Result of FASTA (omim) for
pF1KE1077
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1077, 228 aa
1>>>pF1KE1077 228 - 228 aa - 228 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8663+/-0.000384; mu= 14.2555+/- 0.024
mean_var=223.8807+/-50.541, 0's: 0 Z-trim(119.1): 89 B-trim: 1435 in 1/55
Lambda= 0.085717
statistics sampled from 32644 (32775) to 32644 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.384), width: 16
Scan time: 5.760
The best scores are: opt bits E(85289)
NP_061153 (OMIM: 612451) E3 ubiquitin-protein liga ( 228) 1633 214.1 1.6e-55
XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 151) 288 47.5 1.5e-05
NP_937761 (OMIM: 616319) E3 ubiquitin-protein liga ( 151) 288 47.5 1.5e-05
XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 199) 288 47.7 1.7e-05
NP_057355 (OMIM: 616319) E3 ubiquitin-protein liga ( 245) 288 47.8 1.9e-05
NP_001178253 (OMIM: 616319) E3 ubiquitin-protein l ( 245) 288 47.8 1.9e-05
XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 u ( 191) 279 46.6 3.6e-05
XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 u ( 196) 279 46.6 3.6e-05
XP_011524347 (OMIM: 610432,616260) PREDICTED: E3 u ( 227) 279 46.7 3.9e-05
NP_060301 (OMIM: 610432,616260) E3 ubiquitin-prote ( 232) 233 41.0 0.002
>>NP_061153 (OMIM: 612451) E3 ubiquitin-protein ligase R (228 aa)
initn: 1633 init1: 1633 opt: 1633 Z-score: 1118.0 bits: 214.1 E(85289): 1.6e-55
Smith-Waterman score: 1633; 100.0% identity (100.0% similar) in 228 aa overlap (1-228:1-228)
10 20 30 40 50 60
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 KPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMP
130 140 150 160 170 180
190 200 210 220
pF1KE1 WGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 WGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
190 200 210 220
>>XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (151 aa)
initn: 366 init1: 288 opt: 288 Z-score: 220.7 bits: 47.5 E(85289): 1.5e-05
Smith-Waterman score: 288; 42.4% identity (74.1% similar) in 85 aa overlap (140-224:62-146)
110 120 130 140 150 160
pF1KE1 CSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTK
:: :: : :.:: .. :..::. : .
XP_005 TACQHVNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIV
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE1 SVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
:.::::.:.:::::. . :: :...::.:.: ::. ..::: ... ....:
XP_005 PVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
100 110 120 130 140 150
>>NP_937761 (OMIM: 616319) E3 ubiquitin-protein ligase R (151 aa)
initn: 366 init1: 288 opt: 288 Z-score: 220.7 bits: 47.5 E(85289): 1.5e-05
Smith-Waterman score: 288; 42.4% identity (74.1% similar) in 85 aa overlap (140-224:62-146)
110 120 130 140 150 160
pF1KE1 CSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTK
:: :: : :.:: .. :..::. : .
NP_937 TACQHVNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIV
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE1 SVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
:.::::.:.:::::. . :: :...::.:.: ::. ..::: ... ....:
NP_937 PVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
100 110 120 130 140 150
>>XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (199 aa)
initn: 377 init1: 288 opt: 288 Z-score: 219.7 bits: 47.7 E(85289): 1.7e-05
Smith-Waterman score: 353; 31.9% identity (58.5% similar) in 188 aa overlap (62-224:9-194)
40 50 60 70 80
pF1KE1 CLEVYEKPVQVPCGHVFCSACLQECLKPKKPVC--GVCRSALAPGVRAVELERQIESTET
:.: .: : : ::..:: ...
XP_005 MRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSG
10 20 30
90 100 110 120 130
pF1KE1 SCHGCRKNFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRY----------
::. : :.. . ..: : .:.:::. ::.. : . ... .: :
XP_005 SCRCCAKQIKFYRMRHHYKSCKKYQDEY--GVSSIIPNFQISQDSVGNSNRSETSTSDNT
40 50 60 70 80 90
140 150 160 170 180
pF1KE1 -------------TFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNY
:: :: : :.:: .. :..::. : . :.::::.:.:::::.
XP_005 ETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQ
100 110 120 130 140 150
190 200 210 220
pF1KE1 RSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
. :: :...::.:.: ::. ..::: ... ....:
XP_005 ITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
160 170 180 190
>>NP_057355 (OMIM: 616319) E3 ubiquitin-protein ligase R (245 aa)
initn: 452 init1: 288 opt: 288 Z-score: 218.8 bits: 47.8 E(85289): 1.9e-05
Smith-Waterman score: 460; 32.6% identity (58.1% similar) in 227 aa overlap (27-224:16-240)
10 20 30 40 50
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVP-CGHVFCSACLQECLKP
: :::: :: . ::.. : :::: :. ..
NP_057 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRE
10 20 30 40
60 70 80 90 100 110
pF1KE1 KKPVCGVCRSAL-----APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQ
. : .::. . : ::..:: ... ::. : :.. . ..: : .:.:::
NP_057 SGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQ
50 60 70 80 90 100
120 130 140 150
pF1KE1 NYIMEGVKATIKDASLQPRNVPNRY-----------------------TFPCPYCPEKNF
. ::.. : . ... .: : :: :: : :.::
NP_057 DEY--GVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNF
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE1 DQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDV
.. :..::. : . :.::::.:.:::::. . :: :...::.:.: ::. ..
NP_057 TRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQL
170 180 190 200 210 220
220
pF1KE1 DEEDMMNQVLQRSIIDQ
::: ... ....:
NP_057 DEETQYQTAVEESFQVNI
230 240
>>NP_001178253 (OMIM: 616319) E3 ubiquitin-protein ligas (245 aa)
initn: 452 init1: 288 opt: 288 Z-score: 218.8 bits: 47.8 E(85289): 1.9e-05
Smith-Waterman score: 460; 32.6% identity (58.1% similar) in 227 aa overlap (27-224:16-240)
10 20 30 40 50
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVP-CGHVFCSACLQECLKP
: :::: :: . ::.. : :::: :. ..
NP_001 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRE
10 20 30 40
60 70 80 90 100 110
pF1KE1 KKPVCGVCRSAL-----APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQ
. : .::. . : ::..:: ... ::. : :.. . ..: : .:.:::
NP_001 SGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQ
50 60 70 80 90 100
120 130 140 150
pF1KE1 NYIMEGVKATIKDASLQPRNVPNRY-----------------------TFPCPYCPEKNF
. ::.. : . ... .: : :: :: : :.::
NP_001 DEY--GVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNF
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE1 DQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDV
.. :..::. : . :.::::.:.:::::. . :: :...::.:.: ::. ..
NP_001 TRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQL
170 180 190 200 210 220
220
pF1KE1 DEEDMMNQVLQRSIIDQ
::: ... ....:
NP_001 DEETQYQTAVEESFQVNI
230 240
>>XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (191 aa)
initn: 338 init1: 162 opt: 279 Z-score: 213.8 bits: 46.6 E(85289): 3.6e-05
Smith-Waterman score: 318; 32.7% identity (61.3% similar) in 150 aa overlap (23-171:31-168)
10 20 30 40 50
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSAC
:. : : ::::: ..::.. :::::: .:
XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LQECLKPKKPVCGVCRSAL-APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCS
. :: .: .: ::. : . :: :... ....: .: : ::..:.:. ::.
XP_011 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 KYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSV
:: . : ..... : : ::.: .... ...:..:: : .. . :
XP_011 KYIDKY--GPLQELEETA--ARCV-------CPFC-QRELYEDSLLDHCITHHRSERRPV
130 140 150 160
180 190 200 210 220
pF1KE1 VCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
XP_011 DNNTKIHLSCCCPRPHFHPQVPQ
170 180 190
>>XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (196 aa)
initn: 366 init1: 162 opt: 279 Z-score: 213.7 bits: 46.6 E(85289): 3.6e-05
Smith-Waterman score: 318; 32.7% identity (61.3% similar) in 150 aa overlap (23-171:31-168)
10 20 30 40 50
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSAC
:. : : ::::: ..::.. :::::: .:
XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LQECLKPKKPVCGVCRSAL-APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCS
. :: .: .: ::. : . :: :... ....: .: : ::..:.:. ::.
XP_011 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 KYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSV
:: . : ..... : : ::.: .... ...:..:: : .. . :
XP_011 KYIDKY--GPLQELEETA--ARCV-------CPFC-QRELYEDSLLDHCITHHRSERRPV
130 140 150 160
180 190 200 210 220
pF1KE1 VCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
XP_011 DFNIIEEALIRRVLDRSLLEYVNHSNTT
170 180 190
>>XP_011524347 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (227 aa)
initn: 445 init1: 162 opt: 279 Z-score: 213.1 bits: 46.7 E(85289): 3.9e-05
Smith-Waterman score: 422; 33.2% identity (62.0% similar) in 187 aa overlap (23-208:31-205)
10 20 30 40 50
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSAC
:. : : ::::: ..::.. :::::: .:
XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LQECLKPKKPVCGVCRSAL-APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCS
. :: .: .: ::. : . :: :... ....: .: : ::..:.:. ::.
XP_011 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 KYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSV
:: . : ..... : : ::.: .... ...:..:: : .. . :
XP_011 KYIDKY--GPLQELEETA--ARCV-------CPFC-QRELYEDSLLDHCITHHRSERRPV
130 140 150 160
180 190 200 210 220
pF1KE1 VCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
::.: .: .:. :... .:.: : . :: :.:
XP_011 FCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDNNTKIHLSCCCPRPHFHPQVPQ
170 180 190 200 210 220
>>NP_060301 (OMIM: 610432,616260) E3 ubiquitin-protein l (232 aa)
initn: 494 init1: 190 opt: 233 Z-score: 182.3 bits: 41.0 E(85289): 0.002
Smith-Waterman score: 471; 33.0% identity (64.1% similar) in 206 aa overlap (23-227:31-224)
10 20 30 40 50
pF1KE1 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSAC
:. : : ::::: ..::.. :::::: .:
NP_060 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LQECLKPKKPVCGVCRSAL-APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCS
. :: .: .: ::. : . :: :... ....: .: : ::..:.:. ::.
NP_060 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 KYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSV
:: . : ..... : : ::.: .... ...:..:: : .. . :
NP_060 KYIDKY--GPLQELEETA--ARCV-------CPFC-QRELYEDSLLDHCITHHRSERRPV
130 140 150 160
180 190 200 210 220
pF1KE1 VCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
::.: .: .:. :... .:.: : . :: :.:... :: .. .::.::...
NP_060 FCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNH
170 180 190 200 210 220
NP_060 SNTT
230
228 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:34:05 2016 done: Sat Nov 5 19:34:06 2016
Total Scan time: 5.760 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]