Result of FASTA (omim) for
pF1KE0788
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0788, 419 aa
1>>>pF1KE0788 419 - 419 aa - 419 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7841+/-0.000501; mu= -1.5851+/- 0.031
mean_var=609.1155+/-136.056, 0's: 0 Z-trim(120.9): 1233 B-trim: 1978 in 1/55
Lambda= 0.051967
statistics sampled from 34794 (36694) to 34794 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.43), width: 16
Scan time: 10.010
The best scores are: opt bits E(85289)
NP_660186 (OMIM: 603014) dual specificity mitogen- ( 419) 2823 226.8 7.9e-59
NP_001284485 (OMIM: 603014) dual specificity mitog ( 426) 2799 225.0 2.8e-58
NP_001284484 (OMIM: 603014) dual specificity mitog ( 435) 2577 208.4 2.9e-53
XP_006722863 (OMIM: 603014) PREDICTED: dual specif ( 442) 2553 206.6 1e-52
NP_003001 (OMIM: 601335) dual specificity mitogen- ( 399) 995 89.7 1.4e-17
NP_001268364 (OMIM: 601335) dual specificity mitog ( 410) 995 89.7 1.4e-17
XP_005256810 (OMIM: 601335) PREDICTED: dual specif ( 281) 913 83.3 8.3e-16
NP_002749 (OMIM: 601254) dual specificity mitogen- ( 334) 912 83.4 9.5e-16
XP_011523328 (OMIM: 601254) PREDICTED: dual specif ( 337) 912 83.4 9.6e-16
XP_011523327 (OMIM: 601254) PREDICTED: dual specif ( 345) 912 83.4 9.7e-16
NP_002747 (OMIM: 602315) dual specificity mitogen- ( 318) 874 80.5 6.7e-15
XP_011522261 (OMIM: 602315) PREDICTED: dual specif ( 318) 874 80.5 6.7e-15
XP_016880348 (OMIM: 602315) PREDICTED: dual specif ( 318) 874 80.5 6.7e-15
XP_016880347 (OMIM: 602315) PREDICTED: dual specif ( 318) 874 80.5 6.7e-15
XP_005256780 (OMIM: 602315) PREDICTED: dual specif ( 318) 874 80.5 6.7e-15
NP_001303261 (OMIM: 602315) dual specificity mitog ( 318) 874 80.5 6.7e-15
XP_016880346 (OMIM: 602315) PREDICTED: dual specif ( 343) 874 80.5 7e-15
NP_659731 (OMIM: 602315) dual specificity mitogen- ( 347) 874 80.6 7e-15
NP_001317379 (OMIM: 601254) dual specificity mitog ( 278) 865 79.7 1e-14
XP_005257573 (OMIM: 601254) PREDICTED: dual specif ( 278) 865 79.7 1e-14
XP_011523329 (OMIM: 601254) PREDICTED: dual specif ( 278) 865 79.7 1e-14
XP_006722038 (OMIM: 601254) PREDICTED: dual specif ( 278) 865 79.7 1e-14
XP_005256812 (OMIM: 601335) PREDICTED: dual specif ( 253) 844 78.1 2.8e-14
XP_011522279 (OMIM: 601335) PREDICTED: dual specif ( 253) 844 78.1 2.8e-14
XP_011522278 (OMIM: 601335) PREDICTED: dual specif ( 319) 764 72.2 2e-12
XP_011522260 (OMIM: 602315) PREDICTED: dual specif ( 298) 682 66.1 1.4e-10
NP_001193733 (OMIM: 602520) dual specificity mitog ( 412) 618 61.5 4.6e-09
NP_660143 (OMIM: 602520) dual specificity mitogen- ( 448) 618 61.5 4.8e-09
NP_002746 (OMIM: 163950,176872,615279) dual specif ( 393) 590 59.3 1.9e-08
XP_011520085 (OMIM: 163950,176872,615279) PREDICTE ( 371) 589 59.2 2e-08
NP_109587 (OMIM: 601263,615280) dual specificity m ( 400) 579 58.5 3.4e-08
XP_016882478 (OMIM: 601263,615280) PREDICTED: dual ( 512) 579 58.7 3.9e-08
XP_011508798 (OMIM: 602255) PREDICTED: serine/thre ( 334) 545 55.9 1.8e-07
XP_016858657 (OMIM: 602255) PREDICTED: serine/thre ( 365) 545 55.9 1.9e-07
XP_016858658 (OMIM: 602255) PREDICTED: serine/thre ( 365) 545 55.9 1.9e-07
XP_011508795 (OMIM: 602255) PREDICTED: serine/thre ( 376) 540 55.6 2.5e-07
NP_006365 (OMIM: 602255) serine/threonine-protein ( 426) 540 55.7 2.7e-07
NP_001258906 (OMIM: 602255) serine/threonine-prote ( 426) 540 55.7 2.7e-07
NP_001258907 (OMIM: 602255) serine/threonine-prote ( 426) 540 55.7 2.7e-07
NP_001027467 (OMIM: 604984) serine/threonine-prote ( 431) 522 54.3 6.9e-07
NP_003567 (OMIM: 604984) serine/threonine-protein ( 443) 517 54.0 9e-07
XP_016876284 (OMIM: 604984) PREDICTED: serine/thre ( 474) 514 53.8 1.1e-06
XP_016876283 (OMIM: 604984) PREDICTED: serine/thre ( 517) 512 53.7 1.3e-06
NP_057626 (OMIM: 300547) serine/threonine-protein ( 416) 502 52.8 1.9e-06
XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456) 501 52.8 2.1e-06
NP_006272 (OMIM: 605030) serine/threonine-protein ( 491) 501 52.8 2.2e-06
NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519) 501 52.9 2.2e-06
XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522) 501 52.9 2.3e-06
XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524) 501 52.9 2.3e-06
XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576) 501 52.9 2.4e-06
>>NP_660186 (OMIM: 603014) dual specificity mitogen-acti (419 aa)
initn: 2823 init1: 2823 opt: 2823 Z-score: 1177.1 bits: 226.8 E(85289): 7.9e-59
Smith-Waterman score: 2823; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419)
10 20 30 40 50 60
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
310 320 330 340 350 360
370 380 390 400 410
pF1KE0 LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
370 380 390 400 410
>>NP_001284485 (OMIM: 603014) dual specificity mitogen-a (426 aa)
initn: 2088 init1: 2088 opt: 2799 Z-score: 1167.3 bits: 225.0 E(85289): 2.8e-58
Smith-Waterman score: 2799; 98.4% identity (98.4% similar) in 426 aa overlap (1-419:1-426)
10 20 30 40 50 60
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
250 260 270 280 290 300
310 320 330 340 350
pF1KE0 IRADVWSLGISL-------VELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDF
:::::::::::: :::::::::::::::::::::::::::::::::::::::::
NP_001 IRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDF
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE0 QSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQP
370 380 390 400 410 420
pF1KE0 HLPFFR
::::::
NP_001 HLPFFR
>>NP_001284484 (OMIM: 603014) dual specificity mitogen-a (435 aa)
initn: 2565 init1: 2565 opt: 2577 Z-score: 1077.3 bits: 208.4 E(85289): 2.9e-53
Smith-Waterman score: 2776; 96.1% identity (96.3% similar) in 435 aa overlap (1-419:1-435)
10 20 30 40
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRP----------------TLQ
::::::::::::::::::::::::::::::::::::::::: .::
NP_001 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQ
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP
370 380 390 400 410 420
410
pF1KE0 RTSGVLSQPHLPFFR
:::::::::::::::
NP_001 RTSGVLSQPHLPFFR
430
>>XP_006722863 (OMIM: 603014) PREDICTED: dual specificit (442 aa)
initn: 1830 init1: 1830 opt: 2553 Z-score: 1067.5 bits: 206.6 E(85289): 1e-52
Smith-Waterman score: 2752; 94.6% identity (94.8% similar) in 442 aa overlap (1-419:1-442)
10 20 30 40
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRP----------------TLQ
::::::::::::::::::::::::::::::::::::::::: .::
XP_006 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQ
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
250 260 270 280 290 300
290 300 310 320 330
pF1KE0 APERIDPPDPTKPDYDIRADVWSLGISL-------VELATGQFPYKNCKTDFEVLTKVLQ
:::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_006 APERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQ
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDV
370 380 390 400 410 420
400 410
pF1KE0 MAKTESPRTSGVLSQPHLPFFR
::::::::::::::::::::::
XP_006 MAKTESPRTSGVLSQPHLPFFR
430 440
>>NP_003001 (OMIM: 601335) dual specificity mitogen-acti (399 aa)
initn: 1005 init1: 390 opt: 995 Z-score: 436.6 bits: 89.7 E(85289): 1.4e-17
Smith-Waterman score: 1000; 44.6% identity (70.9% similar) in 392 aa overlap (39-407:4-394)
10 20 30 40 50 60
pF1KE0 KLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQ--HPT
: :. .. .:: .:. .:: ::.
NP_003 MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPA
10 20 30
70 80 90 100 110
pF1KE0 PPARP--RHMLGL----P----STLFT----PRSMESIEIDQKLQEIMKQTGYLTIGG-Q
. :. : : : .. :: : .... .:.. . ....: : :. :
NP_003 VSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQ
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE0 RYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVL
... .::..:::.: :. :.: :: . .:...:::..: . ...:.:..:::::::.
NP_003 HWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVM
100 110 120 130 140 150
180 190 200 210 220
pF1KE0 KSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKR----MQGPIPERILGKMTVAIV
.: ::::::: .:... . : .: ::::.: .:. : .. :::.::::.:.: :
NP_003 RSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE0 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPE
::: .:::. .::::.::::::::. :.::::::::::.:::: ::::.::: :::::
NP_003 KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPE
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE0 RIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPG--
:::: . .. ::.:.:::::::.: :::::.::: . .. :. ::.:.. .:: : .
NP_003 RIDP-SASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSE
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE0 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR
. :: .: .::. :::::. :::::..::.: :: :: :.:: . .. . .
NP_003 EREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATP
340 350 360 370 380 390
410
pF1KE0 TSGVLSQPHLPFFR
.:
NP_003 SSPMYVD
>>NP_001268364 (OMIM: 601335) dual specificity mitogen-a (410 aa)
initn: 722 init1: 390 opt: 995 Z-score: 436.5 bits: 89.7 E(85289): 1.4e-17
Smith-Waterman score: 995; 48.3% identity (75.8% similar) in 331 aa overlap (84-407:76-405)
60 70 80 90 100 110
pF1KE0 RSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGG-QR
: .... .:.. . ....: : :. :.
NP_001 EKAQSKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQH
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 YQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLK
.. .::..:::.: :. :.: :: . .:...:::..: . ...:.:..:::::::..
NP_001 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR
110 120 130 140 150 160
180 190 200 210 220
pF1KE0 SHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKR----MQGPIPERILGKMTVAIVK
: ::::::: .:... . : .: ::::.: .:. : .. :::.::::.:.: ::
NP_001 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE0 ALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPER
:: .:::. .::::.::::::::. :.::::::::::.:::: ::::.::: ::::::
NP_001 ALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPER
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 IDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPG--H
::: . .. ::.:.:::::::.: :::::.::: . .. :. ::.:.. .:: : . .
NP_001 IDP-SASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEE
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRT
:: .: .::. :::::. :::::..::.: :: :: :.:: . .. . . .
NP_001 REFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPS
350 360 370 380 390 400
410
pF1KE0 SGVLSQPHLPFFR
:
NP_001 SPMYVD
410
>>XP_005256810 (OMIM: 601335) PREDICTED: dual specificit (281 aa)
initn: 896 init1: 390 opt: 913 Z-score: 404.8 bits: 83.3 E(85289): 8.3e-16
Smith-Waterman score: 913; 52.0% identity (76.9% similar) in 277 aa overlap (137-407:1-276)
110 120 130 140 150 160
pF1KE0 TIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMD
: . .:...:::..: . ...:.:..:::
XP_005 MVHKPSGQIMAVKRIRSTVDEKEQKQLLMD
10 20 30
170 180 190 200 210 220
pF1KE0 LDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKR----MQGPIPERILGKM
::::..: ::::::: .:... . : .: ::::.: .:. : .. :::.::::.
XP_005 LDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE0 TVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAA
:.: :::: .:::. .::::.::::::::. :.::::::::::.:::: ::::.:::
XP_005 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE0 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL
::::::::: . .. ::.:.:::::::.: :::::.::: . .. :. ::.:.. .::
XP_005 YMAPERIDP-SASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQ
160 170 180 190 200
350 360 370 380 390 400
pF1KE0 LPG--HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK
: . . :: .: .::. :::::. :::::..::.: :: :: :.:: . .. .
XP_005 LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQ
210 220 230 240 250 260
410
pF1KE0 TESPRTSGVLSQPHLPFFR
. .:
XP_005 MPATPSSPMYVD
270 280
>>NP_002749 (OMIM: 601254) dual specificity mitogen-acti (334 aa)
initn: 769 init1: 359 opt: 912 Z-score: 403.7 bits: 83.4 E(85289): 9.5e-16
Smith-Waterman score: 917; 42.9% identity (72.5% similar) in 345 aa overlap (58-398:2-332)
30 40 50 60 70 80
pF1KE0 IDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPAR-PRHMLGLPSTLFTPRS
:.:. .. .: . :.. . :.: ::
NP_002 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPR
10 20 30
90 100 110 120 130 140
pF1KE0 MESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVI
..:.: . ..::.: .... .::: . :.: :. : : ::: .:...
NP_002 ----DLDSK--------ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM
40 50 60 70
150 160 170 180 190 200
pF1KE0 AVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKL
:::..: . :..:.::.:::::. ... :::. : .:... . ::.: :::: : .:.
NP_002 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKF
80 90 100 110 120 130
210 220 230 240 250 260
pF1KE0 KKRM--QGP-IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFG
:.. .: ::: ::::..:.::::: .:. : .::::::::::.:.. ::.:.::::
NP_002 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE0 ISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYK
::: :::: ::: .::: :::::::.: . .. :....:.:::::...::: .:::
NP_002 ISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIELAILRFPYD
200 210 220 230 240 250
330 340 350 360 370 380
pF1KE0 NCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY
. : :. : .:..: : ::. ::..: .:...:: :. ..:: : .:..: :. .
NP_002 SWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLH
260 270 280 290 300 310
390 400 410
pF1KE0 ETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
:. .::::. : ..
NP_002 ESKGTDVASFVKLILGD
320 330
>>XP_011523328 (OMIM: 601254) PREDICTED: dual specificit (337 aa)
initn: 921 init1: 359 opt: 912 Z-score: 403.7 bits: 83.4 E(85289): 9.6e-16
Smith-Waterman score: 912; 46.6% identity (76.4% similar) in 296 aa overlap (106-398:42-335)
80 90 100 110 120 130
pF1KE0 GLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVW
..::.: .... .::: . :.: :. : :
XP_011 RNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVE
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE0 KMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIA
::: .:...:::..: . :..:.::.:::::. ... :::. : .:... . ::.:
XP_011 KMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWIC
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE0 MELMGTCAEKLKKRM--QGP-IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLD
:::: : .:. :.. .: ::: ::::..:.::::: .:. : .::::::::::.:..
XP_011 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN
140 150 160 170 180 190
260 270 280 290 300 310
pF1KE0 ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISL
::.:.::::::: :::: ::: .::: :::::::.: . .. :....:.:::::..
XP_011 ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITM
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE0 VELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYN
.::: .::: . : :. : .:..: : ::. ::..: .:...:: :. ..:: :
XP_011 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYP
260 270 280 290 300
380 390 400 410
pF1KE0 KLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
.:..: :. .:. .::::. : ..
XP_011 ELMQHPFFTLHESKGTDVASFVKLILGD
310 320 330
>>XP_011523327 (OMIM: 601254) PREDICTED: dual specificit (345 aa)
initn: 769 init1: 359 opt: 912 Z-score: 403.6 bits: 83.4 E(85289): 9.7e-16
Smith-Waterman score: 912; 46.6% identity (76.4% similar) in 296 aa overlap (106-398:50-343)
80 90 100 110 120 130
pF1KE0 GLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVW
..::.: .... .::: . :.: :. : :
XP_011 RNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVE
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE0 KMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIA
::: .:...:::..: . :..:.::.:::::. ... :::. : .:... . ::.:
XP_011 KMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWIC
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE0 MELMGTCAEKLKKRM--QGP-IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLD
:::: : .:. :.. .: ::: ::::..:.::::: .:. : .::::::::::.:..
XP_011 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN
140 150 160 170 180 190
260 270 280 290 300 310
pF1KE0 ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISL
::.:.::::::: :::: ::: .::: :::::::.: . .. :....:.:::::..
XP_011 ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITM
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE0 VELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYN
.::: .::: . : :. : .:..: : ::. ::..: .:...:: :. ..:: :
XP_011 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYP
260 270 280 290 300 310
380 390 400 410
pF1KE0 KLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
.:..: :. .:. .::::. : ..
XP_011 ELMQHPFFTLHESKGTDVASFVKLILGD
320 330 340
419 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 03:09:29 2016 done: Sat Nov 5 03:09:31 2016
Total Scan time: 10.010 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]