Result of FASTA (omim) for
pF1KE0043
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0043, 544 aa
1>>>pF1KE0043 544 - 544 aa - 544 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4857+/-0.000546; mu= 17.6846+/- 0.034
mean_var=66.5198+/-13.493, 0's: 0 Z-trim(106.3): 21 B-trim: 14 in 1/52
Lambda= 0.157253
statistics sampled from 14386 (14396) to 14386 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.506), E-opt: 0.2 (0.169), width: 16
Scan time: 9.090
The best scores are: opt bits E(85289)
XP_011524028 (OMIM: 108145,114300,248700,613629,61 (2735) 1954 453.3 4.3e-126
NP_071351 (OMIM: 108145,114300,248700,613629,61714 (2752) 1954 453.3 4.3e-126
XP_011524027 (OMIM: 108145,114300,248700,613629,61 (2766) 1954 453.3 4.3e-126
XP_011524026 (OMIM: 108145,114300,248700,613629,61 (2777) 1954 453.3 4.4e-126
XP_016881407 (OMIM: 108145,114300,248700,613629,61 (2783) 1954 453.3 4.4e-126
XP_011524025 (OMIM: 108145,114300,248700,613629,61 (2796) 1954 453.3 4.4e-126
NP_001136336 (OMIM: 194380,611184,616843) piezo-ty (2521) 1244 292.3 1.2e-77
>>XP_011524028 (OMIM: 108145,114300,248700,613629,617146 (2735 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2384.8 bits: 453.3 E(85289): 4.3e-126
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2160-2735)
10 20 30 40 50 60
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
::::::::::::::::::::::::::::::
XP_011 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
2130 2140 2150 2160 2170 2180
70 80 90 100 110 120
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
2190 2200 2210 2220 2230 2240
130 140 150 160 170 180
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
2250 2260 2270 2280 2290 2300
190 200 210 220 230 240
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
2310 2320 2330 2340 2350 2360
pF1KE0 ------------------------------------------------------------
XP_011 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
2370 2380 2390 2400 2410 2420
250 260 270 280 290
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
2430 2440 2450 2460 2470 2480
300 310 320 330 340 350
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
2490 2500 2510 2520 2530 2540
360 370 380 390 400 410
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
2550 2560 2570 2580 2590 2600
420 430 440 450 460 470
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
2610 2620 2630 2640 2650 2660
480 490 500 510 520 530
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
2670 2680 2690 2700 2710 2720
540
pF1KE0 TREKTN
::::::
XP_011 TREKTN
2730
>--
initn: 195 init1: 195 opt: 195 Z-score: 228.0 bits: 54.3 E(85289): 5.8e-06
Smith-Waterman score: 195; 100.0% identity (100.0% similar) in 31 aa overlap (1-31:2129-2159)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
::::::::::::::::::::::::::::::
XP_011 SQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
2100 2110 2120 2130 2140 2150
40 50 60 70 80 90
pF1KE0 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
:
XP_011 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
2160 2170 2180 2190 2200 2210
>>NP_071351 (OMIM: 108145,114300,248700,613629,617146) p (2752 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2384.7 bits: 453.3 E(85289): 4.3e-126
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2177-2752)
10 20 30 40 50 60
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
::::::::::::::::::::::::::::::
NP_071 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
2150 2160 2170 2180 2190 2200
70 80 90 100 110 120
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
2210 2220 2230 2240 2250 2260
130 140 150 160 170 180
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
2270 2280 2290 2300 2310 2320
190 200 210 220 230 240
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
2330 2340 2350 2360 2370 2380
pF1KE0 ------------------------------------------------------------
NP_071 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
2390 2400 2410 2420 2430 2440
250 260 270 280 290
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
2450 2460 2470 2480 2490 2500
300 310 320 330 340 350
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
2510 2520 2530 2540 2550 2560
360 370 380 390 400 410
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
2570 2580 2590 2600 2610 2620
420 430 440 450 460 470
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
2630 2640 2650 2660 2670 2680
480 490 500 510 520 530
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
2690 2700 2710 2720 2730 2740
540
pF1KE0 TREKTN
::::::
NP_071 TREKTN
2750
>--
initn: 195 init1: 195 opt: 195 Z-score: 228.0 bits: 54.3 E(85289): 5.8e-06
Smith-Waterman score: 195; 100.0% identity (100.0% similar) in 31 aa overlap (1-31:2146-2176)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
::::::::::::::::::::::::::::::
NP_071 SQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
2120 2130 2140 2150 2160 2170
40 50 60 70 80 90
pF1KE0 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
:
NP_071 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
2180 2190 2200 2210 2220 2230
>>XP_011524027 (OMIM: 108145,114300,248700,613629,617146 (2766 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2384.7 bits: 453.3 E(85289): 4.3e-126
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2191-2766)
10 20 30 40 50 60
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
::::::::::::::::::::::::::::::
XP_011 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
2170 2180 2190 2200 2210 2220
70 80 90 100 110 120
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
2230 2240 2250 2260 2270 2280
130 140 150 160 170 180
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
2290 2300 2310 2320 2330 2340
190 200 210 220 230 240
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
2350 2360 2370 2380 2390 2400
pF1KE0 ------------------------------------------------------------
XP_011 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
2410 2420 2430 2440 2450 2460
250 260 270 280 290
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
2470 2480 2490 2500 2510 2520
300 310 320 330 340 350
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
2530 2540 2550 2560 2570 2580
360 370 380 390 400 410
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
2590 2600 2610 2620 2630 2640
420 430 440 450 460 470
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
2650 2660 2670 2680 2690 2700
480 490 500 510 520 530
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
2710 2720 2730 2740 2750 2760
540
pF1KE0 TREKTN
::::::
XP_011 TREKTN
>--
initn: 195 init1: 195 opt: 195 Z-score: 228.0 bits: 54.3 E(85289): 5.8e-06
Smith-Waterman score: 195; 100.0% identity (100.0% similar) in 31 aa overlap (1-31:2160-2190)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
::::::::::::::::::::::::::::::
XP_011 SQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
2130 2140 2150 2160 2170 2180
40 50 60 70 80 90
pF1KE0 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
:
XP_011 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
2190 2200 2210 2220 2230 2240
>>XP_011524026 (OMIM: 108145,114300,248700,613629,617146 (2777 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2384.6 bits: 453.3 E(85289): 4.4e-126
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2202-2777)
10 20 30 40 50 60
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
::::::::::::::::::::::::::::::
XP_011 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
2180 2190 2200 2210 2220 2230
70 80 90 100 110 120
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
2240 2250 2260 2270 2280 2290
130 140 150 160 170 180
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
2300 2310 2320 2330 2340 2350
190 200 210 220 230 240
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
2360 2370 2380 2390 2400 2410
pF1KE0 ------------------------------------------------------------
XP_011 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
2420 2430 2440 2450 2460 2470
250 260 270 280 290
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
2480 2490 2500 2510 2520 2530
300 310 320 330 340 350
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
2540 2550 2560 2570 2580 2590
360 370 380 390 400 410
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
2600 2610 2620 2630 2640 2650
420 430 440 450 460 470
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
2660 2670 2680 2690 2700 2710
480 490 500 510 520 530
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
2720 2730 2740 2750 2760 2770
540
pF1KE0 TREKTN
::::::
XP_011 TREKTN
>--
initn: 195 init1: 195 opt: 195 Z-score: 227.9 bits: 54.3 E(85289): 5.9e-06
Smith-Waterman score: 195; 100.0% identity (100.0% similar) in 31 aa overlap (1-31:2171-2201)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
::::::::::::::::::::::::::::::
XP_011 SQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
2150 2160 2170 2180 2190 2200
40 50 60 70 80 90
pF1KE0 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
:
XP_011 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
2210 2220 2230 2240 2250 2260
>>XP_016881407 (OMIM: 108145,114300,248700,613629,617146 (2783 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2384.6 bits: 453.3 E(85289): 4.4e-126
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2208-2783)
10 20 30 40 50 60
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
::::::::::::::::::::::::::::::
XP_016 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
2180 2190 2200 2210 2220 2230
70 80 90 100 110 120
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
2240 2250 2260 2270 2280 2290
130 140 150 160 170 180
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
2300 2310 2320 2330 2340 2350
190 200 210 220 230 240
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
2360 2370 2380 2390 2400 2410
pF1KE0 ------------------------------------------------------------
XP_016 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
2420 2430 2440 2450 2460 2470
250 260 270 280 290
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
2480 2490 2500 2510 2520 2530
300 310 320 330 340 350
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
2540 2550 2560 2570 2580 2590
360 370 380 390 400 410
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
2600 2610 2620 2630 2640 2650
420 430 440 450 460 470
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
2660 2670 2680 2690 2700 2710
480 490 500 510 520 530
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
2720 2730 2740 2750 2760 2770
540
pF1KE0 TREKTN
::::::
XP_016 TREKTN
2780
>--
initn: 195 init1: 195 opt: 195 Z-score: 227.9 bits: 54.3 E(85289): 5.9e-06
Smith-Waterman score: 195; 100.0% identity (100.0% similar) in 31 aa overlap (1-31:2177-2207)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
::::::::::::::::::::::::::::::
XP_016 SQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
2150 2160 2170 2180 2190 2200
40 50 60 70 80 90
pF1KE0 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
:
XP_016 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
2210 2220 2230 2240 2250 2260
>>XP_011524025 (OMIM: 108145,114300,248700,613629,617146 (2796 aa)
initn: 1954 init1: 1954 opt: 1954 Z-score: 2384.6 bits: 453.3 E(85289): 4.4e-126
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2221-2796)
10 20 30 40 50 60
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
::::::::::::::::::::::::::::::
XP_011 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
2200 2210 2220 2230 2240 2250
70 80 90 100 110 120
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
2260 2270 2280 2290 2300 2310
130 140 150 160 170 180
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
2320 2330 2340 2350 2360 2370
190 200 210 220 230 240
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
2380 2390 2400 2410 2420 2430
pF1KE0 ------------------------------------------------------------
XP_011 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
2440 2450 2460 2470 2480 2490
250 260 270 280 290
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
2500 2510 2520 2530 2540 2550
300 310 320 330 340 350
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
2560 2570 2580 2590 2600 2610
360 370 380 390 400 410
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
2620 2630 2640 2650 2660 2670
420 430 440 450 460 470
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
2680 2690 2700 2710 2720 2730
480 490 500 510 520 530
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
2740 2750 2760 2770 2780 2790
540
pF1KE0 TREKTN
::::::
XP_011 TREKTN
>--
initn: 195 init1: 195 opt: 195 Z-score: 227.9 bits: 54.3 E(85289): 5.9e-06
Smith-Waterman score: 195; 100.0% identity (100.0% similar) in 31 aa overlap (1-31:2190-2220)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
::::::::::::::::::::::::::::::
XP_011 SQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFF
2160 2170 2180 2190 2200 2210
40 50 60 70 80 90
pF1KE0 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
:
XP_011 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLV
2220 2230 2240 2250 2260 2270
>>NP_001136336 (OMIM: 194380,611184,616843) piezo-type m (2521 aa)
initn: 1849 init1: 1239 opt: 1244 Z-score: 1514.8 bits: 292.3 E(85289): 1.2e-77
Smith-Waterman score: 1924; 53.7% identity (74.7% similar) in 574 aa overlap (10-514:1926-2492)
10 20 30
pF1KE0 MEKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYS
. ..: .. . : :...::....: .:
NP_001 EEEGEEEKEAPTGREKRPSRSGGRVRAAGRRLQGFCLSLAQGTYRPLRRFFHDILHTKYR
1900 1910 1920 1930 1940 1950
40 50 60 70 80 90
pF1KE0 AVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTM
:.::::.::::::.::::::.::::::::::::.:::::::.:::: ::::.::::.::
NP_001 AATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDITSSLSDDQVPEAFLVMLLIQFSTM
1960 1970 1980 1990 2000 2010
100 110 120 130 140 150
pF1KE0 VVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFG
:::::::::::::::. ::: ::..::.:::::::.:::: :.::.::::::::::.::.
NP_001 VVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFA
2020 2030 2040 2050 2060 2070
160 170 180 190 200 210
pF1KE0 LSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSS
:::::::::::::.:::::::.::..::::::::::::::.:::::::::::::::::::
NP_001 LSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSS
2080 2090 2100 2110 2120 2130
220 230 240
pF1KE0 WICVEDIYAHIFILKCWRESEK--------------------------------------
:.:::::::.:::.:: ::.::
NP_001 WMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMS
2140 2150 2160 2170 2180 2190
250 260 270
pF1KE0 -------------------------PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQ
:.::::::: .. . :..... . :. . :::
NP_001 LVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQ
2200 2210 2220 2230 2240 2250
280 290 300 310 320 330
pF1KE0 FLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGA
:. .: :::..:..::.:..:: :::::. .: .:: . ...... :.:..::.:. :.
NP_001 FISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGG
2260 2270 2280 2290 2300 2310
340 350 360 370 380 390
pF1KE0 KSEIATDK--LSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPI
: :..: :.. .. .:...:... :.: .: :.: ...: :..::. ...:.
NP_001 TVEYANEKHMLALAPNSTARRQLASLLEGTSDQS----VVIPNLFPKYIRAPNGPEANPV
2320 2330 2340 2350 2360 2370
400 410 420 430 440 450
pF1KE0 KQLLS--ENNFMDITIILSRDNTTKYNS--EWWVLNLTGNRIYNPNSQALELVVFNDKVS
::: : ... . : : :.. . .. ::::..: : . . : .:.:.::::
NP_001 KQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECR---TDCNLLPMVIFSDKVS
2380 2390 2400 2410 2420
460 470 480 490 500 510
pF1KE0 PPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVR
::::::::::::::::.:.::::::::: ::: ::::::::::: :::::::: ::::::
NP_001 PPSLGFLAGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVR
2430 2440 2450 2460 2470 2480
520 530 540
pF1KE0 ETGELELEEDLYAKLIFLYRSPETMIKWTREKTN
:: :
NP_001 ETRELELEEELYAKLIFLYRSPETMIKWTREKE
2490 2500 2510 2520
544 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:21:12 2016 done: Fri Nov 4 06:21:13 2016
Total Scan time: 9.090 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]