FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0165, 187 aa 1>>>pF1KE0165 187 - 187 aa - 187 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0891+/-0.000347; mu= 10.1392+/- 0.022 mean_var=100.4784+/-19.568, 0's: 0 Z-trim(116.0): 25 B-trim: 183 in 1/53 Lambda= 0.127949 statistics sampled from 26860 (26880) to 26860 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.315), width: 16 Scan time: 5.360 The best scores are: opt bits E(85289) NP_003272 (OMIM: 191042) troponin I, slow skeletal ( 187) 1198 231.0 8.8e-61 NP_000354 (OMIM: 115210,191044,611880,613286,61369 ( 210) 706 140.2 2.1e-33 NP_003273 (OMIM: 191043,601680) troponin I, fast s ( 182) 684 136.1 3.1e-32 NP_001139301 (OMIM: 191043,601680) troponin I, fas ( 182) 684 136.1 3.1e-32 NP_001139313 (OMIM: 191043,601680) troponin I, fas ( 182) 682 135.7 4e-32 >>NP_003272 (OMIM: 191042) troponin I, slow skeletal mus (187 aa) initn: 1198 init1: 1198 opt: 1198 Z-score: 1212.3 bits: 231.0 E(85289): 8.8e-61 Smith-Waterman score: 1198; 99.5% identity (99.5% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KE0 MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMALRGKFKRPPLRRVRVSA :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: NP_003 ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDA 130 140 150 160 170 180 pF1KE0 AKSPTSQ ::::::: NP_003 AKSPTSQ >>NP_000354 (OMIM: 115210,191044,611880,613286,613690) t (210 aa) initn: 708 init1: 584 opt: 706 Z-score: 720.7 bits: 140.2 E(85289): 2.1e-33 Smith-Waterman score: 706; 62.6% identity (82.1% similar) in 179 aa overlap (2-180:33-210) 10 20 30 pF1KE0 MPEVERKPKITASRKLLLKSLMLAKAKECWE :....: ::.::::: ::.:.: ::. : NP_000 DGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 QEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNT .: :::..:: : :. : :. ::... ::::::.:::.:. ::::::::::: .: NP_000 REAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 REIKDLKLKVMALRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTE :: :: :.. :::::::: :::::.:::::..::::.. : :.::::.::.::::::: NP_000 TEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTE 130 140 150 160 170 180 160 170 180 pF1KE0 KERPVEVGDWRKNVEAMSGMEGRKKMFDAAKSPTSQ :: ::::::::..:.:::::::: :.. NP_000 KENR-EVGDWRKNIDALSGMEGRKKKFES 190 200 210 >>NP_003273 (OMIM: 191043,601680) troponin I, fast skele (182 aa) initn: 570 init1: 448 opt: 684 Z-score: 699.6 bits: 136.1 E(85289): 3.1e-32 Smith-Waterman score: 684; 58.0% identity (82.9% similar) in 181 aa overlap (1-180:1-180) 10 20 30 40 50 60 pF1KE0 MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS : . :.. . ..:. :::.:: : :.:. .::::: ::::. : :. : :.: NP_003 MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPG-SMS 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMALRGKFKRPPLRRVRVSA .:.::..::::.....::.::.:.. ....:..:.. :.. ::::::::::::::.:: NP_003 EVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSA 60 70 80 90 100 110 130 140 150 160 170 pF1KE0 DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPV-EVGDWRKNVEAMSGMEGRKKMFD ::::.::::::::: ::::::::.:::::::::: . .:::::::.: ::::::::::. NP_003 DAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFE 120 130 140 150 160 170 180 pF1KE0 AAKSPTSQ . NP_003 SES 180 >>NP_001139301 (OMIM: 191043,601680) troponin I, fast sk (182 aa) initn: 570 init1: 448 opt: 684 Z-score: 699.6 bits: 136.1 E(85289): 3.1e-32 Smith-Waterman score: 684; 58.0% identity (82.9% similar) in 181 aa overlap (1-180:1-180) 10 20 30 40 50 60 pF1KE0 MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS : . :.. . ..:. :::.:: : :.:. .::::: ::::. : :. : :.: NP_001 MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPG-SMS 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMALRGKFKRPPLRRVRVSA .:.::..::::.....::.::.:.. ....:..:.. :.. ::::::::::::::.:: NP_001 EVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSA 60 70 80 90 100 110 130 140 150 160 170 pF1KE0 DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPV-EVGDWRKNVEAMSGMEGRKKMFD ::::.::::::::: ::::::::.:::::::::: . .:::::::.: ::::::::::. NP_001 DAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFE 120 130 140 150 160 170 180 pF1KE0 AAKSPTSQ . NP_001 SES 180 >>NP_001139313 (OMIM: 191043,601680) troponin I, fast sk (182 aa) initn: 570 init1: 448 opt: 682 Z-score: 697.7 bits: 135.7 E(85289): 4e-32 Smith-Waterman score: 682; 57.5% identity (82.9% similar) in 181 aa overlap (1-180:1-180) 10 20 30 40 50 60 pF1KE0 MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS : . ... . ..:. :::.:: : :.:. .::::: ::::. : :. : :.: NP_001 MSQCKKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPG-SMS 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMALRGKFKRPPLRRVRVSA .:.::..::::.....::.::.:.. ....:..:.. :.. ::::::::::::::.:: NP_001 EVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSA 60 70 80 90 100 110 130 140 150 160 170 pF1KE0 DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPV-EVGDWRKNVEAMSGMEGRKKMFD ::::.::::::::: ::::::::.:::::::::: . .:::::::.: ::::::::::. NP_001 DAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFE 120 130 140 150 160 170 180 pF1KE0 AAKSPTSQ . NP_001 SES 180 187 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:12:11 2016 done: Thu Nov 3 23:12:12 2016 Total Scan time: 5.360 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]