Result of FASTA (omim) for
pF1KE2259
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2259, 502 aa
1>>>pF1KE2259 502 - 502 aa - 502 aa
Library: /omim/omim.rfq.tfa
65089639 residues in 91964 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1432+/-0.000337; mu= 19.2001+/- 0.021
mean_var=71.3447+/-14.324, 0's: 0 Z-trim(114.9): 178 B-trim: 0 in 0/54
Lambda= 0.151842
statistics sampled from 25756 (25937) to 25756 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.282), width: 16
Scan time: 4.400
The best scores are: opt bits E(91964)
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 3488 773.5 0
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 3360 745.5 9.6e-215
XP_011519478 (OMIM: 118511,612001) neuronal acetyl ( 486) 3060 679.7 5.5e-195
XP_011519479 (OMIM: 118511,612001) neuronal acetyl ( 401) 2694 599.5 6.4e-171
XP_016877372 (OMIM: 118511,612001) neuronal acetyl ( 440) 2690 598.6 1.3e-170
XP_016877371 (OMIM: 118511,612001) neuronal acetyl ( 441) 2690 598.6 1.3e-170
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 2685 597.5 2.6e-170
XP_011520455 (OMIM: 609756) CHRNA7-FAM7A fusion pr ( 412) 2685 597.5 2.6e-170
XP_016877373 (OMIM: 118511,612001) neuronal acetyl ( 321) 2206 492.5 8.2e-139
XP_005254807 (OMIM: 609756) CHRNA7-FAM7A fusion pr ( 321) 2206 492.5 8.2e-139
NP_683709 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 321) 2206 492.5 8.2e-139
XP_011519480 (OMIM: 118511,612001) neuronal acetyl ( 380) 2026 453.1 6.9e-127
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1232 279.3 2.1e-74
XP_011520457 (OMIM: 609756) CHRNA7-FAM7A fusion pr ( 290) 1223 277.1 5e-74
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1220 276.6 1.2e-73
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1132 257.4 7.9e-68
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1131 257.1 8.8e-68
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1118 254.4 7.7e-67
XP_006720445 (OMIM: 118503,612052) neuronal acetyl ( 438) 1091 248.3 3.5e-65
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 1074 244.6 4.8e-64
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 1070 243.8 9.2e-64
XP_011519488 (OMIM: 118509) neuronal acetylcholine ( 495) 1055 240.5 9.2e-63
XP_011519489 (OMIM: 118509) neuronal acetylcholine ( 495) 1055 240.5 9.2e-63
XP_016877378 (OMIM: 118509) neuronal acetylcholine ( 449) 1052 239.8 1.3e-62
XP_016877377 (OMIM: 118509) neuronal acetylcholine ( 462) 1052 239.8 1.4e-62
XP_016877376 (OMIM: 118509) neuronal acetylcholine ( 463) 1052 239.8 1.4e-62
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 1052 239.8 1.5e-62
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1049 239.2 2.3e-62
XP_016877374 (OMIM: 118509) neuronal acetylcholine ( 468) 1046 238.5 3.4e-62
XP_016877375 (OMIM: 118509) neuronal acetylcholine ( 468) 1046 238.5 3.4e-62
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 1019 232.6 2.2e-60
XP_016858746 (OMIM: 100690,253290,601462,608930) a ( 464) 993 226.9 1.1e-58
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 991 226.5 1.4e-58
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 949 217.3 8.4e-56
XP_011519493 (OMIM: 118509) neuronal acetylcholine ( 424) 948 217.0 9.2e-56
XP_011519492 (OMIM: 118509) neuronal acetylcholine ( 424) 948 217.0 9.2e-56
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 946 216.6 1.4e-55
NP_001334635 (OMIM: 118502,610353) neuronal acetyl ( 370) 884 202.9 1.4e-51
NP_001334634 (OMIM: 118502,610353) neuronal acetyl ( 370) 884 202.9 1.4e-51
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 870 200.0 1.4e-50
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 845 194.5 6.3e-49
XP_016858745 (OMIM: 100690,253290,601462,608930) a ( 489) 845 194.5 6.4e-49
NP_001334646 (OMIM: 118508) neuronal acetylcholine ( 384) 828 190.7 7e-48
XP_011526826 (OMIM: 118504,188890,600513) neuronal ( 556) 779 180.1 1.6e-44
NP_001334637 (OMIM: 118502,610353) neuronal acetyl ( 331) 736 170.5 7.3e-42
NP_001334636 (OMIM: 118502,610353) neuronal acetyl ( 331) 736 170.5 7.3e-42
XP_011542691 (OMIM: 118502,610353) neuronal acetyl ( 331) 736 170.5 7.3e-42
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 714 165.8 2.7e-40
NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 478) 714 165.8 2.7e-40
XP_024307590 (OMIM: 118504,188890,600513) neuronal ( 451) 626 146.5 1.7e-34
>>NP_000737 (OMIM: 118511,612001) neuronal acetylcholine (502 aa)
initn: 3488 init1: 3488 opt: 3488 Z-score: 4128.8 bits: 773.5 E(91964): 0
Smith-Waterman score: 3488; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KE2 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
430 440 450 460 470 480
490 500
pF1KE2 ICTIGILMSAPNFVEAVSKDFA
::::::::::::::::::::::
NP_000 ICTIGILMSAPNFVEAVSKDFA
490 500
>>NP_001177384 (OMIM: 118511,612001) neuronal acetylchol (531 aa)
initn: 3474 init1: 3360 opt: 3360 Z-score: 3976.9 bits: 745.5 E(91964): 9.6e-215
Smith-Waterman score: 3420; 94.5% identity (94.5% similar) in 531 aa overlap (1-502:1-531)
10 20 30
pF1KE2 MRCSPGGVWLALAASLLH-----------------------------VSLQGEFQRKLYK
:::::::::::::::::: :::::::::::::
NP_001 MRCSPGGVWLALAASLLHGKATASPPSTPPWDPGHIPGASVRPAPGPVSLQGEFQRKLYK
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 ELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 SEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCY
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD
430 440 450 460 470 480
460 470 480 490 500
pF1KE2 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
490 500 510 520 530
>>XP_011519478 (OMIM: 118511,612001) neuronal acetylchol (486 aa)
initn: 3060 init1: 3060 opt: 3060 Z-score: 3622.2 bits: 679.7 E(91964): 5.5e-195
Smith-Waterman score: 3060; 100.0% identity (100.0% similar) in 437 aa overlap (66-502:50-486)
40 50 60 70 80 90
pF1KE2 NYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYP
::::::::::::::::::::::::::::::
XP_011 AGQGLIGEDTAPADLLLPESHRTSLRRGKGDEKNQVLTTNIWLQMSWTDHYLQWNVSEYP
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE2 GVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVR
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE2 WFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE2 PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE2 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVIL
260 270 280 290 300 310
340 350 360 370 380 390
pF1KE2 LNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV
320 330 340 350 360 370
400 410 420 430 440 450
pF1KE2 HCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEA
380 390 400 410 420 430
460 470 480 490 500
pF1KE2 VCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
440 450 460 470 480
>>XP_011519479 (OMIM: 118511,612001) neuronal acetylchol (401 aa)
initn: 2694 init1: 2694 opt: 2694 Z-score: 3190.1 bits: 599.5 E(91964): 6.4e-171
Smith-Waterman score: 2694; 99.5% identity (99.7% similar) in 389 aa overlap (114-502:13-401)
90 100 110 120 130 140
pF1KE2 DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP
: .:::::::::::::::::::::::::::
XP_011 MKNIQKSLSHKSLSHSADERFDATFHTNVLVNSSGHCQYLPP
10 20 30 40
150 160 170 180 190 200
pF1KE2 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPG
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE2 KRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKIS
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE2 LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPD
170 180 190 200 210 220
330 340 350 360 370 380
pF1KE2 GGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGN
230 240 250 260 270 280
390 400 410 420 430 440
pF1KE2 LLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYI
290 300 310 320 330 340
450 460 470 480 490 500
pF1KE2 ANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
350 360 370 380 390 400
>>XP_016877372 (OMIM: 118511,612001) neuronal acetylchol (440 aa)
initn: 2690 init1: 2690 opt: 2690 Z-score: 3184.8 bits: 598.6 E(91964): 1.3e-170
Smith-Waterman score: 2690; 100.0% identity (100.0% similar) in 386 aa overlap (117-502:55-440)
90 100 110 120 130 140
pF1KE2 LQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIF
::::::::::::::::::::::::::::::
XP_016 GCTAGAHSLDPHPRLCSLLCIGEFCGRDGCSADERFDATFHTNVLVNSSGHCQYLPPGIF
30 40 50 60 70 80
150 160 170 180 190 200
pF1KE2 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS
90 100 110 120 130 140
210 220 230 240 250 260
pF1KE2 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE2 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE2 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE2 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR
330 340 350 360 370 380
450 460 470 480 490 500
pF1KE2 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
390 400 410 420 430 440
>>XP_016877371 (OMIM: 118511,612001) neuronal acetylchol (441 aa)
initn: 2690 init1: 2690 opt: 2690 Z-score: 3184.8 bits: 598.6 E(91964): 1.3e-170
Smith-Waterman score: 2690; 100.0% identity (100.0% similar) in 386 aa overlap (117-502:56-441)
90 100 110 120 130 140
pF1KE2 LQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIF
::::::::::::::::::::::::::::::
XP_016 GCTAGAHSLDPHPRLCSLLCIGEFCGRDGCSADERFDATFHTNVLVNSSGHCQYLPPGIF
30 40 50 60 70 80
150 160 170 180 190 200
pF1KE2 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS
90 100 110 120 130 140
210 220 230 240 250 260
pF1KE2 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE2 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE2 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE2 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR
330 340 350 360 370 380
450 460 470 480 490 500
pF1KE2 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
390 400 410 420 430 440
>>NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion protein i (412 aa)
initn: 2685 init1: 2685 opt: 2685 Z-score: 3179.3 bits: 597.5 E(91964): 2.6e-170
Smith-Waterman score: 2685; 100.0% identity (100.0% similar) in 385 aa overlap (118-502:28-412)
90 100 110 120 130 140
pF1KE2 QWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFK
::::::::::::::::::::::::::::::
NP_647 MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFK
10 20 30 40 50
150 160 170 180 190 200
pF1KE2 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE
60 70 80 90 100 110
210 220 230 240 250 260
pF1KE2 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE2 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE2 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI
240 250 260 270 280 290
390 400 410 420 430 440
pF1KE2 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF
300 310 320 330 340 350
450 460 470 480 490 500
pF1KE2 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
360 370 380 390 400 410
>>XP_011520455 (OMIM: 609756) CHRNA7-FAM7A fusion protei (412 aa)
initn: 2685 init1: 2685 opt: 2685 Z-score: 3179.3 bits: 597.5 E(91964): 2.6e-170
Smith-Waterman score: 2685; 100.0% identity (100.0% similar) in 385 aa overlap (118-502:28-412)
90 100 110 120 130 140
pF1KE2 QWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFK
::::::::::::::::::::::::::::::
XP_011 MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFK
10 20 30 40 50
150 160 170 180 190 200
pF1KE2 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE
60 70 80 90 100 110
210 220 230 240 250 260
pF1KE2 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE2 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE2 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI
240 250 260 270 280 290
390 400 410 420 430 440
pF1KE2 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF
300 310 320 330 340 350
450 460 470 480 490 500
pF1KE2 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
360 370 380 390 400 410
>>XP_016877373 (OMIM: 118511,612001) neuronal acetylchol (321 aa)
initn: 2206 init1: 2206 opt: 2206 Z-score: 2613.7 bits: 492.5 E(91964): 8.2e-139
Smith-Waterman score: 2206; 100.0% identity (100.0% similar) in 321 aa overlap (182-502:1-321)
160 170 180 190 200 210
pF1KE2 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE
::::::::::::::::::::::::::::::
XP_016 MQEADISGYIPNGEWDLVGIPGKRSERFYE
10 20 30
220 230 240 250 260 270
pF1KE2 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE2 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE2 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE2 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD
220 230 240 250 260 270
460 470 480 490 500
pF1KE2 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
280 290 300 310 320
>>XP_005254807 (OMIM: 609756) CHRNA7-FAM7A fusion protei (321 aa)
initn: 2206 init1: 2206 opt: 2206 Z-score: 2613.7 bits: 492.5 E(91964): 8.2e-139
Smith-Waterman score: 2206; 100.0% identity (100.0% similar) in 321 aa overlap (182-502:1-321)
160 170 180 190 200 210
pF1KE2 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE
::::::::::::::::::::::::::::::
XP_005 MQEADISGYIPNGEWDLVGIPGKRSERFYE
10 20 30
220 230 240 250 260 270
pF1KE2 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE2 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE2 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE2 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD
220 230 240 250 260 270
460 470 480 490 500
pF1KE2 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
280 290 300 310 320
502 residues in 1 query sequences
65089639 residues in 91964 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Oct 2 18:31:43 2018 done: Tue Oct 2 18:31:44 2018
Total Scan time: 4.400 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]