Result of FASTA (omim) for
pF1KE0729
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0729, 309 aa
1>>>pF1KE0729 309 - 309 aa - 309 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3692+/-0.00059; mu= -4.7704+/- 0.035
mean_var=511.5118+/-121.104, 0's: 0 Z-trim(116.5): 1992 B-trim: 423 in 1/48
Lambda= 0.056708
statistics sampled from 25010 (27679) to 25010 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.325), width: 16
Scan time: 7.050
The best scores are: opt bits E(85289)
NP_001015878 (OMIM: 243060,603495) aurora kinase C ( 309) 2070 184.3 2.6e-46
NP_001015879 (OMIM: 243060,603495) aurora kinase C ( 290) 1946 174.2 2.9e-43
NP_003151 (OMIM: 243060,603495) aurora kinase C is ( 275) 1855 166.7 4.8e-41
NP_001271455 (OMIM: 604970) aurora kinase B isofor ( 345) 1596 145.6 1.3e-34
NP_004208 (OMIM: 604970) aurora kinase B isoform 1 ( 344) 1594 145.5 1.5e-34
NP_001300879 (OMIM: 604970) aurora kinase B isofor ( 344) 1594 145.5 1.5e-34
NP_001300881 (OMIM: 604970) aurora kinase B isofor ( 304) 1584 144.6 2.4e-34
NP_001300880 (OMIM: 604970) aurora kinase B isofor ( 303) 1582 144.4 2.7e-34
XP_016880796 (OMIM: 604970) PREDICTED: aurora kina ( 303) 1582 144.4 2.7e-34
XP_011522374 (OMIM: 604970) PREDICTED: aurora kina ( 303) 1582 144.4 2.7e-34
NP_001243763 (OMIM: 604970) aurora kinase B isofor ( 303) 1582 144.4 2.7e-34
NP_003591 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1316 122.8 1.1e-27
XP_016883524 (OMIM: 603072) PREDICTED: aurora kina ( 403) 1316 122.8 1.1e-27
NP_001310232 (OMIM: 603072) aurora kinase A [Homo ( 403) 1316 122.8 1.1e-27
NP_940837 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1316 122.8 1.1e-27
NP_940836 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1316 122.8 1.1e-27
NP_001310233 (OMIM: 603072) aurora kinase A [Homo ( 403) 1316 122.8 1.1e-27
NP_940839 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1316 122.8 1.1e-27
NP_940835 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1316 122.8 1.1e-27
NP_001310234 (OMIM: 603072) aurora kinase A [Homo ( 403) 1316 122.8 1.1e-27
NP_940838 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1316 122.8 1.1e-27
XP_016883523 (OMIM: 603072) PREDICTED: aurora kina ( 437) 1316 122.9 1.2e-27
XP_016880797 (OMIM: 604970) PREDICTED: aurora kina ( 271) 1204 113.4 5.2e-25
NP_001300882 (OMIM: 604970) aurora kinase B isofor ( 312) 1204 113.5 5.6e-25
XP_011522372 (OMIM: 604970) PREDICTED: aurora kina ( 312) 1204 113.5 5.6e-25
XP_016880798 (OMIM: 604970) PREDICTED: aurora kina ( 192) 951 92.5 7.3e-19
XP_016880799 (OMIM: 604970) PREDICTED: aurora kina ( 192) 951 92.5 7.3e-19
XP_016880800 (OMIM: 604970) PREDICTED: aurora kina ( 192) 951 92.5 7.3e-19
NP_001300883 (OMIM: 604970) aurora kinase B isofor ( 192) 951 92.5 7.3e-19
NP_001300884 (OMIM: 604970) aurora kinase B isofor ( 176) 941 91.6 1.2e-18
XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660) 618 66.1 2.2e-10
XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213) 618 66.5 3.1e-10
XP_005271541 (OMIM: 614776) PREDICTED: serine/thre (1261) 618 66.5 3.2e-10
NP_001268678 (OMIM: 614776) serine/threonine-prote (1261) 618 66.5 3.2e-10
XP_011541024 (OMIM: 614776) PREDICTED: serine/thre (1309) 618 66.5 3.2e-10
XP_005271539 (OMIM: 614776) PREDICTED: serine/thre (1321) 618 66.5 3.3e-10
NP_079440 (OMIM: 614776) serine/threonine-protein (1321) 618 66.5 3.3e-10
XP_005271538 (OMIM: 614776) PREDICTED: serine/thre (1369) 618 66.6 3.3e-10
XP_011541023 (OMIM: 614776) PREDICTED: serine/thre (1369) 618 66.6 3.3e-10
XP_005262758 (OMIM: 605031,616171) PREDICTED: seri ( 936) 609 65.6 4.5e-10
XP_016863152 (OMIM: 605031,616171) PREDICTED: seri ( 937) 609 65.6 4.5e-10
NP_055079 (OMIM: 605031,616171) serine/threonine-p ( 970) 609 65.6 4.6e-10
XP_016863151 (OMIM: 605031,616171) PREDICTED: seri ( 971) 609 65.6 4.6e-10
XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 600 64.6 6.2e-10
XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 600 64.6 6.5e-10
NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 600 64.6 6.5e-10
XP_016876781 (OMIM: 602678) PREDICTED: MAP/microtu ( 722) 600 64.7 6.5e-10
XP_016876780 (OMIM: 602678) PREDICTED: MAP/microtu ( 728) 600 64.7 6.6e-10
NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 600 64.7 6.6e-10
XP_005267699 (OMIM: 602678) PREDICTED: MAP/microtu ( 737) 600 64.7 6.6e-10
>>NP_001015878 (OMIM: 243060,603495) aurora kinase C iso (309 aa)
initn: 2070 init1: 2070 opt: 2070 Z-score: 952.4 bits: 184.3 E(85289): 2.6e-46
Smith-Waterman score: 2070; 100.0% identity (100.0% similar) in 309 aa overlap (1-309:1-309)
10 20 30 40 50 60
pF1KE0 MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
250 260 270 280 290 300
pF1KE0 LPPCAQMAS
:::::::::
NP_001 LPPCAQMAS
>>NP_001015879 (OMIM: 243060,603495) aurora kinase C iso (290 aa)
initn: 1946 init1: 1946 opt: 1946 Z-score: 897.8 bits: 174.2 E(85289): 2.9e-43
Smith-Waterman score: 1946; 99.7% identity (100.0% similar) in 290 aa overlap (20-309:1-290)
10 20 30 40 50 60
pF1KE0 MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
.::::::::::::::::::::::::::::::::::::::::
NP_001 MATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
10 20 30 40
70 80 90 100 110 120
pF1KE0 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE0 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
230 240 250 260 270 280
pF1KE0 LPPCAQMAS
:::::::::
NP_001 LPPCAQMAS
290
>>NP_003151 (OMIM: 243060,603495) aurora kinase C isofor (275 aa)
initn: 1855 init1: 1855 opt: 1855 Z-score: 857.8 bits: 166.7 E(85289): 4.8e-41
Smith-Waterman score: 1855; 100.0% identity (100.0% similar) in 275 aa overlap (35-309:1-275)
10 20 30 40 50 60
pF1KE0 RAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKE
::::::::::::::::::::::::::::::
NP_003 MRRLTVDDFEIGRPLGKGKFGNVYLARLKE
10 20 30
70 80 90 100 110 120
pF1KE0 SHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE0 RGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIAD
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE0 FGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASH
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE0 SETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPC
220 230 240 250 260 270
pF1KE0 AQMAS
:::::
NP_003 AQMAS
>>NP_001271455 (OMIM: 604970) aurora kinase B isoform 3 (345 aa)
initn: 1563 init1: 1563 opt: 1596 Z-score: 742.4 bits: 145.6 E(85289): 1.3e-34
Smith-Waterman score: 1596; 76.8% identity (90.8% similar) in 306 aa overlap (3-305:35-340)
10 20
pF1KE0 MSSPRAVVQLGKA--QP-AGEELATANQTAQQ
.: :.: .... :: :. . ....
NP_001 ENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGT
10 20 30 40 50 60
30 40 50 60 70 80
pF1KE0 PSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLR
:. . :..:.::::::::::::::::::::: :.:::::::::::::::::::.:::::
NP_001 PDILTRRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLR
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE0 REIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEE
:::::::::.:::::::::::.: ::.::::::::::::::::::: .::::::::.::
NP_001 REIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEE
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE0 LADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPE
::::: ::: ::::::::::::::::..::.::::::::::.::::::::::::::::::
NP_001 LADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPE
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE0 MIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDL
::::: ..:::::::::::::::::: ::::::::.::::::.:::..:: :.:.::.::
NP_001 MIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDL
250 260 270 280 290 300
270 280 290 300
pF1KE0 ISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
::.:::..: :::::::. ::::.:.::::::: :
NP_001 ISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
310 320 330 340
>>NP_004208 (OMIM: 604970) aurora kinase B isoform 1 [Ho (344 aa)
initn: 1580 init1: 1580 opt: 1594 Z-score: 741.5 bits: 145.5 E(85289): 1.5e-34
Smith-Waterman score: 1594; 77.0% identity (90.6% similar) in 309 aa overlap (3-305:35-339)
10 20 30
pF1KE0 MSSPRAVVQLGKA--QPAGEELATANQTAQQP
.: :.: .... ::. :. .: ...
NP_004 ENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPT----AAPGQKVMEN
10 20 30 40 50 60
40 50 60 70 80
pF1KE0 SS--PAM--RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEH
:: : . :..:.::::::::::::::::::::: :.:::::::::::::::::::.::
NP_004 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE0 QLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATI
::::::::::::.:::::::::::.: ::.::::::::::::::::::: .::::::::
NP_004 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE0 IEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYL
.::::::: ::: ::::::::::::::::..::.::::::::::.:::::::::::::::
NP_004 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGA
:::::::: ..:::::::::::::::::: ::::::::.::::::.:::..:: :.:.::
NP_004 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
250 260 270 280 290 300
270 280 290 300
pF1KE0 RDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
.::::.:::..: :::::::. ::::.:.::::::: :
NP_004 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
310 320 330 340
>>NP_001300879 (OMIM: 604970) aurora kinase B isoform 1 (344 aa)
initn: 1580 init1: 1580 opt: 1594 Z-score: 741.5 bits: 145.5 E(85289): 1.5e-34
Smith-Waterman score: 1594; 77.0% identity (90.6% similar) in 309 aa overlap (3-305:35-339)
10 20 30
pF1KE0 MSSPRAVVQLGKA--QPAGEELATANQTAQQP
.: :.: .... ::. :. .: ...
NP_001 ENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPT----AAPGQKVMEN
10 20 30 40 50 60
40 50 60 70 80
pF1KE0 SS--PAM--RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEH
:: : . :..:.::::::::::::::::::::: :.:::::::::::::::::::.::
NP_001 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE0 QLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATI
::::::::::::.:::::::::::.: ::.::::::::::::::::::: .::::::::
NP_001 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE0 IEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYL
.::::::: ::: ::::::::::::::::..::.::::::::::.:::::::::::::::
NP_001 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGA
:::::::: ..:::::::::::::::::: ::::::::.::::::.:::..:: :.:.::
NP_001 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
250 260 270 280 290 300
270 280 290 300
pF1KE0 RDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
.::::.:::..: :::::::. ::::.:.::::::: :
NP_001 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
310 320 330 340
>>NP_001300881 (OMIM: 604970) aurora kinase B isoform 4 (304 aa)
initn: 1563 init1: 1563 opt: 1584 Z-score: 737.6 bits: 144.6 E(85289): 2.4e-34
Smith-Waterman score: 1584; 78.1% identity (90.7% similar) in 301 aa overlap (5-305:3-299)
10 20 30 40 50 60
pF1KE0 MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
:. :: : :. . . ... : :. . :..:.::::::::::::::::::::
NP_001 MSRSNVQ-PTAAPGQKVMENSSGT---PDILTRRHFTIDDFEIGRPLGKGKFGNVYLA
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
: :.:::::::::::::::::::.::::::::::::::.:::::::::::.: ::.::::
NP_001 REKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
::::::::::::::: .::::::::.::::::: ::: ::::::::::::::::..::.
NP_001 EYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
::::::::::.::::::::::::::::::::::: ..:::::::::::::::::: ::::
NP_001 KIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE0 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
::::.::::::.:::..:: :.:.::.::::.:::..: :::::::. ::::.:.::::
NP_001 SASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRV
240 250 260 270 280 290
pF1KE0 LPPCAQMAS
::: :
NP_001 LPPSALQSVA
300
>>NP_001300880 (OMIM: 604970) aurora kinase B isoform 2 (303 aa)
initn: 1580 init1: 1580 opt: 1582 Z-score: 736.7 bits: 144.4 E(85289): 2.7e-34
Smith-Waterman score: 1582; 80.6% identity (92.7% similar) in 289 aa overlap (21-305:10-298)
10 20 30 40 50
pF1KE0 MSSPRAVVQLGKAQPAGEELATANQTAQQPSS--PAM--RRLTVDDFEIGRPLGKGKFGN
:. .: ... :: : . :..:.::::::::::::::::
NP_001 MSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGN
10 20 30 40
60 70 80 90 100 110
pF1KE0 VYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRV
::::: :.:::::::::::::::::::.::::::::::::::.:::::::::::.: ::.
NP_001 VYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 YLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF
::::::::::::::::::: .::::::::.::::::: ::: ::::::::::::::::.
NP_001 YLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE0 RGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGY
.::.::::::::::.::::::::::::::::::::::: ..::::::::::::::::::
NP_001 KGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGN
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE0 PPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH
::::::::.::::::.:::..:: :.:.::.::::.:::..: :::::::. ::::.:.
NP_001 PPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN
230 240 250 260 270 280
300
pF1KE0 SRRVLPPCAQMAS
::::::: :
NP_001 SRRVLPPSALQSVA
290 300
>>XP_016880796 (OMIM: 604970) PREDICTED: aurora kinase B (303 aa)
initn: 1580 init1: 1580 opt: 1582 Z-score: 736.7 bits: 144.4 E(85289): 2.7e-34
Smith-Waterman score: 1582; 80.6% identity (92.7% similar) in 289 aa overlap (21-305:10-298)
10 20 30 40 50
pF1KE0 MSSPRAVVQLGKAQPAGEELATANQTAQQPSS--PAM--RRLTVDDFEIGRPLGKGKFGN
:. .: ... :: : . :..:.::::::::::::::::
XP_016 MSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGN
10 20 30 40
60 70 80 90 100 110
pF1KE0 VYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRV
::::: :.:::::::::::::::::::.::::::::::::::.:::::::::::.: ::.
XP_016 VYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 YLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF
::::::::::::::::::: .::::::::.::::::: ::: ::::::::::::::::.
XP_016 YLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE0 RGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGY
.::.::::::::::.::::::::::::::::::::::: ..::::::::::::::::::
XP_016 KGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGN
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE0 PPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH
::::::::.::::::.:::..:: :.:.::.::::.:::..: :::::::. ::::.:.
XP_016 PPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN
230 240 250 260 270 280
300
pF1KE0 SRRVLPPCAQMAS
::::::: :
XP_016 SRRVLPPSALQSVA
290 300
>>XP_011522374 (OMIM: 604970) PREDICTED: aurora kinase B (303 aa)
initn: 1580 init1: 1580 opt: 1582 Z-score: 736.7 bits: 144.4 E(85289): 2.7e-34
Smith-Waterman score: 1582; 80.6% identity (92.7% similar) in 289 aa overlap (21-305:10-298)
10 20 30 40 50
pF1KE0 MSSPRAVVQLGKAQPAGEELATANQTAQQPSS--PAM--RRLTVDDFEIGRPLGKGKFGN
:. .: ... :: : . :..:.::::::::::::::::
XP_011 MSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGN
10 20 30 40
60 70 80 90 100 110
pF1KE0 VYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRV
::::: :.:::::::::::::::::::.::::::::::::::.:::::::::::.: ::.
XP_011 VYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 YLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF
::::::::::::::::::: .::::::::.::::::: ::: ::::::::::::::::.
XP_011 YLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE0 RGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGY
.::.::::::::::.::::::::::::::::::::::: ..::::::::::::::::::
XP_011 KGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGN
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE0 PPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH
::::::::.::::::.:::..:: :.:.::.::::.:::..: :::::::. ::::.:.
XP_011 PPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN
230 240 250 260 270 280
300
pF1KE0 SRRVLPPCAQMAS
::::::: :
XP_011 SRRVLPPSALQSVA
290 300
309 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 03:00:28 2016 done: Sat Nov 5 03:00:29 2016
Total Scan time: 7.050 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]