Result of FASTA (omim) for
pF1KE0493
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0493, 395 aa
1>>>pF1KE0493 395 - 395 aa - 395 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2758+/-0.000332; mu= 17.6686+/- 0.021
mean_var=76.0043+/-15.246, 0's: 0 Z-trim(115.6): 25 B-trim: 74 in 1/53
Lambda= 0.147114
statistics sampled from 26155 (26180) to 26155 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.307), width: 16
Scan time: 8.030
The best scores are: opt bits E(85289)
NP_005189 (OMIM: 602541,612395) choline/ethanolami ( 395) 2680 578.1 1.2e-164
NP_997634 (OMIM: 118491) choline kinase alpha isof ( 439) 1511 330.1 6.4e-90
NP_001268 (OMIM: 118491) choline kinase alpha isof ( 457) 1227 269.8 9.3e-72
XP_016872637 (OMIM: 118491) PREDICTED: choline kin ( 281) 1208 265.6 1e-70
XP_016872636 (OMIM: 118491) PREDICTED: choline kin ( 419) 1012 224.2 4.7e-58
NP_061108 (OMIM: 609858) ethanolamine kinase 1 iso ( 452) 419 98.3 3.9e-20
XP_016875069 (OMIM: 609858) PREDICTED: ethanolamin ( 425) 374 88.7 2.8e-17
NP_001284689 (OMIM: 609859) ethanolamine kinase 2 ( 394) 349 83.4 1e-15
NP_001284690 (OMIM: 609859) ethanolamine kinase 2 ( 208) 249 62.0 1.5e-09
NP_001284691 (OMIM: 609859) ethanolamine kinase 2 ( 345) 249 62.1 2.3e-09
NP_060678 (OMIM: 609859) ethanolamine kinase 2 iso ( 386) 249 62.2 2.5e-09
XP_016857121 (OMIM: 609859) PREDICTED: ethanolamin ( 216) 233 58.6 1.7e-08
XP_011508016 (OMIM: 609859) PREDICTED: ethanolamin ( 216) 233 58.6 1.7e-08
XP_011508017 (OMIM: 609859) PREDICTED: ethanolamin ( 216) 233 58.6 1.7e-08
XP_016875070 (OMIM: 609858) PREDICTED: ethanolamin ( 337) 227 57.5 5.7e-08
>>NP_005189 (OMIM: 602541,612395) choline/ethanolamine k (395 aa)
initn: 2680 init1: 2680 opt: 2680 Z-score: 3076.8 bits: 578.1 E(85289): 1.2e-164
Smith-Waterman score: 2680; 100.0% identity (100.0% similar) in 395 aa overlap (1-395:1-395)
10 20 30 40 50 60
pF1KE0 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 WRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 VMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQ
310 320 330 340 350 360
370 380 390
pF1KE0 ASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
:::::::::::::::::::::::::::::::::::
NP_005 ASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
370 380 390
>>NP_997634 (OMIM: 118491) choline kinase alpha isoform (439 aa)
initn: 1327 init1: 448 opt: 1511 Z-score: 1735.3 bits: 330.1 E(85289): 6.4e-90
Smith-Waterman score: 1511; 60.8% identity (81.5% similar) in 367 aa overlap (29-388:74-437)
10 20 30 40 50
pF1KE0 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLG
: : .. .: :::: ::.:.:
NP_997 ESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTR---RRAYLWCKEFLP
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE0 GAWRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQ-GVDSLV
:::: .. .:... . :::::.::.::::: ..:.:::.::::::::::: :....:
NP_997 GAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMGAEAMV
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE0 LESVMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGM
::::::::::::::::.:::.::.:::::.:::: : :.:: : .:: :: ::: ::::
NP_997 LESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGM
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE0 EMPFTKEPHWLFGTMERYLKQIQDLPPTG---LPEMNLLEMYSLKDEMGNLRKLLESTPS
.:::.:::.:::::::.:::.. . : . ... : :.: :. :::.:::::::
NP_997 KMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPS
230 240 250 260 270 280
240 250 260 270 280 290
pF1KE0 PVVFCHNDIQEGNILLLSEPENADS--LMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEE
:::::::: :::::::: ::... :::.:::::::::::::::::::::.:::..:.
NP_997 PVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEK
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE0 WPFYKARPTDYPTQEQQLHFIRHYLAEAKKG-ETLSQEEQRKLEEDLLVEVSRYALASHF
.::..: :::..:::::: :: .. :.:: ::. ..:..:.::.:.::::::
NP_997 YPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHF
350 360 370 380 390 400
360 370 380 390
pF1KE0 FWGLWSILQASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
.::::::.::..:.:::::.::::.::. ::.:: .:
NP_997 LWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
410 420 430
>>NP_001268 (OMIM: 118491) choline kinase alpha isoform (457 aa)
initn: 1047 init1: 456 opt: 1227 Z-score: 1409.3 bits: 269.8 E(85289): 9.3e-72
Smith-Waterman score: 1475; 57.9% identity (77.7% similar) in 385 aa overlap (29-388:74-455)
10 20 30 40 50
pF1KE0 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLG
: : .. .: :::: ::.:.:
NP_001 ESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTR---RRAYLWCKEFLP
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE0 GAWRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQ-------
:::: .. .:... . :::::.::.::::: ..:.:::.:::::::::::
NP_001 GAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKE
110 120 130 140 150 160
120 130 140 150
pF1KE0 ------------GVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELR
:....:::::::::::::::::.:::.::.:::::.:::: : :.::
NP_001 GSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELS
170 180 190 200 210 220
160 170 180 190 200 210
pF1KE0 EPVLSAAIATKMAQFHGMEMPFTKEPHWLFGTMERYLKQIQDLPPTG---LPEMNLLEMY
: .:: :: ::: ::::.:::.:::.:::::::.:::.. . : . ... : :
NP_001 LPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSY
230 240 250 260 270 280
220 230 240 250 260 270
pF1KE0 SLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENADS--LMLVDFEYSSYNYRG
.: :. :::.::::::::::::::: :::::::: ::... :::.:::::::::::
NP_001 NLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRG
290 300 310 320 330 340
280 290 300 310 320 330
pF1KE0 FDIGNHFCEWVYDYTHEEWPFYKARPTDYPTQEQQLHFIRHYLAEAKKG-ETLSQEEQRK
::::::::::.:::..:..::..: :::..:::::: :: .. :.:: ::.
NP_001 FDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSI
350 360 370 380 390 400
340 350 360 370 380 390
pF1KE0 LEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHS
..:..:.::.:.::::::.::::::.::..:.:::::.::::.::. ::.:: .:
NP_001 IKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
410 420 430 440 450
pF1KE0 SS
>>XP_016872637 (OMIM: 118491) PREDICTED: choline kinase (281 aa)
initn: 1028 init1: 437 opt: 1208 Z-score: 1390.5 bits: 265.6 E(85289): 1e-70
Smith-Waterman score: 1208; 64.2% identity (83.9% similar) in 279 aa overlap (116-388:1-279)
90 100 110 120 130 140
pF1KE0 SLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYGVFPEGRLE
.:::::::::::::::::.:::.::.::::
XP_016 MVLESVMFAILAERSLGPKLYGIFPQGRLE
10 20 30
150 160 170 180 190 200
pF1KE0 QYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMPFTKEPHWLFGTMERYLKQIQDLPPT
:.:::: : :.:: : .:: :: ::: ::::.:::.:::.:::::::.:::.. . :
XP_016 QFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFT
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE0 G---LPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENADS--L
. ... : :.: :. :::.::::::::::::::: :::::::: ::... :
XP_016 EESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKL
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE0 MLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARPTDYPTQEQQLHFIRHYLAEA
::.:::::::::::::::::::::.:::..:..::..: :::..:::::: ::
XP_016 MLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAF
160 170 180 190 200 210
330 340 350 360 370
pF1KE0 KKG-ETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYAQSRFQ
.. :.:: ::. ..:..:.::.:.::::::.::::::.::..:.:::::.::::.::.
XP_016 QNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFD
220 230 240 250 260 270
380 390
pF1KE0 FYFQQKGQLTSVHSSS
::.:: .:
XP_016 AYFHQKRKLGV
280
>>XP_016872636 (OMIM: 118491) PREDICTED: choline kinase (419 aa)
initn: 1115 init1: 330 opt: 1012 Z-score: 1163.2 bits: 224.2 E(85289): 4.7e-58
Smith-Waterman score: 1258; 53.8% identity (74.0% similar) in 366 aa overlap (29-388:74-417)
10 20 30 40 50
pF1KE0 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLG
: : .. .: :::: ::.:.:
XP_016 ESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTR---RRAYLWCKEFLP
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE0 GAWRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVL
:::: .. .:... . :::::.::.::::: ..:.:::.:::::::::::
XP_016 GAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQ-------
110 120 130 140 150
120 130 140 150 160 170
pF1KE0 ESVMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGME
: . : : ... :. . :: : :.:: : .:: :: ::: ::::.
XP_016 ---MRSCNKEGS---------EQAQKENEFQSRRLDTEELSLPDISAEIAEKMATFHGMK
160 170 180 190 200
180 190 200 210 220 230
pF1KE0 MPFTKEPHWLFGTMERYLKQIQDLPPTG---LPEMNLLEMYSLKDEMGNLRKLLESTPSP
:::.:::.:::::::.:::.. . : . ... : :.: :. :::.::::::::
XP_016 MPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSP
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE0 VVFCHNDIQEGNILLLSEPENADS--LMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEW
::::::: :::::::: ::... :::.:::::::::::::::::::::.:::..:..
XP_016 VVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKY
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE0 PFYKARPTDYPTQEQQLHFIRHYLAEAKKG-ETLSQEEQRKLEEDLLVEVSRYALASHFF
::..: :::..:::::: :: .. :.:: ::. ..:..:.::.:.::::::.
XP_016 PFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFL
330 340 350 360 370 380
360 370 380 390
pF1KE0 WGLWSILQASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
::::::.::..:.:::::.::::.::. ::.:: .:
XP_016 WGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
390 400 410
>>NP_061108 (OMIM: 609858) ethanolamine kinase 1 isoform (452 aa)
initn: 527 init1: 266 opt: 419 Z-score: 482.6 bits: 98.3 E(85289): 3.9e-20
Smith-Waterman score: 555; 30.5% identity (59.0% similar) in 383 aa overlap (29-391:97-448)
10 20 30 40 50
pF1KE0 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCRE---
: .:. . . .: :. . :::
NP_061 SAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLNVTVQDQEE---HRCREGAL
70 80 90 100 110 120
60 70 80 90 100 110
pF1KE0 ----YLGGAWRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQ
.: : .:.:. . . :..: :. : . . . .: ::.:.:: .
NP_061 SLLQHLRPHW---DPQEVTLQLFTDGITNKLIGCYVGNTMEDV------VLVRIYGNKTE
130 140 150 160 170
120 130 140 150 160 170
pF1KE0 GVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKM
. . : : .: .. .:::: .: .: ..: .. : ... .:.. :: ..
NP_061 LLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQL
180 190 200 210 220 230
180 190 200 210 220
pF1KE0 AQFHGMEMP---FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYS--------LKD
:..:... . : :: : .:.. : :::. . .. . . :..
NP_061 AKIHAIHAHNGWIPKSNLWL--KMGKYFSLI----PTGFADEDINKRFLSDIPSSQILQE
240 250 260 270 280
230 240 250 260 270 280
pF1KE0 EMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNH
:: ....: . ::::.::::. ::. :. .....:.:::.::: ..:::::
NP_061 EMTWMKEILSNLGSPVVLCHNDLLCKNIIY---NEKQGDVQFIDYEYSGYNYLAYDIGNH
290 300 310 320 330 340
290 300 310 320 330
pF1KE0 FCEW--VYDYTHEEWPFYKARPTDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDL
: :. : : . . :: .: : ...: :: :. . .. : .: : :
NP_061 FNEFAGVSDVDY----------SLYPDRELQSQWLRAYLEAYKEFKGFGTEVTEKEVEIL
350 360 370 380 390
340 350 360 370 380 390
pF1KE0 LVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
...:...:::::::::::...::..::::: .: :: ::. ::..: ..:..
NP_061 FIQVNQFALASHFFWGLWALIQAKYSTIEFDFLGYAIVRFNQYFKMKPEVTALKVPE
400 410 420 430 440 450
>>XP_016875069 (OMIM: 609858) PREDICTED: ethanolamine ki (425 aa)
initn: 303 init1: 109 opt: 374 Z-score: 431.3 bits: 88.7 E(85289): 2.8e-17
Smith-Waterman score: 374; 26.8% identity (55.6% similar) in 354 aa overlap (29-362:97-419)
10 20 30 40 50
pF1KE0 MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLG
: .:. . . .: :.. :::
XP_016 SAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLNVTVQDQEEHR---CRE---
70 80 90 100 110 120
60 70 80 90 100 110
pF1KE0 GAWRRVQ-------PEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQ
:: .: :.:. . . :..: :. : . . . .: ::.:.:: .
XP_016 GALSLLQHLRPHWDPQEVTLQLFTDGITNKLIGCYVGNTMEDV------VLVRIYGNKTE
130 140 150 160 170
120 130 140 150 160 170
pF1KE0 GVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKM
. . : : .: .. .:::: .: .: ..: .. : ... .:.. :: ..
XP_016 LLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQL
180 190 200 210 220 230
180 190 200 210 220
pF1KE0 AQFHGMEMP---FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYS--------LKD
:..:... . : :: : .:.. : :::. . .. . . :..
XP_016 AKIHAIHAHNGWIPKSNLWL--KMGKYFSLI----PTGFADEDINKRFLSDIPSSQILQE
240 250 260 270 280
230 240 250 260 270 280
pF1KE0 EMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNH
:: ....: . ::::.::::. ::. :. .....:.:::.::: ..:::::
XP_016 EMTWMKEILSNLGSPVVLCHNDLLCKNIIY---NEKQGDVQFIDYEYSGYNYLAYDIGNH
290 300 310 320 330 340
290 300 310 320 330
pF1KE0 FCEW--VYDYTHEEWPFYKARPTDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDL
: :. : : . . :: .: : ...: :: :. . .. : .: : :
XP_016 FNEFAGVSDVDY----------SLYPDRELQSQWLRAYLEAYKEFKGFGTEVTEKEVEIL
350 360 370 380 390
340 350 360 370 380 390
pF1KE0 LVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
...:...::. . ..: .. . :
XP_016 FIQVNQFALTLQSAFSLTAVKRKSGKAYQS
400 410 420
>>NP_001284689 (OMIM: 609859) ethanolamine kinase 2 isof (394 aa)
initn: 365 init1: 125 opt: 349 Z-score: 403.1 bits: 83.4 E(85289): 1e-15
Smith-Waterman score: 392; 29.6% identity (56.9% similar) in 304 aa overlap (55-347:62-338)
30 40 50 60 70
pF1KE0 QSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGAWRRVQ-------PEELRVYPVSGG
. : :: : .: ::..:. . :
NP_001 KAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDG
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE0 LSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYG
..: : : . . . . ::.:.:: . . . : : .: .: .:.::
NP_001 ITNKLVACYVEEDMQDC------VLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYC
100 110 120 130 140
140 150 160 170 180 190
pF1KE0 VFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMPFTKEPHWLFGTMERYLK
.: .: .:. . :. ...::: : :: .::..: .. . :. :. :.
NP_001 TFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFT
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE0 QIQD-LPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPEN
... . :. .. .:. :. :.. :.. : . :::::::::. ::. :
NP_001 LVKNEINPSLSADVPKVEV--LERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDS---I
210 220 230 240 250 260
260 270 280 290 300 310
pF1KE0 ADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARPTDY---PTQEQQLHFI
. ..:.::..:::..::::::: : : . .:: :..: ::...
NP_001 KGHVRFIDYEYAGYNYQAFDIGNHFNE-----------FAGVNEVDYCLYPARETQLQWL
270 280 290 300
320 330 340 350 360 370
pF1KE0 RHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYLDY
:: .:.:: ... .: .. : :.:...::
NP_001 -HYYLQAQKGMAVTPREVQR----LYVQVNKFALGPSCVSSTMTASLQCCRVGNRHGEIA
310 320 330 340 350 360
380 390
pF1KE0 AQSRFQFYFQQKGQLTSVHSSS
NP_001 RLTLSGLFPGVSLLLGSLGPHPEPVLHHRL
370 380 390
>>NP_001284690 (OMIM: 609859) ethanolamine kinase 2 isof (208 aa)
initn: 409 init1: 169 opt: 249 Z-score: 292.3 bits: 62.0 E(85289): 1.5e-09
Smith-Waterman score: 414; 34.7% identity (63.6% similar) in 225 aa overlap (171-391:1-204)
150 160 170 180 190 200
pF1KE0 EGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMPFTKEPHWLFGTMERYLKQIQ
::..: .. . :. :. :. ..
NP_001 MAKIHTIHANGSLPKPILWHKMHNYFTLVK
10 20 30
210 220 230 240 250
pF1KE0 D-LPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENADS
. . :. .. .:. :. :.. :.. : . :::::::::. ::. :
NP_001 NEINPSLSADVPKVEV--LERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDS---IKGH
40 50 60 70 80
260 270 280 290 300 310
pF1KE0 LMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARPTDY---PTQEQQLHFIRHY
. ..:.::..:::..::::::: : : . .:: :..: ::... ::
NP_001 VRFIDYEYAGYNYQAFDIGNHFNE-----------FAGVNEVDYCLYPARETQLQWL-HY
90 100 110 120 130
320 330 340 350 360 370
pF1KE0 LAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYAQS
.:.:: ... .: ..: :.:...::::::::.::...: ..:::.: .: ::
NP_001 YLQAQKGMAVTPREVQRL----YVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVI
140 150 160 170 180
380 390
pF1KE0 RFQFYFQQKGQLTSVHSSS
::. ::. : : ...
NP_001 RFNQYFKVKPQASALEMPK
190 200
>>NP_001284691 (OMIM: 609859) ethanolamine kinase 2 isof (345 aa)
initn: 493 init1: 169 opt: 249 Z-score: 289.2 bits: 62.1 E(85289): 2.3e-09
Smith-Waterman score: 444; 30.3% identity (54.2% similar) in 347 aa overlap (55-391:62-341)
30 40 50 60 70
pF1KE0 QSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGAWRRVQ-------PEELRVYPVSGG
. : :: : .: ::..:. . :
NP_001 KAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDG
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE0 LSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYG
..: : : . . . . ::.:.:: . . . : : .: .: .:.::
NP_001 ITNKLVACYVEEDMQDC------VLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYC
100 110 120 130 140
140 150 160 170 180 190
pF1KE0 VFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMPFTKEPHWLFGTMERYLK
.: .: .:. . :. ...::: : . :
NP_001 TFQNGLCYEYMQGVALEPEHIREPRLFSLSAD----------------------------
150 160 170
200 210 220 230 240 250
pF1KE0 QIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENA
.:....:: :.. :.. : . :::::::::. ::. :
NP_001 ---------VPKVEVLER-----ELAWLKEHLSQLESPVVFCHNDLLCKNIIYDS---IK
180 190 200 210 220
260 270 280 290 300 310
pF1KE0 DSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARPTDY---PTQEQQLHFIR
. ..:.::..:::..::::::: : : . .:: :..: ::...
NP_001 GHVRFIDYEYAGYNYQAFDIGNHFNE-----------FAGVNEVDYCLYPARETQLQWL-
230 240 250 260
320 330 340 350 360 370
pF1KE0 HYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYA
:: .:.:: ... .: .. : :.:...::::::::.::...: ..:::.: .: ::
NP_001 HYYLQAQKGMAVTPREVQR----LYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYA
270 280 290 300 310 320
380 390
pF1KE0 QSRFQFYFQQKGQLTSVHSSS
::. ::. : : ...
NP_001 VIRFNQYFKVKPQASALEMPK
330 340
395 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:23:37 2016 done: Thu Nov 3 04:23:38 2016
Total Scan time: 8.030 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]