Result of FASTA (omim) for
pF1KE2456
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2456, 1709 aa
1>>>pF1KE2456 1709 - 1709 aa - 1709 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.5246+/-0.000517; mu= 0.8079+/- 0.033
mean_var=317.4689+/-65.263, 0's: 0 Z-trim(118.8): 271 B-trim: 887 in 1/58
Lambda= 0.071982
statistics sampled from 31799 (32094) to 31799 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.376), width: 16
Scan time: 18.610
The best scores are: opt bits E(85289)
NP_001261 (OMIM: 602118) chromodomain-helicase-DNA (1710) 11447 1204.2 0
XP_005271924 (OMIM: 602118) PREDICTED: chromodomai (1710) 11447 1204.2 0
XP_011541414 (OMIM: 602118) PREDICTED: chromodomai (1552) 10167 1071.3 0
XP_005271923 (OMIM: 602118) PREDICTED: chromodomai (1798) 9195 970.4 0
NP_001262 (OMIM: 602119,615369) chromodomain-helic (1828) 4996 534.3 3.7e-150
XP_016864481 (OMIM: 602118) PREDICTED: chromodomai ( 869) 2981 324.8 2.1e-87
XP_016864480 (OMIM: 602118) PREDICTED: chromodomai ( 869) 2981 324.8 2.1e-87
XP_016885240 (OMIM: 300012) PREDICTED: probable gl (1036) 1450 165.9 1.7e-39
XP_016885239 (OMIM: 300012) PREDICTED: probable gl (1042) 1450 165.9 1.7e-39
XP_006724845 (OMIM: 300012) PREDICTED: probable gl (1042) 1450 165.9 1.7e-39
NP_001269804 (OMIM: 300012) probable global transc (1058) 1450 165.9 1.8e-39
XP_016879558 (OMIM: 602120) PREDICTED: chromodomai (1888) 1420 163.0 2.4e-38
NP_005843 (OMIM: 602120) chromodomain-helicase-DNA (1966) 1420 163.0 2.4e-38
NP_001005273 (OMIM: 602120) chromodomain-helicase- (2000) 1420 163.0 2.5e-38
XP_006721491 (OMIM: 602120) PREDICTED: chromodomai (2025) 1420 163.0 2.5e-38
XP_016879557 (OMIM: 602120) PREDICTED: chromodomai (2036) 1420 163.0 2.5e-38
XP_016879555 (OMIM: 602120) PREDICTED: chromodomai (2036) 1420 163.0 2.5e-38
XP_016879556 (OMIM: 602120) PREDICTED: chromodomai (2045) 1420 163.0 2.5e-38
XP_016879554 (OMIM: 602120) PREDICTED: chromodomai (2047) 1420 163.0 2.5e-38
XP_016879559 (OMIM: 602120) PREDICTED: chromodomai (2050) 1420 163.0 2.5e-38
XP_016879553 (OMIM: 602120) PREDICTED: chromodomai (2055) 1420 163.0 2.5e-38
XP_016879552 (OMIM: 602120) PREDICTED: chromodomai (2056) 1420 163.0 2.5e-38
NP_001005271 (OMIM: 602120) chromodomain-helicase- (2059) 1420 163.0 2.5e-38
XP_005256486 (OMIM: 602120) PREDICTED: chromodomai (2060) 1420 163.0 2.5e-38
XP_005256485 (OMIM: 602120) PREDICTED: chromodomai (2080) 1420 163.0 2.5e-38
XP_016879551 (OMIM: 602120) PREDICTED: chromodomai (2105) 1420 163.0 2.6e-38
XP_016879550 (OMIM: 602120) PREDICTED: chromodomai (2109) 1420 163.0 2.6e-38
XP_006721487 (OMIM: 602120) PREDICTED: chromodomai (2111) 1420 163.0 2.6e-38
XP_006721486 (OMIM: 602120) PREDICTED: chromodomai (2114) 1420 163.0 2.6e-38
XP_005256484 (OMIM: 602120) PREDICTED: chromodomai (2115) 1420 163.0 2.6e-38
XP_016874217 (OMIM: 603277,617159) PREDICTED: chro (1911) 1407 161.7 6.1e-38
XP_016874216 (OMIM: 603277,617159) PREDICTED: chro (1912) 1407 161.7 6.1e-38
XP_006719023 (OMIM: 603277,617159) PREDICTED: chro (1914) 1407 161.7 6.1e-38
NP_003592 (OMIM: 603375) SWI/SNF-related matrix-as (1052) 1397 160.4 7.9e-38
XP_016874223 (OMIM: 603277,617159) PREDICTED: chro (1892) 1398 160.7 1.1e-37
XP_016874222 (OMIM: 603277,617159) PREDICTED: chro (1893) 1398 160.7 1.1e-37
XP_016874221 (OMIM: 603277,617159) PREDICTED: chro (1895) 1398 160.7 1.1e-37
XP_016874220 (OMIM: 603277,617159) PREDICTED: chro (1899) 1398 160.7 1.2e-37
XP_016874219 (OMIM: 603277,617159) PREDICTED: chro (1900) 1398 160.7 1.2e-37
XP_006719025 (OMIM: 603277,617159) PREDICTED: chro (1902) 1398 160.7 1.2e-37
XP_005253725 (OMIM: 603277,617159) PREDICTED: chro (1905) 1398 160.7 1.2e-37
NP_001284482 (OMIM: 603277,617159) chromodomain-he (1905) 1398 160.7 1.2e-37
XP_016874218 (OMIM: 603277,617159) PREDICTED: chro (1906) 1398 160.7 1.2e-37
XP_006719024 (OMIM: 603277,617159) PREDICTED: chro (1908) 1398 160.7 1.2e-37
NP_001264 (OMIM: 603277,617159) chromodomain-helic (1912) 1398 160.7 1.2e-37
XP_016874215 (OMIM: 603277,617159) PREDICTED: chro (1913) 1398 160.7 1.2e-37
XP_016874214 (OMIM: 603277,617159) PREDICTED: chro (1914) 1398 160.7 1.2e-37
XP_006719022 (OMIM: 603277,617159) PREDICTED: chro (1915) 1398 160.7 1.2e-37
NP_004275 (OMIM: 613039) chromodomain-helicase-DNA ( 897) 1370 157.5 4.9e-37
XP_006719021 (OMIM: 603277,617159) PREDICTED: chro (1940) 1369 157.7 9.4e-37
>>NP_001261 (OMIM: 602118) chromodomain-helicase-DNA-bin (1710 aa)
initn: 11445 init1: 11276 opt: 11447 Z-score: 6437.7 bits: 1204.2 E(85289): 0
Smith-Waterman score: 11447; 99.9% identity (99.9% similar) in 1710 aa overlap (1-1709:1-1710)
10 20 30 40 50 60
pF1KE2 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 IKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 HQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 GSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLD
1630 1640 1650 1660 1670 1680
1690 1700
pF1KE2 QRS-YGSRSPFEHSVEHKSTPEHTWSSRKT
::: ::::::::::::::::::::::::::
NP_001 QRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
1690 1700 1710
>>XP_005271924 (OMIM: 602118) PREDICTED: chromodomain-he (1710 aa)
initn: 11445 init1: 11276 opt: 11447 Z-score: 6437.7 bits: 1204.2 E(85289): 0
Smith-Waterman score: 11447; 99.9% identity (99.9% similar) in 1710 aa overlap (1-1709:1-1710)
10 20 30 40 50 60
pF1KE2 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 IKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 HQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 GSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLD
1630 1640 1650 1660 1670 1680
1690 1700
pF1KE2 QRS-YGSRSPFEHSVEHKSTPEHTWSSRKT
::: ::::::::::::::::::::::::::
XP_005 QRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
1690 1700 1710
>>XP_011541414 (OMIM: 602118) PREDICTED: chromodomain-he (1552 aa)
initn: 10645 init1: 10167 opt: 10167 Z-score: 5719.9 bits: 1071.3 E(85289): 0
Smith-Waterman score: 10167; 99.5% identity (99.8% similar) in 1536 aa overlap (1-1536:1-1536)
10 20 30 40 50 60
pF1KE2 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 IKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDR
::::::::::::::::::::::::::. ..::..
XP_011 IKKRQESQQNSDQNSNLNPHVIRNPDITVTERNTENWMITGVEITGQIWKEV
1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KE2 HQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLE
>>XP_005271923 (OMIM: 602118) PREDICTED: chromodomain-he (1798 aa)
initn: 9386 init1: 9108 opt: 9195 Z-score: 5173.5 bits: 970.4 E(85289): 0
Smith-Waterman score: 10873; 94.9% identity (94.9% similar) in 1741 aa overlap (1-1653:1-1741)
10 20 30 40 50 60
pF1KE2 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360
pF1KE2 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDK-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKDEISSVKHPNK
1330 1340 1350 1360 1370 1380
pF1KE2 ------------------------------------------------------------
XP_005 KIKTERDSEEKPEPDVYIKKEPEEKREAKEKENKKELKREIKEKEDKKDIKEKDFKEKRE
1390 1400 1410 1420 1430 1440
1370 1380 1390 1400 1410
pF1KE2 -----------------LSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQK
:::::::::::::::::::::::::::::::::::::::::::
XP_005 NKVKEAIQKEKDIKEEKLSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQK
1450 1460 1470 1480 1490 1500
1420 1430 1440 1450 1460 1470
pF1KE2 TFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQIK
1510 1520 1530 1540 1550 1560
1480 1490 1500 1510 1520 1530
pF1KE2 QWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLKE
1570 1580 1590 1600 1610 1620
1540 1550 1560 1570 1580 1590
pF1KE2 NTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYK
1630 1640 1650 1660 1670 1680
1600 1610 1620 1630 1640 1650
pF1KE2 QDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHH
1690 1700 1710 1720 1730 1740
1660 1670 1680 1690 1700
pF1KE2 KSSRDYRYHSDWQMDHRASSSGPRSPLDQRSYGSRSPFEHSVEHKSTPEHTWSSRKT
:
XP_005 KSSRDYRYHSDWQMDHRASSSGPRSPLDQRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
1750 1760 1770 1780 1790
>--
initn: 386 init1: 217 opt: 388 Z-score: 230.7 bits: 55.8 E(85289): 4.1e-06
Smith-Waterman score: 388; 98.2% identity (98.2% similar) in 57 aa overlap (1654-1709:1742-1798)
1630 1640 1650 1660 1670 1680
pF1KE2 KDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRS
::::::::::::::::::::::::::::::
XP_005 KDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRS
1720 1730 1740 1750 1760 1770
1690 1700
pF1KE2 -YGSRSPFEHSVEHKSTPEHTWSSRKT
::::::::::::::::::::::::::
XP_005 PYGSRSPFEHSVEHKSTPEHTWSSRKT
1780 1790
>>NP_001262 (OMIM: 602119,615369) chromodomain-helicase- (1828 aa)
initn: 5058 init1: 3063 opt: 4996 Z-score: 2816.8 bits: 534.3 E(85289): 3.7e-150
Smith-Waterman score: 6477; 58.7% identity (79.4% similar) in 1763 aa overlap (2-1669:20-1742)
10 20 30 40
pF1KE2 MNGHS-DEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSD
..:: .::. ..:: :::....:: ::: :: :.:::.
NP_001 MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSG--SQSESEQGSDPGSGHGSESNSSSE
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 GSSSQSGSSDSDSGSESGSQSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAI
.: ::: :.:.: .::.:. ..:. .. : .: ..:. :.. .:.::
NP_001 SSESQS-ESESES---AGSKSQPVLPEAKEKPASKKERIADVKKMWEEYPDVYGVRRS--
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 LKKQQQQQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSG
....: : . .:..::. .: . . . .:. .:.: :.. : . ...:
NP_001 ---------NRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQG
120 130 140 150 160
170 180 190 200 210 220
pF1KE2 SDSESEEEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDD
...::: :..: . . :. : :. : : :. : :..:.: :::.::::
NP_001 TSAESEPEQKKVKARRPV----PRRTV----PKPRVK-KQPKTQRGKRKKQ-DSSDEDDD
170 180 190 200 210
230 240 250 260 270 280
pF1KE2 EEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCR
: . ::..::.:. :::::::....::::::.:. :: : . .... ::::. .: :
NP_001 --DDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDE-QQDNSETIEKVLDSR
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE2 IGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQ
.:.::::::.::.::.::.:::.. :. .:. :::::::::::::.::.:::.::.:.::
NP_001 LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQ
280 290 300 310 320 330
350 360 370 380 390
pF1KE2 NVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIA-----
.:.:.:::.:.:::..: :.:: ..:::::::.::::::...:.::::::::.::
NP_001 KVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASELNKQYQIVERVIAVKTSK
340 350 360 370 380 390
400 410 420 430 440
pF1KE2 ----------HSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQS
:: . . .. :.: :::.::::::::::: :::.:::: ::: . :::.:
NP_001 STLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
400 410 420 430 440 450
450 460 470 480 490 500
pF1KE2 KTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILAD
:: : ..::.::::::::::::::.:.:: :.::::::::.:::::::::::.:: ::::
NP_001 KTIPTRECKALKQRPRFVALKKQPAYLGG-ENLELRDYQLEGLNWLAHSWCKNNSVILAD
460 470 480 490 500
510 520 530 540 550 560
pF1KE2 EMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDIN
::::::::::::::.::::.::::::::.:::::::::::::.. :: ..:.:::.::.
NP_001 EMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPEINVVVYIGDLM
510 520 530 540 550 560
570 580 590 600 610 620
pF1KE2 SRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLL
::: :: .:: : :::::::: :.::::::::::. ::..::::.:::::::::::::::
NP_001 SRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLL
570 580 590 600 610 620
630 640 650 660 670 680
pF1KE2 YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASL
::::::::::::::::::::::::::::::::::::::: ::::::.:::::: :: ::
NP_001 YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSL
630 640 650 660 670 680
690 700 710 720 730 740
pF1KE2 HKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSKGSTS
:: ::::::::::::::::::::::::::.:::::::::::::::::::::.::..::::
NP_001 HKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGSTS
690 700 710 720 730 740
750 760 770 780 790 800
pF1KE2 GFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNR
:::::.::::::::::::::::..:: : :: : ::::::::::::::: ::::::::
NP_001 GFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNR
750 760 770 780 790 800
810 820 830 840 850 860
pF1KE2 VLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRA
:::::::::::::::::: ...::::::::::::.::::::::::.:::::::::::::
NP_001 VLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRA
810 820 830 840 850 860
870 880 890 900 910 920
pF1KE2 GGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEDILERA
::::::::::::::::::::::::::::::::::::::::::::::::::.:::.:.:::
NP_001 GGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEEIIERA
870 880 890 900 910 920
930 940 950 960 970 980
pF1KE2 KKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQE
::::::::::::::::::.:.:...:. :.:.:::::::.::::::::.:::: ::::.:
NP_001 KKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESE
930 940 950 960 970 980
990 1000 1010 1020 1030 1040
pF1KE2 PQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEEI
::::::::::. :::.::: . .. ::::::::::::..: ::. ::: :: :.:.::
NP_001 PQEMDIDEILRLAETRENEVST-SATDELLSQFKVANFATM-EDEEELE-ERPHKDWDEI
990 1000 1010 1020 1030 1040
1050 1060 1070 1080 1090 1100
pF1KE2 IPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEG---RRSRSRRYSGSDSDS-
:::.::...:::::::::::::::::.:. .:. . : :.. . ...: :.:.:..
NP_001 IPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSSASESETE
1050 1060 1070 1080 1090 1100
1110 1120 1130 1140 1150 1160
pF1KE2 -ISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKS
.. :.::.:::::.. .. ..::.:::::::::.::::: :::::. :::::::::::
NP_001 DSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKS
1110 1120 1130 1140 1150 1160
1170 1180 1190 1200 1210
pF1KE2 ETDLRRLGELVHNGCIKALKDSSSGTERT---GGRLGKVKGPTFRISGVQVNAKLVISHE
.::.:::::.::.:..:... ... : :: .:::..:::::::.: .:.::
NP_001 VADLKRLGELIHNSCVSAMQEYEEQLKENASEGKGPGKRRGPTIKISGVQVNVKSIIQHE
1170 1180 1190 1200 1210 1220
1220 1230 1240 1250 1260 1270
pF1KE2 EELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKM
::. :::::: ::::.:.: . :..::::::..:: :::: ::.::::.:::.::.::
NP_001 EEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYGNWELIKT
1230 1240 1250 1260 1270 1280
1280 1290 1300 1310 1320 1330
pF1KE2 DPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSK--RRKARA
::.:.:: :::: . :::::.::::::::::.::: . : :: :..:. .: .:: :.
NP_001 DPELKLTDKILPVETDKKPQGKQLQTRADYLLKLLRKGLEKKGAVTGGEEAKLKKRKPRV
1290 1300 1310 1320 1330 1340
1340 1350 1360
pF1KE2 KKNKAMKSIKVKE-----------------EIKSDS---SPLP----------------S
::.. . .: .. :.:.:. ::. :
NP_001 KKENKVPRLKEEHGIELSSPRHSDNPSEEGEVKDDGLEKSPMKKKQKKKENKENKEKQMS
1350 1360 1370 1380 1390 1400
1370 1380 1390 1400 1410
pF1KE2 EKSDEDDDKLSESKSDGRERSK--------KSSVSDAPVHITASGEPVPISE-ESEELDQ
..:.. :: ....: .:. : ::. :..::::::..:::::.: :...:::
NP_001 SRKDKEGDKERKKSKDKKEKPKSGDAKSSSKSKRSQGPVHITAGSEPVPIGEDEDDDLDQ
1410 1420 1430 1440 1450 1460
1420 1430 1440 1450 1460 1470
pF1KE2 KTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQI
.::::::::::::: ::::::.:.:::. .:::::::.::.::::.:.:::: :.. :.:
NP_001 ETFSICKERMRPVKKALKQLDKPDKGLNVQEQLEHTRNCLLKIGDRIAECLKAYSDQEHI
1470 1480 1490 1500 1510 1520
1480 1490 1500 1510 1520
pF1KE2 KQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKR----QESQQNSDQNSNLNPHVIRNPDV
: ::.:::::::::::::::::::::: : ::: .:.....: ... .: .
NP_001 KLWRRNLWIFVSKFTEFDARKLHKLYKMAHKKRSQEEEEQKKKDDVTGGKKPFRPEASGS
1530 1540 1550 1560 1570 1580
1530 1540 1550 1560 1570
pF1KE2 ER----LKENTNHDDSSRDSYSSDRHLTQYHDHHKD-------RHQGDSYKKSDSRKRPY
: . .:.:. . . : :.: : .: :: ... . . .:.: .
NP_001 SRDSLISQSHTSHNLHPQKPHLPASHGPQMHGHPRDNYNHPNKRHFSNADRGDWQRERKF
1590 1600 1610 1620 1630 1640
1580 1590 1600 1610 1620 1630
pF1KE2 SSFSNGKDHRDWD---HYKQDSRYYSDRE--KHRKLDDHRSRDHRSNLEGSLKDRSHSDH
. ...:... : :.. ....:.:.. .:..: ::: ..: : . . : ....
NP_001 N-YGGGNNNPPWGSDRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPN--NMSRKRPYDQY
1650 1660 1670 1680 1690 1700
1640 1650 1660 1670 1680
pF1KE2 RSHSDHRLHSDHRSSSEYTHHKSSR----DYRYHSDWQMDHRASSSGPRSPLDQRSYGSR
: ::: : :. . :: :.: ..: .. :.: :
NP_001 SSDRDHRGHRDYY---DRHHHDSKRRRSDEFRPQNYHQQDFRRMSDHRPAMGYHGQGPSD
1710 1720 1730 1740 1750 1760
1690 1700
pF1KE2 SPFEHSVEHKSTPEHTWSSRKT
NP_001 HYRSFHTDKLGEYKQPLPPLHPAVSDPRSPPSQKSPHDSKSPLDHRSPLERSLEQKNNPD
1770 1780 1790 1800 1810 1820
>>XP_016864481 (OMIM: 602118) PREDICTED: chromodomain-he (869 aa)
initn: 3172 init1: 2894 opt: 2981 Z-score: 1690.3 bits: 324.8 E(85289): 2.1e-87
Smith-Waterman score: 4659; 89.2% identity (89.2% similar) in 812 aa overlap (930-1653:1-812)
900 910 920 930 940 950
pF1KE2 RIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTP
::::::::::::::::::::::::::::::
XP_016 MVLDHLVIQRMDTTGKTVLHTGSAPSSSTP
10 20 30
960 970 980 990 1000 1010
pF1KE2 FNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQF
40 50 60 70 80 90
1020 1030 1040 1050 1060 1070
pF1KE2 KVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQ
100 110 120 130 140 150
1080 1090 1100 1110 1120 1130
pF1KE2 ISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYK
160 170 180 190 200 210
1140 1150 1160 1170 1180 1190
pF1KE2 KFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKG
220 230 240 250 260 270
1200 1210 1220 1230 1240 1250
pF1KE2 PTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDS
280 290 300 310 320 330
1260 1270 1280 1290 1300 1310
pF1KE2 NLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAK
340 350 360 370 380 390
1320 1330 1340 1350 1360
pF1KE2 KEALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDK----------
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKDEISSVKHPN
400 410 420 430 440 450
pF1KE2 ------------------------------------------------------------
XP_016 KKIKTERDSEEKPEPDVYIKKEPEEKREAKEKENKKELKREIKEKEDKKDIKEKDFKEKR
460 470 480 490 500 510
1370 1380 1390 1400 1410
pF1KE2 ------------------LSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQ
::::::::::::::::::::::::::::::::::::::::::
XP_016 ENKVKEAIQKEKDIKEEKLSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQ
520 530 540 550 560 570
1420 1430 1440 1450 1460 1470
pF1KE2 KTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQI
580 590 600 610 620 630
1480 1490 1500 1510 1520 1530
pF1KE2 KQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLK
640 650 660 670 680 690
1540 1550 1560 1570 1580 1590
pF1KE2 ENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHY
700 710 720 730 740 750
1600 1610 1620 1630 1640 1650
pF1KE2 KQDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTH
760 770 780 790 800 810
1660 1670 1680 1690 1700
pF1KE2 HKSSRDYRYHSDWQMDHRASSSGPRSPLDQRSYGSRSPFEHSVEHKSTPEHTWSSRKT
::
XP_016 HKSSRDYRYHSDWQMDHRASSSGPRSPLDQRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
820 830 840 850 860
>--
initn: 386 init1: 217 opt: 388 Z-score: 235.0 bits: 55.6 E(85289): 2.4e-06
Smith-Waterman score: 388; 98.2% identity (98.2% similar) in 57 aa overlap (1654-1709:813-869)
1630 1640 1650 1660 1670 1680
pF1KE2 KDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRS
::::::::::::::::::::::::::::::
XP_016 KDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRS
790 800 810 820 830 840
1690 1700
pF1KE2 -YGSRSPFEHSVEHKSTPEHTWSSRKT
::::::::::::::::::::::::::
XP_016 PYGSRSPFEHSVEHKSTPEHTWSSRKT
850 860
>>XP_016864480 (OMIM: 602118) PREDICTED: chromodomain-he (869 aa)
initn: 3172 init1: 2894 opt: 2981 Z-score: 1690.3 bits: 324.8 E(85289): 2.1e-87
Smith-Waterman score: 4659; 89.2% identity (89.2% similar) in 812 aa overlap (930-1653:1-812)
900 910 920 930 940 950
pF1KE2 RIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTP
::::::::::::::::::::::::::::::
XP_016 MVLDHLVIQRMDTTGKTVLHTGSAPSSSTP
10 20 30
960 970 980 990 1000 1010
pF1KE2 FNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQF
40 50 60 70 80 90
1020 1030 1040 1050 1060 1070
pF1KE2 KVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQ
100 110 120 130 140 150
1080 1090 1100 1110 1120 1130
pF1KE2 ISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYK
160 170 180 190 200 210
1140 1150 1160 1170 1180 1190
pF1KE2 KFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKG
220 230 240 250 260 270
1200 1210 1220 1230 1240 1250
pF1KE2 PTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDS
280 290 300 310 320 330
1260 1270 1280 1290 1300 1310
pF1KE2 NLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAK
340 350 360 370 380 390
1320 1330 1340 1350 1360
pF1KE2 KEALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDK----------
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKDEISSVKHPN
400 410 420 430 440 450
pF1KE2 ------------------------------------------------------------
XP_016 KKIKTERDSEEKPEPDVYIKKEPEEKREAKEKENKKELKREIKEKEDKKDIKEKDFKEKR
460 470 480 490 500 510
1370 1380 1390 1400 1410
pF1KE2 ------------------LSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQ
::::::::::::::::::::::::::::::::::::::::::
XP_016 ENKVKEAIQKEKDIKEEKLSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQ
520 530 540 550 560 570
1420 1430 1440 1450 1460 1470
pF1KE2 KTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQI
580 590 600 610 620 630
1480 1490 1500 1510 1520 1530
pF1KE2 KQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLK
640 650 660 670 680 690
1540 1550 1560 1570 1580 1590
pF1KE2 ENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHY
700 710 720 730 740 750
1600 1610 1620 1630 1640 1650
pF1KE2 KQDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTH
760 770 780 790 800 810
1660 1670 1680 1690 1700
pF1KE2 HKSSRDYRYHSDWQMDHRASSSGPRSPLDQRSYGSRSPFEHSVEHKSTPEHTWSSRKT
::
XP_016 HKSSRDYRYHSDWQMDHRASSSGPRSPLDQRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
820 830 840 850 860
>--
initn: 386 init1: 217 opt: 388 Z-score: 235.0 bits: 55.6 E(85289): 2.4e-06
Smith-Waterman score: 388; 98.2% identity (98.2% similar) in 57 aa overlap (1654-1709:813-869)
1630 1640 1650 1660 1670 1680
pF1KE2 KDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRS
::::::::::::::::::::::::::::::
XP_016 KDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRS
790 800 810 820 830 840
1690 1700
pF1KE2 -YGSRSPFEHSVEHKSTPEHTWSSRKT
::::::::::::::::::::::::::
XP_016 PYGSRSPFEHSVEHKSTPEHTWSSRKT
850 860
>>XP_016885240 (OMIM: 300012) PREDICTED: probable global (1036 aa)
initn: 1249 init1: 641 opt: 1450 Z-score: 830.0 bits: 165.9 E(85289): 1.7e-39
Smith-Waterman score: 1529; 31.9% identity (60.1% similar) in 1036 aa overlap (287-1253:14-990)
260 270 280 290 300 310
pF1KE2 EVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEI
:. ::.:: ..: : . : ..: :
XP_016 MEQDTAAVAATVAAADATATIVVIE---DEQPGPSTSQEEGAA
10 20 30 40
320 330 340 350 360 370
pF1KE2 QYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNC
. . : ::. :... :...... : . . :. . : ::
XP_016 A--------AATEATAATEKGEKKKE----KNVSSFQLK--LAAKAPKSEKEMDPEY---
50 60 70 80
380 390 400 410 420 430
pF1KE2 QQELTDDLHKQYQIVER---IIAHSNQKSAAGYPDYYCKWQ-GLPYSECSWEDGALISKK
.... : :..... . ..:: : :: : . . : : . . : .:::
XP_016 EEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKD-EKQSLIS--
90 100 110 120 130 140
440 450 460 470 480
pF1KE2 FQACIDEYFSRNQSKTTPFKDCKVLKQRPRF----VALKKQPSYIGGHEGLELRDYQLNG
.: : .: .: ..:.. . . .. .:::. .: :::::. :
XP_016 ----AGDYRHR---RTEQEEDEELLSESRKTSNVCIRFEVSPSYV---KGGPLRDYQIRG
150 160 170 180 190
490 500 510 520 530 540
pF1KE2 LNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQRE
:::: . .: . :::::::::::.:::..:.:: : ... :: ...:: ::: .:. :
XP_016 LNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNE
200 210 220 230 240 250
550 560 570 580 590 600
pF1KE2 IQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNW
.. :. .. .. ..:: ..: . : . ... .:.::...:.:. . ..:
XP_016 FKRWVPSLRVICFVGDKDARAAFIRDEMMPGE-----WDVCVTSYEMVIKEKSVFKKFHW
260 270 280 290 300
610 620 630 640 650 660
pF1KE2 AFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSW
.. .:::::.::. : : . . .:::..:::.:::::::.:.:::.::.:..:. :.:
XP_016 RYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA
310 320 330 340 350 360
670 680 690 700 710 720
pF1KE2 EDFEE----EHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQ
.::. .. : . :: :.::::::.: ::::::: : : . . .: .:..
XP_016 DDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQRE
370 380 390 400 410 420
730 740 750 760 770 780
pF1KE2 YYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLI
.: :: .. .:....: . .:::.:.:.::::: ::. . . :. .: :..
XP_016 WYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDE---HIV
430 440 450 460 470 480
790 800 810 820 830 840
pF1KE2 RSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRK
.:::...::::: .:.:.:.::::::::.:.:::: .: .: . . ::::. : :.
XP_016 SNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEERE
490 500 510 520 530 540
850 860 870 880 890 900
pF1KE2 QALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQK
.:.. ::: .: : :.::::::::::::::::.:...::::::: ::::. ::::::::
XP_016 EAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQK
550 560 570 580 590 600
910 920 930 940 950 960
pF1KE2 KQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEE
: : ..::.: ..::: :.:::. :. :: .:::. :. . ..:. . :::
XP_016 KPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQ----GRLI------DQQSNKLAKEE
610 620 630 640 650
970 980 990 1000 1010 1020
pF1KE2 LSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGP--LTVGDELLSQFKV-
. ... :: ..: ..:.: . :: ::.:.: . : . .:. : .:..
XP_016 MLQMIRHGATHVFA---SKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMD
660 670 680 690 700
1030 1040 1050
pF1KE2 --ANFSNMDEDDIELEPERNSKNWEEIIPEDQRR-------------RLEEEE-------
.. ... .: . . . . .: : :. .:. :. : .
XP_016 IEQSLYKFEGEDYREKQKLGMVEWIEP-PKRERKANYAVDAYFREALRVSEPKIPKAPRP
710 720 730 740 750 760
1060 1070 1080 1090 1100 1110
pF1KE2 -RQKELEEIYMLP-RMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISEGKRPKK-RGRPR
.: ..... ..: :. . .. . . . : . .... .. :: :
XP_016 PKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEP
770 780 790 800 810 820
1120 1130 1140 1150 1160
pF1KE2 TIPREN-------IKGFSDAEIR---RFIKSYKKFGGPLERLDAIARDAELVDKSET---
:.:. .::.. : .:::. .:.: . .: :::..: . :.
XP_016 LTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGR--DDIDNIAREVEGKSPEEVMEY
830 840 850 860 870 880
1170 1180 1190 1200
pF1KE2 ------------DLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP--TFRISGVQV
:.... .. : . .. : . ..... :.: .::.
XP_016 SAVFWERCNELQDIEKIMAQIERGEAR-IQRRISIKKALDAKIARYKAPFHQLRIQYGTS
890 900 910 920 930 940
1210 1220 1230 1240 1250 1260
pF1KE2 NAKLVISHEEELIP--LHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYE
..: .:.... ::: . : :. . : .: .: .::
XP_016 KGKNYTEEEDRFLICMLHK-MGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRC
950 960 970 980 990 1000
1270 1280 1290 1300 1310 1320
pF1KE2 YGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAG
XP_016 NTLISLIEKENMEIEERERAEKKKRATKTPMI
1010 1020 1030
>>XP_016885239 (OMIM: 300012) PREDICTED: probable global (1042 aa)
initn: 1249 init1: 641 opt: 1450 Z-score: 829.9 bits: 165.9 E(85289): 1.7e-39
Smith-Waterman score: 1529; 31.9% identity (60.1% similar) in 1036 aa overlap (287-1253:14-990)
260 270 280 290 300 310
pF1KE2 EVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEI
:. ::.:: ..: : . : ..: :
XP_016 MEQDTAAVAATVAAADATATIVVIE---DEQPGPSTSQEEGAA
10 20 30 40
320 330 340 350 360 370
pF1KE2 QYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNC
. . : ::. :... :...... : . . :. . : ::
XP_016 A--------AATEATAATEKGEKKKE----KNVSSFQLK--LAAKAPKSEKEMDPEY---
50 60 70 80
380 390 400 410 420 430
pF1KE2 QQELTDDLHKQYQIVER---IIAHSNQKSAAGYPDYYCKWQ-GLPYSECSWEDGALISKK
.... : :..... . ..:: : :: : . . : : . . : .:::
XP_016 EEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKD-EKQSLIS--
90 100 110 120 130 140
440 450 460 470 480
pF1KE2 FQACIDEYFSRNQSKTTPFKDCKVLKQRPRF----VALKKQPSYIGGHEGLELRDYQLNG
.: : .: .: ..:.. . . .. .:::. .: :::::. :
XP_016 ----AGDYRHR---RTEQEEDEELLSESRKTSNVCIRFEVSPSYV---KGGPLRDYQIRG
150 160 170 180 190
490 500 510 520 530 540
pF1KE2 LNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQRE
:::: . .: . :::::::::::.:::..:.:: : ... :: ...:: ::: .:. :
XP_016 LNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNE
200 210 220 230 240 250
550 560 570 580 590 600
pF1KE2 IQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNW
.. :. .. .. ..:: ..: . : . ... .:.::...:.:. . ..:
XP_016 FKRWVPSLRVICFVGDKDARAAFIRDEMMPGE-----WDVCVTSYEMVIKEKSVFKKFHW
260 270 280 290 300
610 620 630 640 650 660
pF1KE2 AFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSW
.. .:::::.::. : : . . .:::..:::.:::::::.:.:::.::.:..:. :.:
XP_016 RYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA
310 320 330 340 350 360
670 680 690 700 710 720
pF1KE2 EDFEE----EHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQ
.::. .. : . :: :.::::::.: ::::::: : : . . .: .:..
XP_016 DDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQRE
370 380 390 400 410 420
730 740 750 760 770 780
pF1KE2 YYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLI
.: :: .. .:....: . .:::.:.:.::::: ::. . . :. .: :..
XP_016 WYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDE---HIV
430 440 450 460 470 480
790 800 810 820 830 840
pF1KE2 RSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRK
.:::...::::: .:.:.:.::::::::.:.:::: .: .: . . ::::. : :.
XP_016 SNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEERE
490 500 510 520 530 540
850 860 870 880 890 900
pF1KE2 QALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQK
.:.. ::: .: : :.::::::::::::::::.:...::::::: ::::. ::::::::
XP_016 EAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQK
550 560 570 580 590 600
910 920 930 940 950 960
pF1KE2 KQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEE
: : ..::.: ..::: :.:::. :. :: .:::. :. . ..:. . :::
XP_016 KPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQ----GRLI------DQQSNKLAKEE
610 620 630 640 650
970 980 990 1000 1010 1020
pF1KE2 LSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGP--LTVGDELLSQFKV-
. ... :: ..: ..:.: . :: ::.:.: . : . .:. : .:..
XP_016 MLQMIRHGATHVFA---SKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMD
660 670 680 690 700
1030 1040 1050
pF1KE2 --ANFSNMDEDDIELEPERNSKNWEEIIPEDQRR-------------RLEEEE-------
.. ... .: . . . . .: : :. .:. :. : .
XP_016 IEQSLYKFEGEDYREKQKLGMVEWIEP-PKRERKANYAVDAYFREALRVSEPKIPKAPRP
710 720 730 740 750 760
1060 1070 1080 1090 1100 1110
pF1KE2 -RQKELEEIYMLP-RMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISEGKRPKK-RGRPR
.: ..... ..: :. . .. . . . : . .... .. :: :
XP_016 PKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEP
770 780 790 800 810 820
1120 1130 1140 1150 1160
pF1KE2 TIPREN-------IKGFSDAEIR---RFIKSYKKFGGPLERLDAIARDAELVDKSET---
:.:. .::.. : .:::. .:.: . .: :::..: . :.
XP_016 LTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGR--DDIDNIAREVEGKSPEEVMEY
830 840 850 860 870 880
1170 1180 1190 1200
pF1KE2 ------------DLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP--TFRISGVQV
:.... .. : . .. : . ..... :.: .::.
XP_016 SAVFWERCNELQDIEKIMAQIERGEAR-IQRRISIKKALDAKIARYKAPFHQLRIQYGTS
890 900 910 920 930 940
1210 1220 1230 1240 1250 1260
pF1KE2 NAKLVISHEEELIP--LHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYE
..: .:.... ::: . : :. . : .: .: .::
XP_016 KGKNYTEEEDRFLICMLHK-MGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRC
950 960 970 980 990 1000
1270 1280 1290 1300 1310 1320
pF1KE2 YGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAG
XP_016 NTLISLIEKENMEIEERERAEKKKRATKTPMVKFSAFS
1010 1020 1030 1040
>>XP_006724845 (OMIM: 300012) PREDICTED: probable global (1042 aa)
initn: 1249 init1: 641 opt: 1450 Z-score: 829.9 bits: 165.9 E(85289): 1.7e-39
Smith-Waterman score: 1529; 31.9% identity (60.1% similar) in 1036 aa overlap (287-1253:14-990)
260 270 280 290 300 310
pF1KE2 EVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEI
:. ::.:: ..: : . : ..: :
XP_006 MEQDTAAVAATVAAADATATIVVIE---DEQPGPSTSQEEGAA
10 20 30 40
320 330 340 350 360 370
pF1KE2 QYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNC
. . : ::. :... :...... : . . :. . : ::
XP_006 A--------AATEATAATEKGEKKKE----KNVSSFQLK--LAAKAPKSEKEMDPEY---
50 60 70 80
380 390 400 410 420 430
pF1KE2 QQELTDDLHKQYQIVER---IIAHSNQKSAAGYPDYYCKWQ-GLPYSECSWEDGALISKK
.... : :..... . ..:: : :: : . . : : . . : .:::
XP_006 EEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKD-EKQSLIS--
90 100 110 120 130 140
440 450 460 470 480
pF1KE2 FQACIDEYFSRNQSKTTPFKDCKVLKQRPRF----VALKKQPSYIGGHEGLELRDYQLNG
.: : .: .: ..:.. . . .. .:::. .: :::::. :
XP_006 ----AGDYRHR---RTEQEEDEELLSESRKTSNVCIRFEVSPSYV---KGGPLRDYQIRG
150 160 170 180 190
490 500 510 520 530 540
pF1KE2 LNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQRE
:::: . .: . :::::::::::.:::..:.:: : ... :: ...:: ::: .:. :
XP_006 LNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNE
200 210 220 230 240 250
550 560 570 580 590 600
pF1KE2 IQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNW
.. :. .. .. ..:: ..: . : . ... .:.::...:.:. . ..:
XP_006 FKRWVPSLRVICFVGDKDARAAFIRDEMMPGE-----WDVCVTSYEMVIKEKSVFKKFHW
260 270 280 290 300
610 620 630 640 650 660
pF1KE2 AFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSW
.. .:::::.::. : : . . .:::..:::.:::::::.:.:::.::.:..:. :.:
XP_006 RYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA
310 320 330 340 350 360
670 680 690 700 710 720
pF1KE2 EDFEE----EHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQ
.::. .. : . :: :.::::::.: ::::::: : : . . .: .:..
XP_006 DDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQRE
370 380 390 400 410 420
730 740 750 760 770 780
pF1KE2 YYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLI
.: :: .. .:....: . .:::.:.:.::::: ::. . . :. .: :..
XP_006 WYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDE---HIV
430 440 450 460 470 480
790 800 810 820 830 840
pF1KE2 RSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRK
.:::...::::: .:.:.:.::::::::.:.:::: .: .: . . ::::. : :.
XP_006 SNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEERE
490 500 510 520 530 540
850 860 870 880 890 900
pF1KE2 QALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQK
.:.. ::: .: : :.::::::::::::::::.:...::::::: ::::. ::::::::
XP_006 EAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQK
550 560 570 580 590 600
910 920 930 940 950 960
pF1KE2 KQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEE
: : ..::.: ..::: :.:::. :. :: .:::. :. . ..:. . :::
XP_006 KPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQ----GRLI------DQQSNKLAKEE
610 620 630 640 650
970 980 990 1000 1010 1020
pF1KE2 LSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGP--LTVGDELLSQFKV-
. ... :: ..: ..:.: . :: ::.:.: . : . .:. : .:..
XP_006 MLQMIRHGATHVFA---SKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMD
660 670 680 690 700
1030 1040 1050
pF1KE2 --ANFSNMDEDDIELEPERNSKNWEEIIPEDQRR-------------RLEEEE-------
.. ... .: . . . . .: : :. .:. :. : .
XP_006 IEQSLYKFEGEDYREKQKLGMVEWIEP-PKRERKANYAVDAYFREALRVSEPKIPKAPRP
710 720 730 740 750 760
1060 1070 1080 1090 1100 1110
pF1KE2 -RQKELEEIYMLP-RMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISEGKRPKK-RGRPR
.: ..... ..: :. . .. . . . : . .... .. :: :
XP_006 PKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEP
770 780 790 800 810 820
1120 1130 1140 1150 1160
pF1KE2 TIPREN-------IKGFSDAEIR---RFIKSYKKFGGPLERLDAIARDAELVDKSET---
:.:. .::.. : .:::. .:.: . .: :::..: . :.
XP_006 LTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGR--DDIDNIAREVEGKSPEEVMEY
830 840 850 860 870 880
1170 1180 1190 1200
pF1KE2 ------------DLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP--TFRISGVQV
:.... .. : . .. : . ..... :.: .::.
XP_006 SAVFWERCNELQDIEKIMAQIERGEAR-IQRRISIKKALDAKIARYKAPFHQLRIQYGTS
890 900 910 920 930 940
1210 1220 1230 1240 1250 1260
pF1KE2 NAKLVISHEEELIP--LHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYE
..: .:.... ::: . : :. . : .: .: .::
XP_006 KGKNYTEEEDRFLICMLHK-MGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRC
950 960 970 980 990 1000
1270 1280 1290 1300 1310 1320
pF1KE2 YGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAG
XP_006 NTLISLIEKENMEIEERERAEKKKRATKTPMVKFSAFS
1010 1020 1030 1040
1709 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:14:57 2016 done: Mon Nov 7 20:15:00 2016
Total Scan time: 18.610 Total Display time: 0.770
Function used was FASTA [36.3.4 Apr, 2011]