Result of FASTA (omim) for
pF1KE2188
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2188, 423 aa
1>>>pF1KE2188 423 - 423 aa - 423 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6482+/-0.000375; mu= 21.7233+/- 0.023
mean_var=81.9243+/-16.385, 0's: 0 Z-trim(114.2): 230 B-trim: 9 in 2/53
Lambda= 0.141699
statistics sampled from 23671 (23938) to 23671 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.281), width: 16
Scan time: 8.460
The best scores are: opt bits E(85289)
NP_000814 (OMIM: 139191,612781) growth hormone-rel ( 423) 2954 613.8 2.6e-175
XP_011513565 (OMIM: 139191,612781) PREDICTED: grow ( 359) 2286 477.2 2.9e-134
XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 1238 263.0 1.1e-69
NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 1237 262.8 1.2e-69
NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 1233 262.0 2.2e-69
NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 1194 254.0 5.2e-67
XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 1194 254.0 5.2e-67
XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 1194 254.0 5.2e-67
NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 1184 252.0 2.2e-66
NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 1170 249.1 1.5e-65
XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 1166 248.3 2.9e-65
XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 1165 248.1 3.1e-65
NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 1165 248.1 3.2e-65
NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 1159 246.9 7.6e-65
XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 1139 242.8 1.3e-63
XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 1136 242.2 2e-63
XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 1124 239.7 1.1e-62
XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 1106 236.0 1.3e-61
NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 1063 227.3 6.4e-59
XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 1055 225.6 1.8e-58
XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 1000 214.3 4.4e-55
XP_011532382 (OMIM: 192321) PREDICTED: vasoactive ( 351) 933 200.6 5.3e-51
XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 917 197.4 5.5e-50
NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 883 190.4 7.2e-48
XP_016867226 (OMIM: 102981) PREDICTED: pituitary a ( 475) 877 189.3 1.8e-47
XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 842 182.1 2.5e-45
XP_016868069 (OMIM: 601970) PREDICTED: vasoactive ( 300) 820 177.4 4.3e-44
NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 801 173.7 8.5e-43
XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 769 166.9 5.4e-41
NP_001186565 (OMIM: 102981) pituitary adenylate cy ( 495) 758 165.0 3.9e-40
NP_001186564 (OMIM: 102981) pituitary adenylate cy ( 496) 756 164.6 5.2e-40
XP_006715708 (OMIM: 102981) PREDICTED: pituitary a ( 496) 756 164.6 5.2e-40
XP_016860162 (OMIM: 182098) PREDICTED: secretin re ( 267) 749 162.8 9.3e-40
XP_016867225 (OMIM: 102981) PREDICTED: pituitary a ( 489) 751 163.5 1e-39
XP_016867227 (OMIM: 102981) PREDICTED: pituitary a ( 439) 748 162.9 1.5e-39
NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 725 158.1 3.8e-38
NP_001291451 (OMIM: 601970) vasoactive intestinal ( 358) 675 147.8 4.1e-35
NP_004373 (OMIM: 122561) corticotropin-releasing f ( 415) 657 144.2 5.7e-34
NP_001189404 (OMIM: 602034) corticotropin-releasin ( 438) 641 141.0 5.7e-33
XP_016867241 (OMIM: 602034) PREDICTED: corticotrop ( 397) 632 139.1 1.9e-32
NP_001189410 (OMIM: 602034) corticotropin-releasin ( 397) 632 139.1 1.9e-32
NP_001874 (OMIM: 602034) corticotropin-releasing f ( 411) 632 139.1 2e-32
NP_001189411 (OMIM: 602034) corticotropin-releasin ( 410) 631 138.9 2.3e-32
NP_001158210 (OMIM: 114131,166710) calcitonin rece ( 474) 606 133.9 8.6e-31
NP_001733 (OMIM: 114131,166710) calcitonin recepto ( 474) 606 133.9 8.6e-31
NP_001138619 (OMIM: 122561) corticotropin-releasin ( 375) 574 127.2 6.9e-29
NP_001189412 (OMIM: 602034) corticotropin-releasin ( 387) 571 126.6 1.1e-28
XP_011513431 (OMIM: 602034) PREDICTED: corticotrop ( 387) 571 126.6 1.1e-28
XP_011513430 (OMIM: 602034) PREDICTED: corticotrop ( 370) 568 126.0 1.6e-28
XP_016879936 (OMIM: 125853,138033) PREDICTED: gluc ( 355) 563 124.9 3.2e-28
>>NP_000814 (OMIM: 139191,612781) growth hormone-releasi (423 aa)
initn: 2954 init1: 2954 opt: 2954 Z-score: 3268.5 bits: 613.8 E(85289): 2.6e-175
Smith-Waterman score: 2954; 100.0% identity (100.0% similar) in 423 aa overlap (1-423:1-423)
10 20 30 40 50 60
pF1KE2 MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 AFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLT
370 380 390 400 410 420
pF1KE2 SMC
:::
NP_000 SMC
>>XP_011513565 (OMIM: 139191,612781) PREDICTED: growth h (359 aa)
initn: 2286 init1: 2286 opt: 2286 Z-score: 2531.3 bits: 477.2 E(85289): 2.9e-134
Smith-Waterman score: 2286; 100.0% identity (100.0% similar) in 334 aa overlap (90-423:26-359)
60 70 80 90 100 110
pF1KE2 DGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELL
::::::::::::::::::::::::::::::
XP_011 MVPGTPSPLLGRGKELWLESLACLPGAVKRDCTITGWSEPFPPYPVACPVPLELL
10 20 30 40 50
120 130 140 150 160 170
pF1KE2 AEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAV
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE2 FLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSR
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE2 RAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGL
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE2 FLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLP
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE2 LELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVL
300 310 320 330 340 350
420
pF1KE2 TSMC
::::
XP_011 TSMC
>>XP_005265494 (OMIM: 192321) PREDICTED: vasoactive inte (456 aa)
initn: 1177 init1: 526 opt: 1238 Z-score: 1372.2 bits: 263.0 E(85289): 1.1e-69
Smith-Waterman score: 1238; 45.4% identity (72.5% similar) in 403 aa overlap (14-412:23-421)
10 20 30 40 50
pF1KE2 MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNT
:.: .... :::.. ... ... ::. :. . :
XP_005 MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQ-LENE
10 20 30 40 50
60 70 80 90 100
pF1KE2 TLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESG-AVKRDCTITGWSEPFP-PYP
:.:: ::.: :::.. :. :.: :: .:. ::: .: :.:.:: ::.. : :::
XP_005 TIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYP
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 VACPVPLEL--LAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQ
.:: . . : :. ....:: ::.:...:...:.:: .:: .:.::: :::.: .
XP_005 IACGLDDKAASLDEQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMH
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 LFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYL
:: .:::.:.:::.:: ::: : ..:.:: ..: ::.... .. .:.:: :::.:..::
XP_005 LFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 NCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKG
::: . : :. :: .: :::.: :: .:. .. ::: .::: ..: ::::::
XP_005 YTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSS-LWWIIKG
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 PIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNF
::. :. ::: ::. :::::..::.: . .: : ::..:::.::::::.:::.: :
XP_005 PILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAF
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 LPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAK
.::: ... .:: .::::::.::::::::: ::..:. :::. . . .: :
XP_005 FPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWN--PK
360 370 380 390 400 410
410 420
pF1KE2 WTTPSRSAAKVLTSMC
. ::
XP_005 YRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
420 430 440 450
>>NP_001238814 (OMIM: 192321) vasoactive intestinal poly (430 aa)
initn: 1178 init1: 519 opt: 1237 Z-score: 1371.4 bits: 262.8 E(85289): 1.2e-69
Smith-Waterman score: 1237; 46.2% identity (73.5% similar) in 396 aa overlap (22-412:4-395)
10 20 30 40 50 60
pF1KE2 MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWD
:... :::.. ... ... ::. :. . : :.:: ::
NP_001 MRAGRLQEECDYVQMIEVQHKQCLEEAQ-LENETIGCSKMWD
10 20 30 40
70 80 90 100 110
pF1KE2 GLLCWPTAGSGEWVTLPCPDFFSHFSSESG-AVKRDCTITGWSEPFP-PYPVACPVPLEL
.: :::.. :. :.: :: .:. ::: .: :.:.:: ::.. : :::.:: . .
NP_001 NLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE2 --LAEEESYF-STVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILK
: :....: ..:: ::.:...:...:.:: .:: .:.::: :::.: .:: .:::.
NP_001 ASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE2 AGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTS
:.:::.:: ::: : ..:.:: ..: ::.... .. .:.:: :::.:..:: ::: .
NP_001 AAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSF
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 PSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGV
: :. :: .: :::.: :: .:. .. ::: .::: ..: ::::::::. :. :
NP_001 FSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSS-LWWIIKGPILTSILV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE2 NFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLG
:: ::. :::::..::.: . .: : ::..:::.::::::.:::.: :.:::
NP_001 NFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPE
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE2 IRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSA
... .:: .::::::.::::::::: ::..:. :::. . . .: :. ::
NP_001 VKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWN--PKYRHPSGGS
350 360 370 380 390
420
pF1KE2 AKVLTSMC
NP_001 NGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
400 410 420 430
>>NP_004615 (OMIM: 192321) vasoactive intestinal polypep (457 aa)
initn: 1170 init1: 519 opt: 1233 Z-score: 1366.7 bits: 262.0 E(85289): 2.2e-69
Smith-Waterman score: 1233; 45.5% identity (72.8% similar) in 404 aa overlap (14-412:23-422)
10 20 30 40 50
pF1KE2 MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNT
:.: .... :::.. ... ... ::. :. . :
NP_004 MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQ-LENE
10 20 30 40 50
60 70 80 90 100
pF1KE2 TLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESG-AVKRDCTITGWSEPFP-PYP
:.:: ::.: :::.. :. :.: :: .:. ::: .: :.:.:: ::.. : :::
NP_004 TIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYP
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 VACPVPLEL--LAEEESYF-STVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHT
.:: . . : :....: ..:: ::.:...:...:.:: .:: .:.::: :::.:
NP_004 IACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHM
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 QLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVY
.:: .:::.:.:::.:: ::: : ..:.:: ..: ::.... .. .:.:: :::.:..:
NP_004 HLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLY
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 LNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIK
: ::: . : :. :: .: :::.: :: .:. .. ::: .::: ..: :::::
NP_004 LYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSS-LWWIIK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 GPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFN
:::. :. ::: ::. :::::..::.: . .: : ::..:::.::::::.:::.:
NP_004 GPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 FLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRA
:.::: ... .:: .::::::.::::::::: ::..:. :::. . . .:
NP_004 FFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWN--P
360 370 380 390 400 410
410 420
pF1KE2 KWTTPSRSAAKVLTSMC
:. ::
NP_004 KYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
420 430 440 450
>>NP_001238811 (OMIM: 192321) vasoactive intestinal poly (416 aa)
initn: 1147 init1: 519 opt: 1194 Z-score: 1324.1 bits: 254.0 E(85289): 5.2e-67
Smith-Waterman score: 1194; 47.5% identity (73.2% similar) in 377 aa overlap (41-412:9-381)
20 30 40 50 60 70
pF1KE2 FCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGS
::. :. . : :.:: ::.: :::..
NP_001 MIEVQHKQCLEEAQ-LENETIGCSKMWDNLTCWPATPR
10 20 30
80 90 100 110 120
pF1KE2 GEWVTLPCPDFFSHFSSESG-AVKRDCTITGWSEPFP-PYPVACPVPLEL--LAEEESYF
:. :.: :: .:. ::: .: :.:.:: ::.. : :::.:: . . : :....:
NP_001 GQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 -STVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAA
..:: ::.:...:...:.:: .:: .:.::: :::.: .:: .:::.:.:::.:: :
NP_001 YGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWL
:: : ..:.:: ..: ::.... .. .:.:: :::.:..:: ::: . : :. ::
NP_001 LFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 VLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIR
.: :::.: :: .:. .. ::: .::: ..: ::::::::. :. ::: ::. :::
NP_001 ILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSS-LWWIIKGPILTSILVNFILFICIIR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 ILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLG
::..::.: . .: : ::..:::.::::::.:::.: :.::: ... .:: .:
NP_001 ILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 SFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC
:::::.::::::::: ::..:. :::. . . .: :. ::
NP_001 SFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNP--KYRHPSGGSNGATCSTQVS
340 350 360 370 380 390
NP_001 MLTRVSPGARRSSSFQAEVSLV
400 410
>>XP_011532381 (OMIM: 192321) PREDICTED: vasoactive inte (416 aa)
initn: 1147 init1: 519 opt: 1194 Z-score: 1324.1 bits: 254.0 E(85289): 5.2e-67
Smith-Waterman score: 1194; 47.5% identity (73.2% similar) in 377 aa overlap (41-412:9-381)
20 30 40 50 60 70
pF1KE2 FCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGS
::. :. . : :.:: ::.: :::..
XP_011 MIEVQHKQCLEEAQ-LENETIGCSKMWDNLTCWPATPR
10 20 30
80 90 100 110 120
pF1KE2 GEWVTLPCPDFFSHFSSESG-AVKRDCTITGWSEPFP-PYPVACPVPLEL--LAEEESYF
:. :.: :: .:. ::: .: :.:.:: ::.. : :::.:: . . : :....:
XP_011 GQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 -STVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAA
..:: ::.:...:...:.:: .:: .:.::: :::.: .:: .:::.:.:::.:: :
XP_011 YGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWL
:: : ..:.:: ..: ::.... .. .:.:: :::.:..:: ::: . : :. ::
XP_011 LFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 VLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIR
.: :::.: :: .:. .. ::: .::: ..: ::::::::. :. ::: ::. :::
XP_011 ILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSS-LWWIIKGPILTSILVNFILFICIIR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 ILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLG
::..::.: . .: : ::..:::.::::::.:::.: :.::: ... .:: .:
XP_011 ILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 SFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC
:::::.::::::::: ::..:. :::. . . .: :. ::
XP_011 SFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNP--KYRHPSGGSNGATCSTQVS
340 350 360 370 380 390
XP_011 MLTRVSPGARRSSSFQAEVSLV
400 410
>>XP_005265495 (OMIM: 192321) PREDICTED: vasoactive inte (416 aa)
initn: 1147 init1: 519 opt: 1194 Z-score: 1324.1 bits: 254.0 E(85289): 5.2e-67
Smith-Waterman score: 1194; 47.5% identity (73.2% similar) in 377 aa overlap (41-412:9-381)
20 30 40 50 60 70
pF1KE2 FCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGS
::. :. . : :.:: ::.: :::..
XP_005 MIEVQHKQCLEEAQ-LENETIGCSKMWDNLTCWPATPR
10 20 30
80 90 100 110 120
pF1KE2 GEWVTLPCPDFFSHFSSESG-AVKRDCTITGWSEPFP-PYPVACPVPLEL--LAEEESYF
:. :.: :: .:. ::: .: :.:.:: ::.. : :::.:: . . : :....:
XP_005 GQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 -STVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAA
..:: ::.:...:...:.:: .:: .:.::: :::.: .:: .:::.:.:::.:: :
XP_005 YGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWL
:: : ..:.:: ..: ::.... .. .:.:: :::.:..:: ::: . : :. ::
XP_005 LFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 VLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIR
.: :::.: :: .:. .. ::: .::: ..: ::::::::. :. ::: ::. :::
XP_005 ILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSS-LWWIIKGPILTSILVNFILFICIIR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 ILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLG
::..::.: . .: : ::..:::.::::::.:::.: :.::: ... .:: .:
XP_005 ILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 SFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC
:::::.::::::::: ::..:. :::. . . .: :. ::
XP_005 SFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNP--KYRHPSGGSNGATCSTQVS
340 350 360 370 380 390
XP_005 MLTRVSPGARRSSSFQAEVSLV
400 410
>>NP_001186566 (OMIM: 102981) pituitary adenylate cyclas (447 aa)
initn: 1174 init1: 957 opt: 1184 Z-score: 1312.7 bits: 252.0 E(85289): 2.2e-66
Smith-Waterman score: 1199; 46.1% identity (73.2% similar) in 380 aa overlap (24-391:21-394)
10 20 30 40 50
pF1KE2 MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACL---QAAEEM---PNTTLG
:: .: : ..... :: : :.:. ... :
NP_001 MAGVVHVSLAALLLLPMAPAMHSDCIF----KKEQAMCLEKIQRANELMGFNDSSPG
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 CPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSES--GAVKRDCTITGWSEPFPPYPVAC
::. ::.. :: : :: : . ::..: :. .. :.:.:.:: ::::::: : ::
NP_001 CPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQDMGVVSRNCTEDGWSEPFPHYFDAC
60 70 80 90 100 110
120 130 140 150 160
pF1KE2 PVPLELLAE---EESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLF
: .: .. :. .:: .::::.: :.:.: .:..:: .:.::: ::..: .::
NP_001 GFD-EYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLF
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 TTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNC
..:.:.: .::.:: :. .:..:: .::: ::. .. :. ...:. ::. :..::
NP_001 VSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFT
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 LLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPI
::. : :: :.: .. ::: :.. . .:.. .: :.: .:::..:.. ::.::::.
NP_001 LLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPV
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 VLSVGVNFGLFLNIIRILVRKLE-PAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFL
: :. ::: ::..:: :::.::. : .:. . .: : ::..:::.::::::::: .: :
NP_001 VGSIMVNFVLFIGIIVILVQKLQSPDMGG-NESSIYLRLARSTLLLIPLFGIHYTVFAFS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 PDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKW
:.:.. :: .::::::::::.::.:::::: ::..::.:::
NP_001 PENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRH
360 370 380 390 400 410
410 420
pF1KE2 TTPSRSAAKVLTSMC
NP_001 PSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
420 430 440
>>NP_001238813 (OMIM: 192321) vasoactive intestinal poly (409 aa)
initn: 1169 init1: 526 opt: 1170 Z-score: 1297.7 bits: 249.1 E(85289): 1.5e-65
Smith-Waterman score: 1170; 47.7% identity (73.0% similar) in 363 aa overlap (54-412:15-374)
30 40 50 60 70 80
pF1KE2 MHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFS
:: ::.: :::.. :. :.: :: .:.
NP_001 MRAGRRPRLGPWAGGCSKMWDNLTCWPATPRGQVVVLACPLIFK
10 20 30 40
90 100 110 120 130
pF1KE2 HFSSESG-AVKRDCTITGWSEPFP-PYPVACPVPLEL--LAEEESYFSTVKIIYTVGHSI
::: .: :.:.:: ::.. : :::.:: . . : :. ....:: ::.:...
NP_001 LFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQTMFYGSVKTGYTIGYGL
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE2 SIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFST
:...:.:: .:: .:.::: :::.: .:: .:::.:.:::.:: ::: : ..:.:: ..
NP_001 SLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGS
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE2 VLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGT
: ::.... .. .:.:: :::.:..:: ::: . : :. :: .: :::.: :: .
NP_001 VGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMV
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE2 WVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLH
:. .. ::: .::: ..: ::::::::. :. ::: ::. :::::..::.: .
NP_001 WTIARIHFEDYGCWDTINSS-LWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKS
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE2 TQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFL
.: : ::..:::.::::::.:::.: :.::: ... .:: .::::::.::::::::
NP_001 DSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFL
290 300 310 320 330 340
380 390 400 410 420
pF1KE2 NQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC
: ::..:. :::. . . .: :. ::
NP_001 NGEVQAELRRKWRRWHLQGVLGWNP--KYRHPSGGSNGATCSTQVSMLTRVSPGARRSSS
350 360 370 380 390 400
NP_001 FQAEVSLV
423 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:24:40 2016 done: Sun Nov 6 16:24:42 2016
Total Scan time: 8.460 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]