Result of FASTA (omim) for
pF1KE2359
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2359, 387 aa
1>>>pF1KE2359 387 - 387 aa - 387 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8097+/-0.000436; mu= 19.5975+/- 0.027
mean_var=114.6605+/-33.358, 0's: 0 Z-trim(110.2): 563 B-trim: 1029 in 1/50
Lambda= 0.119775
statistics sampled from 17761 (18522) to 17761 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.573), E-opt: 0.2 (0.217), width: 16
Scan time: 6.610
The best scores are: opt bits E(85289)
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 2628 466.0 6.7e-131
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 2433 432.3 9.3e-121
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 2431 431.9 1.1e-120
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 2428 431.5 1.8e-120
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 2420 430.0 4.3e-120
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 2420 430.1 4.6e-120
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 703 133.4 9.4e-31
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 548 106.6 1.1e-22
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 548 106.6 1.1e-22
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 548 106.7 1.2e-22
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 548 106.7 1.2e-22
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 548 106.7 1.2e-22
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 548 106.7 1.2e-22
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 548 106.7 1.2e-22
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 548 106.7 1.2e-22
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 543 105.8 2.1e-22
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 520 101.7 2.9e-21
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 520 101.7 2.9e-21
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 520 101.8 3e-21
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 101.8 3.2e-21
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 101.8 3.2e-21
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 101.8 3.2e-21
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 101.8 3.2e-21
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 101.8 3.2e-21
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 520 101.8 3.3e-21
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 486 96.0 2e-19
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 469 93.0 1.4e-18
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 469 93.0 1.5e-18
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 469 93.1 1.5e-18
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 448 89.2 1.5e-17
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 448 89.2 1.6e-17
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 448 89.3 1.6e-17
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 447 89.0 1.7e-17
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 446 88.9 2e-17
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 441 88.0 3.4e-17
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 441 88.1 3.8e-17
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 440 88.0 4.5e-17
NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 421 84.6 4e-16
XP_011507678 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
NP_001254539 (OMIM: 612250) G-protein coupled rece ( 529) 422 85.0 4.5e-16
XP_005245113 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
XP_011507679 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
XP_005245114 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
XP_011507677 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
XP_016856350 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
XP_016856349 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
NP_722561 (OMIM: 612250) G-protein coupled recepto ( 529) 422 85.0 4.5e-16
XP_016856351 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
XP_011507680 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.0 4.5e-16
NP_001254540 (OMIM: 612250) G-protein coupled rece ( 546) 422 85.0 4.6e-16
>>NP_001035259 (OMIM: 602164) 5-hydroxytryptamine recept (387 aa)
initn: 2628 init1: 2628 opt: 2628 Z-score: 2471.1 bits: 466.0 E(85289): 6.7e-131
Smith-Waterman score: 2628; 100.0% identity (100.0% similar) in 387 aa overlap (1-387:1-387)
10 20 30 40 50 60
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
310 320 330 340 350 360
370 380
pF1KE2 TVLHRGHHQELEKLPIHNDPESLESCF
:::::::::::::::::::::::::::
NP_001 TVLHRGHHQELEKLPIHNDPESLESCF
370 380
>>NP_000861 (OMIM: 602164) 5-hydroxytryptamine receptor (388 aa)
initn: 2451 init1: 2429 opt: 2433 Z-score: 2289.0 bits: 432.3 E(85289): 9.3e-121
Smith-Waterman score: 2433; 95.8% identity (97.4% similar) in 380 aa overlap (1-380:1-379)
10 20 30 40 50 60
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
310 320 330 340 350 360
370 380
pF1KE2 TVLHRGHHQELEKLPIHNDPESLESCF
.: . : . : . : ..:
NP_000 AV-ECGGQWESQCHPPATSPLVAAQPSDT
370 380
>>NP_001035262 (OMIM: 602164) 5-hydroxytryptamine recept (360 aa)
initn: 2453 init1: 2431 opt: 2431 Z-score: 2287.4 bits: 431.9 E(85289): 1.1e-120
Smith-Waterman score: 2431; 99.7% identity (100.0% similar) in 360 aa overlap (1-360:1-360)
10 20 30 40 50 60
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRF
310 320 330 340 350 360
370 380
pF1KE2 TVLHRGHHQELEKLPIHNDPESLESCF
>>NP_001035263 (OMIM: 602164) 5-hydroxytryptamine recept (428 aa)
initn: 2450 init1: 2428 opt: 2428 Z-score: 2283.9 bits: 431.5 E(85289): 1.8e-120
Smith-Waterman score: 2428; 99.2% identity (99.2% similar) in 363 aa overlap (1-363:1-363)
10 20 30 40 50 60
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRT
310 320 330 340 350 360
370 380
pF1KE2 TVLHRGHHQELEKLPIHNDPESLESCF
:
NP_001 DFLFDRDILARYWTKPARAGPFSGTLSIRCLTARKPVLGDAVECGGQWESQCHPPATSPL
370 380 390 400 410 420
>>NP_955525 (OMIM: 602164) 5-hydroxytryptamine receptor (378 aa)
initn: 2420 init1: 2420 opt: 2420 Z-score: 2276.9 bits: 430.0 E(85289): 4.3e-120
Smith-Waterman score: 2420; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358)
10 20 30 40 50 60
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSG
310 320 330 340 350 360
370 380
pF1KE2 TVLHRGHHQELEKLPIHNDPESLESCF
NP_955 CSPVSSFLLLFCNRPVPV
370
>>NP_001273339 (OMIM: 602164) 5-hydroxytryptamine recept (411 aa)
initn: 2420 init1: 2420 opt: 2420 Z-score: 2276.6 bits: 430.1 E(85289): 4.6e-120
Smith-Waterman score: 2420; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358)
10 20 30 40 50 60
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSS
310 320 330 340 350 360
370 380
pF1KE2 TVLHRGHHQELEKLPIHNDPESLESCF
NP_001 GTETDRKKLWNKEEKIDQTIQMPKRKRKKKASLSYEDLILLGRKSCFREGK
370 380 390 400 410
>>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa)
initn: 589 init1: 254 opt: 703 Z-score: 673.1 bits: 133.4 E(85289): 9.4e-31
Smith-Waterman score: 706; 36.2% identity (64.6% similar) in 356 aa overlap (26-373:40-372)
10 20 30 40 50
pF1KE2 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKT
.: ..: ..::.::..:. ..:. . :
NP_000 FLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV-T
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 NYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCIS
::::.::: :::.... :.:::: .... .: .:. .: ::.::: .:::: :: :.
NP_000 NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 LDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKF
.:::.:: .:. :.. .: . ... :.. . :::::.. : ... .
NP_000 VDRYFAIT-SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-----THQEAI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 NQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQ-RAGA
: .: : : :..:. :::. :.:.::.:...::..: :.. ::.. ..:. . : .
NP_000 NCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV
190 200 210 220 230 240
240 250 260 270 280
pF1KE2 SSESRPQSADQHSTHRMRT-------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY
.. :. .. : .. : .: : :: ::: :::: : ::: :::..::: . :
NP_000 QNLSQVEQ-DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS
. .:. . :.::.:::.::..: . .:: :: .:: :: :. . :
NP_000 LIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC-----LRRSSLKAYGNGYS
310 320 330 340 350
350 360 370 380
pF1KE2 TTTINGSTHVLRYTVLHRGHHQELEKLPIHNDPESLESCF
. ::.: . :.: : ::
NP_000 S---NGNTG------EQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNC
360 370 380 390 400
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 541 init1: 212 opt: 548 Z-score: 528.1 bits: 106.6 E(85289): 1.1e-22
Smith-Waterman score: 598; 32.2% identity (61.2% similar) in 363 aa overlap (16-353:22-369)
10 20 30 40 50
pF1KE2 MDKLDANVSSEEGFGSVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKI
.. :..:: ..:. .::...:::.::...: :.:...
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCC
:.:.::.:: ::::.. :.::.:: : : .:.::: . ...::: ::::. ::
NP_150 -THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 ISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKR
::.::: .. :: : . .: : . : :.. ::. :.. :: . . :
NP_150 ISIDRYIGVS-YPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF-GWRQPAPED-----
120 130 140 150 160 170
180 190 200 210 220
pF1KE2 KFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAH---------
: : . . :.. .. .::.:. .... : :.::.::....
NP_150 -------ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTD
180 190 200 210 220
230 240 250 260 270
pF1KE2 -----QIQM-LQRAGASSESRPQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCW
:. . ..: .: . . ... . .:: .. : :::::: :..::: :::
NP_150 KSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
280 290 300 310 320
pF1KE2 APFFVTNIVDPFIDYTVPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL--CC
:::.. . :. :.. :. .::::.:: .::..: .. :..:: .: :
NP_150 LPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE2 DDERYRRPSILGQTVPCSTTTINGSTHVLRYTVLHRGHHQELEKLPIHNDPESLESCF
.. :: :. . ...:
NP_150 LCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPR
350 360 370 380 390 400
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 541 init1: 212 opt: 548 Z-score: 528.1 bits: 106.6 E(85289): 1.1e-22
Smith-Waterman score: 598; 32.2% identity (61.2% similar) in 363 aa overlap (16-353:22-369)
10 20 30 40 50
pF1KE2 MDKLDANVSSEEGFGSVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKI
.. :..:: ..:. .::...:::.::...: :.:...
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCC
:.:.::.:: ::::.. :.::.:: : : .:.::: . ...::: ::::. ::
XP_006 -THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 ISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKR
::.::: .. :: : . .: : . : :.. ::. :.. :: . . :
XP_006 ISIDRYIGVS-YPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF-GWRQPAPED-----
120 130 140 150 160 170
180 190 200 210 220
pF1KE2 KFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAH---------
: : . . :.. .. .::.:. .... : :.::.::....
XP_006 -------ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTD
180 190 200 210 220
230 240 250 260 270
pF1KE2 -----QIQM-LQRAGASSESRPQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCW
:. . ..: .: . . ... . .:: .. : :::::: :..::: :::
XP_006 KSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
280 290 300 310 320
pF1KE2 APFFVTNIVDPFIDYTVPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL--CC
:::.. . :. :.. :. .::::.:: .::..: .. :..:: .: :
XP_006 LPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE2 DDERYRRPSILGQTVPCSTTTINGSTHVLRYTVLHRGHHQELEKLPIHNDPESLESCF
.. :: :. . ...:
XP_006 LCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPR
350 360 370 380 390 400
>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa)
initn: 541 init1: 212 opt: 548 Z-score: 527.9 bits: 106.7 E(85289): 1.2e-22
Smith-Waterman score: 598; 32.2% identity (61.2% similar) in 363 aa overlap (16-353:22-369)
10 20 30 40 50
pF1KE2 MDKLDANVSSEEGFGSVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKI
.. :..:: ..:. .::...:::.::...: :.:...
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCC
:.:.::.:: ::::.. :.::.:: : : .:.::: . ...::: ::::. ::
NP_150 -THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 ISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKR
::.::: .. :: : . .: : . : :.. ::. :.. :: . . :
NP_150 ISIDRYIGVS-YPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF-GWRQPAPED-----
120 130 140 150 160 170
180 190 200 210 220
pF1KE2 KFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAH---------
: : . . :.. .. .::.:. .... : :.::.::....
NP_150 -------ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTD
180 190 200 210 220
230 240 250 260 270
pF1KE2 -----QIQM-LQRAGASSESRPQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCW
:. . ..: .: . . ... . .:: .. : :::::: :..::: :::
NP_150 KSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
280 290 300 310 320
pF1KE2 APFFVTNIVDPFIDYTVPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL--CC
:::.. . :. :.. :. .::::.:: .::..: .. :..:: .: :
NP_150 LPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE2 DDERYRRPSILGQTVPCSTTTINGSTHVLRYTVLHRGHHQELEKLPIHNDPESLESCF
.. :: :. . ...:
NP_150 LCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPR
350 360 370 380 390 400
387 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:06:05 2016 done: Sun Nov 6 17:06:06 2016
Total Scan time: 6.610 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]