :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
670 680 690 700 710 720
340 350
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA
::::::::::::::::::::::::: :::
NP_068 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA
730 740 750 760 770 780
360 370 380 390 400 410
pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
790 800 810 820 830 840
420 430 440 450 460 470
pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
850 860 870 880 890 900
480 490 500 510 520 530
pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
910 920 930 940 950 960
540 550 560 570 580 590
pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
970 980 990 1000 1010 1020
600 610 620 630 640 650
pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
1030 1040 1050 1060 1070 1080
660 670 680 690 700 710
pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
1090 1100 1110 1120 1130 1140
720 730 740 750 760 770
pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
1150 1160 1170 1180 1190 1200
780 790 800 810 820 830
pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
1210 1220 1230 1240 1250 1260
840 850 860 870 880 890
pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
1270 1280 1290 1300 1310 1320
900 910 920 930 940 950
pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
1330 1340 1350 1360 1370 1380
960 970 980 990 1000 1010
pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
1390 1400 1410 1420 1430 1440
1020 1030 1040 1050 1060 1070
pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
1450 1460 1470 1480 1490 1500
1080 1090 1100 1110 1120 1130
pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
1510 1520 1530 1540 1550 1560
1140 1150 1160 1170 1180 1190
pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
1570 1580 1590 1600 1610 1620
1200 1210 1220 1230 1240 1250
pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
1630 1640 1650 1660 1670 1680
1260 1270 1280 1290 1300 1310
pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
1690 1700 1710 1720 1730 1740
1320 1330 1340 1350 1360 1370
pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
1750 1760 1770 1780 1790 1800
1380 1390 1400 1410 1420 1430
pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
1810 1820 1830 1840 1850 1860
1440 1450 1460 1470 1480 1490
pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
1870 1880 1890 1900 1910 1920
1500 1510 1520 1530 1540 1550
pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
1930 1940 1950 1960 1970 1980
1560 1570 1580 1590 1600 1610
pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
1990 2000 2010 2020 2030 2040
1620 1630 1640 1650 1660 1670
pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
2050 2060 2070 2080 2090 2100
1680 1690 1700 1710 1720 1730
pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
2110 2120 2130 2140 2150 2160
1740 1750 1760 1770 1780
pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
2170 2180 2190 2200 2210
>--
initn: 1840 init1: 1798 opt: 1802 Z-score: 1413.7 bits: 275.1 E(85289): 5.3e-72
Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:1-330)
10 20 30 40 50 60
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV
::::::::::::::::::::::::::::::::::: . .. .. . . : . ..
NP_068 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDTPSLINW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATLQASA
.. . ... : . .: :. :.. : ::
NP_068 PSRVKVREKLVKEESARNSPELASES--VTQRRHQPAPVHYVSFQSEHSAFDRVPSKAAG
310 320 330 340 350
370 380 390 400 410 420
pF1KE2 HQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRM
NP_068 STRQPIRGYVQPADTGHTAKLVTPETPENASECSWVASATQNVPKPPSLTVLEGDGRDSP
360 370 380 390 400 410
>>XP_016872066 (OMIM: 604126) PREDICTED: supervillin iso (2299 aa)
initn: 11337 init1: 9553 opt: 9557 Z-score: 7474.7 bits: 1396.6 E(85289): 0
Smith-Waterman score: 9968; 96.3% identity (96.8% similar) in 1580 aa overlap (244-1788:722-2299)
220 230 240 250 260 270
pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE
:.:.. : . .. . : : .: : :
XP_016 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE
700 710 720 730 740
280 290 300 310 320 330
pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
. :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
750 760 770 780 790 800
340 350
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA
::::::::::::::::::::::::: :::
XP_016 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA
810 820 830 840 850 860
360 370 380 390 400 410
pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
870 880 890 900 910 920
420 430 440 450 460 470
pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
930 940 950 960 970 980
480 490 500 510 520 530
pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
990 1000 1010 1020 1030 1040
540 550 560 570 580 590
pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
1050 1060 1070 1080 1090 1100
600 610 620 630 640 650
pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
1110 1120 1130 1140 1150 1160
660 670 680 690 700 710
pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
1170 1180 1190 1200 1210 1220
720 730 740 750 760 770
pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG
1230 1240 1250 1260 1270 1280
780 790 800 810 820 830
pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD
1290 1300 1310 1320 1330 1340
840 850 860 870 880 890
pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV
1350 1360 1370 1380 1390 1400
900 910 920 930 940 950
pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN
1410 1420 1430 1440 1450 1460
960 970 980 990 1000 1010
pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM
1470 1480 1490 1500 1510 1520
1020 1030 1040 1050 1060 1070
pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ
1530 1540 1550 1560 1570 1580
1080 1090 1100 1110 1120 1130
pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC
1590 1600 1610 1620 1630 1640
1140 1150 1160 1170 1180 1190
pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK
1650 1660 1670 1680 1690 1700
1200 1210 1220 1230 1240 1250
pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE
1710 1720 1730 1740 1750 1760
1260 1270 1280 1290 1300 1310
pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR
1770 1780 1790 1800 1810 1820
1320 1330 1340 1350 1360 1370
pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR
1830 1840 1850 1860 1870 1880
1380 1390 1400 1410 1420 1430
pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV
1890 1900 1910 1920 1930 1940
1440 1450 1460 1470 1480 1490
pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL
1950 1960 1970 1980 1990 2000
1500 1510 1520 1530 1540 1550
pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR
2010 2020 2030 2040 2050 2060
1560 1570 1580 1590 1600 1610
pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP
2070 2080 2090 2100 2110 2120
1620 1630 1640 1650 1660 1670
pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY
2130 2140 2150 2160 2170 2180
1680 1690 1700 1710 1720 1730
pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA
2190 2200 2210 2220 2230 2240
1740 1750 1760 1770 1780
pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
2250 2260 2270 2280 2290
>--
initn: 1828 init1: 1798 opt: 1802 Z-score: 1413.5 bits: 275.1 E(85289): 5.4e-72
Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:86-415)
10 20 30
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV
::::::::::::::::::::::::::::::
XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
::::: . .. .. . . : . .. .. . ... : . .: :. :.. :
XP_016 PEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASES--VT
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
::
XP_016 QRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENA
420 430 440 450 460 470
>>XP_011517932 (OMIM: 604126) PREDICTED: supervillin iso (2315 aa)
initn: 11323 init1: 7012 opt: 7024 Z-score: 5494.9 bits: 1030.3 E(85289): 0
Smith-Waterman score: 9926; 95.3% identity (95.9% similar) in 1596 aa overlap (244-1788:722-2315)
220 230 240 250 260 270
pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE
:.:.. : . .. . : : .: : :
XP_011 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE
700 710 720 730 740
280 290 300 310 320 330
pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
. :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
750 760 770 780 790 800
340 350
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA
::::::::::::::::::::::::: :::
XP_011 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA
810 820 830 840 850 860
360 370 380 390 400 410
pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR
870 880 890 900 910 920
420 430 440 450 460 470
pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA
930 940 950 960 970 980
480 490 500 510 520 530
pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME
990 1000 1010 1020 1030 1040
540 550 560 570 580 590
pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN
1050 1060 1070 1080 1090 1100
600 610 620 630 640 650
pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK
1110 1120 1130 1140 1150 1160
660 670 680 690 700 710
pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN
1170 1180 1190 1200 1210 1220
720 730 740 750 760
pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKK----------------RVTESRESQMTIEERK
:::::::::::::::::::::::::::: ::::::::::::::::
XP_011 RLSRRQEGGKAPASSLHTQEAGRSLIKKEEGGVADDSAISNLLWRVTESRESQMTIEERK
1230 1240 1250 1260 1270 1280
770 780 790 800 810 820
pF1KE2 QLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSK
1290 1300 1310 1320 1330 1340
830 840 850 860 870 880
pF1KE2 PLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETF
1350 1360 1370 1380 1390 1400
890 900 910 920 930 940
pF1KE2 AKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKML
1410 1420 1430 1440 1450 1460
950 960 970 980 990 1000
pF1KE2 AAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNL
1470 1480 1490 1500 1510 1520
1010 1020 1030 1040 1050 1060
pF1KE2 TEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFA
1530 1540 1550 1560 1570 1580
1070 1080 1090 1100 1110 1120
pF1KE2 NVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD
1590 1600 1610 1620 1630 1640
1130 1140 1150 1160 1170 1180
pF1KE2 PKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHG
1650 1660 1670 1680 1690 1700
1190 1200 1210 1220 1230 1240
pF1KE2 KEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTE
1710 1720 1730 1740 1750 1760
1250 1260 1270 1280 1290 1300
pF1KE2 HNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILD
1770 1780 1790 1800 1810 1820
1310 1320 1330 1340 1350 1360
pF1KE2 GVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFM
1830 1840 1850 1860 1870 1880
1370 1380 1390 1400 1410 1420
pF1KE2 VSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQ
1890 1900 1910 1920 1930 1940
1430 1440 1450 1460 1470 1480
pF1KE2 GKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRS
1950 1960 1970 1980 1990 2000
1490 1500 1510 1520 1530 1540
pF1KE2 RTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDE
2010 2020 2030 2040 2050 2060
1550 1560 1570 1580 1590 1600
pF1KE2 GSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVV
2070 2080 2090 2100 2110 2120
1610 1620 1630 1640 1650 1660
pF1KE2 SSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVL
2130 2140 2150 2160 2170 2180
1670 1680 1690 1700 1710 1720
pF1KE2 QYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDV
2190 2200 2210 2220 2230 2240
1730 1740 1750 1760 1770 1780
pF1KE2 LAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLK
2250 2260 2270 2280 2290 2300
pF1KE2 KAKGLF
::::::
XP_011 KAKGLF
2310
>--
initn: 1828 init1: 1798 opt: 1802 Z-score: 1413.4 bits: 275.1 E(85289): 5.4e-72
Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:86-415)
10 20 30
pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV
::::::::::::::::::::::::::::::
XP_011 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE
::::: . .. .. . . : . .. .. . ... : . .: :. :.. :
XP_011 PEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASES--VT
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA
::
XP_011 QRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENA
420 430 440 450 460 470
1788 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:57:55 2016 done: Mon Nov 7 20:57:57 2016
Total Scan time: 12.940 Total Display time: 1.220
Function used was FASTA [36.3.4 Apr, 2011]