Result of FASTA (omim) for
pF1KE0548
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0548, 166 aa
1>>>pF1KE0548 166 - 166 aa - 166 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5096+/-0.000298; mu= 12.2183+/- 0.019
mean_var=72.2849+/-14.941, 0's: 0 Z-trim(118.6): 40 B-trim: 1335 in 1/48
Lambda= 0.150852
statistics sampled from 31620 (31662) to 31620 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.754), E-opt: 0.2 (0.371), width: 16
Scan time: 4.960
The best scores are: opt bits E(85289)
XP_006724289 (OMIM: 609063,616811) PREDICTED: thio ( 166) 1110 249.8 1.5e-66
NP_036605 (OMIM: 609063,616811) thioredoxin, mitoc ( 166) 1110 249.8 1.5e-66
XP_005261565 (OMIM: 609063,616811) PREDICTED: thio ( 197) 1110 249.8 1.7e-66
XP_011528413 (OMIM: 609063,616811) PREDICTED: thio ( 128) 604 139.6 1.7e-33
NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 229 58.0 5.3e-09
NP_005304 (OMIM: 602046) protein disulfide-isomera ( 505) 204 52.9 8.6e-07
NP_000909 (OMIM: 112240,176790) protein disulfide- ( 508) 197 51.4 2.5e-06
NP_006801 (OMIM: 616942) protein disulfide-isomera ( 519) 187 49.2 1.1e-05
NP_001139021 (OMIM: 616412) thioredoxin domain-con ( 324) 179 47.3 2.6e-05
NP_110437 (OMIM: 616412) thioredoxin domain-contai ( 432) 179 47.4 3.3e-05
NP_001258510 (OMIM: 607987) dnaJ homolog subfamily ( 747) 179 47.5 5.1e-05
NP_061854 (OMIM: 607987) dnaJ homolog subfamily C ( 793) 179 47.6 5.4e-05
NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406) 174 46.3 6.6e-05
XP_011524337 (OMIM: 616102) PREDICTED: protein dis ( 229) 156 42.3 0.00062
XP_011524336 (OMIM: 616102) PREDICTED: protein dis ( 231) 156 42.3 0.00062
XP_011508610 (OMIM: 611099) PREDICTED: protein dis ( 402) 156 42.4 0.00099
NP_001269634 (OMIM: 611099) protein disulfide-isom ( 488) 157 42.7 0.001
NP_001269636 (OMIM: 611099) protein disulfide-isom ( 437) 156 42.4 0.0011
NP_005733 (OMIM: 611099) protein disulfide-isomera ( 440) 156 42.4 0.0011
NP_001269635 (OMIM: 611099) protein disulfide-isom ( 445) 156 42.4 0.0011
NP_061895 (OMIM: 616102) protein disulfide-isomera ( 454) 156 42.4 0.0011
NP_001269633 (OMIM: 611099) protein disulfide-isom ( 492) 156 42.4 0.0012
XP_011524565 (OMIM: 603049) PREDICTED: thioredoxin ( 282) 150 41.0 0.0018
XP_016881582 (OMIM: 603049) PREDICTED: thioredoxin ( 289) 150 41.0 0.0019
NP_004777 (OMIM: 603049) thioredoxin-like protein ( 289) 150 41.0 0.0019
XP_006722643 (OMIM: 603049) PREDICTED: thioredoxin ( 292) 150 41.0 0.0019
>>XP_006724289 (OMIM: 609063,616811) PREDICTED: thioredo (166 aa)
initn: 1110 init1: 1110 opt: 1110 Z-score: 1315.8 bits: 249.8 E(85289): 1.5e-66
Smith-Waterman score: 1110; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE0 MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
70 80 90 100 110 120
130 140 150 160
pF1KE0 HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
130 140 150 160
>>NP_036605 (OMIM: 609063,616811) thioredoxin, mitochond (166 aa)
initn: 1110 init1: 1110 opt: 1110 Z-score: 1315.8 bits: 249.8 E(85289): 1.5e-66
Smith-Waterman score: 1110; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE0 MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
70 80 90 100 110 120
130 140 150 160
pF1KE0 HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
::::::::::::::::::::::::::::::::::::::::::::::
NP_036 HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
130 140 150 160
>>XP_005261565 (OMIM: 609063,616811) PREDICTED: thioredo (197 aa)
initn: 1110 init1: 1110 opt: 1110 Z-score: 1314.7 bits: 249.8 E(85289): 1.7e-66
Smith-Waterman score: 1110; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:32-197)
10 20 30
pF1KE0 MAQRLLLRRFLASVISRKPSQGQWPPLTSR
::::::::::::::::::::::::::::::
XP_005 YVPPRGSDDRRALDRQGGLGCASLRSHCREMAQRLLLRRFLASVISRKPSQGQWPPLTSR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 ALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWC
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 GPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVG
130 140 150 160 170 180
160
pF1KE0 IKDEDQLEAFLKKLIG
::::::::::::::::
XP_005 IKDEDQLEAFLKKLIG
190
>>XP_011528413 (OMIM: 609063,616811) PREDICTED: thioredo (128 aa)
initn: 589 init1: 589 opt: 604 Z-score: 722.3 bits: 139.6 E(85289): 1.7e-33
Smith-Waterman score: 604; 92.9% identity (93.9% similar) in 98 aa overlap (1-98:32-128)
10 20 30
pF1KE0 MAQRLLLRRFLASVISRKPSQGQWPPLTSR
::::::::::::::::::::::::::::::
XP_011 YVPPRGSDDRRALDRQGGLGCASLRSHCREMAQRLLLRRFLASVISRKPSQGQWPPLTSR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 ALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_011 ALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQ-C
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 GPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVG
: . :
XP_011 QRCPLCWP
>>NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Homo s (105 aa)
initn: 127 init1: 115 opt: 229 Z-score: 282.5 bits: 58.0 E(85289): 5.3e-09
Smith-Waterman score: 229; 35.9% identity (72.8% similar) in 103 aa overlap (64-165:5-105)
40 50 60 70 80 90
pF1KE0 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP
:.. ::. . . .. ::::: : ::::
NP_003 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP
10 20 30
100 110 120 130 140 150
pF1KE0 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK
::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: :
NP_003 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGA-
40 50 60 70 80 90
160
pF1KE0 DEDQLEAFLKKLIG
....::: ...:.
NP_003 NKEKLEATINELV
100
>>NP_005304 (OMIM: 602046) protein disulfide-isomerase A (505 aa)
initn: 189 init1: 170 opt: 204 Z-score: 243.0 bits: 52.9 E(85289): 8.6e-07
Smith-Waterman score: 204; 28.9% identity (61.7% similar) in 128 aa overlap (42-166:6-133)
20 30 40 50 60 70
pF1KE0 ASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPD-F
:.. :. : . ..:.. .. .. : :
NP_005 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNF
10 20 30
80 90 100 110 120
pF1KE0 QDRVVNSETP--VVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEY
..:. .. . ..:.: : ::: :: :.:. : ... .: : .:::: .:. .:
NP_005 ESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKY
40 50 60 70 80 90
130 140 150 160
pF1KE0 EVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
::. ::. ...:. . . : . : . . ::: :
NP_005 GVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDAS
100 110 120 130 140 150
NP_005 IVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKF
160 170 180 190 200 210
>>NP_000909 (OMIM: 112240,176790) protein disulfide-isom (508 aa)
initn: 180 init1: 99 opt: 197 Z-score: 234.7 bits: 51.4 E(85289): 2.5e-06
Smith-Waterman score: 197; 34.1% identity (70.3% similar) in 91 aa overlap (81-166:44-134)
60 70 80 90 100
pF1KE0 TIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAK---Q
..:.:.: ::: :: :.:. : ..: .
NP_000 LVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAE
20 30 40 50 60 70
110 120 130 140 150 160
pF1KE0 HGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVD--KFVGIKDEDQLEAFLKKLI
... .:::: ...::: .: : . ::. ..:::... .... .. :.. .:::
NP_000 GSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRT
80 90 100 110 120 130
pF1KE0 G
:
NP_000 GPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVF
140 150 160 170 180 190
>>NP_006801 (OMIM: 616942) protein disulfide-isomerase A (519 aa)
initn: 184 init1: 130 opt: 187 Z-score: 222.8 bits: 49.2 E(85289): 1.1e-05
Smith-Waterman score: 187; 36.4% identity (64.8% similar) in 88 aa overlap (60-143:277-362)
30 40 50 60 70 80
pF1KE0 RALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQW
..... : :: :. :. .. :.: ::: :
NP_006 STAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTD-EDF-DQFVKEHSSVLVMFHAPW
250 260 270 280 290 300
90 100 110 120 130 140
pF1KE0 CGPCKILGPRLEKMVAKQHGKV----VMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVV
:: :: . :..:: . ::.. :.: :: . :: ....: ::. .:::.
NP_006 CGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKY
310 320 330 340 350 360
150 160
pF1KE0 DKFVGIKDEDQLEAFLKKLIG
NP_006 AVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAP
370 380 390 400 410 420
>>NP_001139021 (OMIM: 616412) thioredoxin domain-contain (324 aa)
initn: 175 init1: 95 opt: 179 Z-score: 216.4 bits: 47.3 E(85289): 2.6e-05
Smith-Waterman score: 179; 27.3% identity (63.3% similar) in 139 aa overlap (27-162:52-183)
10 20 30 40 50
pF1KE0 MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNP-ARTIYTT
: . ::: . : :::.: .. .
NP_001 AQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEP----VTPEPEVEPPSAP
30 40 50 60 70
60 70 80 90 100 110
pF1KE0 RISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKM-VAKQHGKVV-M
... .... . .:. .:.... . : : ::: :: :.: :.. .. .:...: .
NP_001 ELKQGLYELS-ASNFELHVAQGDH--FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKI
80 90 100 110 120 130
120 130 140 150 160
pF1KE0 AKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
.::: .: .: .: . ::.: ...: ::.. : .: ..:. ...
NP_001 GKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGAT
140 150 160 170 180 190
NP_001 ETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEE
200 210 220 230 240 250
>--
initn: 179 init1: 79 opt: 174 Z-score: 210.6 bits: 46.3 E(85289): 5.5e-05
Smith-Waterman score: 174; 31.2% identity (61.5% similar) in 96 aa overlap (69-161:223-316)
40 50 60 70 80 90
pF1KE0 PGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGP
.:.: . .: . . :.: ::: :: :.:
NP_001 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAP
200 210 220 230 240 250
100 110 120 130 140 150
pF1KE0 RLEKMVAKQH---GKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDED
:.. :. . : .:.:: . .. .: : . ::.: ...: :.. : .: :
NP_001 TWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLD
260 270 280 290 300 310
160
pF1KE0 QLEAFLKKLIG
.:. :.
NP_001 SLHRFVLSQAKDEL
320
>>NP_110437 (OMIM: 616412) thioredoxin domain-containing (432 aa)
initn: 239 init1: 95 opt: 179 Z-score: 214.6 bits: 47.4 E(85289): 3.3e-05
Smith-Waterman score: 179; 27.3% identity (63.3% similar) in 139 aa overlap (27-162:160-291)
10 20 30 40 50
pF1KE0 MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNP-ARTIYTT
: . ::: . : :::.: .. .
NP_110 AQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEP----VTPEPEVEPPSAP
130 140 150 160 170 180
60 70 80 90 100 110
pF1KE0 RISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKM-VAKQHGKVV-M
... .... . .:. .:.... . : : ::: :: :.: :.. .. .:...: .
NP_110 ELKQGLYELS-ASNFELHVAQGDH--FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKI
190 200 210 220 230 240
120 130 140 150 160
pF1KE0 AKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
.::: .: .: .: . ::.: ...: ::.. : .: ..:. ...
NP_110 GKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGAT
250 260 270 280 290 300
NP_110 ETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEE
310 320 330 340 350 360
>--
initn: 179 init1: 79 opt: 174 Z-score: 208.7 bits: 46.3 E(85289): 6.9e-05
Smith-Waterman score: 174; 31.2% identity (61.5% similar) in 96 aa overlap (69-161:331-424)
40 50 60 70 80 90
pF1KE0 PGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGP
.:.: . .: . . :.: ::: :: :.:
NP_110 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAP
310 320 330 340 350
100 110 120 130 140 150
pF1KE0 RLEKMVAKQH---GKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDED
:.. :. . : .:.:: . .. .: : . ::.: ...: :.. : .: :
NP_110 TWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLD
360 370 380 390 400 410
160
pF1KE0 QLEAFLKKLIG
.:. :.
NP_110 SLHRFVLSQAKDEL
420 430
166 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 23:59:31 2016 done: Wed Nov 2 23:59:31 2016
Total Scan time: 4.960 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]