Result of FASTA (omim) for
pF1KE0228
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0228, 110 aa
1>>>pF1KE0228 110 - 110 aa - 110 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7646+/-0.000302; mu= 12.3046+/- 0.019
mean_var=54.4417+/-10.902, 0's: 0 Z-trim(115.9): 68 B-trim: 38 in 1/54
Lambda= 0.173823
statistics sampled from 26623 (26691) to 26623 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.313), width: 16
Scan time: 4.390
The best scores are: opt bits E(85289)
NP_001007233 (OMIM: 609490) caspase recruitment do ( 110) 702 183.4 6.3e-47
XP_011541140 (OMIM: 609490) PREDICTED: caspase rec ( 125) 702 183.4 7e-47
NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 543 143.9 1.9e-34
NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 543 143.9 1.9e-34
NP_443121 (OMIM: 615680) caspase recruitment domai ( 97) 495 131.5 2.4e-31
NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 487 129.8 3e-30
NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 487 129.8 3e-30
NP_001017534 (OMIM: 615680) caspase recruitment do ( 197) 464 123.9 9.5e-29
XP_011540885 (OMIM: 615680) PREDICTED: caspase rec ( 265) 452 120.9 9.8e-28
XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 378 102.5 5e-22
XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 378 102.5 5.3e-22
XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 378 102.5 5.3e-22
XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 322 88.4 8.6e-18
NP_067546 (OMIM: 605354) caspase recruitment domai ( 90) 302 83.1 8.4e-17
NP_001289433 (OMIM: 606831,616050,616115) NLR fami ( 359) 133 41.0 0.0015
NP_150637 (OMIM: 147678) caspase-1 isoform epsilon ( 88) 123 38.2 0.0027
XP_016860108 (OMIM: 606831,616050,616115) PREDICTE ( 788) 127 39.7 0.0082
>>NP_001007233 (OMIM: 609490) caspase recruitment domain (110 aa)
initn: 702 init1: 702 opt: 702 Z-score: 963.4 bits: 183.4 E(85289): 6.3e-47
Smith-Waterman score: 702; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
70 80 90 100 110
>>XP_011541140 (OMIM: 609490) PREDICTED: caspase recruit (125 aa)
initn: 702 init1: 702 opt: 702 Z-score: 962.6 bits: 183.4 E(85289): 7e-47
Smith-Waterman score: 702; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:16-125)
10 20 30 40
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKC
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLSVSAYTRREERKAMADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKC
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 ENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQ
70 80 90 100 110 120
110
pF1KE0 IVLPS
:::::
XP_011 IVLPS
>>NP_150634 (OMIM: 147678) caspase-1 isoform alpha precu (404 aa)
initn: 543 init1: 543 opt: 543 Z-score: 739.6 bits: 143.9 E(85289): 1.9e-34
Smith-Waterman score: 543; 80.9% identity (90.0% similar) in 110 aa overlap (1-110:1-110)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_150 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
:: ::: ::::::::::::::.::::::::: ::::.:. :::: :: :
NP_150 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
70 80 90 100 110 120
NP_150 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
130 140 150 160 170 180
>>NP_001244047 (OMIM: 147678) caspase-1 isoform alpha pr (404 aa)
initn: 543 init1: 543 opt: 543 Z-score: 739.6 bits: 143.9 E(85289): 1.9e-34
Smith-Waterman score: 543; 80.9% identity (90.0% similar) in 110 aa overlap (1-110:1-110)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
:: ::: ::::::::::::::.::::::::: ::::.:. :::: :: :
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
70 80 90 100 110 120
NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
130 140 150 160 170 180
>>NP_443121 (OMIM: 615680) caspase recruitment domain-co (97 aa)
initn: 495 init1: 495 opt: 495 Z-score: 683.7 bits: 131.5 E(85289): 2.4e-31
Smith-Waterman score: 495; 82.5% identity (90.7% similar) in 97 aa overlap (1-97:1-97)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::: ::.:.::::::::: :::.::::.:::.: :: ::::::::.:::.::
NP_443 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
:: ::: ::::::::::::::.:: :::::::: ::
NP_443 VIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN
70 80 90
>>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre (383 aa)
initn: 487 init1: 487 opt: 487 Z-score: 664.0 bits: 129.8 E(85289): 3e-30
Smith-Waterman score: 487; 83.9% identity (93.5% similar) in 93 aa overlap (1-93:1-93)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
:: ::: ::::::::::::::.:::::::::.:
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
70 80 90 100 110 120
NP_001 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
130 140 150 160 170 180
>>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur (383 aa)
initn: 487 init1: 487 opt: 487 Z-score: 664.0 bits: 129.8 E(85289): 3e-30
Smith-Waterman score: 487; 83.9% identity (93.5% similar) in 93 aa overlap (1-93:1-93)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
:: ::: ::::::::::::::.:::::::::.:
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
70 80 90 100 110 120
NP_001 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
130 140 150 160 170 180
>>NP_001017534 (OMIM: 615680) caspase recruitment domain (197 aa)
initn: 464 init1: 464 opt: 464 Z-score: 637.1 bits: 123.9 E(85289): 9.5e-29
Smith-Waterman score: 464; 83.5% identity (92.3% similar) in 91 aa overlap (1-91:1-91)
10 20 30 40 50 60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
::::::::::: ::.:.::::::::: :::.::::.:::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
:: ::: ::::::::::::::.:: ::::::
NP_001 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
70 80 90 100 110 120
NP_001 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
130 140 150 160 170 180
>>XP_011540885 (OMIM: 615680) PREDICTED: caspase recruit (265 aa)
initn: 452 init1: 452 opt: 452 Z-score: 618.9 bits: 120.9 E(85289): 9.8e-28
Smith-Waterman score: 452; 83.1% identity (92.1% similar) in 89 aa overlap (3-91:71-159)
10 20 30
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLET
::::::::: ::.:.::::::::: :::.:
XP_011 LLFQEQVPGKKELWKGLALLEAIISICGSLDKVLKEKRKLFIHSMGEGTINGLLDELLQT
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE0 RVLSQEEIEIVKCENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAG
:::.:::.: :: ::::::::.:::.:::: ::: ::::::::::::::.:: ::::::
XP_011 RVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAA
110 120 130 140 150 160
100 110
pF1KE0 PTSGNHLTTQDSQIVLPS
XP_011 LQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQ
170 180 190 200 210 220
>>XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 isofo (374 aa)
initn: 378 init1: 378 opt: 378 Z-score: 516.4 bits: 102.5 E(85289): 5e-22
Smith-Waterman score: 378; 78.5% identity (88.6% similar) in 79 aa overlap (32-110:2-80)
10 20 30 40 50 60
pF1KE0 ADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDSV
::::..::.: :: ::::::::.:::.:::
XP_016 MTRVLNKEEMEKVKRENATVMDKTRALIDSV
10 20 30
70 80 90 100 110
pF1KE0 IRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
: ::: ::::::::::::::.::::::::: ::::.:. :::: :: :
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
40 50 60 70 80 90
XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
100 110 120 130 140 150
110 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 20:29:13 2016 done: Thu Nov 3 20:29:14 2016
Total Scan time: 4.390 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]