Result of FASTA (omim) for
pF1KE0245
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0245, 240 aa
1>>>pF1KE0245 240 - 240 aa - 240 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.3718+/-0.000299; mu= 19.3048+/- 0.019
mean_var=59.6811+/-12.109, 0's: 0 Z-trim(116.3): 27 B-trim: 0 in 0/52
Lambda= 0.166018
statistics sampled from 27279 (27306) to 27279 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.32), width: 16
Scan time: 7.120
The best scores are: opt bits E(85289)
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 1611 393.8 1.4e-109
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 1611 393.8 1.4e-109
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 1126 277.6 1.2e-74
XP_016882907 (OMIM: 604520) PREDICTED: tumor necro ( 128) 672 168.6 4.5e-42
NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 295 78.6 1.2e-14
NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 234 64.0 2.7e-10
NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 222 61.0 1.7e-09
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 222 61.1 2.1e-09
NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 189 53.3 5.3e-07
XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 179 50.8 2.5e-06
XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 179 50.8 2.5e-06
NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244) 179 50.8 2.5e-06
XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263) 179 50.8 2.7e-06
NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317) 179 50.9 3.1e-06
XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 170 48.6 1e-05
XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 170 48.6 1e-05
NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 170 48.6 1e-05
NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 170 48.6 1e-05
XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 170 48.6 1e-05
XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 170 48.6 1e-05
NP_003802 (OMIM: 606182) tumor necrosis factor lig ( 254) 162 46.8 4.4e-05
>>XP_016882906 (OMIM: 604520) PREDICTED: tumor necrosis (240 aa)
initn: 1611 init1: 1611 opt: 1611 Z-score: 2088.2 bits: 393.8 E(85289): 1.4e-109
Smith-Waterman score: 1611; 100.0% identity (100.0% similar) in 240 aa overlap (1-240:1-240)
10 20 30 40 50 60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
190 200 210 220 230 240
>>NP_003798 (OMIM: 604520) tumor necrosis factor ligand (240 aa)
initn: 1611 init1: 1611 opt: 1611 Z-score: 2088.2 bits: 393.8 E(85289): 1.4e-109
Smith-Waterman score: 1611; 100.0% identity (100.0% similar) in 240 aa overlap (1-240:1-240)
10 20 30 40 50 60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
190 200 210 220 230 240
>>NP_742011 (OMIM: 604520) tumor necrosis factor ligand (204 aa)
initn: 1121 init1: 1121 opt: 1126 Z-score: 1461.3 bits: 277.6 E(85289): 1.2e-74
Smith-Waterman score: 1285; 85.0% identity (85.0% similar) in 240 aa overlap (1-240:1-204)
10 20 30 40 50 60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
:::::::::::::::::::::::::::::::::::::
NP_742 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVAR-----------------------
10 20 30
70 80 90 100 110 120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
:::::::::::::::::::::::::::::::::::::::::::::::
NP_742 -------------DGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
40 50 60 70 80
130 140 150 160 170 180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
150 160 170 180 190 200
>>XP_016882907 (OMIM: 604520) PREDICTED: tumor necrosis (128 aa)
initn: 672 init1: 672 opt: 672 Z-score: 876.3 bits: 168.6 E(85289): 4.5e-42
Smith-Waterman score: 672; 100.0% identity (100.0% similar) in 99 aa overlap (1-99:1-99)
10 20 30 40 50 60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
:::::::::::::::::::::::::::::::::::::::
XP_016 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTVTTFGGHSEIRHRVKSGPVPG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
XP_016 SPGQTASL
>>NP_000630 (OMIM: 134638,211980,601859) tumor necrosis (281 aa)
initn: 196 init1: 146 opt: 295 Z-score: 383.8 bits: 78.6 E(85289): 1.2e-14
Smith-Waterman score: 295; 29.2% identity (62.8% similar) in 226 aa overlap (20-238:70-279)
10 20 30 40
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGA
:. . : .: : .. . .:. :.:
NP_000 PGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRG-NHSTGLCLLVMFFM-VLVALVGL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE0 GLAVQGWF-LLQLHWRLGEMVTRLPD-GPAGSWEQLIQER----RSHEVNPAAHLTGANS
:: : : :..:. .:.:. . :.: :. : . ...:. .::::: ..
NP_000 GL---GMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSN
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE0 SLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTIT
: . :: :: :...: :..:. :.::....: :..:::: . : .: ..
NP_000 SRSM---PLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCN---NLPLS
160 170 180 190 200
170 180 190 200 210 220
pF1KE0 HGLYKRTPRYPEELELLVSQQ-SPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDE
: .: :. .::..: .. ... : : .....: ::.::.: .: ..... : : .
NP_000 HKVYMRNSKYPQDLVMMEGKMMSYC----TTGQMWARSSYLGAVFNLTSADHLYVNVSEL
210 220 230 240 250 260
230 240
pF1KE0 RLVRLRDGTRSYFGAFMV
:: ... ....:: .
NP_000 SLVNFEE-SQTFFGLYKL
270 280
>>NP_000585 (OMIM: 157300,191160,600807,611162) tumor ne (233 aa)
initn: 233 init1: 99 opt: 234 Z-score: 305.9 bits: 64.0 E(85289): 2.7e-10
Smith-Waterman score: 234; 30.7% identity (60.1% similar) in 153 aa overlap (88-236:82-229)
60 70 80 90 100 110
pF1KE0 LLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQ
:. .:.::.. :: . :. : : ..
NP_000 HFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVV-ANPQAEGQ---LQWLNR
60 70 80 90 100
120 130 140 150 160 170
pF1KE0 LGLAFL-RGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEE
. :.: :. .:. ::: . : : :::.: . : ::: . .:: . . . : .
NP_000 RANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCP-STHVLLTHTISRIAVSYQTK
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE0 LELLVSQQSPCGRAT---SSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRS
..:: . .::: : : . .. :.. .:::: .:: :... ... . . .. .
NP_000 VNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQV
170 180 190 200 210 220
240
pF1KE0 YFGAFMV
:::
NP_000 YFGIIAL
230
>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa)
initn: 192 init1: 88 opt: 222 Z-score: 291.5 bits: 61.0 E(85289): 1.7e-09
Smith-Waterman score: 229; 32.1% identity (58.6% similar) in 162 aa overlap (94-240:36-192)
70 80 90 100 110
pF1KE0 RLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTG---SGGPLL-WETQLG
: :::: . .. : . : : :: .::
NP_001 GRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG
10 20 30 40 50 60
120 130 140 150 160
pF1KE0 LAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV----------GCPLGLASTITHGLYK
::: .. ..: . :.. ..: :.:::.: . :. : : . ..:: . :
NP_001 LAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRP-NKPDSITVVITK
70 80 90 100 110 120
170 180 190 200 210 220
pF1KE0 RTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLR
: ::: .::.. .: : ... :.. .::.. :. :.:..: : : ::
NP_001 VTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGAMFSLQEGDKLMVNVSDISLVDYT
130 140 150 160 170 180
230 240
pF1KE0 DGTRSYFGAFMV
...::::..
NP_001 KEDKTFFGAFLL
190
>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa)
initn: 191 init1: 88 opt: 222 Z-score: 290.0 bits: 61.1 E(85289): 2.1e-09
Smith-Waterman score: 246; 28.2% identity (54.6% similar) in 238 aa overlap (20-240:26-251)
10 20 30 40 50
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGL--GLLLLLMGAGLA
: .: . .. .: .. . . :: :. . :
NP_005 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR
10 20 30 40 50 60
60 70 80 90 100
pF1KE0 VQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTG---SG
.:: .:.. :. : : .:. :. .: :::: . .. : .
NP_005 AQGEACVQFQALKGQEF-------APSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQ
70 80 90 100 110
110 120 130 140 150
pF1KE0 GPLL-WETQLGLAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV----------GCPLG
: : :: .::::: .. ..: . :.. ..: :.:::.: . :. : : .
NP_005 FPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRP-N
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE0 LASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVV
..:: . : : ::: .::.. .: : ... :.. .::.. :. :.:..:
NP_005 KPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGAMFSLQEGDKLMV
180 190 200 210 220
220 230 240
pF1KE0 RVLDERLVRLRDGTRSYFGAFMV
: : :: ...::::..
NP_005 NVSDISLVDYTKEDKTFFGAFLL
230 240 250
>>NP_003801 (OMIM: 603598) tumor necrosis factor ligand (281 aa)
initn: 134 init1: 90 opt: 189 Z-score: 246.6 bits: 53.3 E(85289): 5.3e-07
Smith-Waterman score: 202; 26.2% identity (55.3% similar) in 206 aa overlap (60-240:79-280)
30 40 50 60 70 80
pF1KE0 RQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRS
:..:.: ..: .. . . .::...
NP_003 YSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQ
50 60 70 80 90 100
90 100 110 120
pF1KE0 H------EVNP---AAHLTGA----------NSSLTGSGGPLL--WET-QLGLAFLRGLS
. : .: :::.::. ::. . : . ::. . : .:: .:
NP_003 NISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLH
110 120 130 140 150 160
130 140 150 160 170 180
pF1KE0 YHDGALVVTKAGYYYIYSKVQLG---GVGCPLGLASTITHGLYKRTPRYPEELELLVSQQ
..: ::. . :.:::::.. . . . ... .:: : ::. . :. : .
NP_003 LRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTS-YPDPILLMKSAR
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE0 SPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
. : . .. : . ::. .:. .... : : .:.:. . : :.::::.:
NP_003 NSCWSKDAEYGLY--SIYQGGIFELKENDRIFVSVTNEHLIDM-DHEASFFGAFLVG
230 240 250 260 270 280
>>XP_016876292 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa)
initn: 104 init1: 49 opt: 179 Z-score: 234.5 bits: 50.8 E(85289): 2.5e-06
Smith-Waterman score: 179; 26.0% identity (54.6% similar) in 196 aa overlap (52-240:49-240)
30 40 50 60 70 80
pF1KE0 TRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPA-GSW
: :: .:. .: . : . . :::
XP_016 RLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSW
20 30 40 50 60 70
90 100 110 120 130
pF1KE0 EQLIQERRSHEVNPAAHLTGANSSL-TGSGGPLL--WETQLGLAFLRGLSYHDGALVVTK
.: . : . :..: :::: ... .:: : : . : : . .... .: :.:..
XP_016 LDLAK-RSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQ
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE0 AGYYYIYSKVQLGGVGCPLGLASTITHGLY---KRTPRYPEELELLVSQQSPCGRATSSS
:.::.:... . ::. . . : . . : :. . .. ...:
XP_016 DGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTK--YWSGNS
140 150 160 170 180 190
200 210 220 230 240
pF1KE0 RVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
. . : .:: .:..::.. ..: . :. : .::::: :
XP_016 EFHFYSINVGGFFKLRSGEEISIEVSNPSLLD-PDQDATYFGAFKVRDID
200 210 220 230 240
240 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:31:05 2016 done: Thu Nov 3 19:31:06 2016
Total Scan time: 7.120 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]