Result of FASTA (omim) for
pF1KE0084
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0084, 872 aa
1>>>pF1KE0084 872 - 872 aa - 872 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5433+/-0.000402; mu= 11.6228+/- 0.025
mean_var=180.8164+/-36.109, 0's: 0 Z-trim(117.6): 126 B-trim: 860 in 1/59
Lambda= 0.095380
statistics sampled from 29642 (29771) to 29642 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.689), E-opt: 0.2 (0.349), width: 16
Scan time: 14.640
The best scores are: opt bits E(85289)
NP_004510 (OMIM: 121201,602232) potassium voltage- ( 872) 5842 817.1 0
NP_001191753 (OMIM: 121201,602232) potassium volta ( 752) 4998 700.9 5.5e-201
XP_011515328 (OMIM: 121201,602232) PREDICTED: pota ( 752) 4983 698.9 2.3e-200
XP_016868889 (OMIM: 121201,602232) PREDICTED: pota ( 798) 4983 698.9 2.4e-200
XP_006716618 (OMIM: 121201,602232) PREDICTED: pota ( 636) 4271 600.8 6.4e-171
XP_005250971 (OMIM: 121201,602232) PREDICTED: pota ( 457) 2855 405.9 2.3e-112
NP_000209 (OMIM: 130650,192500,220400,607542,60755 ( 676) 1254 185.7 6.3e-46
NP_861463 (OMIM: 130650,192500,220400,607542,60755 ( 549) 1180 175.4 6.3e-43
NP_062816 (OMIM: 607357) potassium voltage-gated c ( 932) 1057 158.7 1.1e-37
NP_001153604 (OMIM: 607357) potassium voltage-gate ( 942) 1022 153.9 3.2e-36
NP_751895 (OMIM: 600101,603537) potassium voltage- ( 641) 1013 152.5 5.8e-36
XP_016866547 (OMIM: 607357) PREDICTED: potassium v ( 496) 976 147.3 1.6e-34
NP_001153606 (OMIM: 607357) potassium voltage-gate ( 822) 976 147.5 2.4e-34
NP_001153602 (OMIM: 607357) potassium voltage-gate ( 923) 976 147.6 2.6e-34
NP_001153605 (OMIM: 607357) potassium voltage-gate ( 951) 976 147.6 2.6e-34
NP_742106 (OMIM: 121200,602235,613720) potassium v ( 841) 704 110.1 4.4e-23
NP_742105 (OMIM: 121200,602235,613720) potassium v ( 872) 654 103.3 5.4e-21
NP_742107 (OMIM: 121200,602235,613720) potassium v ( 393) 645 101.7 7.1e-21
XP_016883333 (OMIM: 121200,602235,613720) PREDICTE ( 853) 641 101.5 1.8e-20
NP_742104 (OMIM: 121200,602235,613720) potassium v ( 854) 641 101.5 1.8e-20
XP_016883332 (OMIM: 121200,602235,613720) PREDICTE ( 867) 641 101.5 1.8e-20
XP_016883331 (OMIM: 121200,602235,613720) PREDICTE ( 868) 641 101.5 1.8e-20
XP_016883330 (OMIM: 121200,602235,613720) PREDICTE ( 889) 641 101.5 1.9e-20
XP_011527112 (OMIM: 121200,602235,613720) PREDICTE ( 890) 641 101.5 1.9e-20
NP_004509 (OMIM: 121200,602235,613720) potassium v ( 844) 635 100.6 3.2e-20
XP_011527113 (OMIM: 121200,602235,613720) PREDICTE ( 880) 635 100.6 3.3e-20
NP_004691 (OMIM: 600101,603537) potassium voltage- ( 695) 618 98.2 1.4e-19
XP_016883334 (OMIM: 121200,602235,613720) PREDICTE ( 544) 544 87.9 1.4e-16
XP_016858281 (OMIM: 600101,603537) PREDICTED: pota ( 356) 460 76.2 3.1e-13
XP_011539703 (OMIM: 176265) PREDICTED: potassium v ( 609) 294 53.6 3.4e-06
XP_006710688 (OMIM: 176265) PREDICTED: potassium v ( 618) 294 53.6 3.4e-06
XP_006710690 (OMIM: 176265) PREDICTED: potassium v ( 624) 294 53.6 3.4e-06
NP_001034663 (OMIM: 176265) potassium voltage-gate ( 626) 294 53.6 3.5e-06
NP_004969 (OMIM: 176265) potassium voltage-gated c ( 635) 294 53.6 3.5e-06
NP_715624 (OMIM: 176256) potassium voltage-gated c ( 558) 278 51.3 1.5e-05
XP_005268912 (OMIM: 176256) PREDICTED: potassium v ( 574) 278 51.3 1.5e-05
NP_001247428 (OMIM: 176256) potassium voltage-gate ( 583) 278 51.4 1.5e-05
XP_006719446 (OMIM: 176256) PREDICTED: potassium v ( 612) 278 51.4 1.6e-05
XP_006719448 (OMIM: 176256) PREDICTED: potassium v ( 612) 278 51.4 1.6e-05
XP_016874771 (OMIM: 176256) PREDICTED: potassium v ( 612) 278 51.4 1.6e-05
XP_006719447 (OMIM: 176256) PREDICTED: potassium v ( 612) 278 51.4 1.6e-05
XP_006719445 (OMIM: 176256) PREDICTED: potassium v ( 613) 278 51.4 1.6e-05
NP_631874 (OMIM: 176256) potassium voltage-gated c ( 613) 278 51.4 1.6e-05
NP_001247426 (OMIM: 176256) potassium voltage-gate ( 618) 278 51.4 1.6e-05
NP_001247427 (OMIM: 176256) potassium voltage-gate ( 629) 278 51.4 1.6e-05
NP_631875 (OMIM: 176256) potassium voltage-gated c ( 638) 278 51.4 1.6e-05
NP_004967 (OMIM: 176258,616187) potassium voltage- ( 511) 275 50.9 1.8e-05
XP_011518382 (OMIM: 176258,616187) PREDICTED: pota ( 535) 275 50.9 1.9e-05
XP_011525230 (OMIM: 176264,605259) PREDICTED: pota ( 728) 277 51.3 1.9e-05
NP_004968 (OMIM: 176264,605259) potassium voltage- ( 757) 277 51.3 2e-05
>>NP_004510 (OMIM: 121201,602232) potassium voltage-gate (872 aa)
initn: 5842 init1: 5842 opt: 5842 Z-score: 4356.1 bits: 817.1 E(85289): 0
Smith-Waterman score: 5842; 100.0% identity (100.0% similar) in 872 aa overlap (1-872:1-872)
10 20 30 40 50 60
pF1KE0 MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
790 800 810 820 830 840
850 860 870
pF1KE0 DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
::::::::::::::::::::::::::::::::
NP_004 DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
850 860 870
>>NP_001191753 (OMIM: 121201,602232) potassium voltage-g (752 aa)
initn: 4998 init1: 4998 opt: 4998 Z-score: 3729.3 bits: 700.9 E(85289): 5.5e-201
Smith-Waterman score: 4998; 99.7% identity (99.9% similar) in 747 aa overlap (126-872:6-752)
100 110 120 130 140 150
pF1KE0 PVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDW
:: .::::::::::::::::::::::::::
NP_001 MKPAEHATMFLIVLGCLILAVLTTFKEYETVSGDW
10 20 30
160 170 180 190 200 210
pF1KE0 LLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 GNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 SFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAAT
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE0 FSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDL
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE0 VATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEE
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE0 SPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTL
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE0 KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPG
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE0 PPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKK
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE0 LDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEP
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE0 PYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLD
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE0 SRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDD
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE0 YVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
700 710 720 730 740 750
>>XP_011515328 (OMIM: 121201,602232) PREDICTED: potassiu (752 aa)
initn: 4983 init1: 4983 opt: 4983 Z-score: 3718.1 bits: 698.9 E(85289): 2.3e-200
Smith-Waterman score: 4983; 100.0% identity (100.0% similar) in 743 aa overlap (130-872:10-752)
100 110 120 130 140 150
pF1KE0 NNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLL
::::::::::::::::::::::::::::::
XP_011 MTCSTSCSRFLIVLGCLILAVLTTFKEYETVSGDWLLLL
10 20 30
160 170 180 190 200 210
pF1KE0 ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQG
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 NVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLV
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 YLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE0 GVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATW
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE0 RFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSK
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE0 EPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAI
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE0 RAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPST
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE0 PKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFL
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE0 VDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSF
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE0 HQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVS
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE0 CHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFG
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE0 PNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
700 710 720 730 740 750
>>XP_016868889 (OMIM: 121201,602232) PREDICTED: potassiu (798 aa)
initn: 4983 init1: 4983 opt: 4983 Z-score: 3717.8 bits: 698.9 E(85289): 2.4e-200
Smith-Waterman score: 4983; 100.0% identity (100.0% similar) in 743 aa overlap (130-872:56-798)
100 110 120 130 140 150
pF1KE0 NNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLL
::::::::::::::::::::::::::::::
XP_016 EGRANRSRRAMVAQAWRTSMRKQREEACFRFLIVLGCLILAVLTTFKEYETVSGDWLLLL
30 40 50 60 70 80
160 170 180 190 200 210
pF1KE0 ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQG
90 100 110 120 130 140
220 230 240 250 260 270
pF1KE0 NVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLV
150 160 170 180 190 200
280 290 300 310 320 330
pF1KE0 YLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLI
210 220 230 240 250 260
340 350 360 370 380 390
pF1KE0 GVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATW
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE0 RFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSK
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE0 EPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAI
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE0 RAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPST
450 460 470 480 490 500
580 590 600 610 620 630
pF1KE0 PKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFL
510 520 530 540 550 560
640 650 660 670 680 690
pF1KE0 VDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSF
570 580 590 600 610 620
700 710 720 730 740 750
pF1KE0 HQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVS
630 640 650 660 670 680
760 770 780 790 800 810
pF1KE0 CHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFG
690 700 710 720 730 740
820 830 840 850 860 870
pF1KE0 PNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
750 760 770 780 790
>>XP_006716618 (OMIM: 121201,602232) PREDICTED: potassiu (636 aa)
initn: 4271 init1: 4271 opt: 4271 Z-score: 3189.6 bits: 600.8 E(85289): 6.4e-171
Smith-Waterman score: 4271; 100.0% identity (100.0% similar) in 636 aa overlap (237-872:1-636)
210 220 230 240 250 260
pF1KE0 IASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWY
::::::::::::::::::::::::::::::
XP_006 MLRMDRRGGTWKLLGSAICAHSKELITAWY
10 20 30
270 280 290 300 310 320
pF1KE0 IGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKT
40 50 60 70 80 90
330 340 350 360 370 380
pF1KE0 WEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYY
100 110 120 130 140 150
390 400 410 420 430 440
pF1KE0 ATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFT
160 170 180 190 200 210
450 460 470 480 490 500
pF1KE0 PLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDF
220 230 240 250 260 270
510 520 530 540 550 560
pF1KE0 PIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQT
280 290 300 310 320 330
570 580 590 600 610 620
pF1KE0 RIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVE
340 350 360 370 380 390
630 640 650 660 670 680
pF1KE0 RQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICN
400 410 420 430 440 450
690 700 710 720 730 740
pF1KE0 YSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPT
460 470 480 490 500 510
750 760 770 780 790 800
pF1KE0 VLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSG
520 530 540 550 560 570
810 820 830 840 850 860
pF1KE0 FSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWT
580 590 600 610 620 630
870
pF1KE0 PSNKPI
::::::
XP_006 PSNKPI
>>XP_005250971 (OMIM: 121201,602232) PREDICTED: potassiu (457 aa)
initn: 2855 init1: 2855 opt: 2855 Z-score: 2138.4 bits: 405.9 E(85289): 2.3e-112
Smith-Waterman score: 2855; 100.0% identity (100.0% similar) in 422 aa overlap (451-872:36-457)
430 440 450 460 470 480
pF1KE0 SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
::::::::::::::::::::::::::::::
XP_005 TGLTWWRHGDFMNQSSLFLSSGKNSWRQHPDAIEESPSKEPKPVGLNNKERFRTAFRMKA
10 20 30 40 50 60
490 500 510 520 530 540
pF1KE0 YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
70 80 90 100 110 120
550 560 570 580 590 600
pF1KE0 YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
130 140 150 160 170 180
610 620 630 640 650 660
pF1KE0 NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
190 200 210 220 230 240
670 680 690 700 710 720
pF1KE0 KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
250 260 270 280 290 300
730 740 750 760 770 780
pF1KE0 PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
310 320 330 340 350 360
790 800 810 820 830 840
pF1KE0 SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
370 380 390 400 410 420
850 860 870
pF1KE0 DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
::::::::::::::::::::::::::::::::
XP_005 DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
430 440 450
>>NP_000209 (OMIM: 130650,192500,220400,607542,607554,60 (676 aa)
initn: 985 init1: 441 opt: 1254 Z-score: 945.6 bits: 185.7 E(85289): 6.3e-46
Smith-Waterman score: 1254; 43.8% identity (71.8% similar) in 500 aa overlap (107-589:106-585)
80 90 100 110 120 130
pF1KE0 GQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWA-LLYHALVFLIVLG
.: .:. :::: :: ..:: ::::::
NP_000 ASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLV
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE0 CLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFAR
:::..::.:...: ... :. .: . .::.:...:.:.::: .: : :::.:::
NP_000 CLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFAR
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE0 KPLCMLDIFVLIASVPVVAVGNQGNVLATS-LRSLRFLQILRMLRMDRRGGTWKLLGSAI
::. ..:..:..::. :. ::..:.:.::: .:..:::::::::..::.::::.::::..
NP_000 KPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVV
200 210 220 230 240 250
260 270 280 290 300 310
pF1KE0 CAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITL
: .::::. ::::: ::.::..:::.:::. :. .: . :: .::::::::..:.
NP_000 FIHRQELITTLYIGFLGLIFSSYFVYLAEKDA--VNESG---RVEFGSYADALWWGVVTV
260 270 280 290 300 310
320 330 340 350 360 370
pF1KE0 ATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKP
.:::::::.:.:: :. ::. ::....:::::::::::::.:::::...:::::...
NP_000 TTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPA
320 330 340 350 360 370
380 390 400 410 420
pF1KE0 AAELIQAAWRYYAT-NPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQ-KLGLL---DR
:: :::.::: ::. ::. .::..: . . : :.. : . : . : ... .
NP_000 AASLIQTAWRCYAAENPDS----STWKIY--IRKAP--RSHTLLSPSPKPKKSVVVKKKK
380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSED
.:.. : . :..: : : .: .: . . . . . .. : . . :
NP_000 FKLDKDNGVTPGEKMLT---VPHITCDPPEERR-LDHFSVDGYDSSVRKSPTLLEVSMPH
430 440 450 460 470
490 500 510 520 530 540
pF1KE0 AGTGDPMAED---RGYGNDFPIEDMIPTLK----AAIRAVRILQFRLYKKKFKETLRPYD
. .::: .: :: : :. :.:...: .:. . ::::... .:::
NP_000 FMRTNSFAEDLDLEGETLLTPITH-ISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYD
480 490 500 510 520 530
550 560 570 580 590
pF1KE0 VKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPS---TPKHKKSQKGSAFTFPSQQSP
:.::::::: :::... ::: :: :.:. . : :: . ..:....::
NP_000 VRDVIEQYSQGHLNLMVRIKELQRRLDQ--SIGKPSLFISVSEKSKDRGSNTIGARLNRV
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE0 RNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYP
NP_000 EDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLP
600 610 620 630 640 650
>>NP_861463 (OMIM: 130650,192500,220400,607542,607554,60 (549 aa)
initn: 936 init1: 441 opt: 1180 Z-score: 891.7 bits: 175.4 E(85289): 6.3e-43
Smith-Waterman score: 1180; 43.7% identity (72.1% similar) in 476 aa overlap (130-589:3-458)
100 110 120 130 140 150
pF1KE0 NNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLL
::::: :::..::.:...: ... :. .
NP_861 MDFLIVLVCLIFSVLSTIEQYAALATGTLFWM
10 20 30
160 170 180 190 200 210
pF1KE0 ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQG
: . .::.:...:.:.::: .: : :::.:::::. ..:..:..::. :. ::..:
NP_861 EIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKG
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 NVLATS-LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFL
.:.::: .:..:::::::::..::.::::.::::.. : .::::. ::::: ::.::..
NP_861 QVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 VYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSL
:::.:::. :. .: . :: .::::::::..:..:::::::.:.:: :. ::. ::.
NP_861 VYLAEKDA--VNESG---RVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSV
160 170 180 190 200
340 350 360 370 380 390
pF1KE0 IGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYAT-NPNRIDLVA
...:::::::::::::.:::::...:::::... :: :::.::: ::. ::. .
NP_861 FAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDS----S
210 220 230 240 250 260
400 410 420 430 440 450
pF1KE0 TWRFYESVVSFPFFRKEQLEAASSQ-KLGLL---DRVRLSNPRGSNTKGKLFTPLNVDAI
::..: . . : :.. : . : . : ... . .:.. : . :..: : :
NP_861 TWKIY--IRKAP--RSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLT---VPHI
270 280 290 300 310
460 470 480 490 500 510
pF1KE0 EESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAED---RGYGNDFPIED
.: .: . . . . . .. : . . : . .::: .: ::
NP_861 TCDPPEERR-LDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITH
320 330 340 350 360 370
520 530 540 550 560
pF1KE0 MIPTLK----AAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQT
: :. :.:...: .:. . ::::... .::::.::::::: :::... ::: ::
NP_861 -ISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQR
380 390 400 410 420 430
570 580 590 600 610 620
pF1KE0 RIDMIFTPGPPS---TPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFV
:.:. . : :: . ..:....::
NP_861 RLDQ--SIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSL
440 450 460 470 480 490
>>NP_062816 (OMIM: 607357) potassium voltage-gated chann (932 aa)
initn: 1637 init1: 614 opt: 1057 Z-score: 797.3 bits: 158.7 E(85289): 1.1e-37
Smith-Waterman score: 2060; 43.5% identity (66.6% similar) in 921 aa overlap (15-845:7-886)
10 20 30 40 50
pF1KE0 MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQ---VTLAL
::. ::..: .. .:. ::::: ..: . :::. .:
NP_062 MPRHHAGGEEGGAAGLWVK-SGAAAAAAGGG--RLGSGMKDVESGRGRVLLN
10 20 30 40
60 70 80 90 100
pF1KE0 GAGADKDGTLLLE--------GGGRDEGQRRTPQG--IGLLAKTPLSRPVK---RNNAKY
.:.: :: ::: ::: . .:: :: ..::.: ::: . : :.::
NP_062 SAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGK-PLSYTSSQSCRRNVKY
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE0 RRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAI
::.:. .:..::::::::..:::.:::.:.:::::.:..:. :. .... ::.:: :
NP_062 RRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMI
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE0 FIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLAT
.:: :: .:::.:::::::.::.:::.:::::.:..: .:::::. ::.. .:::..::
NP_062 VVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFAT
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE0 S-LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVE
: ::::::::::::.::::::::::::::.. :::::::::::::::.::.:::::::::
NP_062 SALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVE
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 KDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSF
::. ..:: ::::::::: :::.::::::::: :: :::..: :.:.:.::
NP_062 KDA----------NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISF
290 300 310 320 330
350 360 370 380 390 400
pF1KE0 FALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFY-
:::::::::::.:::::::::::::::::.:::.::: .:: ::.. . .. .:::. .
NP_062 FALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVS-IATWKPHL
340 350 360 370 380 390
410 420 430 440 450
pF1KE0 ESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTK------GKLFTPLNVDAIEES
... . .::: ::.:::::.. .:::...:::.. : : .: . . : :
NP_062 KALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGS
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE0 PSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTG---DPMAEDRGYGNDFPIEDMIP
:.: : ..:.. ::: ..:.:. . . :: :. : . ...: : .::. :
NP_062 PTKVQKSWSFNDRTRFRPSLRLKS-SQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTP
460 470 480 490 500 510
520 530 540 550 560 570
pF1KE0 TLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFT
::..:::.::..:.. :.:::::::::::::::::::::::::: ::: ::::.:.:.
NP_062 PLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE0 PGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMG
: .. :... : .:. :.. : ::.:. ::::.:::..
NP_062 KGQITSDKKSR-----------------EKITAEHETTD--DLSMLGRVVKVEKQVQSIE
580 590 600 610
640 650 660 670 680
pF1KE0 KKLDFLVDMHMQHMER----------LQVQVTEYYPTKGTSSPAEAEK---KEDNRYSDL
.::: :.:...: ... .:. : :. .::.... . .:
NP_062 SKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLS
620 630 640 650 660 670
690 700 710
pF1KE0 KTIICNYSE-----TGPPE-PPYSFH-----------QVTIDK-----VSPYGFFAHDPV
.. : :. : : .:. :: :.. :. . .:..
NP_062 RSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQIN
680 690 700 710 720 730
720 730 740 750 760 770
pF1KE0 NLPR-GGPSSGKVQATPPSSATTYVERPTVL-PILTLLDSRVS----C--HSQADLQGPY
. :. ..:.. .: :: : .. :: .: : . :. .: : :. ..:
NP_062 TAPKPAAPTT--LQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQ
740 750 760 770 780 790
780 790 800 810
pF1KE0 SDRISPRQ-RRSITRDSDTPLSL-----------MSVNH-----EELERSPSGFSISQDR
:. . :. :.:. ..: ::. .::.. :::. . :: : .:
NP_062 SNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSR
800 810 820 830 840 850
820 830 840 850 860 870
pF1KE0 DDYVFGPNGGSSWMREKRYLAE---GETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNK
. : :. : . : .... : .:.:: :
NP_062 GSQDFYPK----WRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSS
860 870 880 890 900 910
pF1KE0 PI
NP_062 QSICKAGESTDALSLPHVKLK
920 930
>>NP_001153604 (OMIM: 607357) potassium voltage-gated ch (942 aa)
initn: 1534 init1: 571 opt: 1022 Z-score: 771.2 bits: 153.9 E(85289): 3.2e-36
Smith-Waterman score: 2006; 42.7% identity (65.6% similar) in 931 aa overlap (15-845:7-896)
10 20 30 40 50
pF1KE0 MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQ---VTLAL
::. ::..: .. .:. ::::: ..: . :::. .:
NP_001 MPRHHAGGEEGGAAGLWVK-SGAAAAAAGGG--RLGSGMKDVESGRGRVLLN
10 20 30 40
60 70 80 90 100
pF1KE0 GAGADKDGTLLLE--------GGGRDEGQRRTPQG--IGLLAKTPLSRPVK---RNNAKY
.:.: :: ::: ::: . .:: :: ..::.: ::: . : :.::
NP_001 SAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGK-PLSYTSSQSCRRNVKY
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE0 RRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAI
::.:. .:..::::::::..:::.:::.:.:::::.:..:. :. .... ::.:: :
NP_001 RRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMI
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE0 FIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLAT
.:: :: .:::.:::::::.::.:::.:::::.:..: .:::::. ::.. .:::..::
NP_001 VVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFAT
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE0 S-LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVE
: ::::::::::::.::::::::::::::.. :::::::::::::::.::.:::::::::
NP_001 SALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVE
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 KDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSF
::. ..:: ::::::::: :::.::::::::: :: :::..: :.:.:.::
NP_001 KDA----------NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISF
290 300 310 320 330
350 360 370 380 390 400
pF1KE0 FALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYE
:::::::::::.:::::::::::::::::.:::.::: .:: ::.. . .. .:::. .
NP_001 FALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVS-IATWKPHL
340 350 360 370 380 390
410 420 430 440
pF1KE0 SVVSF--PFFR----KEQL-----EAASSQKLGLLDRVRLSNPRGSNTK------GKLFT
... : . :..: .::::.. .:::...:::.. : : .
NP_001 KALHTCSPTNKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQASVGDRRS
400 410 420 430 440 450
450 460 470 480 490 500
pF1KE0 PLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTG---DPMAEDRGYG
: . . : ::.: : ..:.. ::: ..:.:. . . :: :. : . ...:
NP_001 PSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKS-SQPKPVIDADTALGTDDVYDEKGCQ
460 470 480 490 500 510
510 520 530 540 550 560
pF1KE0 NDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKY
: .::. : ::..:::.::..:.. :.:::::::::::::::::::::::::: :::
NP_001 CDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKS
520 530 540 550 560 570
570 580 590 600 610 620
pF1KE0 LQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFV
::::.:.:. : .. :... : .:. :.. : ::.:. :
NP_001 LQTRVDQILGKGQITSDKKSR-----------------EKITAEHETTD--DLSMLGRVV
580 590 600 610
630 640 650 660 670
pF1KE0 KVERQVQDMGKKLDFLVDMHMQHMER----------LQVQVTEYYPTKGTSSPAEAEK--
:::.:::.. .::: :.:...: ... .:. : :. .::....
NP_001 KVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLS
620 630 640 650 660 670
680 690 700
pF1KE0 -KEDNRYSDLKTIICNYSE-----TGPPE-PPYSFH-----------QVTIDK-----VS
. .: .. : :. : : .:. :: :.. :.
NP_001 GSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVA
680 690 700 710 720 730
710 720 730 740 750 760
pF1KE0 PYGFFAHDPVNLPR-GGPSSGKVQATPPSSATTYVERPTVL-PILTLLDSRVS----C--
. .:.. . :. ..:.. .: :: : .. :: .: : . :. .: :
NP_001 ATNTIANQINTAPKPAAPTT--LQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLV
740 750 760 770 780 790
770 780 790 800
pF1KE0 HSQADLQGPYSDRISPRQ-RRSITRDSDTPLSL-----------MSVNH-----EELERS
:. ..: :. . :. :.:. ..: ::. .::.. :::. .
NP_001 ASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQ
800 810 820 830 840 850
810 820 830 840 850 860
pF1KE0 PSGFSISQDRDDYVFGPNGGSSWMREKRYLAE---GETDTDTDPFTPSGSMPLSSTGDGI
:: : .: . : :. : . : .... : .:.:: :
NP_001 LSGSESSGSRGSQDFYPK----WRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASD
860 870 880 890 900 910
870
pF1KE0 SDSVWTPSNKPI
NP_001 SLRTGRSRSSQSICKAGESTDALSLPHVKLK
920 930 940
872 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:48:31 2016 done: Fri Nov 4 03:48:33 2016
Total Scan time: 14.640 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]