Result of FASTA (omim) for
pF1KE0266
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0266, 450 aa
1>>>pF1KE0266 450 - 450 aa - 450 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7781+/-0.00032; mu= 12.1788+/- 0.020
mean_var=119.3758+/-23.912, 0's: 0 Z-trim(119.6): 160 B-trim: 0 in 0/55
Lambda= 0.117386
statistics sampled from 33577 (33760) to 33577 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.396), width: 16
Scan time: 10.700
The best scores are: opt bits E(85289)
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 3067 530.1 4.5e-150
XP_011518536 (OMIM: 606372) PREDICTED: neuronal ac ( 244) 1664 292.3 9.3e-79
NP_001289964 (OMIM: 606372) neuronal acetylcholine ( 244) 1664 292.3 9.3e-79
NP_001289963 (OMIM: 606372) neuronal acetylcholine ( 244) 1664 292.3 9.3e-79
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 1560 274.9 3.2e-73
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1074 192.6 2e-48
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1074 192.7 2.1e-48
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1015 182.6 1.9e-45
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1014 182.5 2.2e-45
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1014 182.5 2.3e-45
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1004 180.8 6.9e-45
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 997 179.6 1.6e-44
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 989 178.3 4.4e-44
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 989 178.3 4.4e-44
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 989 178.3 4.4e-44
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 976 176.0 1.6e-43
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 967 174.5 5.2e-43
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 968 174.8 6e-43
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 965 174.2 6.9e-43
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 953 172.1 2.7e-42
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 953 172.1 2.7e-42
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 953 172.1 2.7e-42
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 953 172.1 2.9e-42
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 932 168.6 3.4e-41
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 932 168.6 3.4e-41
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 924 167.2 8.3e-41
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 924 167.2 8.3e-41
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 917 166.0 1.8e-40
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 909 164.7 5.2e-40
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 907 164.4 6.4e-40
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 899 163.0 1.6e-39
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 871 158.2 4.3e-38
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 871 158.3 4.3e-38
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 854 155.4 3.5e-37
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 847 154.2 7.1e-37
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 827 150.8 6.7e-36
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 827 150.8 6.7e-36
NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 484) 776 142.2 3e-33
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 771 141.3 5.2e-33
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 754 138.4 3.4e-32
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 750 137.7 5.5e-32
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 750 137.7 5.5e-32
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 750 137.7 5.8e-32
XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 750 137.7 5.9e-32
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 660 122.4 2e-27
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 660 122.4 2e-27
XP_011520457 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 290) 653 121.2 3.7e-27
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 640 119.2 2.9e-26
NP_998786 (OMIM: 182139) 5-hydroxytryptamine recep ( 516) 637 118.6 3.8e-26
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 627 116.8 8.6e-26
>>NP_065135 (OMIM: 606372) neuronal acetylcholine recept (450 aa)
initn: 3067 init1: 3067 opt: 3067 Z-score: 2815.3 bits: 530.1 E(85289): 4.5e-150
Smith-Waterman score: 3067; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KE0 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
370 380 390 400 410 420
430 440 450
pF1KE0 RLARVMDRFFLAIFFSMALVMSLLVLVQAL
::::::::::::::::::::::::::::::
NP_065 RLARVMDRFFLAIFFSMALVMSLLVLVQAL
430 440 450
>>XP_011518536 (OMIM: 606372) PREDICTED: neuronal acetyl (244 aa)
initn: 1664 init1: 1664 opt: 1664 Z-score: 1535.0 bits: 292.3 E(85289): 9.3e-79
Smith-Waterman score: 1664; 100.0% identity (100.0% similar) in 244 aa overlap (207-450:1-244)
180 190 200 210 220 230
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA
::::::::::::::::::::::::::::::
XP_011 MPARRRVLTYGCCSEPYPDVTFTLLLRRRA
10 20 30
240 250 260 270 280 290
pF1KE0 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE0 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE0 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
160 170 180 190 200 210
420 430 440 450
pF1KE0 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
::::::::::::::::::::::::::::::::::
XP_011 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
220 230 240
>>NP_001289964 (OMIM: 606372) neuronal acetylcholine rec (244 aa)
initn: 1664 init1: 1664 opt: 1664 Z-score: 1535.0 bits: 292.3 E(85289): 9.3e-79
Smith-Waterman score: 1664; 100.0% identity (100.0% similar) in 244 aa overlap (207-450:1-244)
180 190 200 210 220 230
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA
::::::::::::::::::::::::::::::
NP_001 MPARRRVLTYGCCSEPYPDVTFTLLLRRRA
10 20 30
240 250 260 270 280 290
pF1KE0 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE0 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE0 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
160 170 180 190 200 210
420 430 440 450
pF1KE0 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
::::::::::::::::::::::::::::::::::
NP_001 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
220 230 240
>>NP_001289963 (OMIM: 606372) neuronal acetylcholine rec (244 aa)
initn: 1664 init1: 1664 opt: 1664 Z-score: 1535.0 bits: 292.3 E(85289): 9.3e-79
Smith-Waterman score: 1664; 100.0% identity (100.0% similar) in 244 aa overlap (207-450:1-244)
180 190 200 210 220 230
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA
::::::::::::::::::::::::::::::
NP_001 MPARRRVLTYGCCSEPYPDVTFTLLLRRRA
10 20 30
240 250 260 270 280 290
pF1KE0 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE0 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE0 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
160 170 180 190 200 210
420 430 440 450
pF1KE0 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
::::::::::::::::::::::::::::::::::
NP_001 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
220 230 240
>>NP_060051 (OMIM: 605116) neuronal acetylcholine recept (479 aa)
initn: 1707 init1: 1540 opt: 1560 Z-score: 1435.6 bits: 274.9 E(85289): 3.2e-73
Smith-Waterman score: 1668; 55.4% identity (77.5% similar) in 453 aa overlap (25-449:26-478)
10 20 30 40 50
pF1KE0 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTL
:.:. : ::: ::: .:..::::: :::..:::::
NP_060 MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 EVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLY
..::::: :::::::.:: :::::: : :::: :: . : :::.:::::.::::::::::
NP_060 QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 NKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGG
:::: . ..::::::.:: . :::::::.::: :::. :::: :.:.:::::::..:
NP_060 NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 HQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAY
.:.:. ...:.::.:.:::.: :::: . :..:::::::::::::::::.::.. :
NP_060 NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 VCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIG
. :::.::::::.::::.:.::: ::::::::::.:::.:::::..:: :: .:.:::::
NP_060 IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPC--
:::.:::...: ::::::..::.:.:: .:::: :::...: ...: : : . :: :
NP_060 KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
310 320 330 340 350 360
360 370 380 390
pF1KE0 -GQSRPPE-----LSPSPQSPEGGA-------------------GPPAGPCHEPRCLCRQ
.:: . : :.: .: : . .: . : :
NP_060 PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 -EALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
..: ... ::. ...:.:.. .::..:.:.::::. ::: :..::..:....:
NP_060 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
430 440 450 460 470
>>NP_000737 (OMIM: 118511,612001) neuronal acetylcholine (502 aa)
initn: 758 init1: 536 opt: 1074 Z-score: 990.5 bits: 192.6 E(85289): 2e-48
Smith-Waterman score: 1079; 40.6% identity (65.1% similar) in 456 aa overlap (26-434:22-475)
10 20 30 40 50 60
pF1KE0 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
.:.. ::...: ::. ::::. .: :.: .
NP_000 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFS
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
..: ::.:.::.::::: .:... ::: ::.:. . : :. ..:.:.. .:.:::.:::
NP_000 LSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
.:: . .. :::.. .: .. :.: .::: .:: ::::.::: : ::::..::
NP_000 SADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
.::.. . :... .. : :: ..:.:..: : ::.:::::::::. .:::. :
NP_000 SLDLQMQ--EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYG
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP-AESVPLIG
:::.:::::: :: :.: ::::::::.:::.::::.::::.::.:: :: ..:::::.
NP_000 LNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE----
.:. .:: .: .:...:..... :. :. .: :.:..::. : : ... ::
NP_000 QYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVR
300 310 320 330 340 350
360 370 380
pF1KE0 PCGQSRPP-------ELS---PSPQSP--------EGGAG------PPAGP-CHEPRCL-
: : . :.: : : : .: : : .: : . :
NP_000 PACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSP
360 370 380 390 400 410
390 400 410 420 430
pF1KE0 CRQEALLH----------------HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAI
..: ::: .: ::: :: . .. .:: : :.::. :
NP_000 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA
420 430 440 450 460 470
440 450
pF1KE0 FFSMALVMSLLVLVQAL
:
NP_000 FSVFTIICTIGILMSAPNFVEAVSKDFA
480 490 500
>>NP_001177384 (OMIM: 118511,612001) neuronal acetylchol (531 aa)
initn: 758 init1: 536 opt: 1074 Z-score: 990.1 bits: 192.7 E(85289): 2.1e-48
Smith-Waterman score: 1079; 40.6% identity (65.1% similar) in 456 aa overlap (26-434:51-504)
10 20 30 40 50
pF1KE0 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTL
.:.. ::...: ::. ::::. .: :
NP_001 ATASPPSTPPWDPGHIPGASVRPAPGPVSLQGEFQRKLYKELVKNYNPLERPVANDSQPL
30 40 50 60 70 80
60 70 80 90 100 110
pF1KE0 NVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPD
.: . ..: ::.:.::.::::: .:... ::: ::.:. . : :. ..:.:.. .:.::
NP_001 TVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPD
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE0 IVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSW
:.:::.:: . .. :::.. .: .. :.: .::: .:: ::::.::: : ::::
NP_001 ILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSW
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE0 THGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRR
..:: .::.. . :... .. : :: ..:.:..: : ::.:::::::::. .:::
NP_001 SYGGWSLDLQMQ--EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRR
210 220 230 240 250
240 250 260 270 280 290
pF1KE0 AAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP-AES
. : :::.:::::: :: :.: ::::::::.:::.::::.::::.::.:: :: ..:
NP_001 TLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDS
260 270 280 290 300 310
300 310 320 330 340 350
pF1KE0 VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERG
::::..:. .:: .: .:...:..... :. :. .: :.:..::. : : ... :
NP_001 VPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG
320 330 340 350 360 370
360 370 380
pF1KE0 E----PCGQSRPP-------ELS---PSPQSP--------EGGAG------PPAGP-CHE
: : : . :.: : : : .: : : .: : .
NP_001 EDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR
380 390 400 410 420 430
390 400 410 420
pF1KE0 PRCL-CRQEALLH----------------HVATIANTFRSHRAAQRCHEDWKRLARVMDR
: ..: ::: .: ::: :: . .. .:: : :.::
NP_001 MACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR
440 450 460 470 480 490
430 440 450
pF1KE0 FFLAIFFSMALVMSLLVLVQAL
. : :
NP_001 LCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
500 510 520 530
>>NP_000070 (OMIM: 100690,253290,601462,608930) acetylch (457 aa)
initn: 1005 init1: 569 opt: 1015 Z-score: 937.1 bits: 182.6 E(85289): 1.9e-45
Smith-Waterman score: 1015; 35.5% identity (68.1% similar) in 451 aa overlap (12-450:6-450)
10 20 30 40 50
pF1KE0 MGLRSHHLSLGLLLLFLLPAE--CLGAEG--RLALKLFRDLFANYTSALRPVADTDQTLN
::::: : . ::.: ::. :::.: :.:..::: : :...
NP_000 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKD----YSSVVRPVEDHRQVVE
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDI
::. . : :.:..:: ::..: . ..:.:.: :.:.:. :::. :.::: .::::.
NP_000 VTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 VLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWT
::::.::.. :.:.:.. : . : ::: .: :.. :. :::: :.:.. .:.::
NP_000 VLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSE-PYPDVTFTLLLRRR
. : . . :.. .:..:.:. :: . . .. .::.:: . :: :.:. ....:
NP_000 YDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 AAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAES-
.. :...::.:.:.:. :.:.::.:::::..:...:::.:::: :...: .: . :
NP_000 PLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERG
:::::::.. ::..: : .:....: :. .::.. .: :.: ... . .
NP_000 VPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMK
300 310 320 330 340 350
360 370 380 390 400
pF1KE0 EPCGQSRPPELSPSP---QSPEGGAGPPAGPCHEPRCLCRQ---EALLHHVATIANTFRS
.: ... .. .. : ::: : : : .. .. .. . ::.:..:
NP_000 RPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSP--LIKHPEVKSAIEGIKYIAETMKS
360 370 380 390 400
410 420 430 440 450
pF1KE0 HRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
. .. .:: .: :::...:..:. . .. .: :.. :
NP_000 DQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
410 420 430 440 450
>>NP_001160166 (OMIM: 118503,612052) neuronal acetylchol (489 aa)
initn: 1013 init1: 858 opt: 1014 Z-score: 935.7 bits: 182.5 E(85289): 2.2e-45
Smith-Waterman score: 1018; 39.3% identity (70.3% similar) in 394 aa overlap (10-392:18-407)
10 20 30 40 50
pF1KE0 MGLRSHHLSLGLLLLFLLP-AECLGAEGRLALKLFRDLFANYTSALRPVADT
: :::: ::: :. :: : ::. :: .:. .::::..
NP_001 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHR----LFERLFEDYNEIIRPVANV
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 DQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLV
.. . . .::..::.. .:: ::.. ::..: :.: :.:.:. ::: . .:.:.. .
NP_001 SDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 WRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLT
:.:::::::.: .. . .:...:.. : : : ::: .:::..::. :::: :.: .
NP_001 WKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 FGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLL
::::.. ..:. :.. .: :. :. :: .. :. .. . :.:: : :::.:..:
NP_001 FGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLY
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 LRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP
.:: :. ::..::.:::.:. :.:.::.: ::::.: ..:::.:::: :...:..:
NP_001 IRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 AESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV
. : ::::.: . :: .::.: ..:....:.:: :... .:.:.....:. : : . .
NP_001 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFM
300 310 320 330 340 350
360 370 380 390 400
pF1KE0 RERGEPCGQSRPP------ELSP-SPQSPEGGAGPPAG-PCHEPRC-LCRQEALLHHVAT
. :... : ::: . : . : : ::.. : :..
NP_001 TRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFS
360 370 380 390 400 410
410 420 430 440 450
pF1KE0 IANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
NP_001 ANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEEQKAQEIQQLKRK
420 430 440 450 460 470
>>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine (505 aa)
initn: 1096 init1: 858 opt: 1014 Z-score: 935.5 bits: 182.5 E(85289): 2.3e-45
Smith-Waterman score: 1045; 36.8% identity (65.7% similar) in 470 aa overlap (10-434:18-483)
10 20 30 40 50
pF1KE0 MGLRSHHLSLGLLLLFLLP-AECLGAEGRLALKLFRDLFANYTSALRPVADT
: :::: ::: :. :: :: :. :: .:. .::::..
NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRL----FERLFEDYNEIIRPVANV
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 DQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLV
.. . . .::..::.. .:: ::.. ::..: :.: :.:.:. ::: . .:.:.. .
NP_000 SDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 WRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLT
:.:::::::.: .. . .:...:.. : : : ::: .:::..::. :::: :.: .
NP_000 WKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 FGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLL
::::.. ..:. :.. .: :. :. :: .. :. .. . :.:: : :::.:..:
NP_000 FGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLY
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 LRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP
.:: :. ::..::.:::.:. :.:.::.: ::::.: ..:::.:::: :...:..:
NP_000 IRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 AESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV
. : ::::.: . :: .::.: ..:....:.:: :... .:.:.....:. : : . .
NP_000 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFM
300 310 320 330 340 350
360 370 380
pF1KE0 RERGEPCGQSRPP------ELS-----PSPQSPEGGAGPPA-----GPCHEPRC------
. :... : ::: .: : : : ::. :
NP_000 TRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFS
360 370 380 390 400 410
390 400 410 420
pF1KE0 --LCRQ------EALL-------------HHVATIANTFRSHRAAQRCHEDWKRLARVMD
: :. .:.: . : ::...... :.. ..::: .: :.:
NP_000 ANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVID
420 430 440 450 460 470
430 440 450
pF1KE0 RFFLAIFFSMALVMSLLVLVQAL
:.:: .:
NP_000 RIFLWVFTLVCILGTAGLFLQPLMAREDA
480 490 500
450 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:19:44 2016 done: Thu Nov 3 18:19:46 2016
Total Scan time: 10.700 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]