Result of FASTA (omim) for
pF1KE1059
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1059, 870 aa
1>>>pF1KE1059 870 - 870 aa - 870 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.1538+/-0.00047; mu= -19.6071+/- 0.029
mean_var=594.2939+/-122.018, 0's: 0 Z-trim(123.1): 52 B-trim: 0 in 0/60
Lambda= 0.052611
statistics sampled from 42335 (42390) to 42335 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.497), width: 16
Scan time: 12.690
The best scores are: opt bits E(85289)
NP_055382 (OMIM: 602941) breast cancer anti-estrog ( 870) 5910 464.2 1.2e-129
XP_005256316 (OMIM: 602941) PREDICTED: breast canc ( 870) 5883 462.1 5e-129
NP_001164190 (OMIM: 602941) breast cancer anti-est ( 868) 5881 462.0 5.6e-129
NP_001164189 (OMIM: 602941) breast cancer anti-est ( 870) 5881 462.0 5.6e-129
NP_001164187 (OMIM: 602941) breast cancer anti-est ( 888) 5881 462.0 5.6e-129
NP_001164186 (OMIM: 602941) breast cancer anti-est ( 888) 5881 462.0 5.6e-129
XP_005256315 (OMIM: 602941) PREDICTED: breast canc ( 896) 5881 462.0 5.7e-129
NP_001164185 (OMIM: 602941) breast cancer anti-est ( 916) 5881 462.0 5.8e-129
XP_016879386 (OMIM: 602941) PREDICTED: breast canc ( 916) 5881 462.0 5.8e-129
XP_005256317 (OMIM: 602941) PREDICTED: breast canc ( 841) 5723 450.0 2.2e-125
XP_011521777 (OMIM: 602941) PREDICTED: breast canc ( 841) 5723 450.0 2.2e-125
XP_016879387 (OMIM: 602941) PREDICTED: breast canc ( 886) 4616 366.0 4.5e-100
NP_001164191 (OMIM: 602941) breast cancer anti-est ( 722) 4399 349.4 3.5e-95
NP_001164192 (OMIM: 602941) breast cancer anti-est ( 660) 4397 349.2 3.7e-95
NP_001164188 (OMIM: 602941) breast cancer anti-est ( 888) 3967 316.7 3e-85
XP_016879388 (OMIM: 602941) PREDICTED: breast canc ( 823) 3832 306.4 3.5e-82
NP_001135865 (OMIM: 602265) enhancer of filamentat ( 834) 989 90.6 3.2e-17
NP_006394 (OMIM: 602265) enhancer of filamentation ( 834) 989 90.6 3.2e-17
NP_001257962 (OMIM: 602265) enhancer of filamentat ( 685) 931 86.2 5.9e-16
NP_005855 (OMIM: 609906) embryonal Fyn-associated ( 561) 465 50.7 2.2e-05
NP_115835 (OMIM: 609906) embryonal Fyn-associated ( 468) 445 49.1 5.6e-05
NP_001264103 (OMIM: 609906) embryonal Fyn-associat ( 392) 438 48.5 7.1e-05
NP_892011 (OMIM: 602265) enhancer of filamentation ( 174) 421 46.9 9.5e-05
XP_005267313 (OMIM: 609906) PREDICTED: embryonal F ( 531) 381 44.3 0.0018
>>NP_055382 (OMIM: 602941) breast cancer anti-estrogen r (870 aa)
initn: 5910 init1: 5910 opt: 5910 Z-score: 2448.5 bits: 464.2 E(85289): 1.2e-129
Smith-Waterman score: 5910; 99.9% identity (99.9% similar) in 870 aa overlap (1-870:1-870)
10 20 30 40 50 60
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_055 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
790 800 810 820 830 840
850 860 870
pF1KE1 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::
NP_055 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870
>>XP_005256316 (OMIM: 602941) PREDICTED: breast cancer a (870 aa)
initn: 5881 init1: 5881 opt: 5883 Z-score: 2437.4 bits: 462.1 E(85289): 5e-129
Smith-Waterman score: 5883; 99.5% identity (99.7% similar) in 870 aa overlap (1-870:1-870)
10 20 30 40 50 60
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
:. ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQGKNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_005 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
790 800 810 820 830 840
850 860 870
pF1KE1 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::
XP_005 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870
>>NP_001164190 (OMIM: 602941) breast cancer anti-estroge (868 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.6 bits: 462.0 E(85289): 5.6e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:3-868)
10 20 30 40 50 60
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 KILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE1 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE1 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE1 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE1 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE1 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE1 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE1 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE1 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE1 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
780 790 800 810 820 830
850 860 870
pF1KE1 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::
NP_001 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
840 850 860
>>NP_001164189 (OMIM: 602941) breast cancer anti-estroge (870 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.6 bits: 462.0 E(85289): 5.6e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:5-870)
10 20 30 40 50 60
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVPNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
790 800 810 820 830 840
850 860 870
pF1KE1 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::
NP_001 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870
>>NP_001164187 (OMIM: 602941) breast cancer anti-estroge (888 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.5 bits: 462.0 E(85289): 5.6e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:23-888)
10 20 30 40
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDG
::::::::::::::::::::::::::::::::::::::
NP_001 MLTHRPQEAEQRGRTPGPSFEWNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 WWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPM
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
NP_001 WWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 LPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 DLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 VYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 LLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPA
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 RTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE1 GVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE1 LARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFA
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE1 RSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVAC
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE1 SRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE1 FTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE1 QFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAV
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE1 DAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDL
790 800 810 820 830 840
830 840 850 860 870
pF1KE1 LRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870 880
>>NP_001164186 (OMIM: 602941) breast cancer anti-estroge (888 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.5 bits: 462.0 E(85289): 5.6e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:23-888)
10 20 30 40
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDG
::::::::::::::::::::::::::::::::::::::
NP_001 MHCPGEAPLAAPRPTPKDPCLRNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 WWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPM
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
NP_001 WWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 LPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 DLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 VYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 LLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPA
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 RTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE1 GVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE1 LARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFA
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE1 RSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVAC
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE1 SRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE1 FTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE1 QFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAV
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE1 DAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDL
790 800 810 820 830 840
830 840 850 860 870
pF1KE1 LRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870 880
>>XP_005256315 (OMIM: 602941) PREDICTED: breast cancer a (896 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.4 bits: 462.0 E(85289): 5.7e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:31-896)
10 20 30
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLE
::::::::::::::::::::::::::::::
XP_005 MCHPPQTSGWHWLGSPCLGVAGAGHPQPCQNVLAKALYDNVAESPDELSFRKGDIMTVLE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAP
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_005 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAP
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE1 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVV
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE1 PTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAV
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE1 KGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE1 KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERV
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE1 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE1 ELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE1 VHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLE
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE1 DLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE1 RPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKS
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE1 QLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEAN
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE1 LTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTH
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE1 YSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870 880 890
>>NP_001164185 (OMIM: 602941) breast cancer anti-estroge (916 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.3 bits: 462.0 E(85289): 5.8e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:51-916)
10 20 30
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLE
::::::::::::::::::::::::::::::
NP_001 GPGPQGTGQPCSCGHWAEGQGGPPEPAGGPNVLAKALYDNVAESPDELSFRKGDIMTVLE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAP
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
NP_001 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVV
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 PTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAV
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 KGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERV
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 ELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSA
510 520 530 540 550 560
520 530 540 550 560 570
pF1KE1 VHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLE
570 580 590 600 610 620
580 590 600 610 620 630
pF1KE1 DLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQS
630 640 650 660 670 680
640 650 660 670 680 690
pF1KE1 RPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKS
690 700 710 720 730 740
700 710 720 730 740 750
pF1KE1 QLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEAN
750 760 770 780 790 800
760 770 780 790 800 810
pF1KE1 LTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTH
810 820 830 840 850 860
820 830 840 850 860 870
pF1KE1 YSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
870 880 890 900 910
>>XP_016879386 (OMIM: 602941) PREDICTED: breast cancer a (916 aa)
initn: 5881 init1: 5881 opt: 5881 Z-score: 2436.3 bits: 462.0 E(85289): 5.8e-129
Smith-Waterman score: 5881; 99.9% identity (99.9% similar) in 866 aa overlap (5-870:51-916)
10 20 30
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLE
::::::::::::::::::::::::::::::
XP_016 GPGPQGTGQPCSCGHWAEGQGGPPEPAGGPNVLAKALYDNVAESPDELSFRKGDIMTVLE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAP
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_016 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVV
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 PTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAV
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 KGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERV
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 ELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSA
510 520 530 540 550 560
520 530 540 550 560 570
pF1KE1 VHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLE
570 580 590 600 610 620
580 590 600 610 620 630
pF1KE1 DLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQS
630 640 650 660 670 680
640 650 660 670 680 690
pF1KE1 RPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKS
690 700 710 720 730 740
700 710 720 730 740 750
pF1KE1 QLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEAN
750 760 770 780 790 800
760 770 780 790 800 810
pF1KE1 LTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTH
810 820 830 840 850 860
820 830 840 850 860 870
pF1KE1 YSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
870 880 890 900 910
>>XP_005256317 (OMIM: 602941) PREDICTED: breast cancer a (841 aa)
initn: 5723 init1: 5723 opt: 5723 Z-score: 2372.0 bits: 450.0 E(85289): 2.2e-125
Smith-Waterman score: 5723; 99.9% identity (99.9% similar) in 841 aa overlap (30-870:1-841)
10 20 30 40 50 60
pF1KE1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
:::::::::::::::::::::::::::::::
XP_005 MTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30
70 80 90 100 110 120
pF1KE1 KILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_005 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE1 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE1 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE1 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE1 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE1 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE1 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
760 770 780 790 800 810
850 860 870
pF1KE1 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
::::::::::::::::::::::::::::::
XP_005 SAAQDMVERVKELGHSTQQFRRVLGQLAAA
820 830 840
870 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:19:51 2016 done: Sat Nov 5 22:19:53 2016
Total Scan time: 12.690 Total Display time: 0.260
Function used was FASTA [36.3.4 Apr, 2011]