Result of FASTA (omim) for
pF1KE0576
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0576, 271 aa
1>>>pF1KE0576 271 - 271 aa - 271 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9064+/-0.000314; mu= 17.9145+/- 0.020
mean_var=69.8443+/-14.231, 0's: 0 Z-trim(116.6): 31 B-trim: 0 in 0/54
Lambda= 0.153465
statistics sampled from 27902 (27933) to 27902 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.328), width: 16
Scan time: 5.480
The best scores are: opt bits E(85289)
XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 455) 1954 441.4 1.4e-123
NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 1180 269.9 4.9e-72
XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 442) 1164 266.4 6.3e-71
XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 202) 812 188.2 1e-47
XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 227) 508 121.0 2e-27
NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 508 121.1 2.9e-27
NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 501 119.6 8.3e-27
NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 501 119.6 8.8e-27
NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 331 81.7 1.1e-15
NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 247 63.1 4.4e-10
XP_006724353 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 317) 249 63.7 4.8e-10
XP_016884393 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 457) 249 63.9 6.3e-10
XP_011519075 (OMIM: 605257,605258) PREDICTED: sing ( 145) 241 61.7 9e-10
NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 241 61.8 1.1e-09
NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 220 57.1 2.8e-08
NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 220 57.2 3.3e-08
NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 220 57.2 3.3e-08
NP_001006667 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 213 55.4 5e-08
XP_016884132 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 101) 213 55.4 5e-08
NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 215 56.3 1e-07
XP_016884392 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 524) 215 56.4 1.3e-07
NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 188 50.0 3.2e-06
NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 173 46.8 4.3e-05
NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 170 46.1 5.8e-05
NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 170 46.1 5.8e-05
XP_011528294 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 200) 170 46.1 6.2e-05
NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 170 46.1 6.2e-05
XP_011528293 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 170 46.1 6.3e-05
XP_011528292 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 170 46.1 6.3e-05
>>XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (455 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2339.4 bits: 441.4 E(85289): 1.4e-123
Smith-Waterman score: 1954; 100.0% identity (100.0% similar) in 271 aa overlap (1-271:1-271)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
190 200 210 220 230 240
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:::::::::::::::::::::::::::::::
XP_016 FVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWL
250 260 270 280 290 300
XP_016 CFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWS
310 320 330 340 350 360
>--
initn: 601 init1: 315 opt: 429 Z-score: 514.7 bits: 103.7 E(85289): 6.3e-22
Smith-Waterman score: 429; 42.0% identity (63.7% similar) in 157 aa overlap (7-163:272-416)
10 20 30
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC
:::: :: :: .:.: ::. .:::
XP_016 VCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLC
250 260 270 280 290 300
40 50 60 70 80 90
pF1KE0 YEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANR
. ... . .: .. ::::. : :. . ::: ::::::: . : :
XP_016 FTMEVTKHHSAVFRKRGVFRNQVDPETHC------------HAERCFLSWFCDDILSPNT
310 320 330 340
100 110 120 130 140 150
pF1KE0 RFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGAR
...::..::.:: :. .:..:::.: ::.::: .::: :. : :.. : : . ::
XP_016 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGAS
350 360 370 380 390 400
160 170 180 190 200 210
pF1KE0 VKIMDYEGERCRGQGSMTGRNSLRDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRA
:::: :.
XP_016 VKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
410 420 430 440 450
>>NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme APO (386 aa)
initn: 1464 init1: 1180 opt: 1180 Z-score: 1414.2 bits: 269.9 E(85289): 4.9e-72
Smith-Waterman score: 1330; 74.5% identity (74.5% similar) in 271 aa overlap (1-271:1-202)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
:::::::::::::::::::::::::::::::::::::::::::
NP_689 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYE-----------------
130 140 150 160
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
::::::::
NP_689 ----------------------------------------------------DFAYCWEN
170
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:::::::::::::::::::::::::::::::
NP_689 FVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWL
180 190 200 210 220 230
NP_689 CFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWS
240 250 260 270 280 290
>--
initn: 601 init1: 315 opt: 429 Z-score: 515.6 bits: 103.7 E(85289): 5.6e-22
Smith-Waterman score: 429; 42.0% identity (63.7% similar) in 157 aa overlap (7-163:203-347)
10 20 30
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC
:::: :: :: .:.: ::. .:::
NP_689 VCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLC
180 190 200 210 220 230
40 50 60 70 80 90
pF1KE0 YEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANR
. ... . .: .. ::::. : :. . ::: ::::::: . : :
NP_689 FTMEVTKHHSAVFRKRGVFRNQVDPETHC------------HAERCFLSWFCDDILSPNT
240 250 260 270 280
100 110 120 130 140 150
pF1KE0 RFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGAR
...::..::.:: :. .:..:::.: ::.::: .::: :. : :.. : : . ::
NP_689 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGAS
290 300 310 320 330 340
160 170 180 190 200 210
pF1KE0 VKIMDYEGERCRGQGSMTGRNSLRDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRA
:::: :.
NP_689 VKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
350 360 370 380
>>XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (442 aa)
initn: 1299 init1: 1144 opt: 1164 Z-score: 1394.3 bits: 266.4 E(85289): 6.3e-71
Smith-Waterman score: 1313; 71.2% identity (83.4% similar) in 271 aa overlap (1-271:1-258)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::
XP_011 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRG---
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
.:: . :.:::::::::::::.::: . :::::::::.:: ::.:...::
XP_011 ---------QVYSQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
:::::::::::::::::: .::.: .: :: .::::::::: :::: :::::..::::..
XP_011 AEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEGERWRGQGSVSGRNSMK
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
::::::::::::::::::.: :: :::::::::: ::::::.::.:: ::.:.:::::::
XP_011 DGWICNAMAGGVPGQPAGAGPALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWEN
170 180 190 200 210 220
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: .:::::::::::::::: ::::::::::
XP_011 FVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWL
230 240 250 260 270 280
XP_011 CFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWS
290 300 310 320 330 340
>--
initn: 626 init1: 320 opt: 457 Z-score: 548.3 bits: 109.9 E(85289): 8.4e-24
Smith-Waterman score: 458; 33.3% identity (48.1% similar) in 264 aa overlap (7-270:259-441)
10 20 30
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC
:::: :: :: .:.: :::. .:::
XP_011 VYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLC
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE0 YEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANR
. ... . .: . : ::::. : :. . ::: ::::::: . : :
XP_011 FTMEVVKHHSPVSWKRGVFRNQVDPETHC------------HAERCFLSWFCDDILSPNT
290 300 310 320 330
100 110 120 130 140 150
pF1KE0 RFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGAR
...::..::.:: :. .:..:::.: ::.::: .:::::. : :.. : : . ::
XP_011 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGAS
340 350 360 370 380 390
160 170 180 190 200 210
pF1KE0 VKIMDYEGERCRGQGSMTGRNSLRDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRA
:.:: :.
XP_011 VEIMGYK-----------------------------------------------------
400
220 230 240 250 260 270
pF1KE0 GPGSGESLSASHLFISDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: ::::::: :. .:: :: . :. : :.:::
XP_011 ----------------DFKYCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
410 420 430 440
>>XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (202 aa)
initn: 941 init1: 812 opt: 812 Z-score: 977.7 bits: 188.2 E(85289): 1e-47
Smith-Waterman score: 812; 70.6% identity (83.4% similar) in 163 aa overlap (1-163:1-163)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
::::::::::: . . ::: ::::::: . : : ...::..::.:: :. .:..::
XP_005 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
:.: ::.::: .::: :. : :.. : : . :: :::: :.
XP_005 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
XP_005 KPWKGLQTNFRLLKRRLREILQ
190 200
>>XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (227 aa)
initn: 902 init1: 481 opt: 508 Z-score: 613.3 bits: 121.0 E(85289): 2e-27
Smith-Waterman score: 771; 50.6% identity (59.8% similar) in 271 aa overlap (1-271:1-189)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::
XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRG---
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
.:: . :.:::::::::::::.::: . :::::::::.:: ::.:...::
XP_016 ---------QVYSQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
:::::::::::::::::: .::.: .: :: .::::::::: :
XP_016 AEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDE-----------------
110 120 130 140 150
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
.:::::::
XP_016 ----------------------------------------------------EFAYCWEN
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: .:::::::::::::::: ::::::::::
XP_016 FVYSEGQPFMPWYKFDDNYAFLHRTLKEILRATSIHLRGRPPHSLGSPTWLLPSPWHNRI
160 170 180 190 200 210
XP_016 CHKTGRKWA
220
>>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa)
initn: 1095 init1: 481 opt: 508 Z-score: 610.4 bits: 121.1 E(85289): 2.9e-27
Smith-Waterman score: 771; 50.6% identity (59.8% similar) in 271 aa overlap (1-271:1-189)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::
NP_660 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRG---
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
.:: . :.:::::::::::::.::: . :::::::::.:: ::.:...::
NP_660 ---------QVYSQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
:::::::::::::::::: .::.: .: :: .::::::::: :
NP_660 AEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDE-----------------
110 120 130 140 150
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
.:::::::
NP_660 ----------------------------------------------------EFAYCWEN
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: .:::::::::::::::: ::::::::::
NP_660 FVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWL
160 170 180 190 200 210
NP_660 CFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWS
220 230 240 250 260 270
>--
initn: 626 init1: 320 opt: 457 Z-score: 549.3 bits: 109.9 E(85289): 7.4e-24
Smith-Waterman score: 458; 33.3% identity (48.1% similar) in 264 aa overlap (7-270:190-372)
10 20 30
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC
:::: :: :: .:.: :::. .:::
NP_660 VYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLC
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE0 YEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANR
. ... . .: . : ::::. : :. . ::: ::::::: . : :
NP_660 FTMEVVKHHSPVSWKRGVFRNQVDPETHC------------HAERCFLSWFCDDILSPNT
220 230 240 250 260
100 110 120 130 140 150
pF1KE0 RFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGAR
...::..::.:: :. .:..:::.: ::.::: .:::::. : :.. : : . ::
NP_660 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGAS
270 280 290 300 310 320
160 170 180 190 200 210
pF1KE0 VKIMDYEGERCRGQGSMTGRNSLRDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRA
:.:: :.
NP_660 VEIMGYK-----------------------------------------------------
330
220 230 240 250 260 270
pF1KE0 GPGSGESLSASHLFISDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: ::::::: :. .:: :: . :. : :.:::
NP_660 ----------------DFKYCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
340 350 360 370
>>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa)
initn: 738 init1: 501 opt: 501 Z-score: 602.2 bits: 119.6 E(85289): 8.3e-27
Smith-Waterman score: 976; 59.0% identity (65.3% similar) in 271 aa overlap (1-271:1-190)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRG---
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
.:::. . :::::::::::::.::: . :::::::::.:: ::.:...::
NP_001 ---------QVYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
.::::::::::::::::: .::.: .: :: .:::::::::::
NP_001 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYE-----------------
110 120 130 140 150
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
.:::::::
NP_001 ----------------------------------------------------EFAYCWEN
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: :::: ::::::::.::: ::::::::::
NP_001 FVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYE
160 170 180 190 200 210
NP_001 VERLDNGTWVLMDQHMGFLCNELDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVR
220 230 240 250 260 270
>>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa)
initn: 738 init1: 501 opt: 501 Z-score: 601.8 bits: 119.6 E(85289): 8.8e-27
Smith-Waterman score: 976; 59.0% identity (65.3% similar) in 271 aa overlap (1-271:1-190)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRG---
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
.:::. . :::::::::::::.::: . :::::::::.:: ::.:...::
NP_004 ---------QVYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KE0 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
.::::::::::::::::: .::.: .: :: .:::::::::::
NP_004 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYE-----------------
110 120 130 140 150
190 200 210 220 230 240
pF1KE0 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
.:::::::
NP_004 ----------------------------------------------------EFAYCWEN
250 260 270
pF1KE0 FVCNEGQPFMPWYKFDDNYASLHRTLKEILR
:: :::: ::::::::.::: ::::::::::
NP_004 FVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYE
160 170 180 190 200 210
NP_004 VERLDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFI
220 230 240 250 260 270
>>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa)
initn: 611 init1: 316 opt: 331 Z-score: 402.5 bits: 81.7 E(85289): 1.1e-15
Smith-Waterman score: 482; 36.4% identity (50.7% similar) in 272 aa overlap (1-271:1-190)
10 20 30 40 50
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGPV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::. :
NP_055 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 LPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKF
. .: ::: ::::::: . : : ..:.::..::.:: :. .:..:
NP_055 ---DSETH---------CHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEF
60 70 80 90 100
120 130 140 150 160 170
pF1KE0 LAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSL
::.: ::.::: .:::::.. .. : : . :. :.:::::
NP_055 LARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYE----------------
110 120 130 140 150
180 190 200 210 220 230
pF1KE0 RDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWE
:: ::::
NP_055 -----------------------------------------------------DFKYCWE
240 250 260 270
pF1KE0 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILR
::: :...:: :: . :. :.: :.: :.
NP_055 NFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
160 170 180 190
>>NP_001317272 (OMIM: 605257,605258) single-stranded DNA (188 aa)
initn: 296 init1: 198 opt: 247 Z-score: 302.1 bits: 63.1 E(85289): 4.4e-10
Smith-Waterman score: 278; 33.3% identity (56.9% similar) in 174 aa overlap (12-180:6-161)
10 20 30 40 50 60
pF1KE0 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
: : : .:.: :: :.::: :: . . ... : :
NP_001 MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFG-------
10 20 30 40
70 80 90 100 110
pF1KE0 PKRQSNHRQEVYFRFEN--HAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTK
:.: .: :.:. :: .. : .: ...:::.::.:: :. .:.
NP_001 -----------YLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAD
50 60 70 80 90
120 130 140 150 160 170
pF1KE0 FLAEHPNVTLTISAARLYYYRDRDWRWV-LLRLHKAGARVKIMDYEGERCRGQGSMTG--
:: .::..: : .::::. .:: . : :::.::... :: .. .. : . :
NP_001 FLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKENHERTFKAWEGLH
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE0 RNSLRDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFA
.::.:
NP_001 ENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL
160 170 180
271 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 22:31:48 2016 done: Wed Nov 2 22:31:49 2016
Total Scan time: 5.480 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]