Result of FASTA (omim) for
pF1KE0943
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0943, 336 aa
1>>>pF1KE0943 336 - 336 aa - 336 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5185+/-0.000299; mu= 7.9660+/- 0.019
mean_var=191.1238+/-41.186, 0's: 0 Z-trim(123.0): 11 B-trim: 2522 in 1/50
Lambda= 0.092772
statistics sampled from 42078 (42120) to 42078 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.81), E-opt: 0.2 (0.494), width: 16
Scan time: 8.360
The best scores are: opt bits E(85289)
NP_004064 (OMIM: 602913) serine/threonine-protein ( 646) 336 57.0 1.3e-07
NP_001239155 (OMIM: 607023) serine/threonine-prote ( 671) 332 56.5 1.9e-07
NP_006613 (OMIM: 607023) serine/threonine-protein ( 685) 332 56.5 2e-07
NP_005021 (OMIM: 602098) serine/threonine-protein ( 603) 279 49.3 2.5e-05
>>NP_004064 (OMIM: 602913) serine/threonine-protein kina (646 aa)
initn: 566 init1: 330 opt: 336 Z-score: 257.6 bits: 57.0 E(85289): 1.3e-07
Smith-Waterman score: 543; 34.1% identity (55.4% similar) in 372 aa overlap (1-308:250-615)
10 20 30
pF1KE0 MYTVLTGTPPFMASPLSEMYQNIREGHYPE
:::.: :.::: .. :.: :. :.. ::
NP_004 ICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTL
220 230 240 250 260 270
40 50 60 70 80 90
pF1KE0 PAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHSPPIFAIPPP
:: :: ::.:.. .: .: .:::.:..:. ::::.:.:::::: :: . : .. : :
NP_004 PASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNP
280 290 300 310 320 330
100 110 120 130 140
pF1KE0 LGRIFRKVGQRLLTQCRPPCPFTPK--EASGPGEGGPDPDSMEWDGESSLSAKEVPCLEG
.: :: . :. . . . . :.:: : . . :.. : : .
NP_004 ARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGP---A
340 350 360 370 380 390
150 160 170 180 190
pF1KE0 PIHLVA--------QGTLQSDLAG-PEG-SRRPEVEAALRHLQLCLDVGPPATQDP--LG
:. :: .::: :. : :: . ::.:: :. :. ::: :.: :.
NP_004 PVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLA
400 410 420 430 440 450
200 210 220 230
pF1KE0 EQQPILWAPKWVDYSSKYGFGYQL----------------LDGGRTGRHPHGP-------
. .:..:. ::::::.:.:::::: :...: : ..:
NP_004 QPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVH-YNPTSTKHFS
460 470 480 490 500 510
240 250 260
pF1KE0 ----ATPR---------------------REGTLPT--PVPPAGPGLCLLRFLASEHALL
:.:: . : ::. : .: : ::... ...:::
NP_004 FSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPL-LLQWVKTDQALL
520 530 540 550 560 570
270 280 290 300 310 320
pF1KE0 LLFSNGMVQVSFSGVPAQLVLSGEGEGLQLTLWEQGSPGTSYSLDVPQSHGCAPTTGQHL
.:::.: :::.: : ..:.::: : : .:. .. . .:
NP_004 MLFSDGTVQVNFYGDHTKLILSGW-EPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRL
580 590 600 610 620 630
330
pF1KE0 HHALRMLQSI
NP_004 RYALRLLRDRSPA
640
>>NP_001239155 (OMIM: 607023) serine/threonine-protein k (671 aa)
initn: 555 init1: 317 opt: 332 Z-score: 254.5 bits: 56.5 E(85289): 1.9e-07
Smith-Waterman score: 431; 31.2% identity (51.8% similar) in 369 aa overlap (1-290:256-623)
10 20 30
pF1KE0 MYTVLTGTPPFMASPLSEMYQNIREGHYPE
:::.: : ::: .. :.: :. :::..:
NP_001 ICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTM
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE0 PAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHSPPIFAIPPP
:. : : :..::. .:. :: .::::: ... ::: :::::::: . ::. : : . :
NP_001 PSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSP
290 300 310 320 330 340
100 110 120 130
pF1KE0 LGRIFRKVGQRLLTQCRPPCPF--TPKEASGPGEG-------------GPDPDSMEWDGE
.:.:.. :. . . : ...: : .:.. . : :
NP_001 AKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEE
350 360 370 380 390 400
140 150 160 170 180
pF1KE0 -----SSLSAKEVPCLEGP------IHLVAQGTLQSDLAGPE---GSRRPEV-EAALRHL
.... . .: .:. :.....::: : .. : : : ... : :
NP_001 LQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVL
410 420 430 440 450 460
190 200 210 220
pF1KE0 QLCLDVGPPATQDPLGEQ--QPILWAPKWVDYSSKYGFGYQLLDGG-----RTGRH----
. ::. : : : :: . :. ::::::.:::::::: : .: :
NP_001 RGCLENMPEADCIP-KEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLL
470 480 490 500 510 520
230 240 250
pF1KE0 P-----H-----G-----PATPRRE-----------------------GTLPTPVPPAGP
: : : ::: : : ::. . :
NP_001 PDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRP
530 540 550 560 570 580
260 270 280 290 300 310
pF1KE0 GLCLLRFLASEHALLLLFSNGMVQVSFSGVPAQLVLSGEGEGLQLTLWEQGSPGTSYSLD
: ::..: :..::..::..: ::.: ..... ..
NP_001 RLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLT
590 600 610 620 630 640
320 330
pF1KE0 VPQSHGCAPTTGQHLHHALRMLQSI
NP_001 TLLMSGCSSELKNRMEYALNMLLQRCN
650 660 670
>>NP_006613 (OMIM: 607023) serine/threonine-protein kina (685 aa)
initn: 555 init1: 317 opt: 332 Z-score: 254.4 bits: 56.5 E(85289): 2e-07
Smith-Waterman score: 431; 31.2% identity (51.8% similar) in 369 aa overlap (1-290:270-637)
10 20 30
pF1KE0 MYTVLTGTPPFMASPLSEMYQNIREGHYPE
:::.: : ::: .. :.: :. :::..:
NP_006 ICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTM
240 250 260 270 280 290
40 50 60 70 80 90
pF1KE0 PAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHSPPIFAIPPP
:. : : :..::. .:. :: .::::: ... ::: :::::::: . ::. : : . :
NP_006 PSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSP
300 310 320 330 340 350
100 110 120 130
pF1KE0 LGRIFRKVGQRLLTQCRPPCPF--TPKEASGPGEG-------------GPDPDSMEWDGE
.:.:.. :. . . : ...: : .:.. . : :
NP_006 AKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEE
360 370 380 390 400 410
140 150 160 170 180
pF1KE0 -----SSLSAKEVPCLEGP------IHLVAQGTLQSDLAGPE---GSRRPEV-EAALRHL
.... . .: .:. :.....::: : .. : : : ... : :
NP_006 LQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVL
420 430 440 450 460 470
190 200 210 220
pF1KE0 QLCLDVGPPATQDPLGEQ--QPILWAPKWVDYSSKYGFGYQLLDGG-----RTGRH----
. ::. : : : :: . :. ::::::.:::::::: : .: :
NP_006 RGCLENMPEADCIP-KEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLL
480 490 500 510 520 530
230 240 250
pF1KE0 P-----H-----G-----PATPRRE-----------------------GTLPTPVPPAGP
: : : ::: : : ::. . :
NP_006 PDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRP
540 550 560 570 580 590
260 270 280 290 300 310
pF1KE0 GLCLLRFLASEHALLLLFSNGMVQVSFSGVPAQLVLSGEGEGLQLTLWEQGSPGTSYSLD
: ::..: :..::..::..: ::.: ..... ..
NP_006 RLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLT
600 610 620 630 640 650
320 330
pF1KE0 VPQSHGCAPTTGQHLHHALRMLQSI
NP_006 TLLMSGCSSELKNRMEYALNMLLQRCN
660 670 680
>>NP_005021 (OMIM: 602098) serine/threonine-protein kina (603 aa)
initn: 413 init1: 264 opt: 279 Z-score: 216.7 bits: 49.3 E(85289): 2.5e-05
Smith-Waterman score: 347; 35.7% identity (56.2% similar) in 224 aa overlap (1-222:241-429)
10 20 30
pF1KE0 MYTVLTGTPPFMASPLSEMYQNIREGHYPE
:::.:.: ::: .: :.: : :....:
NP_005 LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSI
220 230 240 250 260 270
40 50 60 70 80
pF1KE0 PAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHS-PPIFAIPP
: :.. : :: ..: .:. ::....::.:.:::.:. : ::: .: . :: :.: :
NP_005 PKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPI-TCLTIPPRFSIAP
280 290 300 310 320
90 100 110 120 130 140
pF1KE0 P-LGRIFRKVGQRLLTQCRPPCPFTPKEASGPGEGGPDPDSMEWDGESSLSAKEVPCLEG
: :: : . : : :.: : .. :: : :
NP_005 SSLDPSNRKPLTVLNKGLENPLPERPREKEEP--------VVRETGEV------VDC---
330 340 350 360 370
150 160 170 180 190 200
pF1KE0 PIHLVAQGTLQSDLAGPEGSRRPEVEAALRHLQLCLDVGPPATQDPLGEQQPILWAPKWV
:: . ::. : . ..:. : .. .:. . ..:: ::.:. :::
NP_005 --HL--SDMLQQ-LHSVNASK-PSERGLVRQEE---------AEDP--ACIPIFWVSKWV
380 390 400 410
210 220 230 240 250 260
pF1KE0 DYSSKYGFGYQLLDGGRTGRHPHGPATPRREGTLPTPVPPAGPGLCLLRFLASEHALLLL
:::.:::.:::: :
NP_005 DYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKK
420 430 440 450 460 470
336 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:38:12 2016 done: Sat Nov 5 04:38:13 2016
Total Scan time: 8.360 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]