Result of FASTA (omim) for
pF1KE1014
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1014, 302 aa
1>>>pF1KE1014 302 - 302 aa - 302 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3506+/-0.000402; mu= 15.4605+/- 0.025
mean_var=84.1021+/-17.205, 0's: 0 Z-trim(112.1): 184 B-trim: 0 in 0/61
Lambda= 0.139853
statistics sampled from 20693 (20894) to 20693 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.245), width: 16
Scan time: 7.460
The best scores are: opt bits E(85289)
NP_056074 (OMIM: 605717) ICOS ligand isoform a pre ( 302) 2005 414.6 1.2e-115
XP_011527817 (OMIM: 605717) PREDICTED: ICOS ligand ( 304) 1982 410.0 3.1e-114
NP_001269979 (OMIM: 605717) ICOS ligand isoform b ( 309) 1982 410.0 3.1e-114
XP_011527816 (OMIM: 605717) PREDICTED: ICOS ligand ( 361) 1982 410.0 3.5e-114
XP_016883799 (OMIM: 605717) PREDICTED: ICOS ligand ( 275) 1837 380.7 1.8e-105
XP_011527818 (OMIM: 605717) PREDICTED: ICOS ligand ( 334) 1814 376.1 5.2e-104
NP_001269981 (OMIM: 605717) ICOS ligand isoform d ( 217) 1446 301.7 8.5e-82
NP_001269980 (OMIM: 605717) ICOS ligand isoform c ( 185) 1124 236.7 2.7e-62
NP_079516 (OMIM: 605715) CD276 antigen isoform b p ( 316) 340 78.7 1.7e-14
NP_001316557 (OMIM: 605715) CD276 antigen isoform ( 316) 340 78.7 1.7e-14
NP_001316558 (OMIM: 605715) CD276 antigen isoform ( 388) 322 75.1 2.4e-13
XP_011520397 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 322 75.2 3.1e-13
XP_016878127 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 322 75.2 3.1e-13
XP_011520398 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 322 75.2 3.1e-13
NP_001019907 (OMIM: 605715) CD276 antigen isoform ( 534) 322 75.2 3.1e-13
XP_005254757 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 322 75.2 3.1e-13
NP_001723 (OMIM: 601610) butyrophilin subfamily 1 ( 526) 234 57.5 6.8e-08
NP_795711 (OMIM: 601020) T-lymphocyte activation a ( 275) 230 56.4 7.3e-08
XP_005249397 (OMIM: 601610) PREDICTED: butyrophili ( 626) 234 57.5 7.7e-08
NP_008820 (OMIM: 601020) T-lymphocyte activation a ( 323) 219 54.3 3.8e-07
NP_787058 (OMIM: 601020) T-lymphocyte activation a ( 329) 219 54.3 3.9e-07
XP_016863009 (OMIM: 112203) PREDICTED: T-lymphocyt ( 249) 217 53.8 4.2e-07
NP_005182 (OMIM: 112203) T-lymphocyte activation a ( 288) 215 53.4 6.2e-07
XP_005248888 (OMIM: 613594) PREDICTED: butyrophili ( 267) 198 50.0 6.3e-06
XP_005248889 (OMIM: 613594) PREDICTED: butyrophili ( 267) 198 50.0 6.3e-06
XP_016866546 (OMIM: 606000,612387) PREDICTED: buty ( 482) 201 50.8 6.4e-06
NP_001291490 (OMIM: 606000,612387) butyrophilin-li ( 482) 201 50.8 6.4e-06
NP_001184177 (OMIM: 613594) butyrophilin subfamily ( 311) 194 49.2 1.2e-05
XP_016865705 (OMIM: 613594) PREDICTED: butyrophili ( 225) 192 48.7 1.3e-05
NP_001184175 (OMIM: 613594) butyrophilin subfamily ( 334) 194 49.2 1.3e-05
XP_016865700 (OMIM: 613594) PREDICTED: butyrophili ( 334) 194 49.2 1.3e-05
NP_001184176 (OMIM: 613594) butyrophilin subfamily ( 334) 194 49.2 1.3e-05
XP_005248884 (OMIM: 613594) PREDICTED: butyrophili ( 334) 194 49.2 1.3e-05
XP_016865701 (OMIM: 613594) PREDICTED: butyrophili ( 334) 194 49.2 1.3e-05
NP_008978 (OMIM: 613594) butyrophilin subfamily 3 ( 334) 194 49.2 1.3e-05
XP_006715044 (OMIM: 613594) PREDICTED: butyrophili ( 339) 194 49.2 1.3e-05
XP_011512569 (OMIM: 613594) PREDICTED: butyrophili ( 339) 194 49.2 1.3e-05
XP_006715042 (OMIM: 613594) PREDICTED: butyrophili ( 339) 194 49.2 1.3e-05
XP_006715043 (OMIM: 613594) PREDICTED: butyrophili ( 339) 194 49.2 1.3e-05
XP_011512570 (OMIM: 613594) PREDICTED: butyrophili ( 339) 194 49.2 1.3e-05
NP_001184163 (OMIM: 613590) butyrophilin subfamily ( 330) 192 48.8 1.7e-05
NP_510961 (OMIM: 613590) butyrophilin subfamily 2 ( 334) 192 48.8 1.7e-05
XP_016865703 (OMIM: 613594) PREDICTED: butyrophili ( 292) 188 48.0 2.7e-05
NP_001184178 (OMIM: 613594) butyrophilin subfamily ( 292) 188 48.0 2.7e-05
XP_011512571 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 48.0 2.8e-05
XP_006715045 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 48.0 2.8e-05
XP_016865702 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 48.0 2.8e-05
XP_011511629 (OMIM: 112203) PREDICTED: T-lymphocyt ( 217) 186 47.5 2.9e-05
NP_001300958 (OMIM: 605402) programmed cell death ( 245) 183 46.9 4.8e-05
NP_001184167 (OMIM: 613591) butyrophilin subfamily ( 336) 184 47.2 5.3e-05
>>NP_056074 (OMIM: 605717) ICOS ligand isoform a precurs (302 aa)
initn: 2005 init1: 2005 opt: 2005 Z-score: 2197.1 bits: 414.6 E(85289): 1.2e-115
Smith-Waterman score: 2005; 100.0% identity (100.0% similar) in 302 aa overlap (1-302:1-302)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
250 260 270 280 290 300
pF1KE1 HV
::
NP_056 HV
>>XP_011527817 (OMIM: 605717) PREDICTED: ICOS ligand iso (304 aa)
initn: 1982 init1: 1982 opt: 1982 Z-score: 2172.0 bits: 410.0 E(85289): 3.1e-114
Smith-Waterman score: 1982; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTV
250 260 270 280 290 300
pF1KE1 HV
XP_011 PGAT
>>NP_001269979 (OMIM: 605717) ICOS ligand isoform b prec (309 aa)
initn: 1982 init1: 1982 opt: 1982 Z-score: 2171.9 bits: 410.0 E(85289): 3.1e-114
Smith-Waterman score: 1982; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTE
250 260 270 280 290 300
pF1KE1 HV
NP_001 SWNLLLLLS
>>XP_011527816 (OMIM: 605717) PREDICTED: ICOS ligand iso (361 aa)
initn: 1982 init1: 1982 opt: 1982 Z-score: 2171.0 bits: 410.0 E(85289): 3.5e-114
Smith-Waterman score: 1982; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTV
250 260 270 280 290 300
pF1KE1 HV
XP_011 SRHGFEQTTDVLPFILKSSLGASCEPTAFPLPPAAPGPCAHLFIWMLAECTPCSPVWSSI
310 320 330 340 350 360
>>XP_016883799 (OMIM: 605717) PREDICTED: ICOS ligand iso (275 aa)
initn: 1837 init1: 1837 opt: 1837 Z-score: 2014.5 bits: 380.7 E(85289): 1.8e-105
Smith-Waterman score: 1837; 100.0% identity (100.0% similar) in 275 aa overlap (28-302:1-275)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
:::::::::::::::::::::::::::::::::
XP_016 MVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
220 230 240 250 260 270
pF1KE1 HV
::
XP_016 HV
>>XP_011527818 (OMIM: 605717) PREDICTED: ICOS ligand iso (334 aa)
initn: 1814 init1: 1814 opt: 1814 Z-score: 1988.2 bits: 376.1 E(85289): 5.2e-104
Smith-Waterman score: 1814; 100.0% identity (100.0% similar) in 272 aa overlap (28-299:1-272)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
:::::::::::::::::::::::::::::::::
XP_011 MVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTV
220 230 240 250 260 270
pF1KE1 HV
XP_011 SRHGFEQTTDVLPFILKSSLGASCEPTAFPLPPAAPGPCAHLFIWMLAECTPCSPVWSSI
280 290 300 310 320 330
>>NP_001269981 (OMIM: 605717) ICOS ligand isoform d [Hom (217 aa)
initn: 1446 init1: 1446 opt: 1446 Z-score: 1589.5 bits: 301.7 E(85289): 8.5e-82
Smith-Waterman score: 1446; 100.0% identity (100.0% similar) in 217 aa overlap (86-302:1-217)
60 70 80 90 100 110
pF1KE1 TSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLV
::::::::::::::::::::::::::::::
NP_001 MSPAGMLRGDFSLRLFNVTPQDEQKFHCLV
10 20 30
120 130 140 150 160 170
pF1KE1 LSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKT
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 DNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGND
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE1 IGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPE
160 170 180 190 200 210
300
pF1KE1 TELTGHV
:::::::
NP_001 TELTGHV
>>NP_001269980 (OMIM: 605717) ICOS ligand isoform c prec (185 aa)
initn: 1124 init1: 1124 opt: 1124 Z-score: 1239.3 bits: 236.7 E(85289): 2.7e-62
Smith-Waterman score: 1124; 100.0% identity (100.0% similar) in 168 aa overlap (135-302:18-185)
110 120 130 140 150 160
pF1KE1 PQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGY
::::::::::::::::::::::::::::::
NP_001 MRLGSPGLLFLLFSSLRAANFSVPVVSAPHSPSQDELTFTCTSINGY
10 20 30 40
170 180 190 200 210 220
pF1KE1 PRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQ
50 60 70 80 90 100
230 240 250 260 270 280
pF1KE1 NLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQH
110 120 130 140 150 160
290 300
pF1KE1 SYAGAWAVSPETELTGHV
::::::::::::::::::
NP_001 SYAGAWAVSPETELTGHV
170 180
>>NP_079516 (OMIM: 605715) CD276 antigen isoform b precu (316 aa)
initn: 251 init1: 83 opt: 340 Z-score: 381.3 bits: 78.7 E(85289): 1.7e-14
Smith-Waterman score: 367; 30.5% identity (56.5% similar) in 308 aa overlap (2-289:4-285)
10 20 30 40
pF1KE1 MRLGSPG-----------LLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDL
: :::: : : : ..:.... : : :.::.:. : :. :.:
NP_079 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 NDVYVYWQTSESKTVVTYHIPQNSSLENVD--SRYRNRALMSPAGMLRGDFSLRLFNVTP
.. . :: ...: .: .: :. : : : ::. . : . .:. :::: :
NP_079 AQLNLIWQLTDTKQLV------HSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRV
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 QDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVS-APHSPSQ--DELTFTCTSIN
:: .: :.: ...: :. :.:.::: .: : .. :.. . : .:.::.:
NP_079 ADEGSFTCFVSIRDFG-----SAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYR
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 GYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLL
:::. .:.: . : .. .. . : .::.:: ::::.. . . .: ..: .:
NP_079 GYPEAEVFWQDGQGVPLTGNVTTSQMA--NEQGLFDVHSVLRVVLGANGTYSCLVRNPVL
170 180 190 200 210 220
230 240 250 260 270
pF1KE1 QQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVC----R
::. :: : :: .:.. . : : ... :... ::...:: .
NP_079 QQDAH-GSVT---------ITGQPMTFPPE--ALWVTVGLSVCLIALLVALAFVCWRKIK
230 240 250 260 270
280 290 300
pF1KE1 DRCLQHSYAGAWAVSPETELTGHV
. : ... :::
NP_079 QSCEEEN-AGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
280 290 300 310
>>NP_001316557 (OMIM: 605715) CD276 antigen isoform b pr (316 aa)
initn: 251 init1: 83 opt: 340 Z-score: 381.3 bits: 78.7 E(85289): 1.7e-14
Smith-Waterman score: 367; 30.5% identity (56.5% similar) in 308 aa overlap (2-289:4-285)
10 20 30 40
pF1KE1 MRLGSPG-----------LLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDL
: :::: : : : ..:.... : : :.::.:. : :. :.:
NP_001 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 NDVYVYWQTSESKTVVTYHIPQNSSLENVD--SRYRNRALMSPAGMLRGDFSLRLFNVTP
.. . :: ...: .: .: :. : : : ::. . : . .:. :::: :
NP_001 AQLNLIWQLTDTKQLV------HSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRV
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 QDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVS-APHSPSQ--DELTFTCTSIN
:: .: :.: ...: :. :.:.::: .: : .. :.. . : .:.::.:
NP_001 ADEGSFTCFVSIRDFG-----SAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYR
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 GYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLL
:::. .:.: . : .. .. . : .::.:: ::::.. . . .: ..: .:
NP_001 GYPEAEVFWQDGQGVPLTGNVTTSQMA--NEQGLFDVHSVLRVVLGANGTYSCLVRNPVL
170 180 190 200 210 220
230 240 250 260 270
pF1KE1 QQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVC----R
::. :: : :: .:.. . : : ... :... ::...:: .
NP_001 QQDAH-GSVT---------ITGQPMTFPPE--ALWVTVGLSVCLIALLVALAFVCWRKIK
230 240 250 260 270
280 290 300
pF1KE1 DRCLQHSYAGAWAVSPETELTGHV
. : ... :::
NP_001 QSCEEEN-AGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
280 290 300 310
302 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 13:24:33 2016 done: Sat Nov 5 13:24:34 2016
Total Scan time: 7.460 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]