Result of FASTA (omim) for
pF1KE0687
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0687, 428 aa
1>>>pF1KE0687 428 - 428 aa - 428 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8828+/-0.000345; mu= 20.6720+/- 0.022
mean_var=96.0119+/-20.633, 0's: 0 Z-trim(115.8): 668 B-trim: 2567 in 2/51
Lambda= 0.130892
statistics sampled from 25726 (26536) to 25726 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.311), width: 16
Scan time: 8.300
The best scores are: opt bits E(85289)
NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 2841 547.0 3.4e-155
NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 1243 245.3 2.4e-64
XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cho ( 381) 1188 234.8 2.9e-61
XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 798 161.3 5.2e-39
NP_001304958 (OMIM: 118445) gastrin/cholecystokini ( 363) 784 158.5 2.6e-38
NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 445 94.5 5.4e-19
NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 445 94.5 5.4e-19
NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 445 94.6 6.2e-19
NP_071429 (OMIM: 607448) neuropeptide FF receptor ( 430) 419 89.6 1.6e-17
XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 399 85.8 2.1e-16
XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 399 85.9 2.2e-16
XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 399 85.9 2.2e-16
NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 399 85.9 2.2e-16
XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 390 83.9 5.4e-16
NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 389 83.9 7.3e-16
NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 388 83.8 9.6e-16
XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 388 83.8 9.8e-16
NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 388 83.8 1e-15
NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 386 83.4 1.2e-15
NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 379 82.0 2.9e-15
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 377 81.7 4.1e-15
XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 377 81.7 4.2e-15
NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 374 81.1 5.4e-15
NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 372 80.7 7.3e-15
NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 370 80.3 9.3e-15
XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 370 80.3 9.3e-15
XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 370 80.3 9.3e-15
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 369 80.2 1.2e-14
NP_006165 (OMIM: 602001) neuropeptide Y receptor t ( 445) 368 80.0 1.3e-14
NP_001304020 (OMIM: 602001) neuropeptide Y recepto ( 445) 368 80.0 1.3e-14
XP_005263095 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 368 80.0 1.3e-14
XP_011530319 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 368 80.0 1.3e-14
NP_001304021 (OMIM: 602001) neuropeptide Y recepto ( 445) 368 80.0 1.3e-14
XP_016863745 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 368 80.0 1.3e-14
XP_011530317 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 368 80.0 1.3e-14
XP_016863744 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 368 80.0 1.3e-14
NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 365 79.4 1.9e-14
NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 365 79.5 2e-14
NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 360 78.4 3.4e-14
NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 347 76.0 1.9e-13
XP_011508791 (OMIM: 604153) PREDICTED: neuromedin- ( 313) 346 75.7 1.9e-13
XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 346 75.8 2.1e-13
XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 346 75.8 2.1e-13
NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 346 75.8 2.1e-13
NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 345 75.6 2.5e-13
XP_006712259 (OMIM: 604153) PREDICTED: neuromedin- ( 333) 341 74.8 3.8e-13
XP_006712258 (OMIM: 604153) PREDICTED: neuromedin- ( 370) 341 74.8 4e-13
XP_011508790 (OMIM: 604153) PREDICTED: neuromedin- ( 376) 341 74.8 4.1e-13
NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 341 74.9 4.4e-13
XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 340 74.7 4.9e-13
>>NP_000721 (OMIM: 118444) cholecystokinin receptor type (428 aa)
initn: 2841 init1: 2841 opt: 2841 Z-score: 2907.2 bits: 547.0 E(85289): 3.4e-155
Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 428 aa overlap (1-428:1-428)
10 20 30 40 50 60
pF1KE0 MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
370 380 390 400 410 420
pF1KE0 MSASVPPQ
::::::::
NP_000 MSASVPPQ
>>NP_795344 (OMIM: 118445) gastrin/cholecystokinin type (447 aa)
initn: 1294 init1: 603 opt: 1243 Z-score: 1276.1 bits: 245.3 E(85289): 2.4e-64
Smith-Waterman score: 1313; 50.4% identity (73.8% similar) in 423 aa overlap (27-426:37-446)
10 20 30 40 50
pF1KE0 MDVVDSLLVNGSNITPPCELGLENETLFCLDQPR----PSKEWQPAVQILLYSLIF
: : . :: ..: . :..: ::..::
NP_795 NRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSC-EPPRIRGAGTRELELAIRITLYAVIF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 LLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSA
:.:: :: :.:.:: ..:.::::: ::::::::::.: . ::::.:.:::. ::::..
NP_795 LMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 VCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI
.::...:.::.::::::..::::.::::.:::.:::.:::::.::: .::.::: :: .
NP_795 ICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 MTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLI
:.:::.:. . : : : :. ..:.: ..:::.::.:::.:: ::::::
NP_795 MVPYPVYTVVQPVGPRVLQ----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLI
190 200 210 220 230 240
240 250 260 270
pF1KE0 SLELYQGIKFEASQKKSAKER-----------------KPSTTSSGKYEDSDGCYLQKTR
: ::: :..:.... .... : .: : . : :::::::.: :
NP_795 SRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVG--EDSDGCYVQLPR
250 260 270 280 290
280 290 300 310 320 330
pF1KE0 PPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAW
::: :.. . . ..: . :.:.:::::.:::.::::::::::.:..:::.:
NP_795 SRPALELTALTAPGPGSGSR----PTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTW
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 RAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFP-CCPNPGPP
::.: .:.: :::.::::: ::::.:.::::..::::..::: . . : ::: : :
NP_795 RAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRP--P
360 370 380 390 400 410
400 410 420
pF1KE0 GARGEVGEEEEGGTTG-ASLSRFSYSHMSASVPPQ
:: .. .:. : . :::::.::. .:. :
NP_795 RARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
420 430 440
>>XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cholecy (381 aa)
initn: 1258 init1: 567 opt: 1188 Z-score: 1220.8 bits: 234.8 E(85289): 2.9e-61
Smith-Waterman score: 1258; 51.3% identity (74.5% similar) in 392 aa overlap (54-426:1-380)
30 40 50 60 70 80
pF1KE0 NETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSL
.:: :: :.:.:: ..:.::::: :::::
XP_016 MSVGGNMLIIVVLGLSRRLRTVTNAFLLSL
10 20 30
90 100 110 120 130 140
pF1KE0 AVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAI
:::::.: . ::::.:.:::. ::::...::...:.::.::::::..::::.::::.::
XP_016 AVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 CKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPND
:.:::.:::::.::: .::.::: :: .:.:::.:. . : : : :.
XP_016 CRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQ----CVHRWPSA
100 110 120 130 140
210 220 230 240 250
pF1KE0 VMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKER----------
..:.: ..:::.::.:::.:: ::::::: ::: :..:.... .... :
XP_016 RVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGA
150 160 170 180 190 200
260 270 280 290 300
pF1KE0 -------KPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLM
.: : . : :::::::.: : ::: :.. . . ..: . :.:.
XP_016 VHQNGRCRPETGAVG--EDSDGCYVQLPRSRPALELTALTAPGPGSGSR----PTQAKLL
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE0 AKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVN
:::::.:::.::::::::::.:..:::.:::.: .:.: :::.::::: ::::.:.:::
XP_016 AKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVN
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE0 PIIYCFMNKRFRLGFMATFP-CCPNPGPPGARGEVGEEEEGGTTG-ASLSRFSYSHMSAS
:..::::..::: . . : ::: : : :: .. .:. : . :::::.::. .:.
XP_016 PLVYCFMHRRFRQACLETCARCCPRP--PRARPRALPDEDPPTPSIASLSRLSYTTISTL
330 340 350 360 370
pF1KE0 VPPQ
:
XP_016 GPG
380
>>XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cholecy (516 aa)
initn: 1294 init1: 629 opt: 798 Z-score: 821.3 bits: 161.3 E(85289): 5.2e-39
Smith-Waterman score: 1098; 43.5% identity (63.6% similar) in 448 aa overlap (27-384:37-473)
10 20 30 40 50
pF1KE0 MDVVDSLLVNGSNITPPCELGLENETLFCLDQPR----PSKEWQPAVQILLYSLIF
: : . :: ..: . :..: ::..::
XP_005 NRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSC-EPPRIRGAGTRELELAIRITLYAVIF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 LLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSA
:.:: :: :.:.:: ..:.::::: ::::::::::.: . ::::.:.:::. ::::..
XP_005 LMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 VCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI
.::...:.::.::::::..::::.::::.:::.:::.:::::.::: .::.::: :: .
XP_005 ICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 MTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLI
:.:::.:. . : : : :. ..:.: ..:::.::.:::.:: ::::::
XP_005 MVPYPVYTVVQPVGPRVLQ----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLI
190 200 210 220 230 240
240 250
pF1KE0 SLELYQGIKFEASQKKSAKER---------------------------------------
: ::: :..:.... .... :
XP_005 SRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKV
250 260 270 280 290 300
260
pF1KE0 -----------------------------------------------KPSTTSSGKYEDS
.: : . : :::
XP_005 RVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVG--EDS
310 320 330 340 350
270 280 290 300 310 320
pF1KE0 DGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCW
::::.: : ::: :.. . . ..: . :.:.:::::.:::.::::::::::
XP_005 DGCYVQLPRSRPALELTALTAPGPGSGSR----PTQAKLLAKKRVVRMLLVIVVLFFLCW
360 370 380 390 400 410
330 340 350 360 370 380
pF1KE0 MPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFP
.:..:::.:::.: .:.: :::.::::: ::::.:.::::..::::..::: . . :
XP_005 LPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCA
420 430 440 450 460 470
390 400 410 420
pF1KE0 CCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
XP_005 RCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
480 490 500 510
>>NP_001304958 (OMIM: 118445) gastrin/cholecystokinin ty (363 aa)
initn: 971 init1: 437 opt: 784 Z-score: 808.8 bits: 158.5 E(85289): 2.6e-38
Smith-Waterman score: 976; 49.4% identity (71.9% similar) in 324 aa overlap (122-426:51-362)
100 110 120 130 140 150
pF1KE0 LFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRV
:.::::::..::::.::::.:::.:::.::
NP_001 LCRPGAPLLNSSSVGNLSCEPPRIRGAGTRGVSVSVSTLSLVAIALERYSAICRPLQARV
30 40 50 60 70 80
160 170 180 190 200 210
pF1KE0 WQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHT
:::.::: .::.::: :: .:.:::.:. . : : : :. ..:.: .
NP_001 WQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQ----CVHRWPSARVRQTWSV
90 100 110 120 130
220 230 240 250
pF1KE0 FLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKER-----------------K
.:::.::.:::.:: ::::::: ::: :..:.... .... : .
NP_001 LLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCR
140 150 160 170 180 190
260 270 280 290 300 310
pF1KE0 PSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRM
: : . : :::::::.: : ::: :.. . . ..: . :.:.:::::.::
NP_001 PETGAVG--EDSDGCYVQLPRSRPALELTALTAPGPGSGSR----PTQAKLLAKKRVVRM
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE0 LIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMN
:.::::::::::.:..:::.:::.: .:.: :::.::::: ::::.:.::::..::::.
NP_001 LLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMH
260 270 280 290 300 310
380 390 400 410 420
pF1KE0 KRFRLGFMATFP-CCPNPGPPGARGEVGEEEEGGTTG-ASLSRFSYSHMSASVPPQ
.::: . . : ::: : : :: .. .:. : . :::::.::. .:. :
NP_001 RRFRQACLETCARCCPRP--PRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
320 330 340 350 360
>>NP_444264 (OMIM: 607449) neuropeptide FF receptor 2 is (420 aa)
initn: 482 init1: 337 opt: 445 Z-score: 462.1 bits: 94.5 E(85289): 5.4e-19
Smith-Waterman score: 518; 28.9% identity (57.8% similar) in 370 aa overlap (40-394:41-359)
10 20 30 40 50 60
pF1KE0 NGSNITPPCELGLENETLFCLDQPRPSKEWQP---AVQILLYSLIFLLSVLGNTLVITVL
:: :. :. : :::.: ..:::.: ..
NP_444 ENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIV
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE0 IRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVS
.:::.:.::::.:.:.::.:::.. .::::..:. :.. . ::...:: . .: ::.
NP_444 MRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVA
80 90 100 110 120 130
130 140 150 160 170
pF1KE0 VSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPI--------
.:.:.::::...:. . :.. .. : . :. .: : :..:::.: .
NP_444 ASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEK
140 150 160 170 180
180 190 200 210 220 230
pF1KE0 YSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQ
: . ..:... . :: ::. :.. . : :. ..: : .... :: :.. :.
NP_444 YYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLF-
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 GIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRS
. .. .:. :.. .. :.
NP_444 ---------------RAAVPHTGR----------KNQEQWHVVSRK--------------
250 260
300 310 320 330 340 350
pF1KE0 NSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAY-DTASAERRLSGTPI-SFIL
:...:.::.....::.: :.:... : : . : .. . : :
NP_444 ---------KQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAH
270 280 290 300 310
360 370 380 390 400 410
pF1KE0 LLSYTSSCVNPIIYCFMNKRFRLGFMATFPC--CPNPGPPGARGEVGEEEEGGTTGASLS
:.. .: :::::: :.:. :: ::. .: : . . :
NP_444 WLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQL
320 330 340 350 360 370
420
pF1KE0 RFSYSHMSASVPPQ
NP_444 VQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
380 390 400 410 420
>>NP_001138228 (OMIM: 607449) neuropeptide FF receptor 2 (423 aa)
initn: 482 init1: 337 opt: 445 Z-score: 462.0 bits: 94.5 E(85289): 5.4e-19
Smith-Waterman score: 518; 28.9% identity (57.8% similar) in 370 aa overlap (40-394:44-362)
10 20 30 40 50 60
pF1KE0 NGSNITPPCELGLENETLFCLDQPRPSKEWQP---AVQILLYSLIFLLSVLGNTLVITVL
:: :. :. : :::.: ..:::.: ..
NP_001 ENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIV
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE0 IRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVS
.:::.:.::::.:.:.::.:::.. .::::..:. :.. . ::...:: . .: ::.
NP_001 MRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVA
80 90 100 110 120 130
130 140 150 160 170
pF1KE0 VSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPI--------
.:.:.::::...:. . :.. .. : . :. .: : :..:::.: .
NP_001 ASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEK
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE0 YSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQ
: . ..:... . :: ::. :.. . : :. ..: : .... :: :.. :.
NP_001 YYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLF-
200 210 220 230 240 250
240 250 260 270 280 290
pF1KE0 GIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRS
. .. .:. :.. .. :.
NP_001 ---------------RAAVPHTGR----------KNQEQWHVVSRK--------------
260 270
300 310 320 330 340 350
pF1KE0 NSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAY-DTASAERRLSGTPI-SFIL
:...:.::.....::.: :.:... : : . : .. . : :
NP_001 ---------KQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAH
280 290 300 310 320
360 370 380 390 400 410
pF1KE0 LLSYTSSCVNPIIYCFMNKRFRLGFMATFPC--CPNPGPPGARGEVGEEEEGGTTGASLS
:.. .: :::::: :.:. :: ::. .: : . . :
NP_001 WLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQL
330 340 350 360 370 380
420
pF1KE0 RFSYSHMSASVPPQ
NP_001 VQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
390 400 410 420
>>NP_004876 (OMIM: 607449) neuropeptide FF receptor 2 is (522 aa)
initn: 482 init1: 337 opt: 445 Z-score: 461.0 bits: 94.6 E(85289): 6.2e-19
Smith-Waterman score: 518; 28.9% identity (57.8% similar) in 370 aa overlap (40-394:143-461)
10 20 30 40 50 60
pF1KE0 NGSNITPPCELGLENETLFCLDQPRPSKEWQP---AVQILLYSLIFLLSVLGNTLVITVL
:: :. :. : :::.: ..:::.: ..
NP_004 ENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIV
120 130 140 150 160 170
70 80 90 100 110 120
pF1KE0 IRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVS
.:::.:.::::.:.:.::.:::.. .::::..:. :.. . ::...:: . .: ::.
NP_004 MRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVA
180 190 200 210 220 230
130 140 150 160 170
pF1KE0 VSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPI--------
.:.:.::::...:. . :.. .. : . :. .: : :..:::.: .
NP_004 ASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEK
240 250 260 270 280 290
180 190 200 210 220 230
pF1KE0 YSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQ
: . ..:... . :: ::. :.. . : :. ..: : .... :: :.. :.
NP_004 YYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLF-
300 310 320 330 340
240 250 260 270 280 290
pF1KE0 GIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRS
. .. .:. :.. .. :.
NP_004 ---------------RAAVPHTGR----------KNQEQWHVVSRK--------------
350 360 370
300 310 320 330 340 350
pF1KE0 NSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAY-DTASAERRLSGTPI-SFIL
:...:.::.....::.: :.:... : : . : .. . : :
NP_004 ---------KQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAH
380 390 400 410 420
360 370 380 390 400 410
pF1KE0 LLSYTSSCVNPIIYCFMNKRFRLGFMATFPC--CPNPGPPGARGEVGEEEEGGTTGASLS
:.. .: :::::: :.:. :: ::. .: : . . :
NP_004 WLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQL
430 440 450 460 470 480
420
pF1KE0 RFSYSHMSASVPPQ
NP_004 VQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
490 500 510 520
>>NP_071429 (OMIM: 607448) neuropeptide FF receptor 1 [H (430 aa)
initn: 506 init1: 346 opt: 419 Z-score: 435.4 bits: 89.6 E(85289): 1.6e-17
Smith-Waterman score: 521; 31.5% identity (57.9% similar) in 375 aa overlap (42-407:44-366)
20 30 40 50 60 70
pF1KE0 SNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKR
:. :. :.::::: ..::::: ....:..
NP_071 PLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRH
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE0 MRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFN
:.::::.:.:.::::::.. .:::: .:. ::. . : .:.:: . .: :::.:.:.
NP_071 MHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFT
80 90 100 110 120 130
140 150 160 170 180
pF1KE0 LVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLV----PF--
::::..::. : .:.. .. : .:: .::. : :.. :: : . ... :
NP_071 LVAIAVERFRCIVHPFREKL--TLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE0 -TKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEA
..: . : :. :.. . : :. ..: : ...: :. :. .: :.
NP_071 DARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQA-----
200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAAN
:. . .:. : .: :: :.: :.
NP_071 ----------PGPAPGGE-EAAD---------PR--------------ASRRRA------
250 260
310 320 330 340 350 360
pF1KE0 LMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERR--LSGTPISFILLLSYTS
::..::......: : :.:... : :: . .. . : :.. .
NP_071 -----RVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFN
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE0 SCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMS
: .::::: ..:. :: ::.:.: : : :.. :. :. ::
NP_071 SSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDS
330 340 350 360 370 380
pF1KE0 ASVPPQ
NP_071 GLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
390 400 410 420 430
>>XP_016856596 (OMIM: 602392) PREDICTED: orexin receptor (389 aa)
initn: 418 init1: 290 opt: 399 Z-score: 415.5 bits: 85.8 E(85289): 2.1e-16
Smith-Waterman score: 509; 28.4% identity (59.9% similar) in 394 aa overlap (11-393:16-381)
10 20 30 40 50
pF1KE0 MDVVDSLLVNGSNITPPCELGLENETLFCL--DQPRPSK-EWQPAVQILLYSLIF
:: : :.: : : : :.. :: : : : .:
XP_016 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEW---VLIAAYVAVF
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 LLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSA
.....::::: .. ::..:::::: :...:...:... .:.: .:. .. ....:: :
XP_016 VVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 VCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI
.::. :....::::....: :.:.:. :::.:: . .: .: : . : .:..:
XP_016 LCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFK--STARRARGSILGIWAVSLAI
120 130 140 150 160 170
180 190 200 210 220
pF1KE0 MTPYPIY---SNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAY
:.: :...: : .. ..: .:.. . .:. .... .: :
XP_016 MVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAP-------L
180 190 200 210 220
230 240 250 260 270 280
pF1KE0 GLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKL-ELRQLSTG
::... .: .. : .. :.:::. . :: .: .:.: .:
XP_016 GLMAMAYFQIFR------KLWGRQIPGTTSA--------LVRNWKRPSDQLGDLEQGLSG
230 240 250 260 270
290 300 310 320 330 340
pF1KE0 SSSRANRIRSNSSAANLM-AKKRVIRMLIVIVVLFFLCWMPIFSANAW-RAYDT--ASAE
. : :. . .. : :.... .::.:....: ::..:: :. :.. ...
XP_016 EPQ--PRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASD
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE0 RRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEE
:. . ..: : :..: .::::: :.. . .. . : ::. :
XP_016 REAVYACFTFSHWLVYANSAANPIIYNFLSGCKEKSLALSCPSCPGHDPHLAAALCS
340 350 360 370 380
410 420
pF1KE0 EGGTTGASLSRFSYSHMSASVPPQ
428 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:53:13 2016 done: Sat Nov 5 18:53:14 2016
Total Scan time: 8.300 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]