Result of FASTA (omim) for
pF1KE0435
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0435, 257 aa
1>>>pF1KE0435 257 - 257 aa - 257 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7142+/-0.000409; mu= 17.5637+/- 0.025
mean_var=60.8469+/-12.918, 0's: 0 Z-trim(110.4): 49 B-trim: 0 in 0/51
Lambda= 0.164420
statistics sampled from 18782 (18804) to 18782 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.22), width: 16
Scan time: 6.480
The best scores are: opt bits E(85289)
NP_112591 (OMIM: 607630) gamma-secretase subunit A ( 257) 1679 406.9 1.8e-113
XP_011520407 (OMIM: 607630) PREDICTED: gamma-secre ( 235) 1314 320.3 1.9e-87
NP_057106 (OMIM: 607629) gamma-secretase subunit A ( 247) 999 245.6 6.3e-65
NP_001071096 (OMIM: 607629) gamma-secretase subuni ( 265) 994 244.4 1.5e-64
NP_001139118 (OMIM: 607630) gamma-secretase subuni ( 216) 755 187.7 1.5e-47
NP_001230700 (OMIM: 607629) gamma-secretase subuni ( 190) 581 146.4 3.6e-35
XP_016856906 (OMIM: 607629) PREDICTED: gamma-secre ( 208) 576 145.2 8.8e-35
NP_001230701 (OMIM: 607629) gamma-secretase subuni ( 195) 517 131.2 1.4e-30
>>NP_112591 (OMIM: 607630) gamma-secretase subunit APH-1 (257 aa)
initn: 1679 init1: 1679 opt: 1679 Z-score: 2158.2 bits: 406.9 E(85289): 1.8e-113
Smith-Waterman score: 1679; 99.6% identity (100.0% similar) in 257 aa overlap (1-257:1-257)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_112 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
190 200 210 220 230 240
250
pF1KE0 CLLCQDKNFLLYNQRSR
:::::::::::::::::
NP_112 CLLCQDKNFLLYNQRSR
250
>>XP_011520407 (OMIM: 607630) PREDICTED: gamma-secretase (235 aa)
initn: 1314 init1: 1314 opt: 1314 Z-score: 1690.8 bits: 320.3 E(85289): 1.9e-87
Smith-Waterman score: 1314; 99.5% identity (100.0% similar) in 202 aa overlap (1-202:1-202)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::::::::::::::::::::::
XP_011 CEKKKWGILLIVLLTHLLVSAQVSLENCSFSVTAAWKSCVFQTRHHDWTLFLALV
190 200 210 220 230
>>NP_057106 (OMIM: 607629) gamma-secretase subunit APH-1 (247 aa)
initn: 972 init1: 536 opt: 999 Z-score: 1286.7 bits: 245.6 E(85289): 6.3e-65
Smith-Waterman score: 999; 58.7% identity (82.6% similar) in 247 aa overlap (1-246:1-247)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
NP_057 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV
: .:. : :::::: ::: ..:.::::::::::::.::: :.. .: :.: .:::
NP_057 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
NP_057 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
NP_057 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
190 200 210 220 230 240
240 250
pF1KE0 LCLLCQDKNFLLYNQRSR
:::.:
NP_057 RSLLCKD
>>NP_001071096 (OMIM: 607629) gamma-secretase subunit AP (265 aa)
initn: 963 init1: 527 opt: 994 Z-score: 1279.8 bits: 244.4 E(85289): 1.5e-64
Smith-Waterman score: 994; 56.8% identity (81.3% similar) in 257 aa overlap (1-253:1-257)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV
: .:. : :::::: ::: ..:.::::::::::::.::: :.. .: :.: .:::
NP_001 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
190 200 210 220 230 240
240 250
pF1KE0 LCLLC---QDKNFLLYNQRSR
::: .:. ..:.
NP_001 RSLLCRRQEDSRVMVYSALRIPPED
250 260
>>NP_001139118 (OMIM: 607630) gamma-secretase subunit AP (216 aa)
initn: 777 init1: 755 opt: 755 Z-score: 974.7 bits: 187.7 E(85289): 1.5e-47
Smith-Waterman score: 1313; 83.7% identity (84.0% similar) in 257 aa overlap (1-257:1-216)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_001 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAY--
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
:::::::::::::::::::::
NP_001 ---------------------------------------AFMTLVIILLHVFWGIVFFDG
120 130
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
140 150 160 170 180 190
250
pF1KE0 CLLCQDKNFLLYNQRSR
:::::::::::::::::
NP_001 CLLCQDKNFLLYNQRSR
200 210
>>NP_001230700 (OMIM: 607629) gamma-secretase subunit AP (190 aa)
initn: 733 init1: 536 opt: 581 Z-score: 752.4 bits: 146.4 E(85289): 3.6e-35
Smith-Waterman score: 645; 44.1% identity (64.0% similar) in 247 aa overlap (1-246:1-190)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.::
NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG----------------------
10 20 30
70 80 90 100 110
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV
::.::: :.. .: :.: .:::
NP_001 -----------------------------------KADEGLASLSEDGRSPISIRQMAYV
40 50 60
120 130 140 150 160 170
pF1KE0 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
70 80 90 100 110 120
180 190 200 210 220 230
pF1KE0 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
130 140 150 160 170 180
240 250
pF1KE0 LCLLCQDKNFLLYNQRSR
:::.:
NP_001 RSLLCKD
190
>>XP_016856906 (OMIM: 607629) PREDICTED: gamma-secretase (208 aa)
initn: 724 init1: 527 opt: 576 Z-score: 745.4 bits: 145.2 E(85289): 8.8e-35
Smith-Waterman score: 640; 42.8% identity (63.4% similar) in 257 aa overlap (1-253:1-200)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.::
XP_016 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG----------------------
10 20 30
70 80 90 100 110
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV
::.::: :.. .: :.: .:::
XP_016 -----------------------------------KADEGLASLSEDGRSPISIRQMAYV
40 50 60
120 130 140 150 160 170
pF1KE0 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
XP_016 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
70 80 90 100 110 120
180 190 200 210 220 230
pF1KE0 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
XP_016 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
130 140 150 160 170 180
240 250
pF1KE0 LCLLC---QDKNFLLYNQRSR
::: .:. ..:.
XP_016 RSLLCRRQEDSRVMVYSALRIPPED
190 200
>>NP_001230701 (OMIM: 607629) gamma-secretase subunit AP (195 aa)
initn: 683 init1: 509 opt: 517 Z-score: 670.2 bits: 131.2 E(85289): 1.4e-30
Smith-Waterman score: 560; 40.2% identity (59.8% similar) in 256 aa overlap (1-253:1-187)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.:: :.:
NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGRC--------SAL---------
10 20 30 40
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
:: . : .:
NP_001 -----PTTSCL-----------------------------------------------IS
50
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::.
NP_001 GLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDA
60 70 80 90 100 110
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
NP_001 CERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQR
120 130 140 150 160 170
250
pF1KE0 CLLC---QDKNFLLYNQRSR
::: .:. ..:.
NP_001 SLLCRRQEDSRVMVYSALRIPPED
180 190
257 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:19:27 2016 done: Thu Nov 3 09:19:28 2016
Total Scan time: 6.480 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]