Result of FASTA (omim) for
pF1KE0680
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0680, 399 aa
1>>>pF1KE0680 399 - 399 aa - 399 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4108+/-0.000415; mu= 12.3301+/- 0.026
mean_var=137.2969+/-29.078, 0's: 0 Z-trim(114.7): 250 B-trim: 471 in 1/52
Lambda= 0.109457
statistics sampled from 24299 (24662) to 24299 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.289), width: 16
Scan time: 7.380
The best scores are: opt bits E(85289)
NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399) 2686 436.0 7.4e-122
NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400) 2674 434.2 2.8e-121
XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421) 2639 428.6 1.3e-119
XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394) 2451 398.9 1.1e-110
NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Ho ( 397) 2275 371.1 2.5e-102
NP_004753 (OMIM: 182115) cytohesin-1 isoform 1 [Ho ( 398) 2263 369.2 9.5e-102
XP_016880825 (OMIM: 182115) PREDICTED: cytohesin-1 ( 399) 2259 368.6 1.5e-101
NP_004218 (OMIM: 605081) cytohesin-3 [Homo sapiens ( 399) 2224 363.1 6.8e-100
XP_016880826 (OMIM: 182115) PREDICTED: cytohesin-1 ( 380) 2165 353.8 4.2e-97
XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338) 2062 337.4 3e-92
NP_001278947 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 2050 335.5 1.1e-91
XP_011523779 (OMIM: 182115) PREDICTED: cytohesin-1 ( 339) 2050 335.5 1.1e-91
NP_001278948 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 2050 335.5 1.1e-91
XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 1940 318.2 1.8e-86
XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 1940 318.2 1.8e-86
NP_037517 (OMIM: 606514) cytohesin-4 isoform 1 [Ho ( 394) 1939 318.1 2.4e-86
NP_001304953 (OMIM: 606514) cytohesin-4 isoform 2 ( 337) 1826 300.2 5e-81
XP_011528449 (OMIM: 606514) PREDICTED: cytohesin-4 ( 337) 1826 300.2 5e-81
XP_011523780 (OMIM: 182115) PREDICTED: cytohesin-1 ( 235) 1439 238.9 9.7e-63
XP_011528450 (OMIM: 606514) PREDICTED: cytohesin-4 ( 211) 887 151.7 1.6e-36
XP_011515744 (OMIM: 604141) PREDICTED: brefeldin A (1649) 617 109.9 4.5e-23
XP_005251193 (OMIM: 604141) PREDICTED: brefeldin A (1800) 617 110.0 4.8e-23
XP_005251192 (OMIM: 604141) PREDICTED: brefeldin A (1843) 617 110.0 4.9e-23
NP_006412 (OMIM: 604141) brefeldin A-inhibited gua (1849) 617 110.0 4.9e-23
XP_005251191 (OMIM: 604141) PREDICTED: brefeldin A (1849) 617 110.0 4.9e-23
XP_005260309 (OMIM: 605371,608097) PREDICTED: bref (1784) 588 105.4 1.1e-21
NP_006411 (OMIM: 605371,608097) brefeldin A-inhibi (1785) 588 105.4 1.1e-21
XP_011532617 (OMIM: 610166) PREDICTED: IQ motif an ( 814) 565 101.4 8.2e-21
NP_001317548 (OMIM: 610166) IQ motif and SEC7 doma ( 814) 565 101.4 8.2e-21
NP_055684 (OMIM: 610166) IQ motif and SEC7 domain- ( 963) 565 101.5 9.2e-21
XP_011532614 (OMIM: 610166) PREDICTED: IQ motif an (1006) 565 101.5 9.5e-21
XP_011532615 (OMIM: 610166) PREDICTED: IQ motif an (1006) 565 101.5 9.5e-21
XP_011532616 (OMIM: 610166) PREDICTED: IQ motif an (1006) 565 101.5 9.5e-21
XP_011532613 (OMIM: 610166) PREDICTED: IQ motif an (1006) 565 101.5 9.5e-21
XP_011532612 (OMIM: 610166) PREDICTED: IQ motif an (1030) 565 101.5 9.6e-21
NP_001127854 (OMIM: 610166) IQ motif and SEC7 doma (1114) 565 101.6 1e-20
XP_011532610 (OMIM: 610166) PREDICTED: IQ motif an (1128) 565 101.6 1e-20
XP_011532609 (OMIM: 610166) PREDICTED: IQ motif an (1129) 565 101.6 1e-20
XP_011532608 (OMIM: 610166) PREDICTED: IQ motif an (1129) 565 101.6 1e-20
XP_011532607 (OMIM: 610166) PREDICTED: IQ motif an (1132) 565 101.6 1e-20
XP_016863071 (OMIM: 610166) PREDICTED: IQ motif an (1207) 565 101.6 1.1e-20
XP_016863070 (OMIM: 610166) PREDICTED: IQ motif an (1212) 565 101.6 1.1e-20
XP_011532606 (OMIM: 610166) PREDICTED: IQ motif an (1222) 565 101.6 1.1e-20
NP_056047 (OMIM: 612118) IQ motif and SEC7 domain- ( 759) 539 97.3 1.3e-19
XP_011519263 (OMIM: 612118) PREDICTED: IQ motif an ( 879) 539 97.3 1.5e-19
XP_016874800 (OMIM: 612118) PREDICTED: IQ motif an (1041) 539 97.4 1.7e-19
XP_016874799 (OMIM: 612118) PREDICTED: IQ motif an (1041) 539 97.4 1.7e-19
XP_011519261 (OMIM: 612118) PREDICTED: IQ motif an (1062) 539 97.4 1.7e-19
XP_011519262 (OMIM: 612118) PREDICTED: IQ motif an (1062) 539 97.4 1.7e-19
XP_011519260 (OMIM: 612118) PREDICTED: IQ motif an (1063) 539 97.4 1.7e-19
>>NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Homo s (399 aa)
initn: 2686 init1: 2686 opt: 2686 Z-score: 2308.7 bits: 436.0 E(85289): 7.4e-122
Smith-Waterman score: 2686; 100.0% identity (100.0% similar) in 399 aa overlap (1-399:1-399)
10 20 30 40 50 60
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ
310 320 330 340 350 360
370 380 390
pF1KE0 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
:::::::::::::::::::::::::::::::::::::::
NP_004 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
370 380 390
>>NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Homo s (400 aa)
initn: 1813 init1: 1813 opt: 2674 Z-score: 2298.5 bits: 434.2 E(85289): 2.8e-121
Smith-Waterman score: 2674; 99.8% identity (99.8% similar) in 400 aa overlap (1-399:1-400)
10 20 30 40 50 60
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
190 200 210 220 230 240
250 260 270 280 290
pF1KE0 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGG-RVKTWKRRWFILTDNCLYYFEYTTDKEP
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_059 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
310 320 330 340 350 360
360 370 380 390
pF1KE0 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
::::::::::::::::::::::::::::::::::::::::
NP_059 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
370 380 390 400
>>XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 iso (421 aa)
initn: 2639 init1: 2639 opt: 2639 Z-score: 2268.3 bits: 428.6 E(85289): 1.3e-119
Smith-Waterman score: 2639; 99.7% identity (100.0% similar) in 393 aa overlap (7-399:29-421)
10 20 30
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLRE
.:::::::::::::::::::::::::::::::
XP_006 MDPVVRITRSPATSPVMESENQGLSPLPKPPDLTPEERMELENIRRRKQELLVEIQRLRE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 ELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIAR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 FLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 KIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 GINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKR
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 RWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 TEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQ
370 380 390 400 410 420
pF1KE0 P
:
XP_006 P
>>XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 iso (394 aa)
initn: 1765 init1: 1765 opt: 2451 Z-score: 2108.2 bits: 398.9 E(85289): 1.1e-110
Smith-Waterman score: 2451; 99.5% identity (99.7% similar) in 366 aa overlap (7-371:29-394)
10 20 30
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLRE
.:::::::::::::::::::::::::::::::
XP_006 MDPVVRITRSPATSPVMESENQGLSPLPKPPDLTPEERMELENIRRRKQELLVEIQRLRE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 ELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIAR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 FLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 KIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 GINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGG-RVKTWK
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_006 GINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWK
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 RRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKAC
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 KTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQE
::::::::::::::::::::::::::::::::::
XP_006 KTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQ
370 380 390
pF1KE0 QP
>>NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Homo s (397 aa)
initn: 2300 init1: 2275 opt: 2275 Z-score: 1958.0 bits: 371.1 E(85289): 2.5e-102
Smith-Waterman score: 2275; 83.0% identity (94.4% similar) in 395 aa overlap (2-396:3-397)
10 20 30 40 50
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTL
:: : : ::: :::.:::::::::::::..::::..:..:. .:.:.: ..: :..
NP_059 MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE
:::...::::::::::::::::::.::.::.:: :.::.::::::::::::::::::::.
NP_059 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVF
:.:. ::::::.::::::::::::::::::::::::::::::::::::::::: :: :::
NP_059 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 QSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIR
::::::::::::.::::::::::::.::: .:::.:::::::.:::::::::::::.::.
NP_059 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
::::::::::::::.: .::::::::::.:: :.::::::::::::::::: ::::::::
NP_059 RGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPT
310 320 330 340 350 360
360 370 380 390
pF1KE0 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
:::.:::: :.::.: ::::::::::::..: :..
NP_059 PEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
370 380 390
>>NP_004753 (OMIM: 182115) cytohesin-1 isoform 1 [Homo s (398 aa)
initn: 2277 init1: 1533 opt: 2263 Z-score: 1947.7 bits: 369.2 E(85289): 9.5e-102
Smith-Waterman score: 2263; 82.8% identity (94.2% similar) in 396 aa overlap (2-396:3-398)
10 20 30 40 50
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTL
:: : : ::: :::.:::::::::::::..::::..:..:. .:.:.: ..: :..
NP_004 MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE
:::...::::::::::::::::::.::.::.:: :.::.::::::::::::::::::::.
NP_004 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVF
:.:. ::::::.::::::::::::::::::::::::::::::::::::::::: :: :::
NP_004 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 QSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIR
::::::::::::.::::::::::::.::: .:::.:::::::.:::::::::::::.::.
NP_004 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGG-RVKTWKRRWFILTDNCLYYFEYTTDKE
:::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
NP_004 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 PRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAP
:::::::::::::::.: .::::::::::.:: :.::::::::::::::::: :::::::
NP_004 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP
310 320 330 340 350 360
360 370 380 390
pF1KE0 TQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
: :::.:::: :.::.: ::::::::::::..: :..
NP_004 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
370 380 390
>>XP_016880825 (OMIM: 182115) PREDICTED: cytohesin-1 iso (399 aa)
initn: 2275 init1: 2250 opt: 2259 Z-score: 1944.3 bits: 368.6 E(85289): 1.5e-101
Smith-Waterman score: 2259; 83.5% identity (95.1% similar) in 389 aa overlap (8-396:11-399)
10 20 30 40 50
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSK
: ::: :::.:::::::::::::..::::..:..:. .:.:.: ..: :
XP_016 MVLKTEEEDVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 TLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE
..:::...::::::::::::::::::.::.::.:: :.::.:::::::::::::::::::
XP_016 NMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 REELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG
:.:.:. ::::::.::::::::::::::::::::::::::::::::::::::::: :: :
XP_016 RDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS
::::::::::::::.::::::::::::.::: .:::.:::::::.:::::::::::::.:
XP_016 VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYES
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 IRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 EPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISA
::::::::::::::::.: .::::::::::.:: :.::::::::::::::::: ::::::
XP_016 EPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISA
310 320 330 340 350 360
360 370 380 390
pF1KE0 PTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
:: :::.:::: :.::.: ::::::::::::..: :..
XP_016 PTPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
370 380 390
>>NP_004218 (OMIM: 605081) cytohesin-3 [Homo sapiens] (399 aa)
initn: 2221 init1: 2221 opt: 2224 Z-score: 1914.4 bits: 363.1 E(85289): 6.8e-100
Smith-Waterman score: 2224; 80.9% identity (94.0% similar) in 397 aa overlap (2-394:3-399)
10 20 30 40 50
pF1KE0 MEDGVYE----PPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEG
::: : : ::. ::: :: .:::::.::. .:.::. :..:.:.:...: . :
NP_004 MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL
::: :::...::::::::::::::::::.::.:::..::..:.:::::::::::.:::::
NP_004 SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 GEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCN
:::.:.:. ::.:::.::::.::::::::::::::::::::::::::::::::.::::::
NP_004 GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 PGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLY
::::::::::::::::.::::::::: :::::: :::.:::::::::::::::::::::
NP_004 PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 DSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTT
.::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 DKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRI
::::::::::::::::::.::::::::::: :..:::.:::::::::::::::::.::::
NP_004 DKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRI
310 320 330 340 350 360
360 370 380 390
pF1KE0 SAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
:::. :::.::.:::.:..: ::::.:::.::.::. ::
NP_004 SAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
370 380 390
>>XP_016880826 (OMIM: 182115) PREDICTED: cytohesin-1 iso (380 aa)
initn: 2165 init1: 2165 opt: 2165 Z-score: 1864.3 bits: 353.8 E(85289): 4.2e-97
Smith-Waterman score: 2165; 83.7% identity (94.4% similar) in 374 aa overlap (2-375:3-376)
10 20 30 40 50
pF1KE0 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTL
:: : : ::: :::.:::::::::::::..::::..:..:. .:.:.: ..: :..
XP_016 MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE
:::...::::::::::::::::::.::.::.:: :.::.::::::::::::::::::::.
XP_016 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVF
:.:. ::::::.::::::::::::::::::::::::::::::::::::::::: :: :::
XP_016 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 QSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIR
::::::::::::.::::::::::::.::: .:::.:::::::.:::::::::::::.::.
XP_016 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
::::::::::::::.: .::::::::::.:: :.::::::::::::::::: ::::::::
XP_016 RGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPT
310 320 330 340 350 360
360 370 380 390
pF1KE0 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
:::.:::: :. ::
XP_016 PEEKEEWIKCIKFQVSPGEP
370 380
>>XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 iso (338 aa)
initn: 2084 init1: 2059 opt: 2062 Z-score: 1777.1 bits: 337.4 E(85289): 3e-92
Smith-Waterman score: 2062; 87.0% identity (96.2% similar) in 338 aa overlap (59-396:1-338)
30 40 50 60 70 80
pF1KE0 LLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENEL
.:::...::::::::::::::::::.::.:
XP_016 MQRNKQVAMGRKKFNMDPKKGIQFLIENDL
10 20 30
90 100 110 120 130 140
pF1KE0 LQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFL
:.:: :.::.::::::::::::::::::::.:.:. ::::::.:::::::::::::::::
XP_016 LKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 WSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKP
:::::::::::::::::::::::: :: :::::::::::::::.::::::::::::.:::
XP_016 WSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKP
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE0 GLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLK
.:::.:::::::.:::::::::::::.::.:::::::::::::::::::::::::::::
XP_016 TVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLK
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE0 LGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPN
:::::::::::::::::::::::::::::::::::::::::::::.: .::::::::::.
XP_016 LGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPD
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE0 NKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKK
:: :.::::::::::::::::: :::::::: :::.:::: :.::.: ::::::::::::
XP_016 NKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISRDPFYEMLAARKK
280 290 300 310 320 330
390
pF1KE0 RISVKKKQEQP
..: :..
XP_016 KVSSTKRH
399 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 17:53:58 2016 done: Wed Nov 2 17:53:59 2016
Total Scan time: 7.380 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]