Result of FASTA (omim) for
pF1KE0334
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0334, 875 aa
1>>>pF1KE0334 875 - 875 aa - 875 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5677+/-0.00048; mu= 14.5870+/- 0.030
mean_var=104.7332+/-20.860, 0's: 0 Z-trim(111.3): 210 B-trim: 253 in 1/50
Lambda= 0.125323
statistics sampled from 19608 (19854) to 19608 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.233), width: 16
Scan time: 11.240
The best scores are: opt bits E(85289)
NP_001074 (OMIM: 603310) cGMP-specific 3',5'-cycli ( 875) 5812 1062.6 0
NP_236914 (OMIM: 603310) cGMP-specific 3',5'-cycli ( 833) 5465 999.9 0
NP_246273 (OMIM: 603310) cGMP-specific 3',5'-cycli ( 823) 5447 996.6 0
XP_016864280 (OMIM: 603310) PREDICTED: cGMP-specif ( 643) 4217 774.2 0
NP_058649 (OMIM: 604961,610475) dual 3',5'-cyclic- ( 933) 1920 359.0 6.1e-98
NP_001070665 (OMIM: 604961,610475) dual 3',5'-cycl ( 683) 1643 308.8 5.6e-83
NP_001070826 (OMIM: 604961,610475) dual 3',5'-cycl ( 575) 1431 270.4 1.7e-71
NP_001070664 (OMIM: 604961,610475) dual 3',5'-cycl ( 489) 1296 246.0 3.3e-64
XP_011533695 (OMIM: 610652,616921,616922) PREDICTE ( 466) 818 159.5 3.3e-38
XP_016865685 (OMIM: 610652,616921,616922) PREDICTE ( 709) 818 159.6 4.6e-38
XP_016865684 (OMIM: 610652,616921,616922) PREDICTE ( 732) 818 159.7 4.8e-38
XP_006715384 (OMIM: 610652,616921,616922) PREDICTE ( 772) 818 159.7 5e-38
XP_011533690 (OMIM: 610652,616921,616922) PREDICTE ( 779) 818 159.7 5e-38
NP_006652 (OMIM: 610652,616921,616922) cAMP and cA ( 779) 818 159.7 5e-38
NP_001124162 (OMIM: 610652,616921,616922) cAMP and ( 789) 818 159.7 5.1e-38
XP_011533689 (OMIM: 610652,616921,616922) PREDICTE ( 831) 818 159.7 5.3e-38
XP_016865683 (OMIM: 610652,616921,616922) PREDICTE ( 800) 719 141.8 1.3e-32
XP_011511778 (OMIM: 163500,180072,613801) PREDICTE ( 857) 559 112.9 6.8e-24
NP_001001580 (OMIM: 602973) high affinity cGMP-spe ( 376) 483 98.9 4.7e-20
NP_001001576 (OMIM: 602973) high affinity cGMP-spe ( 376) 483 98.9 4.7e-20
NP_001001579 (OMIM: 602973) high affinity cGMP-spe ( 386) 483 98.9 4.8e-20
XP_016883855 (OMIM: 602973) PREDICTED: high affini ( 386) 483 98.9 4.8e-20
NP_001001573 (OMIM: 602973) high affinity cGMP-spe ( 386) 483 98.9 4.8e-20
NP_001001572 (OMIM: 602973) high affinity cGMP-spe ( 386) 483 98.9 4.8e-20
NP_001001585 (OMIM: 602973) high affinity cGMP-spe ( 386) 483 98.9 4.8e-20
NP_001001584 (OMIM: 602973) high affinity cGMP-spe ( 386) 483 98.9 4.8e-20
NP_001001575 (OMIM: 602973) high affinity cGMP-spe ( 433) 483 98.9 5.3e-20
NP_001001577 (OMIM: 602973) high affinity cGMP-spe ( 459) 483 99.0 5.5e-20
NP_001001569 (OMIM: 602973) high affinity cGMP-spe ( 465) 483 99.0 5.6e-20
XP_016866230 (OMIM: 604645) PREDICTED: cAMP-specif ( 343) 481 98.5 5.6e-20
NP_001001568 (OMIM: 602973) high affinity cGMP-spe ( 466) 483 99.0 5.6e-20
NP_001302462 (OMIM: 602973) high affinity cGMP-spe ( 485) 483 99.0 5.8e-20
NP_001001578 (OMIM: 602973) high affinity cGMP-spe ( 491) 483 99.0 5.9e-20
NP_001001571 (OMIM: 602973) high affinity cGMP-spe ( 492) 483 99.0 5.9e-20
NP_001001574 (OMIM: 602973) high affinity cGMP-spe ( 507) 483 99.0 6e-20
NP_001001581 (OMIM: 602973) high affinity cGMP-spe ( 526) 483 99.0 6.2e-20
NP_001001567 (OMIM: 602973) high affinity cGMP-spe ( 533) 483 99.0 6.3e-20
NP_001001570 (OMIM: 602973) high affinity cGMP-spe ( 540) 483 99.0 6.3e-20
XP_011527900 (OMIM: 602973) PREDICTED: high affini ( 545) 483 99.0 6.4e-20
NP_001001582 (OMIM: 602973) high affinity cGMP-spe ( 552) 483 99.0 6.5e-20
NP_001001583 (OMIM: 602973) high affinity cGMP-spe ( 567) 483 99.0 6.6e-20
NP_002597 (OMIM: 602973) high affinity cGMP-specif ( 593) 483 99.0 6.8e-20
NP_061818 (OMIM: 604645) cAMP-specific 3',5'-cycli ( 450) 481 98.6 7e-20
XP_011534057 (OMIM: 604645) PREDICTED: cAMP-specif ( 489) 481 98.6 7.5e-20
XP_005266988 (OMIM: 604645) PREDICTED: cAMP-specif ( 502) 481 98.6 7.7e-20
XP_011526360 (OMIM: 600128) PREDICTED: cAMP-specif ( 481) 467 96.1 4.3e-19
XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specif ( 606) 467 96.1 5.2e-19
NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cy ( 606) 467 96.1 5.2e-19
NP_001092288 (OMIM: 600128) cAMP-specific 3',5'-cy ( 680) 467 96.2 5.7e-19
NP_000914 (OMIM: 600128) cAMP-specific 3',5'-cycli ( 712) 467 96.2 5.9e-19
>>NP_001074 (OMIM: 603310) cGMP-specific 3',5'-cyclic ph (875 aa)
initn: 5812 init1: 5812 opt: 5812 Z-score: 5682.8 bits: 1062.6 E(85289): 0
Smith-Waterman score: 5812; 99.7% identity (99.9% similar) in 875 aa overlap (1-875:1-875)
10 20 30 40 50 60
pF1KE0 MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDGHWDFTFSYFVRKATREMVNAWFAE
::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEG
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
NP_001 RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFRMKHEVLCRWIL
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
790 800 810 820 830 840
850 860 870
pF1KE0 PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
:::::::::::::::::::::::::::::::::::
NP_001 PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
850 860 870
>>NP_236914 (OMIM: 603310) cGMP-specific 3',5'-cyclic ph (833 aa)
initn: 5465 init1: 5465 opt: 5465 Z-score: 5344.0 bits: 999.9 E(85289): 0
Smith-Waterman score: 5465; 99.8% identity (100.0% similar) in 826 aa overlap (50-875:8-833)
20 30 40 50 60 70
pF1KE0 QKQQQRDQDSVEAWLDGHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESC
::::::::::::::::::::::::::::::
NP_236 MLPFGDKTREMVNAWFAERVHTIPVCKEGIRGHTESC
10 20 30
80 90 100 110 120 130
pF1KE0 SCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPP
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
NP_236 SCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPP
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 RFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 RFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 LISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 LISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQIT
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 GYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 GYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQL
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE0 YETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 YETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDS
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE0 FSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 FSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTEN
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE0 TGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 TGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFC
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE0 GLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 GLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDF
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE0 SFSDFELSDLETALCTIRMFTDLNLVQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAF
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_236 SFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAF
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE0 NTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 NTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHS
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE0 IMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 IMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE0 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE0 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_236 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ
760 770 780 790 800 810
860 870
pF1KE0 QEKMLINGESGQAKRN
::::::::::::::::
NP_236 QEKMLINGESGQAKRN
820 830
>>NP_246273 (OMIM: 603310) cGMP-specific 3',5'-cyclic ph (823 aa)
initn: 5447 init1: 5447 opt: 5447 Z-score: 5326.5 bits: 996.6 E(85289): 0
Smith-Waterman score: 5447; 99.8% identity (100.0% similar) in 823 aa overlap (53-875:1-823)
30 40 50 60 70 80
pF1KE0 QQRDQDSVEAWLDGHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCP
::::::::::::::::::::::::::::::
NP_246 MVNAWFAERVHTIPVCKEGIRGHTESCSCP
10 20 30
90 100 110 120 130 140
pF1KE0 LQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFD
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 LQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFD
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 HDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 HDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLIS
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE0 RLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 RLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYK
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE0 TQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 TQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYET
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE0 SLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 SLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSS
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE0 VFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 VFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGN
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE0 VNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 VNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLG
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE0 IQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 IQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFS
460 470 480 490 500 510
570 580 590 600 610 620
pF1KE0 DFELSDLETALCTIRMFTDLNLVQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTA
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_246 DFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTA
520 530 540 550 560 570
630 640 650 660 670 680
pF1KE0 QCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 QCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIME
580 590 600 610 620 630
690 700 710 720 730 740
pF1KE0 HHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 HHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE0 QFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 QFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPT
700 710 720 730 740 750
810 820 830 840 850 860
pF1KE0 DLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_246 DLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEK
760 770 780 790 800 810
870
pF1KE0 MLINGESGQAKRN
:::::::::::::
NP_246 MLINGESGQAKRN
820
>>XP_016864280 (OMIM: 603310) PREDICTED: cGMP-specific 3 (643 aa)
initn: 4217 init1: 4217 opt: 4217 Z-score: 4126.2 bits: 774.2 E(85289): 0
Smith-Waterman score: 4217; 99.5% identity (99.8% similar) in 635 aa overlap (1-635:1-635)
10 20 30 40 50 60
pF1KE0 MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDGHWDFTFSYFVRKATREMVNAWFAE
::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
XP_016 MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEG
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFRMKHEVLCRWIL
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_016 QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
:::::::::::::::::::::::::::::::::::
XP_016 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQILTSVGID
610 620 630 640
670 680 690 700 710 720
pF1KE0 NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
>>NP_058649 (OMIM: 604961,610475) dual 3',5'-cyclic-AMP (933 aa)
initn: 1713 init1: 737 opt: 1920 Z-score: 1879.3 bits: 359.0 E(85289): 6.1e-98
Smith-Waterman score: 2044; 43.3% identity (74.9% similar) in 760 aa overlap (129-869:177-919)
100 110 120 130 140 150
pF1KE0 RKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPR-FDHD----EGDQCSRLL
:.. ..: :: .:. . .. . .:
NP_058 EPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE0 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTL
:::::::. ::.:.: .::.. . ...::: ::::: ... : :.:..::: :. :
NP_058 ELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPL
210 220 230 240 250 260
220 230 240 250 260
pF1KE0 EEVSN----NCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM
:. : ... :.:::.:.:. :: .:: :::.: ::: :.:..:::::.:.:::
NP_058 LPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCM
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE0 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR
::.. :..:::::::: .:. ::: ::: . :: ::::.. ::::. .: : .:
NP_058 PIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYER
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE0 NQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM-
...::.... .:::: .:: :.::: .... ..:....... : .:.. :..
NP_058 SRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELM
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE0 --ECEELEKSSDTLTREHDANK---INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG
.: ..: . :... . :: :. : .: :.:: :. .: :: ... .
NP_058 SPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQIS
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE0 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGL
. . :::.::.:: :.. ...::: :..:... :: ::. :....:::::::::
NP_058 GFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLD---GK--PFDDADQRLFEAFVIFCGL
510 520 530 540 550
510 520 530 540 550 560
pF1KE0 GIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSF
::.:: ::. :... ::: :.:.::::::. .. :. ... :: .: .. : : :. :
NP_058 GINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIHF
560 570 580 590 600 610
570 580 590 600 610 620
pF1KE0 SDFELSDLETALCT-IRMFTDLNLVQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN
.:: : :... . . .::: .:..::.:.. .:.::::.:.:.:::: : :::::::::
NP_058 DDFSL-DVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFN
620 630 640 650 660 670
630 640 650 660 670 680
pF1KE0 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI
. : ::: : .. .:. ::..::::.... : :::::::.::.. .: ::::: :
NP_058 VCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSA
680 690 700 710 720 730
690 700 710 720 730
pF1KE0 -MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI
.:::::.. .:::.: :..:...:: .::. ....::.::::::.::..:: :::::.
NP_058 TLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELV
740 750 760 770 780 790
740 750 760 770 780 790
pF1KE0 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI
:.... . .....: .::::::::.:.:::: :....::::..:::.:::::: ::..
NP_058 SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKL
800 810 820 830 840 850
800 810 820 830 840 850
pF1KE0 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ
:. ...:..:...: .:. .::.::. ::.::..:. :.::. ::.::. : .
NP_058 TPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL--H
860 870 880 890 900
860 870
pF1KE0 QEKMLINGESGQAKRN
:...: . :
NP_058 QKRLLASTASSSPASVMVAKEDRN
910 920 930
>>NP_001070665 (OMIM: 604961,610475) dual 3',5'-cyclic-A (683 aa)
initn: 1606 init1: 737 opt: 1643 Z-score: 1610.7 bits: 308.8 E(85289): 5.6e-83
Smith-Waterman score: 1767; 44.1% identity (76.1% similar) in 633 aa overlap (247-869:54-669)
220 230 240 250 260 270
pF1KE0 SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHRE
.: ::: :.:..:::::.:.:::::..
NP_001 ITRLVQISGASLAEKQEKHQDFLIQRQTKTKDRRFNDEIDKLTGYKTKSLLCMPIRSSDG
30 40 50 60 70 80
280 290 300 310 320 330
pF1KE0 EVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDL
:..:::::::: .:. ::: ::: . :: ::::.. ::::. .: : .:...::..
NP_001 EIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEV
90 100 110 120 130 140
340 350 360 370 380 390
pF1KE0 ASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM---ECEEL
.. .:::: .:: :.::: .... ..:....... : .:.. :.. .:
NP_001 VNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSAD
150 160 170 180 190 200
400 410 420 430 440
pF1KE0 EKSSDTLTREHDANK---INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCI
..: . :... . :: :. : .: :.:: :. .: :: ... .. . :
NP_001 AENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFH---I
210 220 230 240 250
450 460 470 480 490 500
pF1KE0 RSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQM
::.::.:: :.. ...::: :..:... : :::. :....:::::::::::.:: :
NP_001 RSVLCVPIWNSN-HQIIGVAQVLNRLD---G--KPFDDADQRLFEAFVIFCGLGINNTIM
260 270 280 290 300 310
510 520 530 540 550 560
pF1KE0 YEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSD
:. :... ::: :.:.::::::. .. :. ... :: .: .. : : :. :.:: : :
NP_001 YDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIHFDDFSL-D
320 330 340 350 360
570 580 590 600 610 620
pF1KE0 LETALCT-IRMFTDLNLVQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFA
... . . .::: .:..::.:.. .:.::::.:.:.:::: : :::::::::. : :::
NP_001 VDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFNVCQLMFA
370 380 390 400 410 420
630 640 650 660 670 680
pF1KE0 ALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI-MEHHHF
: .. .:. ::..::::.... : :::::::.::.. .: ::::: : .:::::
NP_001 MLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHF
430 440 450 460 470 480
690 700 710 720 730 740
pF1KE0 DQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNL
.. .:::.: :..:...:: .::. ....::.::::::.::..:: :::::. :....
NP_001 NHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDW
490 500 510 520 530 540
750 760 770 780 790 800
pF1KE0 EDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMN
. .....: .::::::::.:.:::: :....::::..:::.:::::: ::.. :. ...
NP_001 NIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFD
550 560 570 580 590 600
810 820 830 840 850 860
pF1KE0 REKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLIN
:..:...: .:. .::.::. ::.::..:. :.::. ::.::. : .:...: .
NP_001 RNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL--HQKRLLAS
610 620 630 640 650 660
870
pF1KE0 GESGQAKRN
:
NP_001 TASSSPASVMVAKEDRN
670 680
>>NP_001070826 (OMIM: 604961,610475) dual 3',5'-cyclic-A (575 aa)
initn: 1432 init1: 737 opt: 1431 Z-score: 1404.6 bits: 270.4 E(85289): 1.7e-71
Smith-Waterman score: 1555; 42.9% identity (76.0% similar) in 574 aa overlap (306-869:4-561)
280 290 300 310 320 330
pF1KE0 EEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLD
:: ::::.. ::::. .: : .:...::.
NP_001 MQMYLPFCGIAISNAQLFAASRKEYERSRALLE
10 20 30
340 350 360 370 380 390
pF1KE0 LASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM---ECEE
... .:::: .:: :.::: .... ..:....... : .:.. :.. .:
NP_001 VVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSA
40 50 60 70 80 90
400 410 420 430 440
pF1KE0 LEKSSDTLTREHDANK---INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQC
..: . :... . :: :. : .: :.:: :. .: :: ... .. .
NP_001 DAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFH---
100 110 120 130 140 150
450 460 470 480 490 500
pF1KE0 IRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQ
:::.::.:: :.. ...::: :..:... :: ::. :....:::::::::::.::
NP_001 IRSVLCVPIWNSN-HQIIGVAQVLNRLD---GK--PFDDADQRLFEAFVIFCGLGINNTI
160 170 180 190 200
510 520 530 540 550 560
pF1KE0 MYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELS
::. :... ::: :.:.::::::. .. :. ... :: .: .. : : :. :.:: :
NP_001 MYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIHFDDFSL-
210 220 230 240 250 260
570 580 590 600 610 620
pF1KE0 DLETALCT-IRMFTDLNLVQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMF
:... . . .::: .:..::.:.. .:.::::.:.:.:::: : :::::::::. : ::
NP_001 DVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFNVCQLMF
270 280 290 300 310
630 640 650 660 670 680
pF1KE0 AALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI-MEHHH
: : .. .:. ::..::::.... : :::::::.::.. .: ::::: : .::::
NP_001 AMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHH
320 330 340 350 360 370
690 700 710 720 730 740
pF1KE0 FDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFN
:.. .:::.: :..:...:: .::. ....::.::::::.::..:: :::::. :....
NP_001 FNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYD
380 390 400 410 420 430
750 760 770 780 790 800
pF1KE0 LEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLM
. .....: .::::::::.:.:::: :....::::..:::.:::::: ::.. :. ..
NP_001 WNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIF
440 450 460 470 480 490
810 820 830 840 850 860
pF1KE0 NREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLI
.:..:...: .:. .::.::. ::.::..:. :.::. ::.::. : .:...:
NP_001 DRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL--HQKRLLA
500 510 520 530 540 550
870
pF1KE0 NGESGQAKRN
. :
NP_001 STASSSPASVMVAKEDRN
560 570
>>NP_001070664 (OMIM: 604961,610475) dual 3',5'-cyclic-A (489 aa)
initn: 1432 init1: 737 opt: 1296 Z-score: 1273.7 bits: 246.0 E(85289): 3.3e-64
Smith-Waterman score: 1392; 44.8% identity (76.0% similar) in 496 aa overlap (376-869:5-475)
350 360 370 380 390 400
pF1KE0 SLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDAN
:: . . :. : .:::: ..
NP_001 MSPKCSADAENSFK---ESMEKSS------YSDW
10 20
410 420 430 440 450 460
pF1KE0 KINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVI
:: :. : .: :.:: :. .: :: ... .. . :::.::.:: :.. ...:
NP_001 LINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQII
30 40 50 60 70 80
470 480 490 500 510 520
pF1KE0 GVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEV
:: :..:... :: ::. :....:::::::::::.:: ::. :... ::: :.:.:
NP_001 GVAQVLNRLD---GK--PFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDV
90 100 110 120 130
530 540 550 560 570 580
pF1KE0 LSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT-IRMFTDLNL
:::::. .. :. ... :: .: .. : : :. :.:: : :... . . .::: .:..
NP_001 LSYHATCSKAEVDKFK---AANIPLVSELAIDDIHFDDFSL-DVDAMITAALRMFMELGM
140 150 160 170 180 190
590 600 610 620 630 640
pF1KE0 VQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEIL
::.:.. .:.::::.:.:.:::: : :::::::::. : ::: : .. .:. ::..:::
NP_001 VQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEIL
200 210 220 230 240 250
650 660 670 680 690 700
pF1KE0 ALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSG
:.... : :::::::.::.. .: ::::: : .:::::.. .:::.: :..:...
NP_001 AVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFAN
260 270 280 290 300 310
710 720 730 740 750 760
pF1KE0 LSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTAC
:: .::. ....::.::::::.::..:: :::::. :.... . .....: .::::::
NP_001 LSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTAC
320 330 340 350 360 370
770 780 790 800 810 820
pF1KE0 DLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDA
::.:.:::: :....::::..:::.:::::: ::.. :. ...:..:...: .:. .::.
NP_001 DLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDS
380 390 400 410 420 430
830 840 850 860 870
pF1KE0 ICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
::. ::.::..:. :.::. ::.::. : .:...: . :
NP_001 ICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL--HQKRLLASTASSSPASVMVAKEDRN
440 450 460 470 480
>>XP_011533695 (OMIM: 610652,616921,616922) PREDICTED: c (466 aa)
initn: 1027 init1: 489 opt: 818 Z-score: 807.0 bits: 159.5 E(85289): 3.3e-38
Smith-Waterman score: 1017; 39.0% identity (68.7% similar) in 451 aa overlap (412-861:18-447)
390 400 410 420 430 440
pF1KE0 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NT
: : : : :::::. : :: .. :
XP_011 MLEKLSSAPRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT
10 20 30 40
450 460 470 480 490 500
pF1KE0 GNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCG
: .. :..:: :: . ...:::: :.:::. .:.. :...::. .. :..::.
XP_011 GYTT----RNILCMPIVS--RGSVIGVVQMVNKI---SGSA--FSKTDENNFKMFAVFCA
50 60 70 80 90
510 520 530 540 550 560
pF1KE0 LGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFS
:... ..::. .... ::.: ::::. . :: :.: ..: .: :
XP_011 LALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEE---WQGLMQFTLPVRLCKEIELFH
100 110 120 130 140 150
570 580 590 600 610 620
pF1KE0 FSDFELSDLETALCTIRMFTDLNLVQNFRMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN
:. . .. .. . : .. :.. : :::.:.:::::::. : ::::.:: .
XP_011 FDIGPFENMWPGIF-VYMVHRSCGTSCFEL--EKLCRFIMSVKKNYRR-VPYHNWKHAVT
160 170 180 190 200
630 640 650 660 670 680
pF1KE0 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI
.:.::.: :. . .. .:::: .:::: : ::::::: .:::.:. .:::: :: :
XP_011 VAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTST
210 220 230 240 250 260
690 700 710 720 730 740
pF1KE0 MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIR
::.:::.: . ::. :..:.: :: ::. .:.::..::.:::::::. : .. :. .
XP_011 MEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQ
270 280 290 300 310 320
750 760 770 780 790 800
pF1KE0 KNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIE
...::.. ... ....:::::: ..:: ::. . :. . .::. .:: : :.:.:.
XP_011 TGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQ
330 340 350 360 370 380
810 820 830 840 850 860
pF1KE0 PTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ
: .:.:.::...:. :.:: .:. . : .::.. ::: .:: : ..:. . . .
XP_011 PIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGE
390 400 410 420 430 440
870
pF1KE0 EKMLINGESGQAKRN
:
XP_011 ETATWISSPSVAQKAAASED
450 460
>>XP_016865685 (OMIM: 610652,616921,616922) PREDICTED: c (709 aa)
initn: 1032 init1: 489 opt: 818 Z-score: 804.3 bits: 159.6 E(85289): 4.6e-38
Smith-Waterman score: 1188; 32.4% identity (64.8% similar) in 713 aa overlap (154-861:7-690)
130 140 150 160 170 180
pF1KE0 FLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLIS--
:: . : ..::. . . .. .. ..:.
XP_016 MQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIA
10 20 30
190 200 210 220 230
pF1KE0 --ADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEP
:: ..:... : :... : . ::. . . . : . . ..:: .
XP_016 TKADGFALYFLGE--CNNSLCIFTPPGIKEGKP-RLIPAGPIT--QGTTVSAYVAKSRKT
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE0 LNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD
: ..: : :: . .: . ::.::.:: . ...:. . . .. :. . : .
XP_016 LLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILE-LYRHWGKEA-FCLSH
100 110 120 130 140
300 310 320 330 340 350
pF1KE0 EKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATII
.. .: ::. ....:..:. . ... :. :::... :.. ... .:..:
XP_016 QEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAK
150 160 170 180 190 200
360 370 380 390 400 410
pF1KE0 SFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTM
.......:..: ::. .. .:..: . :. : :.: . :. : : :
XP_016 NLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IEKGIAGQVARTG
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE0 EPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENT
: :::::. : :: .. :: .. :..:: :: . ...:::: :.:::. .
XP_016 EVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGVVQMVNKI---S
270 280 290 300 310
480 490 500 510 520 530
pF1KE0 GKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR
:.. :...::. .. :..::.:... ..::. .... ::.: ::::. . ::
XP_016 GSA--FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEE--
320 330 340 350 360 370
540 550 560 570 580 590
pF1KE0 ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFRMKHEVLCRW
:.: ..: .: : :. . .. .. . : .. :.. : :::.
XP_016 -WQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF-VYMVHRSCGTSCFEL--EKLCRF
380 390 400 410 420 430
600 610 620 630 640 650
pF1KE0 ILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR
:.:::::::. : ::::.:: ..:.::.: :. . .. .:::: .:::: : ::::::
XP_016 IMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHR
440 450 460 470 480
660 670 680 690 700 710
pF1KE0 GVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQ
: .:::.:. .:::: :: : ::.:::.: . ::. :..:.: :: ::. .:.::..
XP_016 GFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRK
490 500 510 520 530 540
720 730 740 750 760 770
pF1KE0 AILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRI
::.:::::::. : .. :. . ...::.. ... ....:::::: ..:: ::. .
XP_016 AIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLT
550 560 570 580 590 600
780 790 800 810 820 830
pF1KE0 AELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSED
:. . .::. .:: : :.:.:.: .:.:.::...:. :.:: .:. . : .::..
XP_016 ANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPP
610 620 630 640 650 660
840 850 860 870
pF1KE0 CFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
::: .:: : ..:. . . .:
XP_016 TEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
670 680 690 700
875 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:28:57 2016 done: Thu Nov 3 15:28:59 2016
Total Scan time: 11.240 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]