Result of FASTA (omim) for
pF1KE1044
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1044, 582 aa
1>>>pF1KE1044 582 - 582 aa - 582 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2370+/-0.000334; mu= 6.9651+/- 0.021
mean_var=213.4481+/-47.286, 0's: 0 Z-trim(120.8): 60 B-trim: 0 in 0/59
Lambda= 0.087787
statistics sampled from 36486 (36555) to 36486 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.429), width: 16
Scan time: 12.360
The best scores are: opt bits E(85289)
NP_001137378 (OMIM: 613197) TRAF-type zinc finger ( 582) 4042 524.8 3e-148
NP_006691 (OMIM: 613197) TRAF-type zinc finger dom ( 582) 4042 524.8 3e-148
NP_059993 (OMIM: 606717) XIAP-associated factor 1 ( 301) 423 66.2 1.8e-10
XP_005256763 (OMIM: 606717) PREDICTED: XIAP-associ ( 256) 267 46.4 0.00014
NP_954590 (OMIM: 606717) XIAP-associated factor 1 ( 282) 265 46.2 0.00018
XP_011522249 (OMIM: 606717) PREDICTED: XIAP-associ ( 307) 237 42.7 0.0022
XP_011522250 (OMIM: 606717) PREDICTED: XIAP-associ ( 243) 235 42.3 0.0022
XP_011522248 (OMIM: 606717) PREDICTED: XIAP-associ ( 403) 237 42.8 0.0027
XP_011522247 (OMIM: 606717) PREDICTED: XIAP-associ ( 403) 237 42.8 0.0027
XP_016880269 (OMIM: 606717) PREDICTED: XIAP-associ ( 241) 227 41.3 0.0044
>>NP_001137378 (OMIM: 613197) TRAF-type zinc finger doma (582 aa)
initn: 4042 init1: 4042 opt: 4042 Z-score: 2782.6 bits: 524.8 E(85289): 3e-148
Smith-Waterman score: 4042; 100.0% identity (100.0% similar) in 582 aa overlap (1-582:1-582)
10 20 30 40 50 60
pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS
490 500 510 520 530 540
550 560 570 580
pF1KE1 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
::::::::::::::::::::::::::::::::::::::::::
NP_001 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
550 560 570 580
>>NP_006691 (OMIM: 613197) TRAF-type zinc finger domain- (582 aa)
initn: 4042 init1: 4042 opt: 4042 Z-score: 2782.6 bits: 524.8 E(85289): 3e-148
Smith-Waterman score: 4042; 100.0% identity (100.0% similar) in 582 aa overlap (1-582:1-582)
10 20 30 40 50 60
pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS
490 500 510 520 530 540
550 560 570 580
pF1KE1 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
::::::::::::::::::::::::::::::::::::::::::
NP_006 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
550 560 570 580
>>NP_059993 (OMIM: 606717) XIAP-associated factor 1 isof (301 aa)
initn: 446 init1: 197 opt: 423 Z-score: 309.2 bits: 66.2 E(85289): 1.8e-10
Smith-Waterman score: 423; 40.4% identity (66.7% similar) in 141 aa overlap (12-149:7-147)
10 20 30 40 50 60
pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
.: :::... :::.:: .: : . .:: :.:: :: :: : ::
NP_059 MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQ
10 20 30 40 50
70 80 90 100 110
pF1KE1 QVTCK-CNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNC
:: : :.....: :. :. .:: : . :. : :.... ::. ::.:::.::::: .:
NP_059 QVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 GRNVLVKDLKTHPEVCGREGEE--KRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDP
:. .. . : : .:: : . : .... :
NP_059 GQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 PMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEES
NP_059 SEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSK
180 190 200 210 220 230
>>XP_005256763 (OMIM: 606717) PREDICTED: XIAP-associated (256 aa)
initn: 302 init1: 191 opt: 267 Z-score: 203.3 bits: 46.4 E(85289): 0.00014
Smith-Waterman score: 267; 38.2% identity (65.7% similar) in 102 aa overlap (51-149:1-102)
30 40 50 60 70
pF1KE1 PVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHE
:: : :: :: : :.....: :. :.
XP_005 MEEHCKLEHQQVGCTMCQQSMQKSSLEFHK
10 20 30
80 90 100 110 120 130
pF1KE1 ETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREG
.:: : . :. : :.... ::. ::.:::.::::: .::. .. . : : .:: :
XP_005 ANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE1 EE--KRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNR
. : .... :
XP_005 AQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLP
100 110 120 130 140 150
>>NP_954590 (OMIM: 606717) XIAP-associated factor 1 isof (282 aa)
initn: 447 init1: 198 opt: 265 Z-score: 201.4 bits: 46.2 E(85289): 0.00018
Smith-Waterman score: 345; 36.4% identity (61.4% similar) in 140 aa overlap (12-149:7-128)
10 20 30 40 50 60
pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
.: :::... :::.:: .: : . .:: :.:: :: :: :::
NP_954 MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETME-----EHC
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
. :.... .:: : . :. : :.... ::. ::.:::.::::: .::
NP_954 K-------------LEHQQANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCG
60 70 80 90
130 140 150 160 170
pF1KE1 RNVLVKDLKTHPEVCGREGEE--KRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPP
. .. . : : .:: : . : .... :
NP_954 QFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE1 MRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESA
NP_954 EFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKN
160 170 180 190 200 210
>>XP_011522249 (OMIM: 606717) PREDICTED: XIAP-associated (307 aa)
initn: 263 init1: 191 opt: 237 Z-score: 181.8 bits: 42.7 E(85289): 0.0022
Smith-Waterman score: 237; 37.0% identity (67.4% similar) in 92 aa overlap (61-149:62-153)
40 50 60 70 80
pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV
:: : :.....: :. :. .:: : .
XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE
40 50 60 70 80 90
90 100 110 120 130 140
pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVA
:. : :.... ::. ::.:::.::::: .::. .. . : : .:: : . : ....
XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERIS
100 110 120 130 140 150
150 160 170 180 190 200
pF1KE1 IPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQ
:
XP_011 APEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTST
160 170 180 190 200 210
>>XP_011522250 (OMIM: 606717) PREDICTED: XIAP-associated (243 aa)
initn: 216 init1: 191 opt: 235 Z-score: 181.7 bits: 42.3 E(85289): 0.0022
Smith-Waterman score: 235; 40.5% identity (69.6% similar) in 79 aa overlap (61-138:158-236)
40 50 60 70 80
pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV
:: : :.....: :. :. .:: : .
XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIP
:. : :.... ::. ::.:::.::::: .::. .. . : : .:: :
XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKG
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE1 PNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVS
>>XP_011522248 (OMIM: 606717) PREDICTED: XIAP-associated (403 aa)
initn: 246 init1: 191 opt: 237 Z-score: 180.2 bits: 42.8 E(85289): 0.0027
Smith-Waterman score: 237; 37.0% identity (67.4% similar) in 92 aa overlap (61-149:158-249)
40 50 60 70 80
pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV
:: : :.....: :. :. .:: : .
XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVA
:. : :.... ::. ::.:::.::::: .::. .. . : : .:: : . : ....
XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERIS
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE1 IPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQ
:
XP_011 APEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTST
250 260 270 280 290 300
>>XP_011522247 (OMIM: 606717) PREDICTED: XIAP-associated (403 aa)
initn: 263 init1: 191 opt: 237 Z-score: 180.2 bits: 42.8 E(85289): 0.0027
Smith-Waterman score: 237; 37.0% identity (67.4% similar) in 92 aa overlap (61-149:158-249)
40 50 60 70 80
pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV
:: : :.....: :. :. .:: : .
XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVA
:. : :.... ::. ::.:::.::::: .::. .. . : : .:: : . : ....
XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERIS
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE1 IPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQ
:
XP_011 APEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTST
250 260 270 280 290 300
>>XP_016880269 (OMIM: 606717) PREDICTED: XIAP-associated (241 aa)
initn: 263 init1: 191 opt: 227 Z-score: 176.3 bits: 41.3 E(85289): 0.0044
Smith-Waterman score: 227; 36.0% identity (68.6% similar) in 86 aa overlap (66-149:2-87)
40 50 60 70 80 90
pF1KE1 IGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDL
:.....: :. :. .:: : . :. : :
XP_016 MCQQSMQKSSLEFHKANECQERPVECKFCKL
10 20 30
100 110 120 130 140 150
pF1KE1 ELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVAIPPNAY
.... ::. ::.:::.::::: .::. .. . : : .:: : . : .... :
XP_016 DMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE1 DESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNN
XP_016 YCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVR
100 110 120 130 140 150
582 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 07:45:46 2016 done: Sat Nov 5 07:45:47 2016
Total Scan time: 12.360 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]