Result of FASTA (omim) for
pF1KE0253
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0253, 392 aa
1>>>pF1KE0253 392 - 392 aa - 392 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0466+/-0.000403; mu= 17.9624+/- 0.025
mean_var=59.9515+/-11.911, 0's: 0 Z-trim(110.7): 13 B-trim: 87 in 2/53
Lambda= 0.165643
statistics sampled from 19115 (19123) to 19115 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.595), E-opt: 0.2 (0.224), width: 16
Scan time: 7.900
The best scores are: opt bits E(85289)
NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] ( 392) 2578 624.8 1.1e-178
NP_056183 (OMIM: 608420) pannexin-1 [Homo sapiens] ( 426) 929 230.8 4.9e-60
NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [ ( 643) 528 135.0 4.9e-31
NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Hom ( 677) 528 135.0 5.1e-31
XP_011541036 (OMIM: 608420) PREDICTED: pannexin-1 ( 284) 429 111.2 3.3e-24
XP_016872953 (OMIM: 608420) PREDICTED: pannexin-1 ( 284) 429 111.2 3.3e-24
>>NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] (392 aa)
initn: 2578 init1: 2578 opt: 2578 Z-score: 3329.1 bits: 624.8 E(85289): 1.1e-178
Smith-Waterman score: 2578; 100.0% identity (100.0% similar) in 392 aa overlap (1-392:1-392)
10 20 30 40 50 60
pF1KE0 MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 LLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKH
310 320 330 340 350 360
370 380 390
pF1KE0 NIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
::::::::::::::::::::::::::::::::
NP_443 NIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
370 380 390
>>NP_056183 (OMIM: 608420) pannexin-1 [Homo sapiens] (426 aa)
initn: 927 init1: 353 opt: 929 Z-score: 1198.8 bits: 230.8 E(85289): 4.9e-60
Smith-Waterman score: 929; 43.3% identity (72.5% similar) in 360 aa overlap (1-355:1-357)
10 20 30 40 50 60
pF1KE0 MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS
:..:. :.::..:: :: . :..::::::: .:..: .::: ::::.:::::::.:
NP_056 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL
:. :::::::.:: ::::.::: :: .. ..:.. ... :: :: .:: :: .:.:
NP_056 GTQISCFSPSSFSWRQAAFVDSYCWAAV-QQKNSLQSESGNLPLWLHKFFPYILLLFAIL
70 80 90 100 110
130 140 150 160 170
pF1KE0 MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHM--LKIRQKS-SDPYVFWNE
.::: :.:..::.: . ::: ::. :::: :::.:. .. : .:. . : : : :
NP_056 LYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 LEKARK--ERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVF
.. . : .:..:..:.:: :. :..:. :. : ::. . .:::..
NP_056 GQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 FQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLC
...:: ::::.:.: ... ::. . :.: ...:::..:. ....:..:.::..:.:
NP_056 LSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPF
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 RWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDT
: .:.:::.::.::.: : : :::.. :::. ::::. :.. :.:: .:..
NP_056 RQKTDVLKVYEILPTFDVLHFKSEG--YNDLSLYNLFLEENISEVKSYKCLKVLENIKSS
300 310 320 330 340 350
360 370 380 390
pF1KE0 TTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
NP_056 GQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNA
360 370 380 390 400 410
>>NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [Homo (643 aa)
initn: 370 init1: 119 opt: 528 Z-score: 678.2 bits: 135.0 E(85289): 4.9e-31
Smith-Waterman score: 528; 30.4% identity (60.0% similar) in 395 aa overlap (1-378:11-389)
10 20 30 40
pF1KE0 MSLAHTAAEYMLSDALLP----DRRGPR---LKGLRLELPLDRIVKFVAV
:. : :.: : . .:: :. : : :.::::.::.: . .:
NP_001 MHHLLEQSADMATALLAGEK-LRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTV
10 20 30 40 50
50 60 70 80 90 100
pF1KE0 GSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKS
:.::..:.:...:. :: :..: ::. :: :. . :: : .. :: : :
NP_001 LVPILLVTLVFTKNFAE-EPIYCYTPHNFTRDQALYARGYCWTEL---RDALPGVDA--S
60 70 80 90 100 110
110 120 130 140 150
pF1KE0 LWP----HKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQ
::: :: :::.:::.: .::.:.: :.. : :.:.: :...:.:. :.:. .
NP_001 LWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRA
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE0 HMLKIRQKSSDPYVFWNE----LEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSL
.. . .:. : . : .:.:.::. : :.:.:: . ::. :. :: :. :
NP_001 PKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVL
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 LLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNL-ITCRLTSLSIFQIVSL
.:..... :: .. . :.::.:.. .. . : . ..:.: :... .:..
NP_001 ILLLSAVPISYLCTYYA-TQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 SSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG-CPINDLNVILLFL
.... .. .:. :: .: . : . ... : . .:.. . :.:.. .:
NP_001 VDIVLLCVMNLIILVNLIHLFIFRKSNF-IFDKLHKVGIKTRRQWRRSQFCDINILAMFC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 RANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
: ... :.. :. . .: :.:: :::.: :
NP_001 NENRDHIKSLNRLDFITNESDLM-----YDNVVR--QLLAALAQSNHDATPTVRDSGVQT
360 370 380 390 400
NP_001 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
410 420 430 440 450 460
>>NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Homo sa (677 aa)
initn: 370 init1: 119 opt: 528 Z-score: 677.9 bits: 135.0 E(85289): 5.1e-31
Smith-Waterman score: 528; 30.4% identity (60.0% similar) in 395 aa overlap (1-378:11-389)
10 20 30 40
pF1KE0 MSLAHTAAEYMLSDALLP----DRRGPR---LKGLRLELPLDRIVKFVAV
:. : :.: : . .:: :. : : :.::::.::.: . .:
NP_443 MHHLLEQSADMATALLAGEK-LRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTV
10 20 30 40 50
50 60 70 80 90 100
pF1KE0 GSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKS
:.::..:.:...:. :: :..: ::. :: :. . :: : .. :: : :
NP_443 LVPILLVTLVFTKNFAE-EPIYCYTPHNFTRDQALYARGYCWTEL---RDALPGVDA--S
60 70 80 90 100 110
110 120 130 140 150
pF1KE0 LWP----HKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQ
::: :: :::.:::.: .::.:.: :.. : :.:.: :...:.:. :.:. .
NP_443 LWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRA
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE0 HMLKIRQKSSDPYVFWNE----LEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSL
.. . .:. : . : .:.:.::. : :.:.:: . ::. :. :: :. :
NP_443 PKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVL
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 LLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNL-ITCRLTSLSIFQIVSL
.:..... :: .. . :.::.:.. .. . : . ..:.: :... .:..
NP_443 ILLLSAVPISYLCTYYA-TQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 SSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG-CPINDLNVILLFL
.... .. .:. :: .: . : . ... : . .:.. . :.:.. .:
NP_443 VDIVLLCVMNLIILVNLIHLFIFRKSNF-IFDKLHKVGIKTRRQWRRSQFCDINILAMFC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 RANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
: ... :.. :. . .: :.:: :::.: :
NP_443 NENRDHIKSLNRLDFITNESDLM-----YDNVVR--QLLAALAQSNHDATPTVRDSGVQT
360 370 380 390 400
NP_443 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
410 420 430 440 450 460
>>XP_011541036 (OMIM: 608420) PREDICTED: pannexin-1 isof (284 aa)
initn: 425 init1: 292 opt: 429 Z-score: 555.7 bits: 111.2 E(85289): 3.3e-24
Smith-Waterman score: 429; 36.4% identity (68.2% similar) in 217 aa overlap (144-355:1-215)
120 130 140 150 160 170
pF1KE0 LLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHM--LKIRQKS-SD
. :::: :::.:. .. : .:. . :
XP_011 MEELDKVYNRAIKAAKSARDLDMRDGACSV
10 20 30
180 190 200 210 220
pF1KE0 PYVFWNELEKARK--ERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLG
: : : .. . : .:..:..:.:: :. :..:. :. : ::. . .:::
XP_011 PGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLG
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE0 HFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVII
.. ...:: ::::.:.: ... ::. . :.: ...:::..:. ....:..:.::..
XP_011 YYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVV
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE0 YNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSV
:.: : .:.:::.::.::.: : : :::.. :::. ::::. :.. :.:
XP_011 YTLFVPFRQKTDVLKVYEILPTFDVLHFKSEG--YNDLSLYNLFLEENISEVKSYKCLKV
160 170 180 190 200
350 360 370 380 390
pF1KE0 LCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
: .:..
XP_011 LENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKA
210 220 230 240 250 260
>>XP_016872953 (OMIM: 608420) PREDICTED: pannexin-1 isof (284 aa)
initn: 425 init1: 292 opt: 429 Z-score: 555.7 bits: 111.2 E(85289): 3.3e-24
Smith-Waterman score: 429; 36.4% identity (68.2% similar) in 217 aa overlap (144-355:1-215)
120 130 140 150 160 170
pF1KE0 LLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHM--LKIRQKS-SD
. :::: :::.:. .. : .:. . :
XP_016 MEELDKVYNRAIKAAKSARDLDMRDGACSV
10 20 30
180 190 200 210 220
pF1KE0 PYVFWNELEKARK--ERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLG
: : : .. . : .:..:..:.:: :. :..:. :. : ::. . .:::
XP_016 PGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLG
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE0 HFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVII
.. ...:: ::::.:.: ... ::. . :.: ...:::..:. ....:..:.::..
XP_016 YYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVV
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE0 YNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSV
:.: : .:.:::.::.::.: : : :::.. :::. ::::. :.. :.:
XP_016 YTLFVPFRQKTDVLKVYEILPTFDVLHFKSEG--YNDLSLYNLFLEENISEVKSYKCLKV
160 170 180 190 200
350 360 370 380 390
pF1KE0 LCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
: .:..
XP_016 LENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKA
210 220 230 240 250 260
392 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:57:06 2016 done: Thu Nov 3 18:57:07 2016
Total Scan time: 7.900 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]