Result of FASTA (omim) for
pF1KB9937
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9937, 522 aa
1>>>pF1KB9937 522 - 522 aa - 522 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.6222+/-0.000348; mu= 8.3741+/- 0.022
mean_var=155.4117+/-31.601, 0's: 0 Z-trim(119.4): 40 B-trim: 1123 in 1/54
Lambda= 0.102880
statistics sampled from 33308 (33351) to 33308 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.391), width: 16
Scan time: 8.880
The best scores are: opt bits E(85289)
NP_003090 (OMIM: 601272) sorting nexin-1 isoform a ( 522) 3365 511.4 2.7e-144
NP_001229862 (OMIM: 601272) sorting nexin-1 isofor ( 557) 3260 495.8 1.4e-139
NP_683758 (OMIM: 601272) sorting nexin-1 isoform b ( 457) 2350 360.7 5.4e-99
XP_005254668 (OMIM: 601272) PREDICTED: sorting nex ( 399) 2220 341.3 3.1e-93
NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 ( 519) 1894 293.0 1.4e-78
NP_001265128 (OMIM: 605929) sorting nexin-2 isofor ( 402) 1869 289.2 1.5e-77
XP_006710740 (OMIM: 614904) PREDICTED: sorting nex ( 422) 305 57.1 1.2e-07
NP_057060 (OMIM: 614904) sorting nexin-7 isoform a ( 451) 305 57.1 1.3e-07
XP_016856917 (OMIM: 614904) PREDICTED: sorting nex ( 336) 293 55.3 3.4e-07
XP_011539866 (OMIM: 614904) PREDICTED: sorting nex ( 387) 293 55.3 3.8e-07
XP_006710741 (OMIM: 614904) PREDICTED: sorting nex ( 387) 293 55.3 3.8e-07
XP_016856915 (OMIM: 614904) PREDICTED: sorting nex ( 387) 293 55.3 3.8e-07
XP_016856914 (OMIM: 614904) PREDICTED: sorting nex ( 387) 293 55.3 3.8e-07
XP_016856916 (OMIM: 614904) PREDICTED: sorting nex ( 387) 293 55.3 3.8e-07
NP_001243114 (OMIM: 300883) sorting nexin-12 isofo ( 162) 252 49.0 1.3e-05
NP_037478 (OMIM: 300883) sorting nexin-12 isoform ( 162) 252 49.0 1.3e-05
NP_003786 (OMIM: 605930) sorting nexin-3 isoform a ( 162) 240 47.2 4.5e-05
NP_001243117 (OMIM: 300883) sorting nexin-12 isofo ( 158) 228 45.4 0.00015
NP_001269383 (OMIM: 605937) sorting nexin-5 isofor ( 299) 205 42.2 0.0027
NP_001287858 (OMIM: 605930) sorting nexin-3 isofor ( 140) 199 41.0 0.0027
>>NP_003090 (OMIM: 601272) sorting nexin-1 isoform a [Ho (522 aa)
initn: 3365 init1: 3365 opt: 3365 Z-score: 2711.6 bits: 511.4 E(85289): 2.7e-144
Smith-Waterman score: 3365; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522)
10 20 30 40 50 60
pF1KB9 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
430 440 450 460 470 480
490 500 510 520
pF1KB9 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
::::::::::::::::::::::::::::::::::::::::::
NP_003 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
490 500 510 520
>>NP_001229862 (OMIM: 601272) sorting nexin-1 isoform d (557 aa)
initn: 3260 init1: 3260 opt: 3260 Z-score: 2627.0 bits: 495.8 E(85289): 1.4e-139
Smith-Waterman score: 3260; 100.0% identity (100.0% similar) in 506 aa overlap (1-506:1-506)
10 20 30 40 50 60
pF1KB9 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
430 440 450 460 470 480
490 500 510 520
pF1KB9 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
::::::::::::::::::::::::::
NP_001 FEKEKSKDFKNHVIKYLETLLYSQQQAGEQLGIRSGILLTKKLPRYSKFFSTVHKFCAAA
490 500 510 520 530 540
>>NP_683758 (OMIM: 601272) sorting nexin-1 isoform b [Ho (457 aa)
initn: 2944 init1: 2349 opt: 2350 Z-score: 1898.2 bits: 360.7 E(85289): 5.4e-99
Smith-Waterman score: 2818; 87.5% identity (87.5% similar) in 522 aa overlap (1-522:1-457)
10 20 30 40 50 60
pF1KB9 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
::::::::::::::::::::::::::::::
NP_683 ITTSLLPINNGSKENGIHEEQDQEPQDLFA------------------------------
70 80 90
130 140 150 160 170 180
pF1KB9 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
:::::::::::::::::::::::::
NP_683 -----------------------------------GDGMNAYVAYKVTTQTSLPLFRSKQ
100 110
190 200 210 220 230 240
pF1KB9 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB9 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB9 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB9 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB9 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
360 370 380 390 400 410
490 500 510 520
pF1KB9 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
::::::::::::::::::::::::::::::::::::::::::
NP_683 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
420 430 440 450
>>XP_005254668 (OMIM: 601272) PREDICTED: sorting nexin-1 (399 aa)
initn: 2220 init1: 2220 opt: 2220 Z-score: 1794.8 bits: 341.3 E(85289): 3.1e-93
Smith-Waterman score: 2220; 100.0% identity (100.0% similar) in 348 aa overlap (159-506:1-348)
130 140 150 160 170 180
pF1KB9 PTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFS
::::::::::::::::::::::::::::::
XP_005 MNAYVAYKVTTQTSLPLFRSKQFAVKRRFS
10 20 30
190 200 210 220 230 240
pF1KB9 DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQR
40 50 60 70 80 90
250 260 270 280 290 300
pF1KB9 IVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIW
100 110 120 130 140 150
310 320 330 340 350 360
pF1KB9 FEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALS
160 170 180 190 200 210
370 380 390 400 410 420
pF1KB9 QLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQ
220 230 240 250 260 270
430 440 450 460 470 480
pF1KB9 KKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKD
280 290 300 310 320 330
490 500 510 520
pF1KB9 FKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
::::::::::::::::::
XP_005 FKNHVIKYLETLLYSQQQAGEQLGIRSGILLTKKLPRYSKFFSTVHKFCAAASLWKWGFF
340 350 360 370 380 390
>>NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 [Ho (519 aa)
initn: 2009 init1: 1868 opt: 1894 Z-score: 1531.7 bits: 293.0 E(85289): 1.4e-78
Smith-Waterman score: 1971; 60.2% identity (80.1% similar) in 532 aa overlap (10-522:2-519)
10 20 30 40 50
pF1KB9 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTG--AAVVSKHQS
:.:: :::. : ..: .. .:::.::. ... :. .:
NP_003 MAAEREPPPL-----------GDGKPTDFEDLEDGEDLFTSTVSTLESSPSS
10 20 30 40
60 70 80 90 100
pF1KB9 PKITTSLLPINNGSKE-NGIHEEQ---DQEPQDLFADATVELSLDSTQNNQ---------
:. .. :: .. : . :: . . :.. .::::.:: :.:::: . .
NP_003 PEPAS--LPAEDISANSNGPKPTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPA
50 60 70 80 90
110 120 130 140 150 160
pF1KB9 -KKVLAKTLISLPPQEATNSSKP---QPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNA
: :::. : :. . : : . . ::.::: . : ::. .:..::::.::::::
NP_003 VTPVTPTTLIA-PRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNA
100 110 120 130 140 150
170 180 190 200 210 220
pF1KB9 YVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK
:.::.:::.::: .: ...:.:::::::::::. ::. :. . :.:::: ::::..::::
NP_003 YMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTK
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB9 VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSG
::::::::::.::.::::::::::::: :.:::.:::::.:.:::. ::::::.::.:::
NP_003 VKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSG
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB9 AGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA
::.:.: :::.:::.:::::::::: ::::: :. : .:.:::::. ::.:: :::::.
NP_003 AGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELS
280 290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIR
::: :::: ::::.:::.:::::::::::::::::.::::::: ::....::::::::
NP_003 ANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIR
340 350 360 370 380 390
410 420 430 440 450 460
pF1KB9 LLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVT
:.: :...::.::: ::.:.::: :: :::::::... ::::::.::::.:: :::..:
NP_003 LIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQ
400 410 420 430 440 450
470 480 490 500 510 520
pF1KB9 QYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAI
: :::::.:: ..:::: :::::. ::::. .:::::.:. .:::: :::::::::::::
NP_003 QGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAI
460 470 480 490 500 510
pF1KB9 S
.
NP_003 A
>>NP_001265128 (OMIM: 605929) sorting nexin-2 isoform 2 (402 aa)
initn: 1893 init1: 1868 opt: 1869 Z-score: 1513.2 bits: 289.2 E(85289): 1.5e-77
Smith-Waterman score: 1869; 71.0% identity (89.6% similar) in 393 aa overlap (130-522:10-402)
100 110 120 130 140 150
pF1KB9 STQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGM
. ::.::: . : ::. .:..::::.::::
NP_001 MSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGM
10 20 30
160 170 180 190 200 210
pF1KB9 NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGM
:::.::.:::.::: .: ...:.:::::::::::. ::. :. . :.:::: ::::..::
NP_001 NAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGM
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB9 TKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTL
::::::::::::.::.::::::::::::: :.:::.:::::.:.:::. ::::::.::.:
NP_001 TKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQAL
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB9 SGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKE
::::.:.: :::.:::.:::::::::: ::::: :. : .:.:::::. ::.:: ::::
NP_001 SGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKE
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB9 LALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY
:. ::: :::: ::::.:::.:::::::::::::::::.::::::: ::....::::::
NP_001 LSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDY
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB9 IRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESR
:::.: :...::.::: ::.:.::: :: :::::::... ::::::.::::.:: :::..
NP_001 IRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAK
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB9 VTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAK
: : :::::.:: ..:::: :::::. ::::. .:::::.:. .:::: :::::::::::
NP_001 VQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAK
340 350 360 370 380 390
520
pF1KB9 AIS
::.
NP_001 AIA
400
>>XP_006710740 (OMIM: 614904) PREDICTED: sorting nexin-7 (422 aa)
initn: 296 init1: 145 opt: 305 Z-score: 258.3 bits: 57.1 E(85289): 1.2e-07
Smith-Waterman score: 335; 22.4% identity (56.2% similar) in 406 aa overlap (57-458:31-418)
30 40 50 60 70 80
pF1KB9 GAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPIN--NGSKENGIHEEQDQE
:.: .: :: . :: . .: .
XP_006 MGTLGGAGLAAAVAAGWARTLGMEGERRASQAP---SSGLPAGGANGESPGGGAPFPGSS
10 20 30 40 50
90 100 110 120 130 140
pF1KB9 PQDLFADATVELSLDSTQNNQKKVLAK--TLISLPPQEATNSSKPQPTYEELEEEEQEDQ
.. . .: : :.:: ... . :..: .:... ..: .... :.. :
XP_006 GSSALLQAEV-LDLDEDEDDLE-VFSKDASLMDMNSFSPMMPTSPLSMINQIKFEDEPDL
60 70 80 90 100 110
150 160 170 180 190 200
pF1KB9 FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHS
:: . . .::. ......:.. :.:: : :..: :.::..::: : :: : :
XP_006 KDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHP
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB9 QNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVR
.:.:: ::: .. : . . .:.: :: ::...:.::..:::. . : .
XP_006 T--LIIPPLPEKFIVK------GMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFK
180 190 200 210 220
270 280 290 300 310 320
pF1KB9 EFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQR
:: . .... .: :::. ..... ::.. ... : : . .: :.
XP_006 IFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQK
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB9 LRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQ
. . . . . ....: . ... . ..::.. : .:...: .. . .
XP_006 INLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEED--LVDTLKDVASCIDRCCKATE
290 300 310 320 330 340
390 400 410 420 430 440
pF1KB9 EQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANK
.. .. : .. .:. .. ... .: . : :... . ..:.. : :.
XP_006 KRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQI-QAELDSKVEVLTYKKADTDLCLATW
350 360 370 380 390 400
450 460 470 480 490 500
pF1KB9 PDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLY
. : . . :: :
XP_006 ESFLTSQTNLHLEEASEDKP
410 420
>>NP_057060 (OMIM: 614904) sorting nexin-7 isoform a [Ho (451 aa)
initn: 296 init1: 145 opt: 305 Z-score: 257.9 bits: 57.1 E(85289): 1.3e-07
Smith-Waterman score: 367; 22.8% identity (56.2% similar) in 464 aa overlap (57-515:9-435)
30 40 50 60 70 80
pF1KB9 GAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPIN--NGSKENGIHEEQDQE
:.: .: :: . :: . .: .
NP_057 MEGERRASQAP---SSGLPAGGANGESPGGGAPFPGSS
10 20 30
90 100 110 120 130 140
pF1KB9 PQDLFADATVELSLDSTQNNQKKVLAK--TLISLPPQEATNSSKPQPTYEELEEEEQEDQ
.. . .: : :.:: ... . :..: .:... ..: .... :.. :
NP_057 GSSALLQAEV-LDLDEDEDDLE-VFSKDASLMDMNSFSPMMPTSPLSMINQIKFEDEPDL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB9 FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHS
:: . . .::. ......:.. :.:: : :..: :.::..::: : :: : :
NP_057 KDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHP
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB9 QNGFIVPPPPEKSLI-GMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDV
.:.:: ::: .. ::. . . .:.: :: ::...:.::..:::. . :
NP_057 T--LIIPPLPEKFIVKGMV-------ERFNDDFIETRRKALHKFLNRIADHPTLTFNEDF
160 170 180 190 200
270 280 290 300 310 320
pF1KB9 REFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ
. :: . .... .: :::. ..... ::.. ... : : . .: :
NP_057 KIFLTAQAWE--LSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQ
210 220 230 240 250 260
330 340 350 360 370 380
pF1KB9 RLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLH
.. . . . . ....: . ... . ..::.. : .:...: .. .
NP_057 KINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEED--LVDTLKDVASCIDRCCKAT
270 280 290 300 310 320
390 400 410 420 430 440
pF1KB9 QEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWAN
... .. : .. .:. .. ... .: . : :... . ..:.. ::
NP_057 EKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQI-QAELDSKVEVLTYKKADTDLL---
330 340 350 360 370
450 460 470 480 490 500
pF1KB9 KPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLL
:... . .:.. : . . :.:: . ..... : :. .. :.: :
NP_057 -PEEIGKLEDKV---ECANNALKADWERWKQNMQNDI----KLAFTDMAEENIHYYE---
380 390 400 410 420
510 520
pF1KB9 YSQQQLAKYWEAFLPEAKAIS
: :: ::.::
NP_057 ---QCLAT-WESFLTSQTNLHLEEASEDKP
430 440 450
>>XP_016856917 (OMIM: 614904) PREDICTED: sorting nexin-7 (336 aa)
initn: 267 init1: 145 opt: 293 Z-score: 250.1 bits: 55.3 E(85289): 3.4e-07
Smith-Waterman score: 323; 23.3% identity (57.9% similar) in 335 aa overlap (125-458:12-332)
100 110 120 130 140 150
pF1KB9 ELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEK
..: .... :.. : :: . . .::.
XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPES
10 20 30 40
160 170 180 190 200 210
pF1KB9 IGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEK
......:.. :.:: : :..: :.::..::: : :: : : .:.:: :::
XP_016 HVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPT--LIIPPLPEK
50 60 70 80 90
220 230 240 250 260 270
pF1KB9 SLI-GMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRA
.. :: :. ..: :.: :: ::...:.::..:::. . : . :: .
XP_016 FIVKGM--VERFNDD-----FIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAW--E
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB9 VGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETL
.... .: :::. ..... ::.. ... : : . .: :.. . . . .
XP_016 LSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB9 VNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLA
....: . ... . ..::.. : .:...: .. . ... .. :
XP_016 YKEEREYFDEMKEYGPIHILWSASEED--LVDTLKDVASCIDRCCKATEKRMSGLSEALL
220 230 240 250 260
400 410 420 430 440 450
pF1KB9 ELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEI
.. .:. .. ... .: . : :... . ..:.. : :. . : . .
XP_016 PVVHEYVLYSEMLMGVMKRRDQI-QAELDSKVEVLTYKKADTDLCLATWESFLTSQTNLH
270 280 290 300 310 320
460 470 480 490 500 510
pF1KB9 LEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEA
:: :
XP_016 LEEASEDKP
330
>>XP_011539866 (OMIM: 614904) PREDICTED: sorting nexin-7 (387 aa)
initn: 267 init1: 145 opt: 293 Z-score: 249.2 bits: 55.3 E(85289): 3.8e-07
Smith-Waterman score: 355; 23.5% identity (57.4% similar) in 392 aa overlap (125-515:12-371)
100 110 120 130 140 150
pF1KB9 ELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEK
..: .... :.. : :: . . .::.
XP_011 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPES
10 20 30 40
160 170 180 190 200 210
pF1KB9 IGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEK
......:.. :.:: : :..: :.::..::: : :: : : .:.:: :::
XP_011 HVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPT--LIIPPLPEK
50 60 70 80 90
220 230 240 250 260 270
pF1KB9 SLI-GMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRA
.. :: :. ..: :.: :: ::...:.::..:::. . : . :: .
XP_011 FIVKGM--VERFNDD-----FIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWE--
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB9 VGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETL
.... .: :::. ..... ::.. ... : : . .: :.. . . . .
XP_011 LSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB9 VNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLA
....: . ... . ..::.. : .:...: .. . ... .. :
XP_011 YKEEREYFDEMKEYGPIHILWSASEED--LVDTLKDVASCIDRCCKATEKRMSGLSEALL
220 230 240 250 260
400 410 420 430 440 450
pF1KB9 ELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEI
.. .:. .. ... .: . : :... . ..:.. :: :... . .:..
XP_011 PVVHEYVLYSEMLMGVMKRRDQI-QAELDSKVEVLTYKKADTDLL----PEEIGKLEDKV
270 280 290 300 310 320
460 470 480 490 500 510
pF1KB9 LEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEA
: . . :.:: . ..... : :. .. :.: : : :: ::.
XP_011 ---ECANNALKADWERWKQNMQNDI----KLAFTDMAEENIHYYE------QCLAT-WES
330 340 350 360
520
pF1KB9 FLPEAKAIS
::
XP_011 FLTSQTNLHLEEASEDKP
370 380
522 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 09:30:40 2016 done: Fri Nov 4 09:30:41 2016
Total Scan time: 8.880 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]