Result of FASTA (omim) for
pF1KE1963
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1963, 524 aa
1>>>pF1KE1963 524 - 524 aa - 524 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3656+/-0.000336; mu= 14.7383+/- 0.021
mean_var=116.2472+/-23.655, 0's: 0 Z-trim(117.7): 21 B-trim: 183 in 1/57
Lambda= 0.118955
statistics sampled from 29978 (29999) to 29978 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.352), width: 16
Scan time: 10.170
The best scores are: opt bits E(85289)
NP_954987 (OMIM: 191290,605407) tyrosine 3-monooxy ( 524) 3492 610.3 4.4e-174
NP_954986 (OMIM: 191290,605407) tyrosine 3-monooxy ( 528) 3474 607.2 3.8e-173
XP_011518637 (OMIM: 191290,605407) PREDICTED: tyro ( 501) 3103 543.5 5.3e-154
NP_000351 (OMIM: 191290,605407) tyrosine 3-monooxy ( 497) 3102 543.4 6e-154
NP_000268 (OMIM: 261600,612349) phenylalanine-4-hy ( 452) 1516 271.2 4.8e-72
NP_775489 (OMIM: 607478,608516,613003) tryptophan ( 490) 1437 257.6 6.1e-68
NP_004170 (OMIM: 191060) tryptophan 5-hydroxylase ( 444) 1422 255.0 3.4e-67
XP_016874859 (OMIM: 261600,612349) PREDICTED: phen ( 240) 581 110.5 6e-24
>>NP_954987 (OMIM: 191290,605407) tyrosine 3-monooxygena (524 aa)
initn: 3492 init1: 3492 opt: 3492 Z-score: 3246.3 bits: 610.3 E(85289): 4.4e-174
Smith-Waterman score: 3492; 99.8% identity (100.0% similar) in 524 aa overlap (1-524:1-524)
10 20 30 40 50 60
pF1KE1 MPTPDATTPQAKGFRRAVSELDAKQAEAIMGAPGPSLTGSPWPGTAAPAASYTPTPRSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 MPTPDATTPQAKGFRRAVSELDAKQAEAIMGAPGPSLTGSPWPGTAAPAASYTPTPRSPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 FIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKP
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_954 FIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 SALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 DVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 RHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 RHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 DVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 DVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 SSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQR
430 440 450 460 470 480
490 500 510 520
pF1KE1 PFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
::::::::::::::::::::::::::::::::::::::::::::
NP_954 PFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
490 500 510 520
>>NP_954986 (OMIM: 191290,605407) tyrosine 3-monooxygena (528 aa)
initn: 3478 init1: 3299 opt: 3474 Z-score: 3229.6 bits: 607.2 E(85289): 3.8e-173
Smith-Waterman score: 3474; 99.1% identity (99.2% similar) in 528 aa overlap (1-524:1-528)
10 20 30 40 50
pF1KE1 MPTPDATTPQAKGFRRAVSELDAKQAEAIM----GAPGPSLTGSPWPGTAAPAASYTPTP
:::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
NP_954 MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPR
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_954 RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
430 440 450 460 470 480
480 490 500 510 520
pF1KE1 RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
490 500 510 520
>>XP_011518637 (OMIM: 191290,605407) PREDICTED: tyrosine (501 aa)
initn: 3282 init1: 3103 opt: 3103 Z-score: 2885.8 bits: 543.5 E(85289): 5.3e-154
Smith-Waterman score: 3238; 94.8% identity (95.4% similar) in 524 aa overlap (1-524:1-501)
10 20 30 40 50 60
pF1KE1 MPTPDATTPQAKGFRRAVSELDAKQAEAIMGAPGPSLTGSPWPGTAAPAASYTPTPRSPR
:::::::::::::::::::::::::::::: . : .:::
XP_011 MPTPDATTPQAKGFRRAVSELDAKQAEAIM------VRG-----------------QSPR
10 20 30
70 80 90 100 110 120
pF1KE1 FIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKP
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
XP_011 FIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 SALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSE
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 DVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 RHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 DVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 SSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQR
400 410 420 430 440 450
490 500 510 520
pF1KE1 PFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
460 470 480 490 500
>>NP_000351 (OMIM: 191290,605407) tyrosine 3-monooxygena (497 aa)
initn: 3281 init1: 3102 opt: 3102 Z-score: 2884.9 bits: 543.4 E(85289): 6e-154
Smith-Waterman score: 3231; 94.7% identity (94.8% similar) in 524 aa overlap (1-524:1-497)
10 20 30 40 50 60
pF1KE1 MPTPDATTPQAKGFRRAVSELDAKQAEAIMGAPGPSLTGSPWPGTAAPAASYTPTPRSPR
:::::::::::::::::::::::::::::: :::
NP_000 MPTPDATTPQAKGFRRAVSELDAKQAEAIM---------------------------SPR
10 20 30
70 80 90 100 110 120
pF1KE1 FIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKP
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_000 FIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 SALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSE
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 DVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 RHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 DVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 SSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQR
400 410 420 430 440 450
490 500 510 520
pF1KE1 PFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
::::::::::::::::::::::::::::::::::::::::::::
NP_000 PFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
460 470 480 490
>>NP_000268 (OMIM: 261600,612349) phenylalanine-4-hydrox (452 aa)
initn: 1521 init1: 1442 opt: 1516 Z-score: 1414.5 bits: 271.2 E(85289): 4.8e-72
Smith-Waterman score: 1516; 53.2% identity (78.3% similar) in 423 aa overlap (109-523:35-451)
80 90 100 110 120 130
pF1KE1 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKPSALSRAVKVFETFEAKIH
..:.:: . . .::......:: ....
NP_000 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT
10 20 30 40 50 60
140 150 160 170 180 190
pF1KE1 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV
:.:.::. : . :.:..:. : .: :: . .. . .:. :. :
NP_000 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV
70 80 90 100 110
200 210 220 230 240 250
pF1KE1 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE
::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.::::::
NP_000 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
120 130 140 150 160 170
260 270 280 290 300 310
pF1KE1 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT
: :: :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. :
NP_000 YMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT
180 190 200 210 220 230
320 330 340 350 360 370
pF1KE1 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT
::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::.
NP_000 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS
240 250 260 270 280 290
380 390 400 410 420 430
pF1KE1 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL
::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .::
NP_000 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL
300 310 320 330 340 350
440 450 460 470 480 490
pF1KE1 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT
::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..::::
NP_000 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT
360 370 380 390 400 410
500 510 520
pF1KE1 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
:.:::. : .. .....:. : ::. :
NP_000 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK
420 430 440 450
>>NP_775489 (OMIM: 607478,608516,613003) tryptophan 5-hy (490 aa)
initn: 1460 init1: 1436 opt: 1437 Z-score: 1340.7 bits: 257.6 E(85289): 6.1e-68
Smith-Waterman score: 1462; 47.3% identity (74.8% similar) in 480 aa overlap (58-523:9-484)
30 40 50 60 70 80
pF1KE1 AIMGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQSLIEDARKEREAAVAAAAAAV
: .. .:: ...: :.. .....
NP_775 MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNK
10 20 30
90 100 110 120 130 140
pF1KE1 P-SEPGDPLEAVAFEEKEG---KAMLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETR
: : .: . ..:. .. ..:: . .. ..: .:...:. .... :.:.:
NP_775 PNSGKNDDKGNKGSSKREAATESGKTAVVFSLK-NEVGGLVKALRLFQEKRVNMVHIESR
40 50 60 70 80 90
150 160 170 180 190
pF1KE1 PAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR-QVSEDVRSPAG---------PKVPWF
..: :.. ..: :: : . .. :.. .. :.. . .: ::::
NP_775 KSRR-RSS--EVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE1 PRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTA
:::.:::::: : : . .:: :::::.:.::::::: ....:. :..:.::::::::
NP_775 PRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTE
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE1 EEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQ
:: :: :. :. :: :::: :.:. : :: .. ::::::.::::::: :::::.::
NP_775 EETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFT
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE1 LRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQ
.::::: :: :::::.::.:::.:::::::.:.:...:::: :::::::::.::: :::
NP_775 VRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQ
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE1 FSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEE
:::.:::::::::::...::.: :.::.:::::::.:...::::::::: ::: : ::..
NP_775 FSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDK
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE1 PEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAI
..::::... .: :.: .::::::: .::.:.:..:. : ::::: :.::: .:
NP_775 ACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSI
400 410 420 430 440 450
500 510 520
pF1KE1 DVLDSPQAVRRSLEGVQDELDTLAHALSAIG
..: . .... .. ....:.:. ::. .
NP_775 EILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
460 470 480 490
>>NP_004170 (OMIM: 191060) tryptophan 5-hydroxylase 1 [H (444 aa)
initn: 1426 init1: 1402 opt: 1422 Z-score: 1327.4 bits: 255.0 E(85289): 3.4e-67
Smith-Waterman score: 1449; 50.3% identity (78.7% similar) in 431 aa overlap (103-523:14-438)
80 90 100 110 120 130
pF1KE1 RKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKPSALSRAVKVFET
..:.: .:.:: . .. ..: .:.:.:.
NP_004 MIEDNKENKDHSLERGRA--SLIFSLK-NEVGGLIKALKIFQE
10 20 30 40
140 150 160 170 180
pF1KE1 FEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRR---GDLAALL---SGVRQVS-ED---V
.... :.:.: ..: . ..: :: .. : .:. :: ..: .:. : .
NP_004 KHVNLLHIESRKSKRRNS---EFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTL
50 60 70 80 90
190 200 210 220 230 240
pF1KE1 RSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRH
. . :::::.:.:.::.: . : . .:: :::::.:.:::.::: .:..:..:.:
NP_004 KEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKH
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 GDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDV
:::::.::.: ::: :: :. :. :: :::: :.:. . :: .. :::::::::::::
NP_004 GDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDV
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE1 SRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGH
: ::::::::..::::: :: ::::..::::::.::::.::.:.:...:::: :::::::
NP_004 SNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGH
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE1 VPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSS
::.::. .::::::.:::::::::.: ..::.: :.::::::::::.:.....:::::::
NP_004 VPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSS
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE1 YGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPF
.:: : :: . ... :::. . : :.:.:::::::: :::.:.: ... :.:::
NP_004 ISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPF
340 350 360 370 380 390
490 500 510 520
pF1KE1 SVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
.::..::: .:..: . ... ... .: .::... ::. .
NP_004 GVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
400 410 420 430 440
>>XP_016874859 (OMIM: 261600,612349) PREDICTED: phenylal (240 aa)
initn: 586 init1: 507 opt: 581 Z-score: 551.0 bits: 110.5 E(85289): 6e-24
Smith-Waterman score: 581; 44.0% identity (71.0% similar) in 207 aa overlap (109-307:35-235)
80 90 100 110 120 130
pF1KE1 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKPSALSRAVKVFETFEAKIH
..:.:: . . .::......:: ....
XP_016 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT
10 20 30 40 50 60
140 150 160 170 180 190
pF1KE1 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV
:.:.::. : . :.:..:. : .: :: . .. . .:. :. :
XP_016 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV
70 80 90 100 110
200 210 220 230 240 250
pF1KE1 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE
::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.::::::
XP_016 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
120 130 140 150 160 170
260 270 280 290 300 310
pF1KE1 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT
: :: :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::.
XP_016 YMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQIPA
180 190 200 210 220 230
320 330 340 350 360 370
pF1KE1 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT
XP_016 VL
240
524 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:35:16 2016 done: Mon Nov 7 02:35:18 2016
Total Scan time: 10.170 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]