Result of FASTA (omim) for
pF1KE0650
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0650, 382 aa
1>>>pF1KE0650 382 - 382 aa - 382 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4425+/-0.000431; mu= 3.9624+/- 0.026
mean_var=494.2929+/-111.615, 0's: 0 Z-trim(121.4): 1512 B-trim: 0 in 0/55
Lambda= 0.057688
statistics sampled from 35780 (37929) to 35780 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.445), width: 16
Scan time: 9.580
The best scores are: opt bits E(85289)
NP_001230854 (OMIM: 602130,617111) MAP kinase-acti ( 382) 2628 233.4 7e-61
NP_004626 (OMIM: 602130,617111) MAP kinase-activat ( 382) 2628 233.4 7e-61
NP_001230855 (OMIM: 602130,617111) MAP kinase-acti ( 382) 2628 233.4 7e-61
NP_116584 (OMIM: 602006) MAP kinase-activated prot ( 400) 1762 161.3 3.6e-39
NP_004750 (OMIM: 602006) MAP kinase-activated prot ( 370) 1603 148.0 3.3e-35
XP_005273410 (OMIM: 602006) PREDICTED: MAP kinase- ( 371) 1603 148.0 3.3e-35
XP_016858299 (OMIM: 602006) PREDICTED: MAP kinase- ( 307) 1587 146.6 7.6e-35
NP_001006945 (OMIM: 603606) ribosomal protein S6 k ( 766) 671 71.0 1.1e-11
NP_065172 (OMIM: 614994) calcium/calmodulin-depend ( 476) 666 70.2 1.1e-11
XP_016857355 (OMIM: 614994) PREDICTED: calcium/cal ( 476) 666 70.2 1.1e-11
NP_001287731 (OMIM: 603606) ribosomal protein S6 k ( 765) 667 70.7 1.3e-11
XP_016874016 (OMIM: 603606) PREDICTED: ribosomal p ( 398) 657 69.4 1.7e-11
NP_003647 (OMIM: 604998) calcium/calmodulin-depend ( 370) 655 69.1 1.9e-11
NP_001317370 (OMIM: 601684) ribosomal protein S6 k ( 719) 660 70.0 1.9e-11
NP_002944 (OMIM: 601684) ribosomal protein S6 kina ( 735) 660 70.1 1.9e-11
NP_001006666 (OMIM: 601684) ribosomal protein S6 k ( 744) 660 70.1 2e-11
XP_005265573 (OMIM: 604998) PREDICTED: calcium/cal ( 413) 655 69.2 2e-11
NP_001305290 (OMIM: 603606) ribosomal protein S6 k ( 709) 657 69.8 2.3e-11
XP_005274437 (OMIM: 603606) PREDICTED: ribosomal p ( 717) 657 69.8 2.3e-11
NP_003933 (OMIM: 603606) ribosomal protein S6 kina ( 772) 657 69.8 2.4e-11
NP_001735 (OMIM: 114080) calcium/calmodulin-depend ( 473) 638 67.9 5.6e-11
NP_001310303 (OMIM: 114080) calcium/calmodulin-dep ( 473) 638 67.9 5.6e-11
NP_001310304 (OMIM: 114080) calcium/calmodulin-dep ( 473) 638 67.9 5.6e-11
NP_001309156 (OMIM: 603607) ribosomal protein S6 k ( 521) 634 67.6 7.4e-11
NP_001309159 (OMIM: 603607) ribosomal protein S6 k ( 535) 634 67.7 7.5e-11
NP_001309160 (OMIM: 603607) ribosomal protein S6 k ( 563) 634 67.7 7.6e-11
XP_016877275 (OMIM: 603607) PREDICTED: ribosomal p ( 583) 634 67.7 7.8e-11
NP_001309167 (OMIM: 603607) ribosomal protein S6 k ( 583) 634 67.7 7.8e-11
NP_001309163 (OMIM: 603607) ribosomal protein S6 k ( 610) 634 67.8 7.9e-11
NP_001309164 (OMIM: 603607) ribosomal protein S6 k ( 723) 634 67.9 8.6e-11
NP_001309166 (OMIM: 603607) ribosomal protein S6 k ( 723) 634 67.9 8.6e-11
NP_001309161 (OMIM: 603607) ribosomal protein S6 k ( 729) 634 67.9 8.7e-11
NP_001309162 (OMIM: 603607) ribosomal protein S6 k ( 748) 634 67.9 8.8e-11
NP_001309157 (OMIM: 603607) ribosomal protein S6 k ( 766) 634 67.9 8.9e-11
NP_001309165 (OMIM: 603607) ribosomal protein S6 k ( 774) 634 67.9 8.9e-11
NP_004746 (OMIM: 603607) ribosomal protein S6 kina ( 802) 634 68.0 9.1e-11
XP_016862843 (OMIM: 604998) PREDICTED: calcium/cal ( 326) 621 66.2 1.2e-10
XP_005265574 (OMIM: 604998) PREDICTED: calcium/cal ( 369) 621 66.3 1.3e-10
NP_001129212 (OMIM: 300680) calcium/calmodulin-dep ( 360) 617 66.0 1.6e-10
XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 616 65.9 1.7e-10
NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 616 65.9 1.7e-10
XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 616 65.9 1.7e-10
NP_001182345 (OMIM: 604742) serine/threonine-prote ( 433) 617 66.1 1.8e-10
NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 616 65.9 1.8e-10
XP_011529414 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 615 65.8 1.8e-10
XP_016884767 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 615 65.8 1.8e-10
XP_011529413 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 615 65.8 1.8e-10
XP_011529412 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 615 65.8 1.8e-10
XP_005274708 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 615 65.8 1.8e-10
XP_011529409 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 615 65.8 1.8e-10
>>NP_001230854 (OMIM: 602130,617111) MAP kinase-activate (382 aa)
initn: 2628 init1: 2628 opt: 2628 Z-score: 1214.0 bits: 233.4 E(85289): 7e-61
Smith-Waterman score: 2628; 100.0% identity (100.0% similar) in 382 aa overlap (1-382:1-382)
10 20 30 40 50 60
pF1KE0 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
310 320 330 340 350 360
370 380
pF1KE0 LLNKRRKKQAGSSSASQGCNNQ
::::::::::::::::::::::
NP_001 LLNKRRKKQAGSSSASQGCNNQ
370 380
>>NP_004626 (OMIM: 602130,617111) MAP kinase-activated p (382 aa)
initn: 2628 init1: 2628 opt: 2628 Z-score: 1214.0 bits: 233.4 E(85289): 7e-61
Smith-Waterman score: 2628; 100.0% identity (100.0% similar) in 382 aa overlap (1-382:1-382)
10 20 30 40 50 60
pF1KE0 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
310 320 330 340 350 360
370 380
pF1KE0 LLNKRRKKQAGSSSASQGCNNQ
::::::::::::::::::::::
NP_004 LLNKRRKKQAGSSSASQGCNNQ
370 380
>>NP_001230855 (OMIM: 602130,617111) MAP kinase-activate (382 aa)
initn: 2628 init1: 2628 opt: 2628 Z-score: 1214.0 bits: 233.4 E(85289): 7e-61
Smith-Waterman score: 2628; 100.0% identity (100.0% similar) in 382 aa overlap (1-382:1-382)
10 20 30 40 50 60
pF1KE0 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
310 320 330 340 350 360
370 380
pF1KE0 LLNKRRKKQAGSSSASQGCNNQ
::::::::::::::::::::::
NP_001 LLNKRRKKQAGSSSASQGCNNQ
370 380
>>NP_116584 (OMIM: 602006) MAP kinase-activated protein (400 aa)
initn: 1017 init1: 972 opt: 1762 Z-score: 824.3 bits: 161.3 E(85289): 3.6e-39
Smith-Waterman score: 1768; 70.7% identity (86.2% similar) in 369 aa overlap (12-368:21-389)
10 20 30 40
pF1KE0 MDGETAEEQGGPVPP-PVAPGGPGLGGAPGGRREP----------KKYAVT
: :: :. : :. : .. : :: :.
NP_116 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCI
:::....::::::.:::::. :..:: .: :::.: : ::::.::. ::.:: :::: :
NP_116 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 LDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH
.:::::.. :..::::.:::..:::::::::.:::::::::::.:::..:: :::.:::
NP_116 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
130 140 150 160 170 180
170 180 190 200 210
pF1KE0 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETT-QNALQTPCYTPYYVAPEVLGPEKY
:::::::::::::::::. .:.::::::::::::: .:.: :::::::::::::::::::
NP_116 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 DKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQ
:::::::::::::::::::.:::::: : ::::::: :::.::: :::::::::::..:.
NP_116 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 LIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSAL
::: ::::.::.:.:::.::::::: :: ::::::::.:::.:::..:..:::::::::
NP_116 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
310 320 330 340 350 360
340 350 360 370 380
pF1KE0 ATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
:::::::.:.::: .. ..: :: :::::
NP_116 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
370 380 390 400
>>NP_004750 (OMIM: 602006) MAP kinase-activated protein (370 aa)
initn: 858 init1: 813 opt: 1603 Z-score: 753.1 bits: 148.0 E(85289): 3.3e-35
Smith-Waterman score: 1609; 70.6% identity (85.9% similar) in 333 aa overlap (12-332:21-353)
10 20 30 40
pF1KE0 MDGETAEEQGGPVPP-PVAPGGPGLGGAPGGRREP----------KKYAVT
: :: :. : :. : .. : :: :.
NP_004 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCI
:::....::::::.:::::. :..:: .: :::.: : ::::.::. ::.:: :::: :
NP_004 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 LDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH
.:::::.. :..::::.:::..:::::::::.:::::::::::.:::..:: :::.:::
NP_004 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
130 140 150 160 170 180
170 180 190 200 210
pF1KE0 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETT-QNALQTPCYTPYYVAPEVLGPEKY
:::::::::::::::::. .:.::::::::::::: .:.: :::::::::::::::::::
NP_004 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 DKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQ
:::::::::::::::::::.:::::: : ::::::: :::.::: :::::::::::..:.
NP_004 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 LIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSAL
::: ::::.::.:.:::.::::::: :: ::::::::.:::.:::..:..::
NP_004 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKGCLHDKN
310 320 330 340 350 360
340 350 360 370 380
pF1KE0 ATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
NP_004 SDQATWLTRL
370
>>XP_005273410 (OMIM: 602006) PREDICTED: MAP kinase-acti (371 aa)
initn: 858 init1: 813 opt: 1603 Z-score: 753.1 bits: 148.0 E(85289): 3.3e-35
Smith-Waterman score: 1609; 70.6% identity (85.9% similar) in 333 aa overlap (12-332:21-353)
10 20 30 40
pF1KE0 MDGETAEEQGGPVPP-PVAPGGPGLGGAPGGRREP----------KKYAVT
: :: :. : :. : .. : :: :.
XP_005 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCI
:::....::::::.:::::. :..:: .: :::.: : ::::.::. ::.:: :::: :
XP_005 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 LDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH
.:::::.. :..::::.:::..:::::::::.:::::::::::.:::..:: :::.:::
XP_005 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
130 140 150 160 170 180
170 180 190 200 210
pF1KE0 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETT-QNALQTPCYTPYYVAPEVLGPEKY
:::::::::::::::::. .:.::::::::::::: .:.: :::::::::::::::::::
XP_005 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 DKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQ
:::::::::::::::::::.:::::: : ::::::: :::.::: :::::::::::..:.
XP_005 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 LIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSAL
::: ::::.::.:.:::.::::::: :: ::::::::.:::.:::..:..::
XP_005 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKGCLHDKN
310 320 330 340 350 360
340 350 360 370 380
pF1KE0 ATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
XP_005 SDQATWLTRRR
370
>>XP_016858299 (OMIM: 602006) PREDICTED: MAP kinase-acti (307 aa)
initn: 972 init1: 972 opt: 1587 Z-score: 746.6 bits: 146.6 E(85289): 7.6e-35
Smith-Waterman score: 1587; 77.4% identity (91.9% similar) in 296 aa overlap (74-368:1-296)
50 60 70 80 90 100
pF1KE0 QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDV
.: : ::::.::. ::.:: :::: :.::
XP_016 MLQDCPKARREVELHWRASQCPHIVRIVDV
10 20 30
110 120 130 140 150 160
pF1KE0 YENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIA
:::.. :..::::.:::..:::::::::.:::::::::::.:::..:: :::.::: :::
XP_016 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE0 HRDVKPENLLYTSKEKDAVLKLTDFGFAKETT-QNALQTPCYTPYYVAPEVLGPEKYDKS
::::::::::::::. .:.::::::::::::: .:.: ::::::::::::::::::::::
XP_016 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE0 CDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIR
::::::::::::::::.:::::: : ::::::: :::.::: :::::::::::..:.:::
XP_016 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE0 LLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATM
::::.::.:.:::.::::::: :: ::::::::.:::.:::..:..::::::::::::
XP_016 NLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATM
220 230 240 250 260 270
350 360 370 380
pF1KE0 RVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
::::.:.::: .. ..: :: :::::
XP_016 RVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
280 290 300
>>NP_001006945 (OMIM: 603606) ribosomal protein S6 kinas (766 aa)
initn: 518 init1: 219 opt: 671 Z-score: 331.1 bits: 71.0 E(85289): 1.1e-11
Smith-Waterman score: 671; 33.6% identity (64.8% similar) in 369 aa overlap (22-377:382-736)
10 20 30 40
pF1KE0 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLS--KQV
:: : :: : . :. ..:.:. . .
NP_001 DPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPG-RAAVARSAMMQQYELDLREPA
360 370 380 390 400 410
50 60 70 80 90 100
pF1KE0 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKA--RQEVDHHWQASGGPHIVCILDVYENM
:: : . .: .:..::. :.:.: .: ..:: .. :..: . .:
NP_001 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEV----
420 430 440 450 460
110 120 130 140 150 160
pF1KE0 HHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH-NIAHRD
:: . ...: ..::::. .:... . :.: ::..:.:.. .:..:.: . ...:::
NP_001 HHDQLHTYLVLELLRGGELLEHIRKK--RHFSESEASQILRSLVSAVSFMHEEAGVVHRD
470 480 490 500 510 520
170 180 190 200 210 220
pF1KE0 VKPENLLYTSKEKDAVLKLTDFGFAKETTQNA---LQTPCYTPYYVAPEVLGPEKYDKSC
.::::.::.. : .:. :::::. :. .::::.: :.:::.:. . ::.::
NP_001 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC
530 540 550 560 570 580
230 240 250 260 270 280
pF1KE0 DMWSLGVIMYILLCGFPPFYSNTGQAISPGMKR---RIRLGQYGFPNPEWSEVSEDAKQL
:.::::::.:..: : :: . .::. . . .:: :.... . :. :::.::.:
NP_001 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL
590 600 610 620 630 640
290 300 310 320 330 340
pF1KE0 IRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALA
.: :: .::..:: . . . :.... . . ::.: ::. . . :.:
NP_001 VRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSG-------PAVRSGLN
650 660 670 680 690
350 360 370 380
pF1KE0 TMRVDYDQVKIKD--LKTSNNRLLNKRRKKQAGSSSASQGCNNQ
. . ... : . ::. .: : ::::.. :..::.
NP_001 ATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPR
700 710 720 730 740 750
NP_001 RANGPLPPS
760
>>NP_065172 (OMIM: 614994) calcium/calmodulin-dependent (476 aa)
initn: 594 init1: 400 opt: 666 Z-score: 330.7 bits: 70.2 E(85289): 1.1e-11
Smith-Waterman score: 666; 35.9% identity (66.5% similar) in 334 aa overlap (48-374:27-346)
20 30 40 50 60 70
pF1KE0 APGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYD
.::: :. ..:. .: ::. ::: .
NP_065 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK
10 20 30 40 50
80 90 100 110 120 130
pF1KE0 SPKARQEVDHHWQAS----GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQER
:: :. .. : .:: . :.::. : ..:. . :::::.:: ::
NP_065 SPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTH----YYLVMQLVSGGELFDRILER
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE0 GDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE
: ..::..:. ..... .:...:: ..:.:::.::::::: . :... . .::::..:
NP_065 G--VYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE0 TTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG
.. ..: : :: :::::::. . :.:. : ::.::: ::::::.:::: .: . .
NP_065 EQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLF--
180 190 200 210 220
260 270 280 290 300 310
pF1KE0 MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQT
..:. : : : .: :...::.::..: ::. ::.:: : . ..::::. . .. .
NP_065 --EKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTAL-HR
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE0 PLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIK-DLKTSNNR--LLNKRRKKQA
.. . :: .:. .: . .:. . : . . :.. .:.. . : . :. . ::
NP_065 DIYPSVSLQIQKNF---AKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQA
290 300 310 320 330 340
380
pF1KE0 GSSSASQGCNNQ
. .:
NP_065 SETSRPSSPEITITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSS
350 360 370 380 390 400
>>XP_016857355 (OMIM: 614994) PREDICTED: calcium/calmodu (476 aa)
initn: 594 init1: 400 opt: 666 Z-score: 330.7 bits: 70.2 E(85289): 1.1e-11
Smith-Waterman score: 666; 35.9% identity (66.5% similar) in 334 aa overlap (48-374:27-346)
20 30 40 50 60 70
pF1KE0 APGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYD
.::: :. ..:. .: ::. ::: .
XP_016 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK
10 20 30 40 50
80 90 100 110 120 130
pF1KE0 SPKARQEVDHHWQAS----GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQER
:: :. .. : .:: . :.::. : ..:. . :::::.:: ::
XP_016 SPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTH----YYLVMQLVSGGELFDRILER
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE0 GDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE
: ..::..:. ..... .:...:: ..:.:::.::::::: . :... . .::::..:
XP_016 G--VYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE0 TTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG
.. ..: : :: :::::::. . :.:. : ::.::: ::::::.:::: .: . .
XP_016 EQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLF--
180 190 200 210 220
260 270 280 290 300 310
pF1KE0 MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQT
..:. : : : .: :...::.::..: ::. ::.:: : . ..::::. . .. .
XP_016 --EKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTAL-HR
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE0 PLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIK-DLKTSNNR--LLNKRRKKQA
.. . :: .:. .: . .:. . : . . :.. .:.. . : . :. . ::
XP_016 DIYPSVSLQIQKNF---AKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQA
290 300 310 320 330 340
380
pF1KE0 GSSSASQGCNNQ
. .:
XP_016 SETSRPSSPEITITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSS
350 360 370 380 390 400
382 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:01:19 2016 done: Wed Nov 2 19:01:21 2016
Total Scan time: 9.580 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]