Result of FASTA (omim) for
pF1KE0996
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0996, 659 aa
1>>>pF1KE0996 659 - 659 aa - 659 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4809+/-0.000551; mu= -2.8817+/- 0.034
mean_var=719.4331+/-162.037, 0's: 0 Z-trim(118.6): 1356 B-trim: 1846 in 1/57
Lambda= 0.047817
statistics sampled from 31394 (33089) to 31394 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.358), width: 16
Scan time: 5.620
The best scores are: opt bits E(92320)
NP_000052 (OMIM: 300300,300755,307200) tyrosine-pr ( 659) 4462 324.4 9.2e-88
NP_001274273 (OMIM: 300300,300755,307200) tyrosine ( 693) 4462 324.4 9.4e-88
NP_001274274 (OMIM: 300300,300755,307200) tyrosine ( 483) 2360 179.1 3.5e-44
XP_016864058 (OMIM: 600583) tyrosine-protein kinas ( 515) 1981 153.0 2.7e-36
XP_011512039 (OMIM: 600583) tyrosine-protein kinas ( 595) 1981 153.1 2.9e-36
XP_024309961 (OMIM: 600583) tyrosine-protein kinas ( 631) 1981 153.2 3e-36
NP_003206 (OMIM: 600583) tyrosine-protein kinase T ( 631) 1981 153.2 3e-36
NP_003319 (OMIM: 600058) tyrosine-protein kinase T ( 527) 1933 149.7 2.7e-35
XP_024309968 (OMIM: 600058) tyrosine-protein kinas ( 530) 1917 148.6 5.8e-35
XP_016864070 (OMIM: 600058) tyrosine-protein kinas ( 502) 1915 148.5 6.2e-35
XP_016864932 (OMIM: 186973,613011) tyrosine-protei ( 495) 1790 139.8 2.4e-32
NP_005537 (OMIM: 186973,613011) tyrosine-protein k ( 620) 1790 140.0 2.7e-32
NP_001307795 (OMIM: 300101) cytoplasmic tyrosine-p ( 674) 1722 135.4 7.4e-31
NP_001712 (OMIM: 300101) cytoplasmic tyrosine-prot ( 675) 1722 135.4 7.4e-31
NP_975010 (OMIM: 300101) cytoplasmic tyrosine-prot ( 675) 1722 135.4 7.4e-31
XP_011512049 (OMIM: 600058) tyrosine-protein kinas ( 508) 1659 130.8 1.3e-29
XP_016864071 (OMIM: 600058) tyrosine-protein kinas ( 338) 1466 117.2 1.1e-25
XP_011512050 (OMIM: 600058) tyrosine-protein kinas ( 289) 1303 105.8 2.4e-22
XP_011512043 (OMIM: 600583) tyrosine-protein kinas ( 466) 1236 101.6 7.6e-21
NP_005148 (OMIM: 189980,608232,617602) tyrosine-pr (1130) 1171 97.7 2.6e-19
NP_009297 (OMIM: 189980,608232,617602) tyrosine-pr (1149) 1171 97.7 2.7e-19
NP_001129472 (OMIM: 164690) tyrosine-protein kinas (1064) 1153 96.4 6.1e-19
NP_005149 (OMIM: 164690) tyrosine-protein kinase A (1167) 1153 96.5 6.3e-19
NP_001129473 (OMIM: 164690) tyrosine-protein kinas ( 542) 1142 95.2 7.3e-19
XP_024302814 (OMIM: 153390,615758) tyrosine-protei ( 567) 1142 95.2 7.5e-19
XP_024302815 (OMIM: 153390,615758) tyrosine-protei ( 567) 1142 95.2 7.5e-19
NP_001161709 (OMIM: 164690) tyrosine-protein kinas (1079) 1147 96.0 8.1e-19
NP_009298 (OMIM: 164690) tyrosine-protein kinase A (1182) 1147 96.1 8.5e-19
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 1138 94.9 8.6e-19
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 1138 94.9 8.6e-19
XP_016856524 (OMIM: 164690) tyrosine-protein kinas (1182) 1146 96.0 8.9e-19
NP_001161711 (OMIM: 164690) tyrosine-protein kinas (1043) 1142 95.7 1e-18
NP_001161710 (OMIM: 164690) tyrosine-protein kinas (1058) 1142 95.7 1e-18
XP_005245145 (OMIM: 164690) tyrosine-protein kinas (1146) 1142 95.7 1.1e-18
NP_001161708 (OMIM: 164690) tyrosine-protein kinas (1161) 1142 95.7 1.1e-18
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 1133 94.5 1.1e-18
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 1133 94.5 1.1e-18
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 1131 94.4 1.2e-18
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 1131 94.4 1.2e-18
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 1131 94.4 1.2e-18
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 1131 94.4 1.2e-18
XP_005266937 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_011533957 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_016866134 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_011533955 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1117 93.4 2.3e-18
XP_005266938 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_011533956 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_005266939 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 1114 93.2 2.7e-18
>>NP_000052 (OMIM: 300300,300755,307200) tyrosine-protei (659 aa)
initn: 4462 init1: 4462 opt: 4462 Z-score: 1697.3 bits: 324.4 E(92320): 9.2e-88
Smith-Waterman score: 4462; 100.0% identity (100.0% similar) in 659 aa overlap (1-659:1-659)
10 20 30 40 50 60
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
550 560 570 580 590 600
610 620 630 640 650
pF1KE0 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
610 620 630 640 650
>>NP_001274273 (OMIM: 300300,300755,307200) tyrosine-pro (693 aa)
initn: 4462 init1: 4462 opt: 4462 Z-score: 1697.1 bits: 324.4 E(92320): 9.4e-88
Smith-Waterman score: 4462; 100.0% identity (100.0% similar) in 659 aa overlap (1-659:35-693)
10 20 30
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLF
::::::::::::::::::::::::::::::
NP_001 SIQQMVIGCPLCGRHCSGGEHTGELQKEEAMAAVILESIFLKRSQQKKKTSPLNFKKRLF
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEME
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 QISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDG
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 QYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 VSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGV
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMM
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM
610 620 630 640 650 660
640 650
pF1KE0 YSCWHEKADERPTFKILLSNILDVMDEES
:::::::::::::::::::::::::::::
NP_001 YSCWHEKADERPTFKILLSNILDVMDEES
670 680 690
>>NP_001274274 (OMIM: 300300,300755,307200) tyrosine-pro (483 aa)
initn: 2402 init1: 2360 opt: 2360 Z-score: 914.8 bits: 179.1 E(92320): 3.5e-44
Smith-Waterman score: 2915; 73.3% identity (73.3% similar) in 659 aa overlap (1-659:1-483)
10 20 30 40 50 60
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLA-------------
310 320 330 340
370 380 390 400 410 420
pF1KE0 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
NP_001 ------------------------------------------------------------
430 440 450 460 470 480
pF1KE0 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
NP_001 ------------------------------------------------------------
490 500 510 520 530 540
pF1KE0 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
:::::::::::::::::
NP_001 -------------------------------------------ARNCLVNDQGVVKVSDF
350 360
550 560 570 580 590 600
pF1KE0 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
370 380 390 400 410 420
610 620 630 640 650
pF1KE0 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
430 440 450 460 470 480
>>XP_016864058 (OMIM: 600583) tyrosine-protein kinase Te (515 aa)
initn: 2090 init1: 1469 opt: 1981 Z-score: 773.2 bits: 153.0 E(92320): 2.7e-36
Smith-Waterman score: 2087; 56.4% identity (82.1% similar) in 521 aa overlap (141-658:3-510)
120 130 140 150 160 170
pF1KE0 LYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILEN
:::: :: ::.: :: :: : : ::. .
XP_016 MIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNL
10 20 30
180 190 200 210 220 230
pF1KE0 RNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNA
..:.. : :::.:: . ..: :: : .. :. :::.::.. ..
XP_016 FESSIR---------KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEG
40 50 60 70
240 250 260 270 280
pF1KE0 NDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRS
.::.:..:.::.:::.... ::::::: :.:::::::::: . .....:::: ..:.::
XP_016 HDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRS
80 90 100 110 120 130
290 300 310 320 330 340
pF1KE0 QAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLA
.:::::..: :::::.:::::. : ::::...: :. .. .::: . : : .::::
XP_016 KAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLA
140 150 160 170 180 190
350 360 370 380 390 400
pF1KE0 EKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKE
::: :..:::.:.::.::.:::..::.:::: ..::::.:::..: .:::.:..:::..:
XP_016 EKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRE
200 210 220 230 240 250
410 420 430 440 450 460
pF1KE0 LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ
::.: ::::. ::::.:: :::: :.::.: :..:::::::::.:.: ::::::::::.:
XP_016 LGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQ
260 270 280 290 300 310
470 480 490 500 510 520
pF1KE0 RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNC
.::.:.::.: :::::.::. . .:. . :: ::.::::.::::: ..:.:::::::::
XP_016 KPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNC
320 330 340 350 360 370
530 540 550 560 570 580
pF1KE0 LVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLM
::.. :::::::::..::::::.:::: :.::::.: ::::. ::.::::::.:.:::::
XP_016 LVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLM
380 390 400 410 420 430
590 600 610 620 630 640
pF1KE0 WEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKIL
::... :.::.:..:: :.. ...: :::.:.:::. :: .: ::.:: . ::.:. :
XP_016 WEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDL
440 450 460 470 480 490
650
pF1KE0 LSNILDVMDEES
: .: .... :
XP_016 LRTIDELVECEETFGR
500 510
>>XP_011512039 (OMIM: 600583) tyrosine-protein kinase Te (595 aa)
initn: 2018 init1: 1469 opt: 1981 Z-score: 772.7 bits: 153.1 E(92320): 2.9e-36
Smith-Waterman score: 2242; 53.4% identity (78.7% similar) in 610 aa overlap (52-658:14-590)
30 40 50 60 70 80
pF1KE0 PLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPR
.:: ::: :: ::: : :: . ::
XP_011 MKSGNSIHHQKKYRKGFIDVSKIKCVEIV---KN--DDGVIPC
10 20 30
90 100 110 120 130 140
pF1KE0 RGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQK
... ::::::.: . ::.:.:. . : :...::. :. :.... :
XP_011 QNK---------------YPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK
40 50 60 70 80
150 160 170 180 190 200
pF1KE0 YHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKP
::: :: ::.: :: :: : : ::. . ..:.. : :::.:: . ..:
XP_011 YHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR---------KALPPAPETKK--RRP
90 100 110 120 130
210 220 230 240 250 260
pF1KE0 LPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQE
:: : .. :. :::.::.. ...::.:..:.::.:::.... ::::::: :.:
XP_011 PPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNE
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE0 GYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVF
::::::::: . .....:::: ..:.::.:::::..: :::::.:::::. : ::::..
XP_011 GYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLY
200 210 220 230 240 250
330 340 350 360 370
pF1KE0 AKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVS
.: :. .. .::: . : : .::::::: :..:::.:.::.::.:::..::.::::
XP_011 TKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVS
260 270 280 290 300 310
380 390 400 410 420 430
pF1KE0 QQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMS
..::::.:::..: .:::.:..:::..:::.: ::::. ::::.:: :::: :.::.:
XP_011 VKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMC
320 330 340 350 360 370
440 450 460 470 480 490
pF1KE0 EDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQL
:..:::::::::.:.: ::::::::::.:.::.:.::.: :::::.::. . .:. . :
XP_011 EEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVL
380 390 400 410 420 430
500 510 520 530 540 550
pF1KE0 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK
: ::.::::.::::: ..:.:::::::::::.. :::::::::..::::::.:::: :.:
XP_011 LSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK
440 450 460 470 480 490
560 570 580 590 600 610
pF1KE0 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR
:::.: ::::. ::.::::::.:.:::::::... :.::.:..:: :.. ...: :::.
XP_011 FPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQ
500 510 520 530 540 550
620 630 640 650
pF1KE0 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
:.:::. :: .: ::.:: . ::.:. :: .: .... :
XP_011 PKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR
560 570 580 590
>>XP_024309961 (OMIM: 600583) tyrosine-protein kinase Te (631 aa)
initn: 2174 init1: 1469 opt: 1981 Z-score: 772.4 bits: 153.2 E(92320): 3e-36
Smith-Waterman score: 2399; 53.9% identity (78.7% similar) in 657 aa overlap (5-658:6-626)
10 20 30 40 50
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVE
::: :..:::::::::::::.:.:::.:: :.::: :... .:: :::
XP_024 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVS
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 KITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEE
:: ::: : :: . :: ... ::::::.: . ::.:.:. .
XP_024 KIKCVEIV---KN--DDGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQ
60 70 80 90
120 130 140 150 160 170
pF1KE0 LRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGS
: :...::. :. :.... :::: :: ::.: :: :: : : ::. . ..:..
XP_024 SRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR---
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE0 SHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGD
: :::.:: . ..: :: : .. :. :::.::.. ...::.:..:.
XP_024 ------KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQ
160 170 180 190 200
240 250 260 270 280 290
pF1KE0 EYFILEESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQE
::.:::.... ::::::: :.:::::::::: . .....:::: ..:.::.:::::..:
XP_024 EYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSE
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE0 GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIP
:::::.:::::. : ::::...: :. .. .::: . : : .::::::: :..::
XP_024 DKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIP
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE0 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVV
:.:.::.::.:::..::.:::: ..::::.:::..: .:::.:..:::..:::.: ::::
XP_024 EIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVV
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE0 KYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEY
. ::::.:: :::: :.::.: :..:::::::::.:.: ::::::::::.:.::.:.::.
XP_024 RLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEF
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE0 MANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVK
: :::::.::. . .:. . :: ::.::::.::::: ..:.:::::::::::.. ::::
XP_024 MERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVK
450 460 470 480 490 500
540 550 560 570 580 590
pF1KE0 VSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKM
:::::..::::::.:::: :.::::.: ::::. ::.::::::.:.:::::::... :.:
XP_024 VSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRM
510 520 530 540 550 560
600 610 620 630 640 650
pF1KE0 PYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD
:.:..:: :.. ...: :::.:.:::. :: .: ::.:: . ::.:. :: .: ....
XP_024 PFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE
570 580 590 600 610 620
pF1KE0 EES
:
XP_024 CEETFGR
630
>>NP_003206 (OMIM: 600583) tyrosine-protein kinase Tec [ (631 aa)
initn: 2174 init1: 1469 opt: 1981 Z-score: 772.4 bits: 153.2 E(92320): 3e-36
Smith-Waterman score: 2399; 53.9% identity (78.7% similar) in 657 aa overlap (5-658:6-626)
10 20 30 40 50
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVE
::: :..:::::::::::::.:.:::.:: :.::: :... .:: :::
NP_003 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVS
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 KITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEE
:: ::: : :: . :: ... ::::::.: . ::.:.:. .
NP_003 KIKCVEIV---KN--DDGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQ
60 70 80 90
120 130 140 150 160 170
pF1KE0 LRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGS
: :...::. :. :.... :::: :: ::.: :: :: : : ::. . ..:..
NP_003 SRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR---
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE0 SHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGD
: :::.:: . ..: :: : .. :. :::.::.. ...::.:..:.
NP_003 ------KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQ
160 170 180 190 200
240 250 260 270 280 290
pF1KE0 EYFILEESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQE
::.:::.... ::::::: :.:::::::::: . .....:::: ..:.::.:::::..:
NP_003 EYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSE
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE0 GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIP
:::::.:::::. : ::::...: :. .. .::: . : : .::::::: :..::
NP_003 DKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIP
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE0 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVV
:.:.::.::.:::..::.:::: ..::::.:::..: .:::.:..:::..:::.: ::::
NP_003 EIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVV
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE0 KYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEY
. ::::.:: :::: :.::.: :..:::::::::.:.: ::::::::::.:.::.:.::.
NP_003 RLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEF
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE0 MANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVK
: :::::.::. . .:. . :: ::.::::.::::: ..:.:::::::::::.. ::::
NP_003 MERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVK
450 460 470 480 490 500
540 550 560 570 580 590
pF1KE0 VSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKM
:::::..::::::.:::: :.::::.: ::::. ::.::::::.:.:::::::... :.:
NP_003 VSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRM
510 520 530 540 550 560
600 610 620 630 640 650
pF1KE0 PYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD
:.:..:: :.. ...: :::.:.:::. :: .: ::.:: . ::.:. :: .: ....
NP_003 PFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE
570 580 590 600 610 620
pF1KE0 EES
:
NP_003 CEETFGR
630
>>NP_003319 (OMIM: 600058) tyrosine-protein kinase TXK [ (527 aa)
initn: 1928 init1: 1657 opt: 1933 Z-score: 755.3 bits: 149.7 E(92320): 2.7e-35
Smith-Waterman score: 1933; 52.9% identity (80.5% similar) in 512 aa overlap (154-656:17-525)
130 140 150 160 170 180
pF1KE0 WIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRK
:: .. : : :: . . : ..:.
NP_003 MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRR
10 20 30 40
190 200 210 220 230
pF1KE0 -------TKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELK-KVVALYDYMPMNANDLQL
..: : . . .::::: : : ..: : .: ::::..: . .: :
NP_003 RPWLSQLSNKKQSNTGRVQPSKRKPLPPLP---PSEVAEEKIQVKALYDFLPREPCNLAL
50 60 70 80 90 100
240 250 260 270 280 290
pF1KE0 RKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAE-DSIEMYEWYSKHMTRSQAEQL
:...::.:::. : ::.:::. :.:: :::::::: . ..:.:::: ...::.:::.:
NP_003 RRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHL
110 120 130 140 150 160
300 310 320 330 340 350
pF1KE0 LKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFST
:.::.:::.:::::: . :.::.::: . . ...:.:: . .. ..:.:.::.: :..
NP_003 LRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQS
170 180 190 200 210 220
360 370 380 390 400 410
pF1KE0 IPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFG
::::: :::::.:::..::.:::. ... :.:::..: .:::::..:.:.::.:.::::
NP_003 IPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFG
230 240 250 260 270 280
420 430 440 450 460 470
pF1KE0 VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIIT
::. :.::.. .:::: :.::::::..:::::::::.::: ::::::::: ...:..:.:
NP_003 VVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVT
290 300 310 320 330 340
480 490 500 510 520 530
pF1KE0 EYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV
:.: :::::::::: . ... ..:: .:.:.::.::::: . ..:::::::::::.. .
NP_003 EFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCI
350 360 370 380 390 400
540 550 560 570 580 590
pF1KE0 VKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG
::.::::..::::::::.:: :.:::..::::::....:.:::::.:.:::::::... :
NP_003 VKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEG
410 420 430 440 450 460
600 610 620 630 640 650
pF1KE0 KMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDV
:::.: .: ...: :..:.:::::::: ..: .:::::::: . :::: :: . ..
NP_003 KMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI
470 480 490 500 510 520
pF1KE0 MDEES
.
NP_003 AETW
>>XP_024309968 (OMIM: 600058) tyrosine-protein kinase TX (530 aa)
initn: 1899 init1: 1657 opt: 1917 Z-score: 749.3 bits: 148.6 E(92320): 5.8e-35
Smith-Waterman score: 1917; 52.3% identity (80.5% similar) in 518 aa overlap (144-656:15-528)
120 130 140 150 160 170
pF1KE0 FSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKN---AMGCQILEN
::..: .. : . . .. :.
XP_024 MVELGFKLLFLITIPCLFITKRHHQMRQMRTQISLSTDEELPEK
10 20 30 40
180 190 200 210 220
pF1KE0 RNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELK-KVVALYDYMPMN
. .: :. ..:: : . . .::::: : : ..: : .: ::::..: .
XP_024 YTQRRRPWLSQLSNKKQ-SNTGRVQPSKRKPLPPLP---PSEVAEEKIQVKALYDFLPRE
50 60 70 80 90 100
230 240 250 260 270 280
pF1KE0 ANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAE-DSIEMYEWYSKHMTR
.: ::...::.:::. : ::.:::. :.:: :::::::: . ..:.:::: ...::
XP_024 PCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITR
110 120 130 140 150 160
290 300 310 320 330 340
pF1KE0 SQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAE
.:::.::.::.:::.:::::: . :.::.::: . . ...:.:: . .. ..:.:.::
XP_024 NQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAE
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE0 KHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKEL
.: :..::::: :::::.:::..::.:::. ... :.:::..: .:::::..:.:.::.
XP_024 RHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEI
230 240 250 260 270 280
410 420 430 440 450 460
pF1KE0 GTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR
:.::::::. :.::.. .:::: :.::::::..:::::::::.::: ::::::::: ...
XP_024 GSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRK
290 300 310 320 330 340
470 480 490 500 510 520
pF1KE0 PIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCL
:..:.::.: :::::::::: . ... ..:: .:.:.::.::::: . ..::::::::::
XP_024 PLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCL
350 360 370 380 390 400
530 540 550 560 570 580
pF1KE0 VNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMW
:.. .::.::::..::::::::.:: :.:::..::::::....:.:::::.:.::::::
XP_024 VSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMW
410 420 430 440 450 460
590 600 610 620 630 640
pF1KE0 EIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILL
:... ::::.: .: ...: :..:.:::::::: ..: .:::::::: . :::: ::
XP_024 EVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELL
470 480 490 500 510 520
650
pF1KE0 SNILDVMDEES
. .. .
XP_024 RAVTEIAETW
530
>>XP_016864070 (OMIM: 600058) tyrosine-protein kinase TX (502 aa)
initn: 1899 init1: 1657 opt: 1915 Z-score: 748.7 bits: 148.5 E(92320): 6.2e-35
Smith-Waterman score: 1915; 56.7% identity (85.0% similar) in 460 aa overlap (199-656:44-500)
170 180 190 200 210 220
pF1KE0 ENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELK-KVVALYDYMP
.::::: : : ..: : .: ::::..:
XP_016 PEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLP---PSEVAEEKIQVKALYDFLP
20 30 40 50 60 70
230 240 250 260 270 280
pF1KE0 MNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAE-DSIEMYEWYSKHM
. .: ::...::.:::. : ::.:::. :.:: :::::::: . ..:.:::: ...
XP_016 REPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNI
80 90 100 110 120 130
290 300 310 320 330 340
pF1KE0 TRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYL
::.:::.::.::.:::.:::::: . :.::.::: . . ...:.:: . .. ..:.:.
XP_016 TRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYV
140 150 160 170 180 190
350 360 370 380 390 400
pF1KE0 AEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLK
::.: :..::::: :::::.:::..::.:::. ... :.:::..: .:::::..:.:.:
XP_016 AERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIK
200 210 220 230 240 250
410 420 430 440 450 460
pF1KE0 ELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTK
:.:.::::::. :.::.. .:::: :.::::::..:::::::::.::: ::::::::: .
XP_016 EIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQ
260 270 280 290 300 310
470 480 490 500 510 520
pF1KE0 QRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN
..:..:.::.: :::::::::: . ... ..:: .:.:.::.::::: . ..::::::::
XP_016 RKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARN
320 330 340 350 360 370
530 540 550 560 570 580
pF1KE0 CLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVL
:::.. .::.::::..::::::::.:: :.:::..::::::....:.:::::.:.::::
XP_016 CLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVL
380 390 400 410 420 430
590 600 610 620 630 640
pF1KE0 MWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKI
:::... ::::.: .: ...: :..:.:::::::: ..: .:::::::: . ::::
XP_016 MWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAE
440 450 460 470 480 490
650
pF1KE0 LLSNILDVMDEES
:: . .. .
XP_016 LLRAVTEIAETW
500
659 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:27:16 2019 done: Thu Oct 24 21:27:17 2019
Total Scan time: 5.620 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]