Result of FASTA (omim) for
pF1KE2119
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2119, 912 aa
1>>>pF1KE2119 912 - 912 aa - 912 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.2469+/-0.00058; mu= -6.7484+/- 0.035
mean_var=605.2497+/-133.225, 0's: 0 Z-trim(118.6): 1756 B-trim: 0 in 0/51
Lambda= 0.052132
statistics sampled from 29433 (31765) to 29433 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.372), width: 16
Scan time: 14.620
The best scores are: opt bits E(85289)
NP_002733 (OMIM: 605435) serine/threonine-protein ( 912) 6162 480.1 2.1e-134
NP_001316998 (OMIM: 605435) serine/threonine-prote ( 920) 6136 478.2 8.2e-134
XP_011535266 (OMIM: 605435) PREDICTED: serine/thre ( 844) 5555 434.4 1.1e-120
XP_011535267 (OMIM: 605435) PREDICTED: serine/thre ( 824) 5486 429.2 4e-119
XP_016876950 (OMIM: 605435) PREDICTED: serine/thre ( 824) 5486 429.2 4e-119
XP_016876951 (OMIM: 605435) PREDICTED: serine/thre ( 747) 5048 396.2 3.1e-109
XP_016859230 (OMIM: 607077) PREDICTED: serine/thre ( 717) 3291 264.0 1.8e-69
XP_016859231 (OMIM: 607077) PREDICTED: serine/thre ( 717) 3291 264.0 1.8e-69
XP_005264295 (OMIM: 607077) PREDICTED: serine/thre ( 786) 3291 264.1 1.9e-69
XP_005264294 (OMIM: 607077) PREDICTED: serine/thre ( 890) 3291 264.2 2.1e-69
NP_005804 (OMIM: 607077) serine/threonine-protein ( 890) 3291 264.2 2.1e-69
XP_016859232 (OMIM: 607077) PREDICTED: serine/thre ( 631) 3220 258.6 6.9e-68
XP_016859233 (OMIM: 607077) PREDICTED: serine/thre ( 631) 3220 258.6 6.9e-68
XP_005258773 (OMIM: 607074) PREDICTED: serine/thre ( 721) 2605 212.5 6.2e-54
NP_001073351 (OMIM: 607074) serine/threonine-prote ( 721) 2605 212.5 6.2e-54
NP_001073349 (OMIM: 607074) serine/threonine-prote ( 878) 2605 212.6 7e-54
NP_057541 (OMIM: 607074) serine/threonine-protein ( 878) 2605 212.6 7e-54
NP_001073350 (OMIM: 607074) serine/threonine-prote ( 878) 2605 212.6 7e-54
XP_016884050 (OMIM: 114480,176807,259500,604373,60 ( 322) 648 64.8 7.9e-10
XP_011528147 (OMIM: 114480,176807,259500,604373,60 ( 322) 648 64.8 7.9e-10
NP_001244316 (OMIM: 114480,176807,259500,604373,60 ( 322) 648 64.8 7.9e-10
NP_009125 (OMIM: 114480,176807,259500,604373,60926 ( 543) 648 65.1 1.1e-09
XP_016884049 (OMIM: 114480,176807,259500,604373,60 ( 584) 648 65.1 1.1e-09
NP_001005735 (OMIM: 114480,176807,259500,604373,60 ( 586) 648 65.1 1.1e-09
XP_011528141 (OMIM: 114480,176807,259500,604373,60 ( 596) 648 65.1 1.1e-09
XP_006724179 (OMIM: 114480,176807,259500,604373,60 ( 362) 634 63.8 1.8e-09
XP_011528145 (OMIM: 114480,176807,259500,604373,60 ( 476) 635 64.0 2e-09
XP_011528144 (OMIM: 114480,176807,259500,604373,60 ( 486) 635 64.0 2e-09
XP_011528143 (OMIM: 114480,176807,259500,604373,60 ( 519) 635 64.1 2.1e-09
XP_006724177 (OMIM: 114480,176807,259500,604373,60 ( 394) 629 63.5 2.4e-09
NP_208382 (OMIM: 613167) serine/threonine-protein ( 648) 622 63.2 4.6e-09
XP_011532469 (OMIM: 613167) PREDICTED: serine/thre ( 648) 622 63.2 4.6e-09
XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 606 61.7 7.5e-09
NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 606 61.7 7.5e-09
XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 606 61.7 7.6e-09
NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 606 61.7 7.8e-09
NP_003647 (OMIM: 604998) calcium/calmodulin-depend ( 370) 589 60.4 1.9e-08
XP_005265573 (OMIM: 604998) PREDICTED: calcium/cal ( 413) 589 60.5 2e-08
XP_016863321 (OMIM: 613166) PREDICTED: serine/thre ( 717) 594 61.2 2.1e-08
XP_005262843 (OMIM: 613166) PREDICTED: serine/thre ( 765) 594 61.2 2.2e-08
NP_001035350 (OMIM: 613166) serine/threonine-prote ( 766) 594 61.2 2.2e-08
XP_005262842 (OMIM: 613166) PREDICTED: serine/thre ( 782) 594 61.2 2.2e-08
NP_001035351 (OMIM: 613166) serine/threonine-prote ( 783) 594 61.3 2.2e-08
XP_006717544 (OMIM: 607957) PREDICTED: calcium/cal ( 366) 584 60.0 2.4e-08
XP_011517893 (OMIM: 607957) PREDICTED: calcium/cal ( 372) 582 59.9 2.7e-08
NP_065172 (OMIM: 614994) calcium/calmodulin-depend ( 476) 583 60.1 2.9e-08
XP_016857355 (OMIM: 614994) PREDICTED: calcium/cal ( 476) 583 60.1 2.9e-08
NP_001310303 (OMIM: 114080) calcium/calmodulin-dep ( 473) 562 58.5 8.8e-08
NP_001735 (OMIM: 114080) calcium/calmodulin-depend ( 473) 562 58.5 8.8e-08
NP_001310304 (OMIM: 114080) calcium/calmodulin-dep ( 473) 562 58.5 8.8e-08
>>NP_002733 (OMIM: 605435) serine/threonine-protein kina (912 aa)
initn: 6162 init1: 6162 opt: 6162 Z-score: 2534.0 bits: 480.1 E(85289): 2.1e-134
Smith-Waterman score: 6162; 100.0% identity (100.0% similar) in 912 aa overlap (1-912:1-912)
10 20 30 40 50 60
pF1KE2 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET
850 860 870 880 890 900
910
pF1KE2 EMKALGERVSIL
::::::::::::
NP_002 EMKALGERVSIL
910
>>NP_001316998 (OMIM: 605435) serine/threonine-protein k (920 aa)
initn: 6148 init1: 4592 opt: 6136 Z-score: 2523.4 bits: 478.2 E(85289): 8.2e-134
Smith-Waterman score: 6136; 99.1% identity (99.1% similar) in 920 aa overlap (1-912:1-920)
10 20 30 40 50 60
pF1KE2 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
130 140 150 160 170 180
190 200 210 220 230
pF1KE2 GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLL--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 QKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 GLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSER
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 NSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 VKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEIL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 SLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMW
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 EIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 QFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETP
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 ERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENV
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 LLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVI
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 IYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE2 TLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHS
850 860 870 880 890 900
900 910
pF1KE2 DTPETEETEMKALGERVSIL
::::::::::::::::::::
NP_001 DTPETEETEMKALGERVSIL
910 920
>>XP_011535266 (OMIM: 605435) PREDICTED: serine/threonin (844 aa)
initn: 5567 init1: 4592 opt: 5555 Z-score: 2287.6 bits: 434.4 E(85289): 1.1e-120
Smith-Waterman score: 5560; 98.3% identity (98.8% similar) in 840 aa overlap (83-912:5-844)
60 70 80 90 100 110
pF1KE2 LQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQK--FPECGFYGMYDKILLFRHDPTS
:.:... ::::::::::::::::::::::
XP_011 MWPPSVVEEEIMFPECGFYGMYDKILLFRHDPTS
10 20 30
120 130 140 150 160 170
pF1KE2 ENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 VRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEP
100 110 120 130 140 150
240 250 260 270 280
pF1KE2 LL--------QKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPT
:: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSPVSPGFEQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPT
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE2 VCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVME
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE2 EGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSN
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE2 NIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRY
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE2 YKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTS
400 410 420 430 440 450
530 540 550 560 570 580
pF1KE2 GVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQ
460 470 480 490 500 510
590 600 610 620 630 640
pF1KE2 IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGV
520 530 540 550 560 570
650 660 670 680 690 700
pF1KE2 VNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNI
580 590 600 610 620 630
710 720 730 740 750 760
pF1KE2 VHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR
640 650 660 670 680 690
770 780 790 800 810 820
pF1KE2 SLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQV
700 710 720 730 740 750
830 840 850 860 870 880
pF1KE2 KMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPT
760 770 780 790 800 810
890 900 910
pF1KE2 HLINPSASHSDTPETEETEMKALGERVSIL
::::::::::::::::::::::::::::::
XP_011 HLINPSASHSDTPETEETEMKALGERVSIL
820 830 840
>>XP_011535267 (OMIM: 605435) PREDICTED: serine/threonin (824 aa)
initn: 5498 init1: 4592 opt: 5486 Z-score: 2259.7 bits: 429.2 E(85289): 4e-119
Smith-Waterman score: 5486; 99.0% identity (99.0% similar) in 824 aa overlap (97-912:1-824)
70 80 90 100 110 120
pF1KE2 DSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEG
::::::::::::::::::::::::::::::
XP_011 MYDKILLFRHDPTSENILQLVKAASDIQEG
10 20 30
130 140 150 160 170 180
pF1KE2 DLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHK
40 50 60 70 80 90
190 200 210 220 230
pF1KE2 RCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLL--------QKSPSE
:::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_011 RCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSE
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 SFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQG
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 LQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMD
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 DMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKR
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE2 KSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVK
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE2 TSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQH
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE2 ALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVY
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE2 GGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVV
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE2 MEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD
580 590 600 610 620 630
720 730 740 750 760 770
pF1KE2 PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLS
640 650 660 670 680 690
780 790 800 810 820 830
pF1KE2 GTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPW
700 710 720 730 740 750
840 850 860 870 880 890
pF1KE2 LQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETE
760 770 780 790 800 810
900 910
pF1KE2 ETEMKALGERVSIL
::::::::::::::
XP_011 ETEMKALGERVSIL
820
>>XP_016876950 (OMIM: 605435) PREDICTED: serine/threonin (824 aa)
initn: 5498 init1: 4592 opt: 5486 Z-score: 2259.7 bits: 429.2 E(85289): 4e-119
Smith-Waterman score: 5486; 99.0% identity (99.0% similar) in 824 aa overlap (97-912:1-824)
70 80 90 100 110 120
pF1KE2 DSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEG
::::::::::::::::::::::::::::::
XP_016 MYDKILLFRHDPTSENILQLVKAASDIQEG
10 20 30
130 140 150 160 170 180
pF1KE2 DLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHK
40 50 60 70 80 90
190 200 210 220 230
pF1KE2 RCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLL--------QKSPSE
:::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 RCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSE
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 SFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQG
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 LQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMD
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 DMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKR
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE2 KSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVK
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE2 TSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQH
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE2 ALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVY
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE2 GGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVV
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE2 MEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD
580 590 600 610 620 630
720 730 740 750 760 770
pF1KE2 PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLS
640 650 660 670 680 690
780 790 800 810 820 830
pF1KE2 GTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPW
700 710 720 730 740 750
840 850 860 870 880 890
pF1KE2 LQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETE
760 770 780 790 800 810
900 910
pF1KE2 ETEMKALGERVSIL
::::::::::::::
XP_016 ETEMKALGERVSIL
820
>>XP_016876951 (OMIM: 605435) PREDICTED: serine/threonin (747 aa)
initn: 5048 init1: 5048 opt: 5048 Z-score: 2082.1 bits: 396.2 E(85289): 3.1e-109
Smith-Waterman score: 5048; 100.0% identity (100.0% similar) in 747 aa overlap (166-912:1-747)
140 150 160 170 180 190
pF1KE2 SATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN
::::::::::::::::::::::::::::::
XP_016 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNN
10 20 30
200 210 220 230 240 250
pF1KE2 CSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGR
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 PIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPK
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 VPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAEC
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE2 QNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSK
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE2 DTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEIT
280 290 300 310 320 330
500 510 520 530 540 550
pF1KE2 TANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTN
340 350 360 370 380 390
560 570 580 590 600 610
pF1KE2 LHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID
400 410 420 430 440 450
620 630 640 650 660 670
pF1KE2 KLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEK
460 470 480 490 500 510
680 690 700 710 720 730
pF1KE2 GRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIG
520 530 540 550 560 570
740 750 760 770 780 790
pF1KE2 EKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQN
580 590 600 610 620 630
800 810 820 830 840 850
pF1KE2 AAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKI
640 650 660 670 680 690
860 870 880 890 900 910
pF1KE2 GERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
700 710 720 730 740
>>XP_016859230 (OMIM: 607077) PREDICTED: serine/threonin (717 aa)
initn: 3534 init1: 2005 opt: 3291 Z-score: 1368.1 bits: 264.0 E(85289): 1.8e-69
Smith-Waterman score: 3575; 73.4% identity (86.0% similar) in 736 aa overlap (166-893:1-716)
140 150 160 170 180 190
pF1KE2 SATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN
::::::::::::::::::::::::::::::
XP_016 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNN
10 20 30
200 210 220 230 240 250
pF1KE2 CSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSE-SFIGREKRSNSQSYIG
:::::.:::::::: : . ::. : .: ::: : . .: . :. :
XP_016 CSGVRKRRLSNVSLPGPG--------LSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSG
40 50 60 70 80
260 270 280 290 300 310
pF1KE2 RPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAP
::: ..:..: .:::::::..:::::::.:::::.:::::::::.:::::.::::::::
XP_016 RPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCAS
90 100 110 120 130 140
320 330 340 350 360 370
pF1KE2 KVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAE
::: .::::::.::. : :...:. :. ..: .:. . :: :: :: . .: .
XP_016 KVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGL-DDTEEPSPPEDKMFFL-
150 160 170 180 190 200
380 390 400 410 420 430
pF1KE2 CQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTS
: ... : . : :.: .::::::::::::::::::.:::::::::..::::::::::
XP_016 ---DPSDL-DVERD-EEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTS
210 220 230 240 250
440 450 460 470 480 490
pF1KE2 KDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEI
.:.:::::::::::::.:::::..::.::::::::::: . . . : .:.:::::::
XP_016 RDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEI
260 270 280 290 300 310
500 510 520 530 540 550
pF1KE2 TTANVVYYVGENVVNPSSPSPNNSVLT-SGVGADVARMWEIAIQHALMPVIPKGS---SV
: ..::.:::: .. : .: ::. .::: :::. :: ::..::::: :..: :
XP_016 ITDTMVYFVGEN----NGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP
320 330 340 350 360 370
560 570 580 590 600 610
pF1KE2 GTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVA
: : . :.:.:.:::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 GQGKD-HKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVA
380 390 400 410 420 430
620 630 640 650 660 670
pF1KE2 IKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMI
::.:::.::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_016 IKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMI
440 450 460 470 480 490
680 690 700 710 720 730
pF1KE2 LSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGF
:::::.::::.::::..::::::::.:::::::::::::::::::::.::::::::::::
XP_016 LSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGF
500 510 520 530 540 550
740 750 760 770 780 790
pF1KE2 ARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIH
::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::.
XP_016 ARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIN
560 570 580 590 600 610
800 810 820 830 840 850
pF1KE2 DQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRE
:::::::::::::::.::: ::::::::::::::::::::::.:::::::::::::::::
XP_016 DQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLRE
620 630 640 650 660 670
860 870 880 890 900
pF1KE2 LECKIGERYITHESDDLRWEKYAGEQGLQYPTHLI---NPSASHSDTPETEETEMKALGE
.: .:::::::::::: ::: .: ..: :: :.: ::. . :
XP_016 FETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
680 690 700 710
910
pF1KE2 RVSIL
>>XP_016859231 (OMIM: 607077) PREDICTED: serine/threonin (717 aa)
initn: 3534 init1: 2005 opt: 3291 Z-score: 1368.1 bits: 264.0 E(85289): 1.8e-69
Smith-Waterman score: 3575; 73.4% identity (86.0% similar) in 736 aa overlap (166-893:1-716)
140 150 160 170 180 190
pF1KE2 SATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN
::::::::::::::::::::::::::::::
XP_016 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNN
10 20 30
200 210 220 230 240 250
pF1KE2 CSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSE-SFIGREKRSNSQSYIG
:::::.:::::::: : . ::. : .: ::: : . .: . :. :
XP_016 CSGVRKRRLSNVSLPGPG--------LSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSG
40 50 60 70 80
260 270 280 290 300 310
pF1KE2 RPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAP
::: ..:..: .:::::::..:::::::.:::::.:::::::::.:::::.::::::::
XP_016 RPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCAS
90 100 110 120 130 140
320 330 340 350 360 370
pF1KE2 KVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAE
::: .::::::.::. : :...:. :. ..: .:. . :: :: :: . .: .
XP_016 KVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGL-DDTEEPSPPEDKMFFL-
150 160 170 180 190 200
380 390 400 410 420 430
pF1KE2 CQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTS
: ... : . : :.: .::::::::::::::::::.:::::::::..::::::::::
XP_016 ---DPSDL-DVERD-EEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTS
210 220 230 240 250
440 450 460 470 480 490
pF1KE2 KDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEI
.:.:::::::::::::.:::::..::.::::::::::: . . . : .:.:::::::
XP_016 RDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEI
260 270 280 290 300 310
500 510 520 530 540 550
pF1KE2 TTANVVYYVGENVVNPSSPSPNNSVLT-SGVGADVARMWEIAIQHALMPVIPKGS---SV
: ..::.:::: .. : .: ::. .::: :::. :: ::..::::: :..: :
XP_016 ITDTMVYFVGEN----NGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP
320 330 340 350 360 370
560 570 580 590 600 610
pF1KE2 GTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVA
: : . :.:.:.:::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 GQGKD-HKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVA
380 390 400 410 420 430
620 630 640 650 660 670
pF1KE2 IKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMI
::.:::.::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_016 IKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMI
440 450 460 470 480 490
680 690 700 710 720 730
pF1KE2 LSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGF
:::::.::::.::::..::::::::.:::::::::::::::::::::.::::::::::::
XP_016 LSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGF
500 510 520 530 540 550
740 750 760 770 780 790
pF1KE2 ARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIH
::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::.
XP_016 ARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIN
560 570 580 590 600 610
800 810 820 830 840 850
pF1KE2 DQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRE
:::::::::::::::.::: ::::::::::::::::::::::.:::::::::::::::::
XP_016 DQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLRE
620 630 640 650 660 670
860 870 880 890 900
pF1KE2 LECKIGERYITHESDDLRWEKYAGEQGLQYPTHLI---NPSASHSDTPETEETEMKALGE
.: .:::::::::::: ::: .: ..: :: :.: ::. . :
XP_016 FETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
680 690 700 710
910
pF1KE2 RVSIL
>>XP_005264295 (OMIM: 607077) PREDICTED: serine/threonin (786 aa)
initn: 3907 init1: 2005 opt: 3291 Z-score: 1367.7 bits: 264.1 E(85289): 1.9e-69
Smith-Waterman score: 3948; 73.7% identity (86.7% similar) in 805 aa overlap (97-893:1-785)
70 80 90 100 110 120
pF1KE2 DSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEG
::::::::::: .:::::::. .:..:.::
XP_005 MYDKILLFRHDMNSENILQLITSADEIHEG
10 20 30
130 140 150 160 170 180
pF1KE2 DLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHK
::.:::::: :: ::::::::.:.::::.::.:::.::::::::::::::::::::::::
XP_005 DLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHK
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE2 RCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSE-SFIGREK
::::::::::::::.:::::::: : . ::. : .: ::: : . .:
XP_005 RCAFKIPNNCSGVRKRRLSNVSLPGPG--------LSVPRPLQPEYVALPSEESHVHQEP
100 110 120 130 140
250 260 270 280 290 300
pF1KE2 RSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCR
. :. :::: ..:..: .:::::::..:::::::.:::::.:::::::::.:::::.
XP_005 SKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCK
150 160 170 180 190 200
310 320 330 340 350 360
pF1KE2 FNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMV
:::::::: ::: .::::::.::. : :...:. :. ..: .:. . :: :: ::
XP_005 FNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGL-DDTEEPSP
210 220 230 240 250 260
370 380 390 400 410 420
pF1KE2 QDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMK
. .: . : ... : . : :.: .::::::::::::::::::.:::::::::..:
XP_005 PEDKMFFL----DPSDL-DVERD-EEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVK
270 280 290 300 310
430 440 450 460 470 480
pF1KE2 EGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPN
:::::::::.:.:::::::::::::.:::::..::.::::::::::: . . . : .
XP_005 EGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQ
320 330 340 350 360 370
490 500 510 520 530 540
pF1KE2 GANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLT-SGVGADVARMWEIAIQHALMPVI
:.::::::: : ..::.:::: .. : .: ::. .::: :::. :: ::..:::::
XP_005 GSNPHCFEIITDTMVYFVGEN----NGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVT
380 390 400 410 420 430
550 560 570 580 590 600
pF1KE2 PKGS---SVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGK
:..: : : : . :.:.:.:::::::::::::::::::::: ::::::::::::::::
XP_005 PQASVCTSPGQGKD-HKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGK
440 450 460 470 480 490
610 620 630 640 650 660
pF1KE2 HRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEK
:::::::::::.:::.::::::::::::::::::::::::.:::::::::::::::::::
XP_005 HRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEK
500 510 520 530 540 550
670 680 690 700 710 720
pF1KE2 LHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP
::::::::::::::.::::.::::..::::::::.:::::::::::::::::::::.:::
XP_005 LHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFP
560 570 580 590 600 610
730 740 750 760 770 780
pF1KE2 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTF
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
XP_005 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTF
620 630 640 650 660 670
790 800 810 820 830 840
pF1KE2 PFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD
::::::::.:::::::::::::::.::: ::::::::::::::::::::::.::::::::
XP_005 PFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD
680 690 700 710 720 730
850 860 870 880 890
pF1KE2 YQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLI---NPSASHSDTPETE
:::::::::.: .:::::::::::: ::: .: ..: :: :.: ::. . :
XP_005 YQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
740 750 760 770 780
900 910
pF1KE2 ETEMKALGERVSIL
>>XP_005264294 (OMIM: 607077) PREDICTED: serine/threonin (890 aa)
initn: 4094 init1: 2005 opt: 3291 Z-score: 1367.1 bits: 264.2 E(85289): 2.1e-69
Smith-Waterman score: 4144; 70.1% identity (84.2% similar) in 900 aa overlap (2-893:17-889)
10 20 30 40
pF1KE2 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAP
.: :.. : . : .. .. .: : :: :: :. .
XP_005 MSANNSPPSAQKSVLPTAIPAVLPAAS--PCSSPKTGLSARLSNGSFS--APSLTNSRGS
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 VGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFR
: .:: :::::.:: : . . . ::. :....:::: ::::::::.::::::::::
XP_005 VHTVSFLLQIGLTRESVTI---EAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFR
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 HDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGE
:: .:::::::. .:..:.::::.:::::: :: ::::::::.:.::::.::.:::.:::
XP_005 HDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTS
:::::::::::::::::::::::::::::::::::.:::::::: : . ::.
XP_005 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPG--------LSVP
180 190 200 210 220
230 240 250 260 270 280
pF1KE2 APDEPLLQKSPSE-SFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVC
: .: ::: : . .: . :. :::: ..:..: .:::::::..:::::::.:
XP_005 RPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTIC
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 QYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEG
::::.:::::::::.:::::.:::::::: ::: .::::::.::. : :...:. :.
XP_005 QYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDID
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE2 SDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNI
..: .:. . :: :: :: . .: . : ... : . : :.: .::::::::::
XP_005 NNDINSDSSRGL-DDTEEPSPPEDKMFFL----DPSDL-DVERD-EEAVKTISPSTSNNI
350 360 370 380 390
410 420 430 440 450 460
pF1KE2 PLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYK
::::::::.:::::::::..::::::::::.:.:::::::::::::.:::::..::.:::
XP_005 PLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYK
400 410 420 430 440 450
470 480 490 500 510 520
pF1KE2 EIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLT-SG
:::::::: . . . : .:.::::::: : ..::.:::: .. : .: ::. .:
XP_005 EIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGEN----NGDSSHNPVLAATG
460 470 480 490 500 510
530 540 550 560 570 580
pF1KE2 VGADVARMWEIAIQHALMPVIPKGS---SVGTGTNLHRDISVSISVSNCQIQENVDISTV
:: :::. :: ::..::::: :..: : : : . :.:.:.::::::::::::::::::
XP_005 VGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKD-HKDLSTSISVSNCQIQENVDISTV
520 530 540 550 560 570
590 600 610 620 630 640
pF1KE2 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP
:::: :::::::::::::::::::::::::::.:::.:::::::::::::::::::::::
XP_005 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP
580 590 600 610 620 630
650 660 670 680 690 700
pF1KE2 GVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFK
:.:::::::::::::::::::::::::::::::::.::::.::::..::::::::.::::
XP_005 GIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFK
640 650 660 670 680 690
710 720 730 740 750 760
pF1KE2 NIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGY
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::.:::
XP_005 NIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGY
700 710 720 730 740 750
770 780 790 800 810 820
pF1KE2 NRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLL
:::::::::::::::::::::::::::::.:::::::::::::::.::: ::::::::::
XP_005 NRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLL
760 770 780 790 800 810
830 840 850 860 870 880
pF1KE2 QVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQY
::::::::::::.:::::::::::::::::.: .:::::::::::: ::: .: ..: :
XP_005 QVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVY
820 830 840 850 860 870
890 900 910
pF1KE2 PTHLI---NPSASHSDTPETEETEMKALGERVSIL
: :.: ::. . :
XP_005 PKHFIMAPNPDDMEEDP
880 890
912 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:28:04 2016 done: Sun Nov 6 14:28:06 2016
Total Scan time: 14.620 Total Display time: 0.330
Function used was FASTA [36.3.4 Apr, 2011]