Result of FASTA (omim) for
pF1KE0700
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0700, 1690 aa
1>>>pF1KE0700 1690 - 1690 aa - 1690 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1001+/-0.000435; mu= 17.0068+/- 0.027
mean_var=154.9021+/-31.999, 0's: 0 Z-trim(115.3): 294 B-trim: 866 in 1/55
Lambda= 0.103049
statistics sampled from 25299 (25610) to 25299 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.3), width: 16
Scan time: 20.910
The best scores are: opt bits E(85289)
NP_004312 (OMIM: 201300,601255,610357,614213,61425 (1690) 11204 1679.3 0
XP_005247084 (OMIM: 201300,601255,610357,614213,61 (1698) 11178 1675.5 0
NP_001317219 (OMIM: 201300,601255,610357,614213,61 (1724) 8657 1300.7 0
NP_001307634 (OMIM: 201300,601255,610357,614213,61 (1699) 8656 1300.5 0
XP_016859877 (OMIM: 201300,601255,610357,614213,61 (1732) 8631 1296.8 0
XP_016859879 (OMIM: 201300,601255,610357,614213,61 (1699) 8207 1233.8 0
XP_006712668 (OMIM: 201300,601255,610357,614213,61 (1782) 5692 859.9 0
NP_001230937 (OMIM: 201300,601255,610357,614213,61 (1791) 5692 859.9 0
XP_016859875 (OMIM: 201300,601255,610357,614213,61 (1816) 5692 859.9 0
XP_016859876 (OMIM: 201300,601255,610357,614213,61 (1733) 5660 855.1 0
NP_001317218 (OMIM: 201300,601255,610357,614213,61 (1708) 5659 855.0 0
XP_005247081 (OMIM: 201300,601255,610357,614213,61 (1791) 5603 846.7 0
NP_055889 (OMIM: 118210,171300,256700,605995) kine (1770) 4544 689.2 8.6e-197
NP_904325 (OMIM: 118210,171300,256700,605995) kine (1153) 3615 550.9 2.4e-155
XP_011509669 (OMIM: 201300,601255,610357,614213,61 (1465) 3486 531.8 1.7e-149
XP_011509668 (OMIM: 201300,601255,610357,614213,61 (1465) 3486 531.8 1.7e-149
XP_005256481 (OMIM: 603060,611302) PREDICTED: kine (1103) 3279 501.0 2.5e-140
NP_006603 (OMIM: 603060,611302) kinesin-like prote (1103) 3279 501.0 2.5e-140
XP_016859874 (OMIM: 201300,601255,610357,614213,61 (1824) 3056 468.0 3.4e-130
XP_016859873 (OMIM: 201300,601255,610357,614213,61 (1825) 3056 468.0 3.4e-130
XP_016859872 (OMIM: 201300,601255,610357,614213,61 (1825) 3056 468.0 3.4e-130
XP_016859880 (OMIM: 201300,601255,610357,614213,61 (1799) 3055 467.8 3.8e-130
XP_011509666 (OMIM: 201300,601255,610357,614213,61 (1800) 3055 467.8 3.8e-130
XP_005247079 (OMIM: 201300,601255,610357,614213,61 (1800) 3055 467.8 3.8e-130
NP_001099038 (OMIM: 605433) kinesin-like protein K (1749) 1478 233.4 1.4e-59
NP_001099037 (OMIM: 605433) kinesin-like protein K (1757) 1478 233.4 1.4e-59
XP_016866681 (OMIM: 605433) PREDICTED: kinesin-lik (1762) 1478 233.4 1.4e-59
NP_001099036 (OMIM: 605433) kinesin-like protein K (1770) 1478 233.4 1.4e-59
XP_016866679 (OMIM: 605433) PREDICTED: kinesin-lik (1784) 1478 233.4 1.4e-59
XP_016866678 (OMIM: 605433) PREDICTED: kinesin-lik (1792) 1478 233.4 1.4e-59
XP_016866677 (OMIM: 605433) PREDICTED: kinesin-lik (1797) 1478 233.4 1.4e-59
NP_071396 (OMIM: 605433) kinesin-like protein KIF1 (1805) 1478 233.4 1.4e-59
XP_016868746 (OMIM: 607350) PREDICTED: kinesin-lik (1490) 1451 229.3 2e-58
XP_005273515 (OMIM: 607350) PREDICTED: kinesin-lik (1805) 1451 229.4 2.3e-58
XP_011542760 (OMIM: 607350) PREDICTED: kinesin-lik (1826) 1451 229.4 2.3e-58
NP_056069 (OMIM: 607350) kinesin-like protein KIF1 (1826) 1451 229.4 2.3e-58
XP_011542759 (OMIM: 607350) PREDICTED: kinesin-lik (1847) 1451 229.4 2.3e-58
XP_016866680 (OMIM: 605433) PREDICTED: kinesin-lik (1771) 1341 213.0 1.9e-53
XP_011542761 (OMIM: 607350) PREDICTED: kinesin-lik (1783) 1315 209.2 2.8e-52
XP_011542763 (OMIM: 607350) PREDICTED: kinesin-lik (1783) 1315 209.2 2.8e-52
XP_011542762 (OMIM: 607350) PREDICTED: kinesin-lik (1783) 1315 209.2 2.8e-52
XP_016858496 (OMIM: 611279,616258) PREDICTED: kine (1459) 1187 190.1 1.3e-46
XP_011508537 (OMIM: 611279,616258) PREDICTED: kine (1524) 1187 190.1 1.3e-46
XP_016858495 (OMIM: 611279,616258) PREDICTED: kine (1605) 1187 190.1 1.4e-46
XP_011508535 (OMIM: 611279,616258) PREDICTED: kine (1620) 1187 190.1 1.4e-46
XP_011508533 (OMIM: 611279,616258) PREDICTED: kine (1648) 1187 190.1 1.4e-46
XP_016858494 (OMIM: 611279,616258) PREDICTED: kine (1648) 1187 190.1 1.4e-46
XP_011508534 (OMIM: 611279,616258) PREDICTED: kine (1648) 1187 190.1 1.4e-46
NP_055690 (OMIM: 611279,616258) kinesin-like prote (1648) 1187 190.1 1.4e-46
XP_016866682 (OMIM: 605433) PREDICTED: kinesin-lik (1694) 1112 179.0 3.3e-43
>>NP_004312 (OMIM: 201300,601255,610357,614213,614255) k (1690 aa)
initn: 11204 init1: 11204 opt: 11204 Z-score: 9005.4 bits: 1679.3 E(85289): 0
Smith-Waterman score: 11204; 100.0% identity (100.0% similar) in 1690 aa overlap (1-1690:1-1690)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPY
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE0 REKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 REKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE0 VTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE0 KLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE0 LEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE0 TLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQ
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE0 RLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLN
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE0 LATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKL
1630 1640 1650 1660 1670 1680
1690
pF1KE0 SRRRSAQMRV
::::::::::
NP_004 SRRRSAQMRV
1690
>>XP_005247084 (OMIM: 201300,601255,610357,614213,614255 (1698 aa)
initn: 8200 init1: 8200 opt: 11178 Z-score: 8984.5 bits: 1675.5 E(85289): 0
Smith-Waterman score: 11178; 99.5% identity (99.5% similar) in 1698 aa overlap (1-1690:1-1698)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KE0 RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDR--------TFYQFEAAWDSSMHNSL
::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_005 RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRVSLGNDTRTFYQFEAAWDSSMHNSL
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE0 LLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGS
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE0 LRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLI
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE0 LDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPL
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE0 SAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDP
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE0 SMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARA
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE0 TETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKD
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE0 TVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLL
1630 1640 1650 1660 1670 1680
1680 1690
pF1KE0 AGTIRSKLSRRRSAQMRV
::::::::::::::::::
XP_005 AGTIRSKLSRRRSAQMRV
1690
>>NP_001317219 (OMIM: 201300,601255,610357,614213,614255 (1724 aa)
initn: 8657 init1: 8657 opt: 8657 Z-score: 6958.9 bits: 1300.7 E(85289): 0
Smith-Waterman score: 11108; 98.0% identity (98.0% similar) in 1722 aa overlap (3-1690:3-1724)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITD---------------------------
:::::::::::::::::::::::::::::::::
NP_001 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNE
370 380 390 400 410 420
400 410 420 430 440
pF1KE0 -------MTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE
.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APDPLSTVTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE0 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE0 LLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE0 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE0 LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE0 NEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE0 VQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE0 QRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE0 VHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESC
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE0 PVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGP
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE0 LDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPP
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE0 LGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRV
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE0 MPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE0 FLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSG
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE0 YIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKD
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE0 FCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGSPGMQRRRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGSPGMQRRRRR
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE0 VLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQR
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KE0 PVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNRE
1450 1460 1470 1480 1490 1500
1470 1480 1490 1500 1510 1520
pF1KE0 YTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQP
1510 1520 1530 1540 1550 1560
1530 1540 1550 1560 1570 1580
pF1KE0 CSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLE
1570 1580 1590 1600 1610 1620
1590 1600 1610 1620 1630 1640
pF1KE0 PHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCT
1630 1640 1650 1660 1670 1680
1650 1660 1670 1680 1690
pF1KE0 EHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
1690 1700 1710 1720
>>NP_001307634 (OMIM: 201300,601255,610357,614213,614255 (1699 aa)
initn: 8656 init1: 8656 opt: 8656 Z-score: 6958.1 bits: 1300.5 E(85289): 0
Smith-Waterman score: 11172; 99.4% identity (99.5% similar) in 1699 aa overlap (1-1690:1-1699)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390 400 410
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITD---------MTNALVGMSPSSSLSALS
::::::::::::::::::::::::::::::::: .:::::::::::::::::
NP_001 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE0 SRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE0 MGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVL
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE0 SGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHV
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE0 FRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRR
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE0 EREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE0 RKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEA
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE0 AKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE0 NVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAIS
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE0 ADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE0 DVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE0 ISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQP
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE0 IVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHC
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE0 KYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRW
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE0 KEVRELVVGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEVRELVVGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNS
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE0 LLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSG
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE0 SLRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSL
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE0 ILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSP
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE0 LSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRD
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE0 PSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPAR
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE0 ATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDK
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE0 DTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPL
1630 1640 1650 1660 1670 1680
1680 1690
pF1KE0 LAGTIRSKLSRRRSAQMRV
:::::::::::::::::::
NP_001 LAGTIRSKLSRRRSAQMRV
1690
>>XP_016859877 (OMIM: 201300,601255,610357,614213,614255 (1732 aa)
initn: 5653 init1: 5653 opt: 8631 Z-score: 6938.0 bits: 1296.8 E(85289): 0
Smith-Waterman score: 11082; 97.5% identity (97.6% similar) in 1730 aa overlap (3-1690:3-1732)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITD---------------------------
:::::::::::::::::::::::::::::::::
XP_016 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNE
370 380 390 400 410 420
400 410 420 430 440
pF1KE0 -------MTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE
.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APDPLSTVTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE0 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE0 LLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE0 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE0 LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE0 NEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE0 VQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE0 QRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE0 VHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESC
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE0 PVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGP
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE0 LDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPP
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE0 LGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRV
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE0 MPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE0 FLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSG
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270
pF1KE0 YIHPAQDDR--------TFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCT
::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_016 YIHPAQDDRVSLGNDTRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCT
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE0 QPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGSP
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE0 GMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLR
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE0 EKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLRL
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE0 LTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGA
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE0 TDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVSK
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE0 KGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLKT
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE0 PNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
1690 1700 1710 1720 1730
>>XP_016859879 (OMIM: 201300,601255,610357,614213,614255 (1699 aa)
initn: 8207 init1: 8207 opt: 8207 Z-score: 6597.4 bits: 1233.8 E(85289): 0
Smith-Waterman score: 11176; 99.5% identity (99.5% similar) in 1699 aa overlap (1-1690:1-1699)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KE0 RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDR---------TFYQFEAAWDSSMHNS
::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHNS
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE0 LLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSG
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE0 SLRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSL
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE0 ILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSP
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE0 LSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRD
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE0 PSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPAR
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE0 ATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDK
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE0 DTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPL
1630 1640 1650 1660 1670 1680
1680 1690
pF1KE0 LAGTIRSKLSRRRSAQMRV
:::::::::::::::::::
XP_016 LAGTIRSKLSRRRSAQMRV
1690
>>XP_006712668 (OMIM: 201300,601255,610357,614213,614255 (1782 aa)
initn: 5689 init1: 5689 opt: 5692 Z-score: 4576.4 bits: 859.9 E(85289): 0
Smith-Waterman score: 10611; 94.7% identity (94.7% similar) in 1722 aa overlap (61-1690:61-1782)
40 50 60 70 80 90
pF1KE0 SGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYN
::::::::::::::::::::::::::::::
XP_006 SGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYN
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE0 VCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIY
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE0 CERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNM
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE0 NETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGAN
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE0 INKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAA
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE0 LSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGD
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE0 ITDMTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ITDMTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNET
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE0 WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
460 470 480 490 500 510
520 530 540 550 560 570
pF1KE0 IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE0 KVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQ
580 590 600 610 620 630
640 650 660 670 680 690
pF1KE0 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEE
640 650 660 670 680 690
700 710 720 730 740 750
pF1KE0 EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ
700 710 720 730 740 750
760 770 780 790 800 810
pF1KE0 FVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLD
760 770 780 790 800 810
820 830 840 850
pF1KE0 LMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVG-------------------
:::::::::::::::::::::::::::::::::::::::::
XP_006 LMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGSSAISGCNSYPLLNTCMSE
820 830 840 850 860 870
pF1KE0 ------------------------------------------------------------
XP_006 RMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEEEEDEEEEDLEDDVFPEHALCDGRD
880 890 900 910 920 930
860 870 880 890
pF1KE0 -------------RAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPD
:::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPD
940 950 960 970 980 990
900 910 920 930 940 950
pF1KE0 YGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSAD
1000 1010 1020 1030 1040 1050
960 970 980 990 1000 1010
pF1KE0 EVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYAD
1060 1070 1080 1090 1100 1110
1020 1030 1040 1050 1060 1070
pF1KE0 IFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFG
1120 1130 1140 1150 1160 1170
1080 1090 1100 1110 1120 1130
pF1KE0 HYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVY
1180 1190 1200 1210 1220 1230
1140 1150 1160 1170 1180 1190
pF1KE0 FEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELV
1240 1250 1260 1270 1280 1290
1200 1210 1220 1230 1240 1250
pF1KE0 VGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVT
1300 1310 1320 1330 1340 1350
1260 1270 1280 1290 1300 1310
pF1KE0 PYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASES
1360 1370 1380 1390 1400 1410
1320 1330 1340 1350 1360 1370
pF1KE0 NRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWE
1420 1430 1440 1450 1460 1470
1380 1390 1400 1410 1420 1430
pF1KE0 LEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRP
1480 1490 1500 1510 1520 1530
1440 1450 1460 1470 1480 1490
pF1KE0 SPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG
1540 1550 1560 1570 1580 1590
1500 1510 1520 1530 1540 1550
pF1KE0 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKE
1600 1610 1620 1630 1640 1650
1560 1570 1580 1590 1600 1610
pF1KE0 PQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFV
1660 1670 1680 1690 1700 1710
1620 1630 1640 1650 1660 1670
pF1KE0 LNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRS
1720 1730 1740 1750 1760 1770
1680 1690
pF1KE0 KLSRRRSAQMRV
::::::::::::
XP_006 KLSRRRSAQMRV
1780
>--
initn: 399 init1: 399 opt: 399 Z-score: 323.6 bits: 73.0 E(85289): 2.8e-11
Smith-Waterman score: 399; 100.0% identity (100.0% similar) in 60 aa overlap (1-60:1-60)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
XP_006 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
>>NP_001230937 (OMIM: 201300,601255,610357,614213,614255 (1791 aa)
initn: 8264 init1: 5689 opt: 5692 Z-score: 4576.4 bits: 859.9 E(85289): 0
Smith-Waterman score: 10520; 94.1% identity (94.1% similar) in 1722 aa overlap (70-1690:70-1791)
40 50 60 70 80 90
pF1KE0 PKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQT
::::::::::::::::::::::::::::::
NP_001 PKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQT
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE0 GAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLN
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE0 PKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHA
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE0 VFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLG
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE0 KVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYD
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE0 ETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPG
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE0 ---MTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNET
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNET
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE0 WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
460 470 480 490 500 510
520 530 540 550 560 570
pF1KE0 IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE0 KVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQ
580 590 600 610 620 630
640 650 660 670 680 690
pF1KE0 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEE
640 650 660 670 680 690
700 710 720 730 740 750
pF1KE0 EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ
700 710 720 730 740 750
760 770 780 790 800 810
pF1KE0 FVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLD
760 770 780 790 800 810
820 830 840 850
pF1KE0 LMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVG-------------------
:::::::::::::::::::::::::::::::::::::::::
NP_001 LMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGSSAISGCNSYPLLNTCMSE
820 830 840 850 860 870
pF1KE0 ------------------------------------------------------------
NP_001 RMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEEEEDEEEEDLEDDVFPEHALCDGRD
880 890 900 910 920 930
860 870 880 890
pF1KE0 -------------RAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPD
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPD
940 950 960 970 980 990
900 910 920 930 940 950
pF1KE0 YGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSAD
1000 1010 1020 1030 1040 1050
960 970 980 990 1000 1010
pF1KE0 EVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYAD
1060 1070 1080 1090 1100 1110
1020 1030 1040 1050 1060 1070
pF1KE0 IFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFG
1120 1130 1140 1150 1160 1170
1080 1090 1100 1110 1120 1130
pF1KE0 HYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVY
1180 1190 1200 1210 1220 1230
1140 1150 1160 1170 1180 1190
pF1KE0 FEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELV
1240 1250 1260 1270 1280 1290
1200 1210 1220 1230 1240 1250
pF1KE0 VGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVT
1300 1310 1320 1330 1340 1350
1260 1270 1280 1290 1300 1310
pF1KE0 PYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASES
1360 1370 1380 1390 1400 1410
1320 1330 1340 1350 1360 1370
pF1KE0 NRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWE
1420 1430 1440 1450 1460 1470
1380 1390 1400 1410 1420 1430
pF1KE0 LEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRP
1480 1490 1500 1510 1520 1530
1440 1450 1460 1470 1480 1490
pF1KE0 SPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG
1540 1550 1560 1570 1580 1590
1500 1510 1520 1530 1540 1550
pF1KE0 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKE
1600 1610 1620 1630 1640 1650
1560 1570 1580 1590 1600 1610
pF1KE0 PQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFV
1660 1670 1680 1690 1700 1710
1620 1630 1640 1650 1660 1670
pF1KE0 LNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRS
1720 1730 1740 1750 1760 1770
1680 1690
pF1KE0 KLSRRRSAQMRV
::::::::::::
NP_001 KLSRRRSAQMRV
1780 1790
>--
initn: 458 init1: 458 opt: 458 Z-score: 371.0 bits: 81.8 E(85289): 6.3e-14
Smith-Waterman score: 458; 100.0% identity (100.0% similar) in 69 aa overlap (1-69:1-69)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
:::::::::
NP_001 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
>>XP_016859875 (OMIM: 201300,601255,610357,614213,614255 (1816 aa)
initn: 8258 init1: 5689 opt: 5692 Z-score: 4576.3 bits: 859.9 E(85289): 0
Smith-Waterman score: 10293; 92.6% identity (92.7% similar) in 1722 aa overlap (95-1690:95-1816)
70 80 90 100 110 120
pF1KE0 INYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCE
::::::::::::::::::::::::::::::
XP_016 INYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 AVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 PYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDP
310 320 330 340 350 360
370 380 390
pF1KE0 NNKLIRELKDEVTRLRDLLYAQGLGDITD-------------------------------
:::::::::::::::::::::::::::::
XP_016 NNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDP
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 ---MTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNET
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSTVTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNET
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 KVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQ
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE0 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE0 EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 FVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLD
790 800 810 820 830 840
820 830 840 850
pF1KE0 LMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVG-------------------
:::::::::::::::::::::::::::::::::::::::::
XP_016 LMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGSSAISGCNSYPLLNTCMSE
850 860 870 880 890 900
pF1KE0 ------------------------------------------------------------
XP_016 RMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEEEEDEEEEDLEDDVFPEHALCDGRD
910 920 930 940 950 960
860 870 880 890
pF1KE0 -------------RAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPD
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPD
970 980 990 1000 1010 1020
900 910 920 930 940 950
pF1KE0 YGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSAD
1030 1040 1050 1060 1070 1080
960 970 980 990 1000 1010
pF1KE0 EVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYAD
1090 1100 1110 1120 1130 1140
1020 1030 1040 1050 1060 1070
pF1KE0 IFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFG
1150 1160 1170 1180 1190 1200
1080 1090 1100 1110 1120 1130
pF1KE0 HYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVY
1210 1220 1230 1240 1250 1260
1140 1150 1160 1170 1180 1190
pF1KE0 FEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELV
1270 1280 1290 1300 1310 1320
1200 1210 1220 1230 1240 1250
pF1KE0 VGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVT
1330 1340 1350 1360 1370 1380
1260 1270 1280 1290 1300 1310
pF1KE0 PYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASES
1390 1400 1410 1420 1430 1440
1320 1330 1340 1350 1360 1370
pF1KE0 NRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWE
1450 1460 1470 1480 1490 1500
1380 1390 1400 1410 1420 1430
pF1KE0 LEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRP
1510 1520 1530 1540 1550 1560
1440 1450 1460 1470 1480 1490
pF1KE0 SPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG
1570 1580 1590 1600 1610 1620
1500 1510 1520 1530 1540 1550
pF1KE0 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKE
1630 1640 1650 1660 1670 1680
1560 1570 1580 1590 1600 1610
pF1KE0 PQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFV
1690 1700 1710 1720 1730 1740
1620 1630 1640 1650 1660 1670
pF1KE0 LNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRS
1750 1760 1770 1780 1790 1800
1680 1690
pF1KE0 KLSRRRSAQMRV
::::::::::::
XP_016 KLSRRRSAQMRV
1810
>--
initn: 633 init1: 633 opt: 633 Z-score: 511.5 bits: 107.8 E(85289): 9.4e-22
Smith-Waterman score: 633; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::
XP_016 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
XP_016 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
>>XP_016859876 (OMIM: 201300,601255,610357,614213,614255 (1733 aa)
initn: 5660 init1: 5660 opt: 5660 Z-score: 4550.8 bits: 855.1 E(85289): 0
Smith-Waterman score: 11080; 97.5% identity (97.5% similar) in 1731 aa overlap (3-1690:3-1733)
10 20 30 40 50 60
pF1KE0 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
310 320 330 340 350 360
370 380 390
pF1KE0 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITD---------------------------
:::::::::::::::::::::::::::::::::
XP_016 NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNE
370 380 390 400 410 420
400 410 420 430 440
pF1KE0 -------MTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE
.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APDPLSTVTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE0 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE0 LLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE0 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE0 LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEV
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE0 NEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKK
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE0 VQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE0 QRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPL
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE0 VHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESC
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE0 PVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGP
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE0 LDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPP
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE0 LGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRV
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE0 MPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE0 FLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSG
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270
pF1KE0 YIHPAQDDR---------TFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENC
::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_016 YIHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENC
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE0 TQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGS
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE0 PGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLL
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE0 REKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLR
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE0 LLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYG
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE0 ATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVS
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE0 KKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLK
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE0 TPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
1690 1700 1710 1720 1730
1690 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:02:28 2016 done: Sat Nov 5 23:02:31 2016
Total Scan time: 20.910 Total Display time: 1.200
Function used was FASTA [36.3.4 Apr, 2011]