Result of FASTA (omim) for
pF1KE2395
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2395, 1129 aa
1>>>pF1KE2395 1129 - 1129 aa - 1129 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1510+/-0.000465; mu= 8.2031+/- 0.029
mean_var=186.3475+/-38.269, 0's: 0 Z-trim(115.0): 167 B-trim: 145 in 1/50
Lambda= 0.093953
statistics sampled from 24961 (25140) to 24961 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.295), width: 16
Scan time: 14.720
The best scores are: opt bits E(85289)
NP_009017 (OMIM: 608126) WD repeat and HMG-box DNA (1129) 7571 1040.2 0
XP_006720075 (OMIM: 608126) PREDICTED: WD repeat a (1127) 7544 1036.6 0
NP_001008397 (OMIM: 608126) WD repeat and HMG-box (1006) 6737 927.1 0
XP_016876429 (OMIM: 608126) PREDICTED: WD repeat a (1004) 6710 923.5 0
XP_011534675 (OMIM: 608126) PREDICTED: WD repeat a ( 766) 5082 702.7 2.1e-201
XP_016876430 (OMIM: 608126) PREDICTED: WD repeat a ( 764) 5055 699.1 2.7e-200
NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 267 49.8 3.3e-05
XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 267 49.8 3.3e-05
NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 267 49.8 3.3e-05
NP_001132939 (OMIM: 300196) F-box-like/WD repeat-c ( 526) 247 47.2 0.00031
NP_001132940 (OMIM: 300196) F-box-like/WD repeat-c ( 526) 247 47.2 0.00031
XP_011543873 (OMIM: 300196) PREDICTED: F-box-like/ ( 526) 247 47.2 0.00031
NP_005638 (OMIM: 300196) F-box-like/WD repeat-cont ( 577) 247 47.3 0.00033
NP_001132938 (OMIM: 300196) F-box-like/WD repeat-c ( 577) 247 47.3 0.00033
NP_001308124 (OMIM: 270710,602342,608628,616944) F ( 427) 232 45.1 0.0011
NP_078941 (OMIM: 270710,602342,608628,616944) F-bo ( 514) 232 45.2 0.0012
NP_001308123 (OMIM: 270710,602342,608628,616944) F ( 514) 232 45.2 0.0012
NP_001308122 (OMIM: 270710,602342,608628,616944) F ( 514) 232 45.2 0.0012
XP_006713809 (OMIM: 270710,602342,608628,616944) P ( 514) 232 45.2 0.0012
XP_011511444 (OMIM: 270710,602342,608628,616944) P ( 514) 232 45.2 0.0012
XP_016862674 (OMIM: 270710,602342,608628,616944) P ( 514) 232 45.2 0.0012
XP_011511443 (OMIM: 270710,602342,608628,616944) P ( 514) 232 45.2 0.0012
XP_005247832 (OMIM: 270710,602342,608628,616944) P ( 514) 232 45.2 0.0012
XP_011511445 (OMIM: 270710,602342,608628,616944) P ( 514) 232 45.2 0.0012
NP_599020 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 231 45.0 0.0014
NP_150600 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 231 45.0 0.0014
NP_599021 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 231 45.0 0.0014
XP_005262629 (OMIM: 400033) PREDICTED: F-box-like/ ( 536) 231 45.1 0.0014
XP_016885575 (OMIM: 400033) PREDICTED: F-box-like/ ( 577) 229 44.8 0.0018
XP_016885576 (OMIM: 400033) PREDICTED: F-box-like/ ( 540) 226 44.4 0.0023
NP_001151 (OMIM: 602233) apoptotic protease-activa (1194) 222 44.1 0.0061
NP_863658 (OMIM: 602233) apoptotic protease-activa (1205) 222 44.1 0.0061
NP_079510 (OMIM: 609540) WD repeat-containing prot ( 305) 208 41.8 0.0079
XP_011520396 (OMIM: 609540) PREDICTED: WD repeat-c ( 305) 208 41.8 0.0079
NP_001290176 (OMIM: 609540) WD repeat-containing p ( 305) 208 41.8 0.0079
>>NP_009017 (OMIM: 608126) WD repeat and HMG-box DNA-bin (1129 aa)
initn: 7571 init1: 7571 opt: 7571 Z-score: 5557.7 bits: 1040.2 E(85289): 0
Smith-Waterman score: 7571; 100.0% identity (100.0% similar) in 1129 aa overlap (1-1129:1-1129)
10 20 30 40 50 60
pF1KE2 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KE2 KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
1090 1100 1110 1120
>>XP_006720075 (OMIM: 608126) PREDICTED: WD repeat and H (1127 aa)
initn: 6111 init1: 6111 opt: 7544 Z-score: 5537.9 bits: 1036.6 E(85289): 0
Smith-Waterman score: 7544; 99.8% identity (99.8% similar) in 1129 aa overlap (1-1129:1-1127)
10 20 30 40 50 60
pF1KE2 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 --VTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE2 IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE2 GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120
pF1KE2 KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
1080 1090 1100 1110 1120
>>NP_001008397 (OMIM: 608126) WD repeat and HMG-box DNA- (1006 aa)
initn: 6737 init1: 6737 opt: 6737 Z-score: 4947.4 bits: 927.1 E(85289): 0
Smith-Waterman score: 6737; 100.0% identity (100.0% similar) in 1006 aa overlap (124-1129:1-1006)
100 110 120 130 140 150
pF1KE2 TTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLAS
::::::::::::::::::::::::::::::
NP_001 MDSSQQKTFRGHDAPVLSLSFDPKDIFLAS
10 20 30
160 170 180 190 200 210
pF1KE2 ASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLY
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE2 RRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE2 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE2 NAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGS
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE2 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE2 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE2 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE2 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE2 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE2 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE2 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE2 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
700 710 720 730 740 750
880 890 900 910 920 930
pF1KE2 EEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARST
760 770 780 790 800 810
940 950 960 970 980 990
pF1KE2 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
820 830 840 850 860 870
1000 1010 1020 1030 1040 1050
pF1KE2 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
880 890 900 910 920 930
1060 1070 1080 1090 1100 1110
pF1KE2 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
940 950 960 970 980 990
1120
pF1KE2 DFSTNQKLSAFAFKQE
::::::::::::::::
NP_001 DFSTNQKLSAFAFKQE
1000
>>XP_016876429 (OMIM: 608126) PREDICTED: WD repeat and H (1004 aa)
initn: 5277 init1: 5277 opt: 6710 Z-score: 4927.7 bits: 923.5 E(85289): 0
Smith-Waterman score: 6710; 99.8% identity (99.8% similar) in 1006 aa overlap (124-1129:1-1004)
100 110 120 130 140 150
pF1KE2 TTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLAS
::::::::::::::::::::::::::::::
XP_016 MDSSQQKTFRGHDAPVLSLSFDPKDIFLAS
10 20 30
160 170 180 190 200 210
pF1KE2 ASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLY
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE2 RRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE2 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE2 NAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGS
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE2 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE2 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE2 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE2 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE2 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE2 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE2 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE2 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
700 710 720 730 740 750
880 890 900 910 920 930
pF1KE2 EEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARST
::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_016 EEKPEIHKPGQNSFSKSTNSSDVSAKS--VTFSSQGRVNPFKVSASSKEPAMSMNSARST
760 770 780 790 800
940 950 960 970 980 990
pF1KE2 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
810 820 830 840 850 860
1000 1010 1020 1030 1040 1050
pF1KE2 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
870 880 890 900 910 920
1060 1070 1080 1090 1100 1110
pF1KE2 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
930 940 950 960 970 980
1120
pF1KE2 DFSTNQKLSAFAFKQE
::::::::::::::::
XP_016 DFSTNQKLSAFAFKQE
990 1000
>>XP_011534675 (OMIM: 608126) PREDICTED: WD repeat and H (766 aa)
initn: 5082 init1: 5082 opt: 5082 Z-score: 3736.7 bits: 702.7 E(85289): 2.1e-201
Smith-Waterman score: 5082; 100.0% identity (100.0% similar) in 766 aa overlap (364-1129:1-766)
340 350 360 370 380 390
pF1KE2 NAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGS
::::::::::::::::::::::::::::::
XP_011 MMASGRPRQRSHILEDDENSVDISMLKTGS
10 20 30
400 410 420 430 440 450
pF1KE2 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
40 50 60 70 80 90
460 470 480 490 500 510
pF1KE2 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
100 110 120 130 140 150
520 530 540 550 560 570
pF1KE2 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
160 170 180 190 200 210
580 590 600 610 620 630
pF1KE2 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
220 230 240 250 260 270
640 650 660 670 680 690
pF1KE2 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
280 290 300 310 320 330
700 710 720 730 740 750
pF1KE2 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
340 350 360 370 380 390
760 770 780 790 800 810
pF1KE2 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
400 410 420 430 440 450
820 830 840 850 860 870
pF1KE2 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
460 470 480 490 500 510
880 890 900 910 920 930
pF1KE2 EEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARST
520 530 540 550 560 570
940 950 960 970 980 990
pF1KE2 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
580 590 600 610 620 630
1000 1010 1020 1030 1040 1050
pF1KE2 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
640 650 660 670 680 690
1060 1070 1080 1090 1100 1110
pF1KE2 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
700 710 720 730 740 750
1120
pF1KE2 DFSTNQKLSAFAFKQE
::::::::::::::::
XP_011 DFSTNQKLSAFAFKQE
760
>>XP_016876430 (OMIM: 608126) PREDICTED: WD repeat and H (764 aa)
initn: 3622 init1: 3622 opt: 5055 Z-score: 3716.9 bits: 699.1 E(85289): 2.7e-200
Smith-Waterman score: 5055; 99.7% identity (99.7% similar) in 766 aa overlap (364-1129:1-764)
340 350 360 370 380 390
pF1KE2 NAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGS
::::::::::::::::::::::::::::::
XP_016 MMASGRPRQRSHILEDDENSVDISMLKTGS
10 20 30
400 410 420 430 440 450
pF1KE2 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIG
40 50 60 70 80 90
460 470 480 490 500 510
pF1KE2 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHC
100 110 120 130 140 150
520 530 540 550 560 570
pF1KE2 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPV
160 170 180 190 200 210
580 590 600 610 620 630
pF1KE2 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFS
220 230 240 250 260 270
640 650 660 670 680 690
pF1KE2 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCK
280 290 300 310 320 330
700 710 720 730 740 750
pF1KE2 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEEST
340 350 360 370 380 390
760 770 780 790 800 810
pF1KE2 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLS
400 410 420 430 440 450
820 830 840 850 860 870
pF1KE2 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADD
460 470 480 490 500 510
880 890 900 910 920 930
pF1KE2 EEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARST
::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_016 EEKPEIHKPGQNSFSKSTNSSDVSAKS--VTFSSQGRVNPFKVSASSKEPAMSMNSARST
520 530 540 550 560
940 950 960 970 980 990
pF1KE2 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVK
570 580 590 600 610 620
1000 1010 1020 1030 1040 1050
pF1KE2 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIR
630 640 650 660 670 680
1060 1070 1080 1090 1100 1110
pF1KE2 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPL
690 700 710 720 730 740
1120
pF1KE2 DFSTNQKLSAFAFKQE
::::::::::::::::
XP_016 DFSTNQKLSAFAFKQE
750 760
>>NP_438172 (OMIM: 609012) WD repeat-containing protein (334 aa)
initn: 393 init1: 134 opt: 267 Z-score: 214.4 bits: 49.8 E(85289): 3.3e-05
Smith-Waterman score: 267; 23.5% identity (57.7% similar) in 293 aa overlap (11-296:43-324)
10 20 30 40
pF1KE2 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIW
:::.. . : :. .: .... ..: ..::
NP_438 ARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW
20 30 40 50 60 70
50 60 70 80 90
pF1KE2 EDLDDDDPKFIN---VGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNA
: : :. .: . . . :. ::.: ...:... : : . ..
NP_438 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG---KCLKTLKGHS
80 90 100 110 120
100 110 120 130 140 150
pF1KE2 NHVV---FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASA
:.: :: ... :..:: : :.: :: .. ::. .:. :: .. :. ...:.
NP_438 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 SCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYR
: :: :.:. .. : :. : : . . ..:.. .:: .....::.
NP_438 SYDGLCRIWDTASGQC------LKTLIDDDNPP-VSFVKFSPNGKYILAATLDNTLKLWD
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 RESWSHQFDLSDNFISQTLNIVTWSPCG-QYLAAGSINGLIIVWNVETKDCMERVKHEKG
. . . . . ....: : .....:: ..:. .::..::. ..... .
NP_438 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
.: . : ::: . :. . :..
NP_438 VVI-STACHPTENIIASAALENDKTIKLWKSDC
310 320 330
>>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa)
initn: 393 init1: 134 opt: 267 Z-score: 214.4 bits: 49.8 E(85289): 3.3e-05
Smith-Waterman score: 267; 23.5% identity (57.7% similar) in 293 aa overlap (11-296:43-324)
10 20 30 40
pF1KE2 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIW
:::.. . : :. .: .... ..: ..::
XP_005 ARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW
20 30 40 50 60 70
50 60 70 80 90
pF1KE2 EDLDDDDPKFIN---VGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNA
: : :. .: . . . :. ::.: ...:... : : . ..
XP_005 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG---KCLKTLKGHS
80 90 100 110 120
100 110 120 130 140 150
pF1KE2 NHVV---FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASA
:.: :: ... :..:: : :.: :: .. ::. .:. :: .. :. ...:.
XP_005 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 SCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYR
: :: :.:. .. : :. : : . . ..:.. .:: .....::.
XP_005 SYDGLCRIWDTASGQC------LKTLIDDDNPP-VSFVKFSPNGKYILAATLDNTLKLWD
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 RESWSHQFDLSDNFISQTLNIVTWSPCG-QYLAAGSINGLIIVWNVETKDCMERVKHEKG
. . . . . ....: : .....:: ..:. .::..::. ..... .
XP_005 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
.: . : ::: . :. . :..
XP_005 VVI-STACHPTENIIASAALENDKTIKLWKSDC
310 320 330
>>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa)
initn: 393 init1: 134 opt: 267 Z-score: 214.4 bits: 49.8 E(85289): 3.3e-05
Smith-Waterman score: 267; 23.5% identity (57.7% similar) in 293 aa overlap (11-296:43-324)
10 20 30 40
pF1KE2 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIW
:::.. . : :. .: .... ..: ..::
NP_060 ARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW
20 30 40 50 60 70
50 60 70 80 90
pF1KE2 EDLDDDDPKFIN---VGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNA
: : :. .: . . . :. ::.: ...:... : : . ..
NP_060 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG---KCLKTLKGHS
80 90 100 110 120
100 110 120 130 140 150
pF1KE2 NHVV---FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASA
:.: :: ... :..:: : :.: :: .. ::. .:. :: .. :. ...:.
NP_060 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 SCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYR
: :: :.:. .. : :. : : . . ..:.. .:: .....::.
NP_060 SYDGLCRIWDTASGQC------LKTLIDDDNPP-VSFVKFSPNGKYILAATLDNTLKLWD
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 RESWSHQFDLSDNFISQTLNIVTWSPCG-QYLAAGSINGLIIVWNVETKDCMERVKHEKG
. . . . . ....: : .....:: ..:. .::..::. ..... .
NP_060 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 YAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMS
.: . : ::: . :. . :..
NP_060 VVI-STACHPTENIIASAALENDKTIKLWKSDC
310 320 330
>>NP_001132939 (OMIM: 300196) F-box-like/WD repeat-conta (526 aa)
initn: 189 init1: 122 opt: 247 Z-score: 197.0 bits: 47.2 E(85289): 0.00031
Smith-Waterman score: 247; 21.9% identity (57.9% similar) in 292 aa overlap (17-301:241-523)
10 20 30 40
pF1KE2 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDD
: . .. .:....: . :: .::: . :
NP_001 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---D
220 230 240 250 260
50 60 70 80 90 100
pF1KE2 DPKFINVGE-KAYSCALKSGK----LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVV
..:. :. ::: .. ...: ..: . : . .. : :
NP_001 GNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD
270 280 290 300 310 320
110 120 130 140 150 160
pF1KE2 FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVR
.. ..: .:. :.:. ... . . :::.:: : ....::. ..::: : : ...
NP_001 WQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK
330 340 350 360 370 380
170 180 190 200 210 220
pF1KE2 VWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLA-IPVEKSVKLYRRESWSH
.:......: . .: .:. . . .:.:. .:: ...:.:. :
NP_001 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC
390 400 410 420 430 440
230 240 250 260 270
pF1KE2 QFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG-YAICGL
:. . .. . :..:: :.:::.::.. . .::... . .. . : . .:
NP_001 THTLTKH--QEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC--
450 460 470 480 490 500
280 290 300 310 320 330
pF1KE2 AWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFL
:. ... . ..:.. .:.
NP_001 -WNARGDKVGASASDGSVCVLDLRK
510 520
1129 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:28:17 2016 done: Sun Nov 6 09:28:19 2016
Total Scan time: 14.720 Total Display time: 0.370
Function used was FASTA [36.3.4 Apr, 2011]