Result of FASTA (omim) for
pF1KE2443
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2443, 321 aa
1>>>pF1KE2443 321 - 321 aa - 321 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5324+/-0.000376; mu= 10.7181+/- 0.024
mean_var=108.5991+/-22.039, 0's: 0 Z-trim(116.3): 49 B-trim: 1412 in 2/48
Lambda= 0.123073
statistics sampled from 27248 (27298) to 27248 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.32), width: 16
Scan time: 7.820
The best scores are: opt bits E(85289)
NP_065711 (OMIM: 607058) gap junction delta-2 prot ( 321) 2145 391.4 1.3e-108
XP_016877927 (OMIM: 607058) PREDICTED: gap junctio ( 270) 1833 335.9 5.5e-92
NP_689343 (OMIM: 607425) gap junction delta-3 prot ( 294) 433 87.4 4e-17
XP_011507719 (OMIM: 116200,600897,612474) PREDICTE ( 427) 433 87.5 5.4e-17
NP_005258 (OMIM: 116200,600897,612474) gap junctio ( 433) 433 87.5 5.4e-17
XP_011507718 (OMIM: 116200,600897,612474) PREDICTE ( 433) 433 87.5 5.4e-17
XP_016856532 (OMIM: 121012) PREDICTED: gap junctio ( 333) 428 86.5 8.1e-17
XP_005270807 (OMIM: 121012) PREDICTED: gap junctio ( 333) 428 86.5 8.1e-17
NP_002051 (OMIM: 121012) gap junction alpha-4 prot ( 333) 428 86.5 8.1e-17
NP_068773 (OMIM: 121015,601885) gap junction alpha ( 435) 422 85.5 2.1e-16
XP_011533350 (OMIM: 121015,601885) PREDICTED: gap ( 435) 422 85.5 2.1e-16
NP_065168 (OMIM: 608803,608804,613206,613480) gap ( 439) 417 84.7 3.9e-16
NP_005488 (OMIM: 608655) gap junction gamma-1 prot ( 396) 416 84.5 4.1e-16
NP_001073852 (OMIM: 608655) gap junction gamma-1 p ( 396) 416 84.5 4.1e-16
XP_005256978 (OMIM: 608655) PREDICTED: gap junctio ( 396) 416 84.5 4.1e-16
XP_005256977 (OMIM: 608655) PREDICTED: gap junctio ( 396) 416 84.5 4.1e-16
NP_005257 (OMIM: 108770,121013,612474,614049) gap ( 358) 403 82.1 1.9e-15
NP_859054 (OMIM: 108770,121013,612474,614049) gap ( 358) 403 82.1 1.9e-15
XP_016856533 (OMIM: 108770,121013,612474,614049) P ( 358) 403 82.1 1.9e-15
XP_005273008 (OMIM: 108770,121013,612474,614049) P ( 358) 403 82.1 1.9e-15
NP_115991 (OMIM: 611924) gap junction alpha-10 pro ( 543) 399 81.5 4.3e-15
NP_110399 (OMIM: 611923) gap junction alpha-9 prot ( 515) 391 80.1 1.1e-14
XP_016884897 (OMIM: 302800,304040) PREDICTED: gap ( 283) 377 77.4 3.8e-14
XP_011529209 (OMIM: 302800,304040) PREDICTED: gap ( 283) 377 77.4 3.8e-14
NP_001091111 (OMIM: 302800,304040) gap junction be ( 283) 377 77.4 3.8e-14
NP_000157 (OMIM: 302800,304040) gap junction beta- ( 283) 377 77.4 3.8e-14
NP_003995 (OMIM: 121011,124500,148210,148350,14920 ( 226) 358 74.0 3.3e-13
XP_011533351 (OMIM: 121011,124500,148210,148350,14 ( 226) 358 74.0 3.3e-13
NP_000156 (OMIM: 104100,121014,133200,164200,18610 ( 382) 358 74.1 5e-13
XP_011538981 (OMIM: 133200,605425) PREDICTED: gap ( 266) 355 73.5 5.4e-13
NP_694944 (OMIM: 133200,605425) gap junction beta- ( 266) 355 73.5 5.4e-13
NP_001103689 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
XP_016875848 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
XP_016875849 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
NP_001103691 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
XP_016875847 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
NP_006774 (OMIM: 129500,220290,304400,604418,61264 ( 261) 348 72.3 1.3e-12
NP_001103690 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
XP_016875846 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12
NP_001005752 (OMIM: 133200,220290,603324,612644) g ( 270) 338 70.5 4.4e-12
NP_076872 (OMIM: 133200,220290,603324,612644) gap ( 270) 338 70.5 4.4e-12
NP_005259 (OMIM: 604493) gap junction beta-5 prote ( 273) 331 69.3 1.1e-11
XP_005270808 (OMIM: 604493) PREDICTED: gap junctio ( 273) 331 69.3 1.1e-11
NP_940970 (OMIM: 611921) gap junction beta-7 prote ( 223) 320 67.2 3.5e-11
XP_005248773 (OMIM: 611921) PREDICTED: gap junctio ( 223) 320 67.2 3.5e-11
NP_853516 (OMIM: 611925) gap junction gamma-3 prot ( 279) 308 65.2 1.8e-10
NP_699199 (OMIM: 611922) gap junction delta-4 prot ( 370) 300 63.8 6.1e-10
>>NP_065711 (OMIM: 607058) gap junction delta-2 protein (321 aa)
initn: 2145 init1: 2145 opt: 2145 Z-score: 2070.7 bits: 391.4 E(85289): 1.3e-108
Smith-Waterman score: 2145; 100.0% identity (100.0% similar) in 321 aa overlap (1-321:1-321)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK
250 260 270 280 290 300
310 320
pF1KE2 DLPRVSVPNFGRTQSSDSAYV
:::::::::::::::::::::
NP_065 DLPRVSVPNFGRTQSSDSAYV
310 320
>>XP_016877927 (OMIM: 607058) PREDICTED: gap junction de (270 aa)
initn: 1833 init1: 1833 opt: 1833 Z-score: 1772.4 bits: 335.9 E(85289): 5.5e-92
Smith-Waterman score: 1833; 100.0% identity (100.0% similar) in 270 aa overlap (52-321:1-270)
30 40 50 60 70 80
pF1KE2 IGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVF
::::::::::::::::::::::::::::::
XP_016 MFVCNTLQPGCNQACYDRAFPISHIRYWVF
10 20 30
90 100 110 120 130 140
pF1KE2 QIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKRE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 DKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYII
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE2 QVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVS
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 GICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV
220 230 240 250 260 270
>>NP_689343 (OMIM: 607425) gap junction delta-3 protein (294 aa)
initn: 692 init1: 396 opt: 433 Z-score: 428.5 bits: 87.4 E(85289): 4e-17
Smith-Waterman score: 592; 37.8% identity (60.5% similar) in 304 aa overlap (1-303:1-239)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::::..: ::.: :: .: ..::. :.:..:::::..: :: .:..::: ::::::::
NP_689 MGEWAFLGSLLDA-VQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
:: :.:::::::.:: :.:.:.:... .: . :..::.:...:.
NP_689 GCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKE----------------
60 70 80 90 100
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
.::. . : : :. : .: : .
NP_689 -----------AGGA------EAAAQCA--PGL----------PEAQCA--------PCA
110 120
190 200 210 220 230 240
pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
::. :: . : :...:..: :. :: :: .:::: : . : :: . :
NP_689 LRA------RRAR---RCYLLSVALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTV
130 140 150 160 170
250 260 270 280 290
pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWR-KIKLAVRGAQAKRKSIYEIRN
.:.::::::::::..:.:::. . ..:..:::.:: :. . . . : . .: .: .
NP_689 DCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRCNR--AHEEAQ
180 190 200 210 220 230
300 310 320
pF1KE2 KDLPRVSVPNFGRTQSSDSAYV
: ::
NP_689 KLLPPPPPPPPPPALPSRRPGPEPCAPPAYAHPAPASLRECGSGRGKASPATGRRDLAI
240 250 260 270 280 290
>>XP_011507719 (OMIM: 116200,600897,612474) PREDICTED: g (427 aa)
initn: 712 init1: 381 opt: 433 Z-score: 426.1 bits: 87.5 E(85289): 5.4e-17
Smith-Waterman score: 725; 40.6% identity (67.3% similar) in 315 aa overlap (1-314:1-264)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.:..: .:: :..:::.:::. :::. ::::::.. ..: :. :::. ::::: ::
XP_011 MGDWSFLGNILEE-VNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...:::.:::::::: ::.:::.: :::: .. ..:: ....:.: : :.
XP_011 GCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHY-VRMEEKRKS-------REA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
: .: .::.:: :: ::. ::
XP_011 -EELGQQAGTNGG--------------------------------PDQGSVKK----SSG
120 130
190 200 210 220 230
pF1KE2 LRTASKSKLRRQEG-ISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKE
. ..: .: :: . : :: ...:.. .:.::.::.:::::: . ::.:.:.:: .
XP_011 SKGTKKFRL---EGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNV
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE2 VECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRN
:.:.::::::::.:..::..:... . ::. ::.::: . :. :.. . .. . :: .
XP_011 VDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK--RPVEQPLGEIPE
200 210 220 230 240
300 310 320
pF1KE2 KDLPRVSVPNFGRTQSSDSAYV
:.: ..: .. ...
XP_011 KSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPL
250 260 270 280 290 300
>>NP_005258 (OMIM: 116200,600897,612474) gap junction al (433 aa)
initn: 712 init1: 381 opt: 433 Z-score: 426.0 bits: 87.5 E(85289): 5.4e-17
Smith-Waterman score: 725; 40.6% identity (67.3% similar) in 315 aa overlap (1-314:1-264)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.:..: .:: :..:::.:::. :::. ::::::.. ..: :. :::. ::::: ::
NP_005 MGDWSFLGNILEE-VNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...:::.:::::::: ::.:::.: :::: .. ..:: ....:.: : :.
NP_005 GCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHY-VRMEEKRKS-------REA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
: .: .::.:: :: ::. ::
NP_005 -EELGQQAGTNGG--------------------------------PDQGSVKK----SSG
120 130
190 200 210 220 230
pF1KE2 LRTASKSKLRRQEG-ISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKE
. ..: .: :: . : :: ...:.. .:.::.::.:::::: . ::.:.:.:: .
NP_005 SKGTKKFRL---EGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNV
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE2 VECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRN
:.:.::::::::.:..::..:... . ::. ::.::: . :. :.. . .. . :: .
NP_005 VDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK--RPVEQPLGEIPE
200 210 220 230 240
300 310 320
pF1KE2 KDLPRVSVPNFGRTQSSDSAYV
:.: ..: .. ...
NP_005 KSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPL
250 260 270 280 290 300
>>XP_011507718 (OMIM: 116200,600897,612474) PREDICTED: g (433 aa)
initn: 712 init1: 381 opt: 433 Z-score: 426.0 bits: 87.5 E(85289): 5.4e-17
Smith-Waterman score: 725; 40.6% identity (67.3% similar) in 315 aa overlap (1-314:1-264)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.:..: .:: :..:::.:::. :::. ::::::.. ..: :. :::. ::::: ::
XP_011 MGDWSFLGNILEE-VNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...:::.:::::::: ::.:::.: :::: .. ..:: ....:.: : :.
XP_011 GCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHY-VRMEEKRKS-------REA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
: .: .::.:: :: ::. ::
XP_011 -EELGQQAGTNGG--------------------------------PDQGSVKK----SSG
120 130
190 200 210 220 230
pF1KE2 LRTASKSKLRRQEG-ISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKE
. ..: .: :: . : :: ...:.. .:.::.::.:::::: . ::.:.:.:: .
XP_011 SKGTKKFRL---EGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNV
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE2 VECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRN
:.:.::::::::.:..::..:... . ::. ::.::: . :. :.. . .. . :: .
XP_011 VDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK--RPVEQPLGEIPE
200 210 220 230 240
300 310 320
pF1KE2 KDLPRVSVPNFGRTQSSDSAYV
:.: ..: .. ...
XP_011 KSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPL
250 260 270 280 290 300
>>XP_016856532 (OMIM: 121012) PREDICTED: gap junction al (333 aa)
initn: 694 init1: 381 opt: 428 Z-score: 422.9 bits: 86.5 E(85289): 8.1e-17
Smith-Waterman score: 624; 38.3% identity (65.5% similar) in 290 aa overlap (1-290:1-246)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.: .::.::. ::.:::..:.: :::. ::::::....::.:. :::. : ::: ::
XP_016 MGDWGFLEKLLDQ-VQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...:::.:::::::::::.:...: ::.: .. . .. : .::.: : .
XP_016 GCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLS--RREER-------LRQKE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
: . :. .: ... :.. : ..
XP_016 GELRALPA------------KDPQVERALAAVERQMAK----------------------
120 130
190 200 210 220 230 240
pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
. .: ..:: . .. :. .:. ...:: ::: ::. :::... .. :.: :: :
XP_016 ISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLV
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK
.:.::::::::.:..::..:. : .:::: :: :: : .. ..:. :..
XP_016 DCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS
200 210 220 230 240 250
310 320
pF1KE2 DLPRVSVPNFGRTQSSDSAYV
XP_016 DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNG
260 270 280 290 300 310
>>XP_005270807 (OMIM: 121012) PREDICTED: gap junction al (333 aa)
initn: 694 init1: 381 opt: 428 Z-score: 422.9 bits: 86.5 E(85289): 8.1e-17
Smith-Waterman score: 624; 38.3% identity (65.5% similar) in 290 aa overlap (1-290:1-246)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.: .::.::. ::.:::..:.: :::. ::::::....::.:. :::. : ::: ::
XP_005 MGDWGFLEKLLDQ-VQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...:::.:::::::::::.:...: ::.: .. . .. : .::.: : .
XP_005 GCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLS--RREER-------LRQKE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
: . :. .: ... :.. : ..
XP_005 GELRALPA------------KDPQVERALAAVERQMAK----------------------
120 130
190 200 210 220 230 240
pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
. .: ..:: . .. :. .:. ...:: ::: ::. :::... .. :.: :: :
XP_005 ISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLV
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK
.:.::::::::.:..::..:. : .:::: :: :: : .. ..:. :..
XP_005 DCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS
200 210 220 230 240 250
310 320
pF1KE2 DLPRVSVPNFGRTQSSDSAYV
XP_005 DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNG
260 270 280 290 300 310
>>NP_002051 (OMIM: 121012) gap junction alpha-4 protein (333 aa)
initn: 694 init1: 381 opt: 428 Z-score: 422.9 bits: 86.5 E(85289): 8.1e-17
Smith-Waterman score: 624; 38.3% identity (65.5% similar) in 290 aa overlap (1-290:1-246)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.: .::.::. ::.:::..:.: :::. ::::::....::.:. :::. : ::: ::
NP_002 MGDWGFLEKLLDQ-VQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...:::.:::::::::::.:...: ::.: .. . .. : .::.: : .
NP_002 GCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLS--RREER-------LRQKE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
: . :. .: ... :.. : ..
NP_002 GELRALPA------------KDPQVERALAAVERQMAK----------------------
120 130
190 200 210 220 230 240
pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
. .: ..:: . .. :. .:. ...:: ::: ::. :::... .. :.: :: :
NP_002 ISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLV
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK
.:.::::::::.:..::..:. : .:::: :: :: : .. ..:. :..
NP_002 DCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS
200 210 220 230 240 250
310 320
pF1KE2 DLPRVSVPNFGRTQSSDSAYV
NP_002 DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNG
260 270 280 290 300 310
>>NP_068773 (OMIM: 121015,601885) gap junction alpha-3 p (435 aa)
initn: 679 init1: 371 opt: 422 Z-score: 415.5 bits: 85.5 E(85289): 2.1e-16
Smith-Waterman score: 712; 38.3% identity (65.3% similar) in 311 aa overlap (1-308:1-261)
10 20 30 40 50 60
pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
::.:..: :::: : :.:::.::.. :::. :::::... ..: :. :::. :.::: ::
NP_068 MGDWSFLGRLLENA-QEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
::...::::::::::::.:..:::.: ::.: .. . .: ....:.. .:.
NP_068 GCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHI-VRMEEKKK-------EREE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
:.. :::. . :: : .::.
NP_068 EEQL--------------KRESP----------------SPKEPPQD---------NPSS
120 130
190 200 210 220 230 240
pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
.....: .. : :.....:.. .:.::..:::::::: . ::.:.:.:: . :
NP_068 --RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTV
140 150 160 170 180 190
250 260 270 280 290
pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVR---GAQAKRKSIYEI
.:..:::::::.:..::.::. ..::. :. ::::.:.: .: : .:.. .
NP_068 DCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTA
200 210 220 230 240 250
300 310 320
pF1KE2 RNKDLPRVSVPNFGRTQSSDSAYV
:: : :
NP_068 DPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQ
260 270 280 290 300 310
321 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 19:59:33 2016 done: Mon Nov 7 19:59:34 2016
Total Scan time: 7.820 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]