FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1052, 375 aa 1>>>pF1KE1052 375 - 375 aa - 375 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1165+/-0.000397; mu= 13.2185+/- 0.025 mean_var=101.4241+/-20.025, 0's: 0 Z-trim(114.1): 78 B-trim: 69 in 2/54 Lambda= 0.127351 statistics sampled from 23663 (23734) to 23663 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.278), width: 16 Scan time: 7.250 The best scores are: opt bits E(85289) NP_006198 (OMIM: 114550,604584) platelet-derived g ( 375) 2501 470.2 3.4e-132 NP_001153503 (OMIM: 165070) vascular endothelial g ( 541) 347 74.6 6.2e-13 NP_001153392 (OMIM: 165070) vascular endothelial g ( 687) 347 74.6 7.5e-13 XP_011533316 (OMIM: 165070) PREDICTED: vascular en ( 720) 347 74.7 7.8e-13 NP_001153502 (OMIM: 165070) vascular endothelial g ( 733) 347 74.7 7.9e-13 XP_016875974 (OMIM: 165070) PREDICTED: vascular en (1300) 347 74.8 1.2e-12 NP_002010 (OMIM: 165070) vascular endothelial grow (1338) 347 74.9 1.3e-12 NP_002011 (OMIM: 136352,153100,602089) vascular en (1298) 231 53.5 3.2e-06 XP_016864757 (OMIM: 136352,153100,602089) PREDICTE (1337) 231 53.5 3.3e-06 NP_891555 (OMIM: 136352,153100,602089) vascular en (1363) 231 53.5 3.3e-06 XP_016864756 (OMIM: 136352,153100,602089) PREDICTE (1375) 231 53.5 3.3e-06 XP_016864755 (OMIM: 136352,153100,602089) PREDICTE (1375) 231 53.5 3.3e-06 XP_016864754 (OMIM: 136352,153100,602089) PREDICTE (1385) 231 53.5 3.4e-06 XP_016864752 (OMIM: 136352,153100,602089) PREDICTE (1385) 231 53.5 3.4e-06 XP_016864753 (OMIM: 136352,153100,602089) PREDICTE (1385) 231 53.5 3.4e-06 XP_011532780 (OMIM: 136352,153100,602089) PREDICTE (1440) 231 53.6 3.5e-06 XP_011532786 (OMIM: 136352,153100,602089) PREDICTE (1210) 187 45.4 0.00082 NP_002600 (OMIM: 131440,173410,213600,228550,60181 (1106) 171 42.5 0.0059 XP_011535960 (OMIM: 131440,173410,213600,228550,60 (1106) 171 42.5 0.0059 XP_011535961 (OMIM: 131440,173410,213600,228550,60 (1106) 171 42.5 0.0059 XP_016863771 (OMIM: 173490,606764,607685) PREDICTE ( 807) 168 41.8 0.0067 XP_016863770 (OMIM: 173490,606764,607685) PREDICTE ( 820) 168 41.8 0.0068 XP_006714104 (OMIM: 173490,606764,607685) PREDICTE ( 832) 168 41.8 0.0069 XP_011532687 (OMIM: 173490,606764,607685) PREDICTE (1089) 168 41.9 0.0085 NP_006197 (OMIM: 173490,606764,607685) platelet-de (1089) 168 41.9 0.0085 XP_005265800 (OMIM: 173490,606764,607685) PREDICTE (1089) 168 41.9 0.0085 XP_016863769 (OMIM: 173490,606764,607685) PREDICTE (1102) 168 41.9 0.0086 XP_006714102 (OMIM: 173490,606764,607685) PREDICTE (1114) 168 41.9 0.0087 >>NP_006198 (OMIM: 114550,604584) platelet-derived growt (375 aa) initn: 2501 init1: 2501 opt: 2501 Z-score: 2494.2 bits: 470.2 E(85289): 3.4e-132 Smith-Waterman score: 2501; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KE1 MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 APKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 APKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 QNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ 310 320 330 340 350 360 370 pF1KE1 NLQGQTTVATTVEFS ::::::::::::::: NP_006 NLQGQTTVATTVEFS 370 >>NP_001153503 (OMIM: 165070) vascular endothelial growt (541 aa) initn: 267 init1: 80 opt: 347 Z-score: 353.2 bits: 74.6 E(85289): 6.2e-13 Smith-Waterman score: 347; 26.0% identity (58.7% similar) in 300 aa overlap (86-372:43-326) 60 70 80 90 100 110 pF1KE1 DSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG-WSYPAYLDTFKD . ::::..:.:.: :: : ... .. NP_001 ALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK-ES 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 SRLSVKQNE--RYGQ-----LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFF :::. .. : :. ::: .. . :: .:: . . .: :... . :::. NP_001 ERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSC--KYLAVPTSKKKETES-AIYIFI 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 TEKGELFVPSPSYF-DVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYD .. :. :: : . ...... :. :.::::: . ::: ..:: . .: :..: NP_001 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTL-KKFPLDTLIPDGKRIIWD 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 MKRGFVYLQPHSEHQGVVYCRAEAGGR----SQISVKYQLLYVAVPSGPPSTTILASSNK ..::. . .. :.. :.: ..:. . .. . . : . : . : NP_001 SRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV------K 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI . : . . ::. ...:..:: .: .:..: .... : : .. .:.. : ::. NP_001 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKR-ASVR---RRIDQSNSHAN-IFYSVL 250 260 270 280 290 350 360 370 pF1KE1 TVEDFETIDAGYYICTAQNLQGQTTVATTVEFS :.. ... : : : : ... . .: :.: NP_001 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 300 310 320 330 340 350 >>NP_001153392 (OMIM: 165070) vascular endothelial growt (687 aa) initn: 267 init1: 80 opt: 347 Z-score: 351.7 bits: 74.6 E(85289): 7.5e-13 Smith-Waterman score: 347; 26.0% identity (58.7% similar) in 300 aa overlap (86-372:43-326) 60 70 80 90 100 110 pF1KE1 DSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG-WSYPAYLDTFKD . ::::..:.:.: :: : ... .. NP_001 ALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK-ES 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 SRLSVKQNE--RYGQ-----LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFF :::. .. : :. ::: .. . :: .:: . . .: :... . :::. NP_001 ERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSC--KYLAVPTSKKKETES-AIYIFI 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 TEKGELFVPSPSYF-DVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYD .. :. :: : . ...... :. :.::::: . ::: ..:: . .: :..: NP_001 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTL-KKFPLDTLIPDGKRIIWD 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 MKRGFVYLQPHSEHQGVVYCRAEAGGR----SQISVKYQLLYVAVPSGPPSTTILASSNK ..::. . .. :.. :.: ..:. . .. . . : . : . : NP_001 SRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV------K 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI . : . . ::. ...:..:: .: .:..: .... : : .. .:.. : ::. NP_001 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKR-ASVR---RRIDQSNSHAN-IFYSVL 250 260 270 280 290 350 360 370 pF1KE1 TVEDFETIDAGYYICTAQNLQGQTTVATTVEFS :.. ... : : : : ... . .: :.: NP_001 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 300 310 320 330 340 350 >>XP_011533316 (OMIM: 165070) PREDICTED: vascular endoth (720 aa) initn: 267 init1: 80 opt: 347 Z-score: 351.4 bits: 74.7 E(85289): 7.8e-13 Smith-Waterman score: 347; 26.0% identity (58.7% similar) in 300 aa overlap (86-372:43-326) 60 70 80 90 100 110 pF1KE1 DSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG-WSYPAYLDTFKD . ::::..:.:.: :: : ... .. XP_011 ALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK-ES 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 SRLSVKQNE--RYGQ-----LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFF :::. .. : :. ::: .. . :: .:: . . .: :... . :::. XP_011 ERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSC--KYLAVPTSKKKETES-AIYIFI 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 TEKGELFVPSPSYF-DVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYD .. :. :: : . ...... :. :.::::: . ::: ..:: . .: :..: XP_011 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTL-KKFPLDTLIPDGKRIIWD 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 MKRGFVYLQPHSEHQGVVYCRAEAGGR----SQISVKYQLLYVAVPSGPPSTTILASSNK ..::. . .. :.. :.: ..:. . .. . . : . : . : XP_011 SRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV------K 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI . : . . ::. ...:..:: .: .:..: .... : : .. .:.. : ::. XP_011 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKR-ASVR---RRIDQSNSHAN-IFYSVL 250 260 270 280 290 350 360 370 pF1KE1 TVEDFETIDAGYYICTAQNLQGQTTVATTVEFS :.. ... : : : : ... . .: :.: XP_011 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 300 310 320 330 340 350 >>NP_001153502 (OMIM: 165070) vascular endothelial growt (733 aa) initn: 267 init1: 80 opt: 347 Z-score: 351.3 bits: 74.7 E(85289): 7.9e-13 Smith-Waterman score: 347; 26.0% identity (58.7% similar) in 300 aa overlap (86-372:43-326) 60 70 80 90 100 110 pF1KE1 DSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG-WSYPAYLDTFKD . ::::..:.:.: :: : ... .. NP_001 ALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK-ES 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 SRLSVKQNE--RYGQ-----LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFF :::. .. : :. ::: .. . :: .:: . . .: :... . :::. NP_001 ERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSC--KYLAVPTSKKKETES-AIYIFI 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 TEKGELFVPSPSYF-DVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYD .. :. :: : . ...... :. :.::::: . ::: ..:: . .: :..: NP_001 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTL-KKFPLDTLIPDGKRIIWD 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 MKRGFVYLQPHSEHQGVVYCRAEAGGR----SQISVKYQLLYVAVPSGPPSTTILASSNK ..::. . .. :.. :.: ..:. . .. . . : . : . : NP_001 SRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV------K 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI . : . . ::. ...:..:: .: .:..: .... : : .. .:.. : ::. NP_001 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKR-ASVR---RRIDQSNSHAN-IFYSVL 250 260 270 280 290 350 360 370 pF1KE1 TVEDFETIDAGYYICTAQNLQGQTTVATTVEFS :.. ... : : : : ... . .: :.: NP_001 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 300 310 320 330 340 350 >>XP_016875974 (OMIM: 165070) PREDICTED: vascular endoth (1300 aa) initn: 293 init1: 80 opt: 347 Z-score: 347.9 bits: 74.8 E(85289): 1.2e-12 Smith-Waterman score: 347; 26.0% identity (58.7% similar) in 300 aa overlap (86-372:43-326) 60 70 80 90 100 110 pF1KE1 DSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG-WSYPAYLDTFKD . ::::..:.:.: :: : ... .. XP_016 ALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK-ES 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 SRLSVKQNE--RYGQ-----LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFF :::. .. : :. ::: .. . :: .:: . . .: :... . :::. XP_016 ERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSC--KYLAVPTSKKKETES-AIYIFI 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 TEKGELFVPSPSYF-DVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYD .. :. :: : . ...... :. :.::::: . ::: ..:: . .: :..: XP_016 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTL-KKFPLDTLIPDGKRIIWD 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 MKRGFVYLQPHSEHQGVVYCRAEAGGR----SQISVKYQLLYVAVPSGPPSTTILASSNK ..::. . .. :.. :.: ..:. . .. . . : . : . : XP_016 SRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV------K 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI . : . . ::. ...:..:: .: .:..: .... : : .. .:.. : ::. XP_016 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKR-ASVR---RRIDQSNSHAN-IFYSVL 250 260 270 280 290 350 360 370 pF1KE1 TVEDFETIDAGYYICTAQNLQGQTTVATTVEFS :.. ... : : : : ... . .: :.: XP_016 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 300 310 320 330 340 350 >>NP_002010 (OMIM: 165070) vascular endothelial growth f (1338 aa) initn: 267 init1: 80 opt: 347 Z-score: 347.7 bits: 74.9 E(85289): 1.3e-12 Smith-Waterman score: 347; 26.0% identity (58.7% similar) in 300 aa overlap (86-372:43-326) 60 70 80 90 100 110 pF1KE1 DSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG-WSYPAYLDTFKD . ::::..:.:.: :: : ... .. NP_002 ALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK-ES 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 SRLSVKQNE--RYGQ-----LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFF :::. .. : :. ::: .. . :: .:: . . .: :... . :::. NP_002 ERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSC--KYLAVPTSKKKETES-AIYIFI 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 TEKGELFVPSPSYF-DVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYD .. :. :: : . ...... :. :.::::: . ::: ..:: . .: :..: NP_002 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTL-KKFPLDTLIPDGKRIIWD 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 MKRGFVYLQPHSEHQGVVYCRAEAGGR----SQISVKYQLLYVAVPSGPPSTTILASSNK ..::. . .. :.. :.: ..:. . .. . . : . : . : NP_002 SRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV------K 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI . : . . ::. ...:..:: .: .:..: .... : : .. .:.. : ::. NP_002 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKR-ASVR---RRIDQSNSHAN-IFYSVL 250 260 270 280 290 350 360 370 pF1KE1 TVEDFETIDAGYYICTAQNLQGQTTVATTVEFS :.. ... : : : : ... . .: :.: NP_002 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 300 310 320 330 340 350 >>NP_002011 (OMIM: 136352,153100,602089) vascular endoth (1298 aa) initn: 193 init1: 79 opt: 231 Z-score: 232.7 bits: 53.5 E(85289): 3.2e-06 Smith-Waterman score: 262; 24.4% identity (55.1% similar) in 287 aa overlap (89-361:44-314) 60 70 80 90 100 110 pF1KE1 NSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSR-IGWSYPAYLDTF----K :... . :.:.. . :..:. .. : NP_002 CLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDK 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 DSRLS--VKQNER-----YGQLTLVNSTSA-DTGEFSCWVQLCSGYICRKDEAKTG-STY ::. . :.. : : .. :.. . : ::: . :. . :: . :. :. :.: NP_002 DSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYK----YIKARIEGTTAASSY 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 IFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIV .: . . :. .: :.. .: ::: :.. . .:::. . .. . .: ..: NP_002 VFVRDFEQPFINKP---DTLLVNRKDAMWVPCLVSIPGLNVTLRSQ--SSVLWPDGQEVV 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 YDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVK .: .::.. : . . :.. : .. .: . :.... . .: .. NP_002 WDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPF-LVHITGNELYDIQLLPRKSLELL 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 SGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITV :. . . ::: .: . : : : .::.. :: : .:. :..: :..:. NP_002 VGEKLVLNCTVWAEFNSGVTFDWDYPGKQAER-----GKWVPERRSQQTHTELS-SILTI 250 260 270 280 290 350 360 370 pF1KE1 EDFETIDAGYYICTAQNLQGQTTVATTVEFS .. : : :.: :.: NP_002 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 300 310 320 330 340 350 >>XP_016864757 (OMIM: 136352,153100,602089) PREDICTED: v (1337 aa) initn: 133 init1: 79 opt: 231 Z-score: 232.5 bits: 53.5 E(85289): 3.3e-06 Smith-Waterman score: 262; 24.4% identity (55.1% similar) in 287 aa overlap (89-361:18-288) 60 70 80 90 100 110 pF1KE1 NSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSR-IGWSYPAYLDTF----K :... . :.:.. . :..:. .. : XP_016 MTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDK 10 20 30 40 120 130 140 150 160 pF1KE1 DSRLS--VKQNER-----YGQLTLVNSTSA-DTGEFSCWVQLCSGYICRKDEAKTG-STY ::. . :.. : : .. :.. . : ::: . :. . :: . :. :. :.: XP_016 DSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYK----YIKARIEGTTAASSY 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE1 IFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIV .: . . :. .: :.. .: ::: :.. . .:::. . .. . .: ..: XP_016 VFVRDFEQPFINKP---DTLLVNRKDAMWVPCLVSIPGLNVTLRSQ--SSVLWPDGQEVV 110 120 130 140 150 230 240 250 260 270 280 pF1KE1 YDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVK .: .::.. : . . :.. : .. .: . :.... . .: .. XP_016 WDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPF-LVHITGNELYDIQLLPRKSLELL 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE1 SGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITV :. . . ::: .: . : : : .::.. :: : .:. :..: :..:. XP_016 VGEKLVLNCTVWAEFNSGVTFDWDYPGKQAER-----GKWVPERRSQQTHTELS-SILTI 220 230 240 250 260 270 350 360 370 pF1KE1 EDFETIDAGYYICTAQNLQGQTTVATTVEFS .. : : :.: :.: XP_016 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 280 290 300 310 320 330 >>NP_891555 (OMIM: 136352,153100,602089) vascular endoth (1363 aa) initn: 167 init1: 79 opt: 231 Z-score: 232.4 bits: 53.5 E(85289): 3.3e-06 Smith-Waterman score: 262; 24.4% identity (55.1% similar) in 287 aa overlap (89-361:44-314) 60 70 80 90 100 110 pF1KE1 NSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSR-IGWSYPAYLDTF----K :... . :.:.. . :..:. .. : NP_891 CLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDK 20 30 40 50 60 70 120 130 140 150 160 pF1KE1 DSRLS--VKQNER-----YGQLTLVNSTSA-DTGEFSCWVQLCSGYICRKDEAKTG-STY ::. . :.. : : .. :.. . : ::: . :. . :: . :. :. :.: NP_891 DSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYK----YIKARIEGTTAASSY 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 IFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIV .: . . :. .: :.. .: ::: :.. . .:::. . .. . .: ..: NP_891 VFVRDFEQPFINKP---DTLLVNRKDAMWVPCLVSIPGLNVTLRSQ--SSVLWPDGQEVV 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE1 YDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVK .: .::.. : . . :.. : .. .: . :.... . .: .. NP_891 WDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPF-LVHITGNELYDIQLLPRKSLELL 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 SGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITV :. . . ::: .: . : : : .::.. :: : .:. :..: :..:. NP_891 VGEKLVLNCTVWAEFNSGVTFDWDYPGKQAER-----GKWVPERRSQQTHTELS-SILTI 250 260 270 280 290 350 360 370 pF1KE1 EDFETIDAGYYICTAQNLQGQTTVATTVEFS .. : : :.: :.: NP_891 HNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVK 300 310 320 330 340 350 375 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:49:48 2016 done: Sat Nov 5 07:49:49 2016 Total Scan time: 7.250 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]