FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0411, 311 aa 1>>>pF1KE0411 311 - 311 aa - 311 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1432+/-0.000407; mu= 16.0850+/- 0.025 mean_var=62.8503+/-13.289, 0's: 0 Z-trim(111.1): 15 B-trim: 508 in 1/51 Lambda= 0.161778 statistics sampled from 19605 (19615) to 19605 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.23), width: 16 Scan time: 7.110 The best scores are: opt bits E(85289) NP_057559 (OMIM: 611176) JNK1/MAPK8-associated mem ( 311) 2098 498.5 6.9e-141 NP_001271130 (OMIM: 611176) JNK1/MAPK8-associated ( 325) 2089 496.4 3.1e-140 NP_001092095 (OMIM: 611176) JNK1/MAPK8-associated ( 305) 2051 487.6 1.4e-137 NP_001271131 (OMIM: 611176) JNK1/MAPK8-associated ( 319) 2046 486.4 3.2e-137 NP_001271132 (OMIM: 611176) JNK1/MAPK8-associated ( 248) 1632 389.7 3.2e-108 NP_001271133 (OMIM: 611176) JNK1/MAPK8-associated ( 213) 1471 352.1 5.7e-97 XP_006720234 (OMIM: 611176) PREDICTED: JNK1/MAPK8- ( 227) 1462 350.0 2.6e-96 XP_016876855 (OMIM: 611176) PREDICTED: JNK1/MAPK8- ( 207) 1424 341.1 1.1e-93 >>NP_057559 (OMIM: 611176) JNK1/MAPK8-associated membran (311 aa) initn: 2098 init1: 2098 opt: 2098 Z-score: 2650.3 bits: 498.5 E(85289): 6.9e-141 Smith-Waterman score: 2098; 100.0% identity (100.0% similar) in 311 aa overlap (1-311:1-311) 10 20 30 40 50 60 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP 250 260 270 280 290 300 310 pF1KE0 SRILSEGANGH ::::::::::: NP_057 SRILSEGANGH 310 >>NP_001271130 (OMIM: 611176) JNK1/MAPK8-associated memb (325 aa) initn: 2089 init1: 2089 opt: 2089 Z-score: 2638.7 bits: 496.4 E(85289): 3.1e-140 Smith-Waterman score: 2089; 99.4% identity (100.0% similar) in 311 aa overlap (1-311:15-325) 10 20 30 40 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYC ..:::::::::::::::::::::::::::::::::::::::::::: NP_001 MKGEIQQSLGAWVLLTVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYC 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 QPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 LVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 LMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 VTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPT 250 260 270 280 290 300 290 300 310 pF1KE0 PALFYLFTAKFTEPSRILSEGANGH ::::::::::::::::::::::::: NP_001 PALFYLFTAKFTEPSRILSEGANGH 310 320 >>NP_001092095 (OMIM: 611176) JNK1/MAPK8-associated memb (305 aa) initn: 2051 init1: 2051 opt: 2051 Z-score: 2591.2 bits: 487.6 E(85289): 1.4e-137 Smith-Waterman score: 2051; 100.0% identity (100.0% similar) in 304 aa overlap (8-311:2-305) 10 20 30 40 50 60 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP 240 250 260 270 280 290 310 pF1KE0 SRILSEGANGH ::::::::::: NP_001 SRILSEGANGH 300 >>NP_001271131 (OMIM: 611176) JNK1/MAPK8-associated memb (319 aa) initn: 2046 init1: 2046 opt: 2046 Z-score: 2584.6 bits: 486.4 E(85289): 3.2e-137 Smith-Waterman score: 2046; 100.0% identity (100.0% similar) in 303 aa overlap (9-311:17-319) 10 20 30 40 50 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTES :::::::::::::::::::::::::::::::::::::::::::: NP_001 MKGEIQQSLGAWVLLTCLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTES 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 GVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 PLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVY 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 MSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYL 250 260 270 280 290 300 300 310 pF1KE0 FTAKFTEPSRILSEGANGH ::::::::::::::::::: NP_001 FTAKFTEPSRILSEGANGH 310 >>NP_001271132 (OMIM: 611176) JNK1/MAPK8-associated memb (248 aa) initn: 1632 init1: 1632 opt: 1632 Z-score: 2064.0 bits: 389.7 E(85289): 3.2e-108 Smith-Waterman score: 1632; 100.0% identity (100.0% similar) in 248 aa overlap (64-311:1-248) 40 50 60 70 80 90 pF1KE0 CPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHIT :::::::::::::::::::::::::::::: NP_001 MAMLPLVLHWFFIEWYSGKKSSSALFQHIT 10 20 30 100 110 120 130 140 150 pF1KE0 ALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE0 YTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE0 YYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDK 160 170 180 190 200 210 280 290 300 310 pF1KE0 LEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH :::::::::::::::::::::::::::::::::::::: NP_001 LEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH 220 230 240 >>NP_001271133 (OMIM: 611176) JNK1/MAPK8-associated memb (213 aa) initn: 1471 init1: 1471 opt: 1471 Z-score: 1861.9 bits: 352.1 E(85289): 5.7e-97 Smith-Waterman score: 1471; 100.0% identity (100.0% similar) in 213 aa overlap (1-213:1-213) 10 20 30 40 50 60 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN ::::::::::::::::::::::::::::::::: NP_001 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 190 200 210 250 260 270 280 290 300 pF1KE0 CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP >>XP_006720234 (OMIM: 611176) PREDICTED: JNK1/MAPK8-asso (227 aa) initn: 1462 init1: 1462 opt: 1462 Z-score: 1850.1 bits: 350.0 E(85289): 2.6e-96 Smith-Waterman score: 1462; 99.1% identity (100.0% similar) in 213 aa overlap (1-213:15-227) 10 20 30 40 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYC ..:::::::::::::::::::::::::::::::::::::::::::: XP_006 MKGEIQQSLGAWVLLTVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYC 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 QPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 LVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 LMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSL ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 190 200 210 220 230 240 250 260 270 280 pF1KE0 VTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPT >>XP_016876855 (OMIM: 611176) PREDICTED: JNK1/MAPK8-asso (207 aa) initn: 1424 init1: 1424 opt: 1424 Z-score: 1802.8 bits: 341.1 E(85289): 1.1e-93 Smith-Waterman score: 1424; 100.0% identity (100.0% similar) in 206 aa overlap (8-213:2-207) 10 20 30 40 50 60 pF1KE0 MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN ::::::::::::::::::::::::::::::::: XP_016 CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 180 190 200 250 260 270 280 290 300 pF1KE0 CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP 311 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:48:29 2016 done: Thu Nov 3 11:48:30 2016 Total Scan time: 7.110 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]