Result of FASTA (omim) for
pF1KE0594
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0594, 170 aa
1>>>pF1KE0594 170 - 170 aa - 170 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7491+/-0.000295; mu= 17.2093+/- 0.019
mean_var=105.9608+/-21.272, 0's: 0 Z-trim(120.2): 254 B-trim: 84 in 1/54
Lambda= 0.124595
statistics sampled from 34760 (35091) to 34760 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.411), width: 16
Scan time: 6.110
The best scores are: opt bits E(85289)
NP_036278 (OMIM: 611441) double homeobox protein 1 ( 170) 1136 213.7 1.2e-55
NP_036281 (OMIM: 611444) double homeobox protein 5 ( 197) 1136 213.7 1.3e-55
NP_001292997 (OMIM: 606009) double homeobox protei ( 424) 917 174.8 1.4e-43
NP_001280727 (OMIM: 606009) double homeobox protei ( 424) 917 174.8 1.4e-43
XP_011529816 (OMIM: 606009) PREDICTED: double home ( 160) 881 167.8 7.2e-42
NP_001012747 (OMIM: 611168) double homeobox protei ( 204) 265 57.2 1.8e-08
NP_006252 (OMIM: 262600,601538) homeobox protein p ( 226) 221 49.3 4.6e-06
NP_116142 (OMIM: 605726,610362,610381,613757) reti ( 184) 219 48.9 5.2e-06
NP_055377 (OMIM: 600036) homeobox protein OTX1 [Ho ( 354) 222 49.8 5.3e-06
NP_001186699 (OMIM: 600036) homeobox protein OTX1 ( 354) 222 49.8 5.3e-06
NP_001306003 (OMIM: 605726,610362,610381,613757) r ( 230) 219 49.0 5.9e-06
NP_114150 (OMIM: 609852) homeobox protein MIXL1 is ( 232) 219 49.0 6e-06
NP_000545 (OMIM: 120970,268000,602225,613829) cone ( 299) 214 48.3 1.3e-05
XP_016870292 (OMIM: 604675) PREDICTED: paired meso ( 193) 211 47.5 1.4e-05
NP_038463 (OMIM: 601881,611038) retinal homeobox p ( 346) 213 48.2 1.6e-05
NP_068374 (OMIM: 600037,610125,613986) homeobox pr ( 297) 212 47.9 1.6e-05
NP_001257454 (OMIM: 600037,610125,613986) homeobox ( 297) 212 47.9 1.6e-05
NP_057391 (OMIM: 604675) paired mesoderm homeobox ( 253) 211 47.6 1.7e-05
NP_005020 (OMIM: 107250,602669,610623) pituitary h ( 302) 211 47.7 1.9e-05
XP_006713442 (OMIM: 182230,601802) PREDICTED: home ( 185) 206 46.5 2.6e-05
XP_016862910 (OMIM: 182230,601802) PREDICTED: home ( 185) 206 46.5 2.6e-05
NP_003856 (OMIM: 182230,601802) homeobox expressed ( 185) 206 46.5 2.6e-05
XP_005265583 (OMIM: 182230,601802) PREDICTED: home ( 185) 206 46.5 2.6e-05
XP_011532507 (OMIM: 182230,601802) PREDICTED: home ( 185) 206 46.5 2.6e-05
XP_011532506 (OMIM: 182230,601802) PREDICTED: home ( 185) 206 46.5 2.6e-05
NP_115485 (OMIM: 604529) homeobox protein orthoped ( 325) 208 47.2 2.9e-05
NP_758840 (OMIM: 600037,610125,613986) homeobox pr ( 289) 207 47.0 3e-05
NP_001257453 (OMIM: 600037,610125,613986) homeobox ( 289) 207 47.0 3e-05
NP_001257452 (OMIM: 600037,610125,613986) homeobox ( 289) 207 47.0 3e-05
NP_878314 (OMIM: 142993,610092,610093) visual syst ( 361) 206 46.9 3.9e-05
NP_001128726 (OMIM: 167410,268220) paired box prot ( 505) 207 47.3 4.2e-05
NP_039236 (OMIM: 167410,268220) paired box protein ( 518) 207 47.3 4.3e-05
NP_002575 (OMIM: 167410,268220) paired box protein ( 520) 207 47.3 4.3e-05
XP_016883326 (OMIM: 122000,148300,605020,614195) P ( 280) 203 46.2 4.9e-05
NP_001243201 (OMIM: 122000,148300,605020,614195) v ( 301) 203 46.3 5.1e-05
NP_852126 (OMIM: 122880,148820,193500,268220,60659 ( 403) 204 46.6 5.4e-05
NP_852125 (OMIM: 122880,148820,193500,268220,60659 ( 407) 204 46.6 5.4e-05
NP_055403 (OMIM: 122000,148300,605020,614195) visu ( 365) 203 46.4 5.7e-05
NP_852122 (OMIM: 122880,148820,193500,268220,60659 ( 479) 204 46.7 5.9e-05
NP_001120838 (OMIM: 122880,148820,193500,268220,60 ( 483) 204 46.7 6e-05
NP_852123 (OMIM: 122880,148820,193500,268220,60659 ( 484) 204 46.7 6e-05
NP_852124 (OMIM: 122880,148820,193500,268220,60659 ( 505) 204 46.8 6.1e-05
NP_671725 (OMIM: 607410) diencephalon/mesencephalo ( 382) 201 46.1 7.5e-05
NP_006483 (OMIM: 136760,606014) homeobox protein a ( 343) 200 45.8 8e-05
NP_001269331 (OMIM: 609852) homeobox protein MIXL1 ( 240) 197 45.1 9.4e-05
NP_620689 (OMIM: 300004,300215,300382,300419,30835 ( 562) 201 46.3 9.5e-05
NP_703149 (OMIM: 300154) homeobox protein ESX1 [Ho ( 406) 199 45.7 0.0001
NP_068745 (OMIM: 605420,609597,613451,615529) home ( 411) 199 45.7 0.0001
NP_005160 (OMIM: 602078,602753) paired mesoderm ho ( 284) 197 45.2 0.0001
XP_006711451 (OMIM: 167420,202650) PREDICTED: pair ( 198) 194 44.4 0.00012
>>NP_036278 (OMIM: 611441) double homeobox protein 1 [Ho (170 aa)
initn: 1136 init1: 1136 opt: 1136 Z-score: 1120.1 bits: 213.7 E(85289): 1.2e-55
Smith-Waterman score: 1136; 97.6% identity (98.8% similar) in 170 aa overlap (1-170:1-170)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEQLAQGIDIPE
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
NP_036 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAAPIG
: :::::::::::::::::.::::::::: ::::::::::::::::::::
NP_036 IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
130 140 150 160 170
>>NP_036281 (OMIM: 611444) double homeobox protein 5 [Ho (197 aa)
initn: 1136 init1: 1136 opt: 1136 Z-score: 1119.4 bits: 213.7 E(85289): 1.3e-55
Smith-Waterman score: 1136; 97.6% identity (98.8% similar) in 170 aa overlap (1-170:28-197)
10 20 30
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDA
:::::::::::::::::::::::::::::::::
NP_036 MPAEVHGSPPASLCPCQSVKFRPGLPEMALLTALDDTLPEEAQGPGRRMILLSTPSQSDA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LRACFERNLYPGIATKEQLAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQK
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
NP_036 LRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 GRRKRTAITGSQTALLLRAFEKDRFPGIPAREELARETGLPESRIQLWFQNRRARHWGQS
:::::::::::::::::::::::::::: :::::::::::::::::.::::::::: :::
NP_036 GRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQS
130 140 150 160 170 180
160 170
pF1KE0 GRAPTQASIRCNAAPIG
:::::::::::::::::
NP_036 GRAPTQASIRCNAAPIG
190
>>NP_001292997 (OMIM: 606009) double homeobox protein 4 (424 aa)
initn: 1106 init1: 917 opt: 917 Z-score: 903.1 bits: 174.8 E(85289): 1.4e-43
Smith-Waterman score: 917; 80.6% identity (89.4% similar) in 170 aa overlap (1-170:1-170)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEQLAQGIDIPE
::: : :.::: ::.: ::: :. :::::.::::::::: ::::::.:.:::.: :::
NP_001 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:::::::::::: :::::::.:::::::: : .:::::::.:::::::::::::::::::
NP_001 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAAPIG
: :::::::::::::::::.::::::::: ::.::::.::. :.::: :
NP_001 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF
130 140 150 160 170 180
NP_001 AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA
190 200 210 220 230 240
>>NP_001280727 (OMIM: 606009) double homeobox protein 4 (424 aa)
initn: 1106 init1: 917 opt: 917 Z-score: 903.1 bits: 174.8 E(85289): 1.4e-43
Smith-Waterman score: 917; 80.6% identity (89.4% similar) in 170 aa overlap (1-170:1-170)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEQLAQGIDIPE
::: : :.::: ::.: ::: :. :::::.::::::::: ::::::.:.:::.: :::
NP_001 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:::::::::::: :::::::.:::::::: : .:::::::.:::::::::::::::::::
NP_001 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAAPIG
: :::::::::::::::::.::::::::: ::.::::.::. :.::: :
NP_001 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF
130 140 150 160 170 180
NP_001 AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA
190 200 210 220 230 240
>>XP_011529816 (OMIM: 606009) PREDICTED: double homeobox (160 aa)
initn: 1070 init1: 881 opt: 881 Z-score: 872.7 bits: 167.8 E(85289): 7.2e-42
Smith-Waterman score: 881; 82.4% identity (90.6% similar) in 159 aa overlap (1-159:1-159)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEQLAQGIDIPE
::: : :.::: ::.: ::: :. :::::.::::::::: ::::::.:.:::.: :::
XP_011 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:::::::::::: :::::::.:::::::: : .:::::::.:::::::::::::::::::
XP_011 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAAPIG
: :::::::::::::::::.::::::::: ::.::::.:
XP_011 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQV
130 140 150 160
>>NP_001012747 (OMIM: 611168) double homeobox protein A (204 aa)
initn: 231 init1: 231 opt: 265 Z-score: 273.1 bits: 57.2 E(85289): 1.8e-08
Smith-Waterman score: 363; 43.0% identity (63.8% similar) in 149 aa overlap (20-157:16-164)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEQLAQGIDIPE
:: : : : :... ::: :::..:: :. :
NP_001 MAEDTYSHKMVKTNHRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEE
10 20 30 40 50
70 80 90 100
pF1KE0 PRVQIWFQNERSCQLRQHR----------RQSRPWPGRR-DPQKGRRKRTAITGSQTALL
:.::::::.:. . :.: :.. :: . . ...:: ::. ..:: :
NP_001 SRIQIWFQNRRARHGFQKRPEAETLESSQSQGQDQPGVEFQSREARRCRTTYSASQLHTL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 LRAFEKDRFPGIPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAAPI
..:: :. .::: .:::::.: :.::::.:.::::::.: : : :
NP_001 IKAFMKNPYPGIDSREELAKEIGVPESRVQIWFQNRRSRLLLQRKREPVASLEQEEQGKI
120 130 140 150 160 170
170
pF1KE0 G
NP_001 PEGLQGAEDTQNGTNFTSDSHFSGARTW
180 190 200
>>NP_006252 (OMIM: 262600,601538) homeobox protein proph (226 aa)
initn: 208 init1: 208 opt: 221 Z-score: 229.9 bits: 49.3 E(85289): 4.6e-06
Smith-Waterman score: 221; 48.0% identity (70.7% similar) in 75 aa overlap (79-152:53-127)
50 60 70 80 90 100
pF1KE0 KEQLAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRD-PQKGRRKRTAITGSQTA
: . : :.: :.. ::.::... :
NP_006 PERHPATGTPTTTVDSSAPPCRRLPGAGGGRSRFSPQGGQRGRPHSRRRHRTTFSPVQLE
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE0 LLLRAFEKDRFPGIPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAA
: :: ....: : ::: :::.::: :.:::.:::::::.. :
NP_006 QLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPAA
90 100 110 120 130 140
170
pF1KE0 PIG
NP_006 FSSFLPESTACPYSYAAPPPPVTCFPHPYSHALPSQPSTGGAFALSHQSEDWYPTLHPAP
150 160 170 180 190 200
>>NP_116142 (OMIM: 605726,610362,610381,613757) retina a (184 aa)
initn: 194 init1: 194 opt: 219 Z-score: 228.9 bits: 48.9 E(85289): 5.2e-06
Smith-Waterman score: 219; 49.3% identity (74.6% similar) in 71 aa overlap (86-155:18-87)
60 70 80 90 100 110
pF1KE0 IDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKG-RRKRTAITGSQTALLLRAFE
::.. :.: ::.::..: : : ::::
NP_116 MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFE
10 20 30 40
120 130 140 150 160 170
pF1KE0 KDRFPGIPAREELARETGLPESRIQLWFQNRRARHWGQSGRAPTQASIRCNAAPIG
...: . .::::: .. ::: :.:.:::::::. : .. :
NP_116 ASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAK-WRRQERLESGSGAVAAPRLPEAPAL
50 60 70 80 90 100
NP_116 PFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASL
110 120 130 140 150 160
>>NP_055377 (OMIM: 600036) homeobox protein OTX1 [Homo s (354 aa)
initn: 331 init1: 190 opt: 222 Z-score: 228.8 bits: 49.8 E(85289): 5.3e-06
Smith-Waterman score: 222; 44.4% identity (69.1% similar) in 81 aa overlap (91-169:35-115)
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:.: ::.::..: :: .: : : :.:
NP_055 LKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPD
10 20 30 40 50 60
130 140 150 160 170
pF1KE0 IPAREELARETGLPESRIQLWFQNRRA--RHWGQSGRAPTQASIRCNAAPIG
: :::.: . .:::::.:.::.:::: :. ::: . . . ...:.
NP_055 IFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESS
70 80 90 100 110 120
NP_055 GQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISP
130 140 150 160 170 180
>>NP_001186699 (OMIM: 600036) homeobox protein OTX1 [Hom (354 aa)
initn: 331 init1: 190 opt: 222 Z-score: 228.8 bits: 49.8 E(85289): 5.3e-06
Smith-Waterman score: 222; 44.4% identity (69.1% similar) in 81 aa overlap (91-169:35-115)
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:.: ::.::..: :: .: : : :.:
NP_001 LKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPD
10 20 30 40 50 60
130 140 150 160 170
pF1KE0 IPAREELARETGLPESRIQLWFQNRRA--RHWGQSGRAPTQASIRCNAAPIG
: :::.: . .:::::.:.::.:::: :. ::: . . . ...:.
NP_001 IFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESS
70 80 90 100 110 120
NP_001 GQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISP
130 140 150 160 170 180
170 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 20:47:39 2016 done: Wed Nov 2 20:47:40 2016
Total Scan time: 6.110 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]