Result of FASTA (ccds) for
pF1KB9891
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9891, 467 aa
1>>>pF1KB9891 467 - 467 aa - 467 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7538+/-0.000773; mu= 11.6190+/- 0.047
mean_var=105.1015+/-20.904, 0's: 0 Z-trim(111.5): 20 B-trim: 76 in 1/52
Lambda= 0.125104
statistics sampled from 12392 (12408) to 12392 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.381), width: 16
Scan time: 3.370
The best scores are: opt bits E(32554)
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 ( 467) 3251 597.1 1.3e-170
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 ( 381) 2342 433.0 2.6e-121
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 ( 425) 2342 433.0 2.8e-121
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 ( 320) 2067 383.4 1.9e-106
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 ( 430) 1625 303.6 2.6e-82
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 ( 230) 1496 280.2 1.5e-75
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 ( 465) 1402 263.4 3.6e-70
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 ( 467) 1320 248.6 1e-65
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 ( 465) 1297 244.5 1.8e-64
CCDS10221.1 SMAD6 gene_id:4091|Hs108|chr15 ( 496) 396 81.9 1.7e-15
CCDS54186.1 SMAD7 gene_id:4092|Hs108|chr18 ( 211) 324 68.7 6.8e-12
>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 (467 aa)
initn: 3251 init1: 3251 opt: 3251 Z-score: 3176.8 bits: 597.1 E(32554): 1.3e-170
Smith-Waterman score: 3251; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467)
10 20 30 40 50 60
pF1KB9 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
370 380 390 400 410 420
430 440 450 460
pF1KB9 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
430 440 450 460
>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 (381 aa)
initn: 2178 init1: 1454 opt: 2342 Z-score: 2291.5 bits: 433.0 E(32554): 2.6e-121
Smith-Waterman score: 2342; 91.4% identity (98.3% similar) in 359 aa overlap (109-467:25-381)
80 90 100 110 120 130
pF1KB9 STCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH
::::::::::::::::::::::::::::::
CCDS45 MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH
10 20 30 40 50
140 150 160 170 180 190
pF1KB9 SHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTH
:::::.:.: ::.:::.::::::::::::::::::::::::::::::: .:.::::::.:
CCDS45 SHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSH
60 70 80 90 100 110
200 210 220 230 240 250
pF1KB9 SIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVN
::::::::::::::::: :::::::::.::::::::.:.:.:::.::: .:::. .::..
CCDS45 SIPENTNFPAGIEPQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSP-NLSPNPMSPAH
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB9 HSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSN
..:::::::: ::::::::.::::::::::::::::::.:::::::::::::::::::::
CCDS45 NNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSN
180 190 200 210 220 230
320 330 340 350 360 370
pF1KB9 VNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP
:::::.::.:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 VNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP
240 250 260 270 280 290
380 390 400 410 420 430
pF1KB9 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI
300 310 320 330 340 350
440 450 460
pF1KB9 ELHLNGPLQWLDKVLTQMGSPSVRCSSMS
::::::::::::::::::::::.::::.:
CCDS45 ELHLNGPLQWLDKVLTQMGSPSIRCSSVS
360 370 380
>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 (425 aa)
initn: 2301 init1: 1454 opt: 2342 Z-score: 2290.8 bits: 433.0 E(32554): 2.8e-121
Smith-Waterman score: 2678; 83.9% identity (89.9% similar) in 467 aa overlap (1-467:1-425)
10 20 30 40 50 60
pF1KB9 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
::::::::::.::::::::: ::::::::::::::::::::::::::.:::
CCDS10 MSSILPFTPPIVKRLLGWKK----------GEQNGQEEKWCEKAVKSLVKKLKKTGQLDE
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
::::::::: ::::.::: ::::::::::::
CCDS10 LEKAITTQNVNTKCITIP------------------------------RSLDGRLQVSHR
60 70 80
130 140 150 160 170 180
pF1KB9 KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
:::::::::::::::::::::::.:.: ::.:::.:::::::::::::::::::::::::
CCDS10 KGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLV
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB9 PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
:::::: .:.::::::.:::::::::::::::::: :::::::::.::::::::.:.:.:
CCDS10 PRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSN-IPETPPPGYLSEDGETSDHQMNHS
150 160 170 180 190
250 260 270 280 290 300
pF1KB9 MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
::.::: .:::. .::....:::::::: ::::::::.::::::::::::::::::.:::
CCDS10 MDAGSP-NLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVD
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB9 GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
:::::::::::::::::::::::.::.:::::::::::::::::::::::::::::::::
CCDS10 GFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB9 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
320 330 340 350 360 370
430 440 450 460
pF1KB9 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
::::::::::::::::::::::::::::::::::::::::.::::.:
CCDS10 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
380 390 400 410 420
>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 (320 aa)
initn: 1903 init1: 1454 opt: 2067 Z-score: 2024.4 bits: 383.4 E(32554): 1.9e-106
Smith-Waterman score: 2067; 90.7% identity (98.1% similar) in 322 aa overlap (146-467:1-320)
120 130 140 150 160 170
pF1KB9 QVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVL
.: ::.:::.::::::::::::::::::::
CCDS53 MELCEFAFNMKKDEVCVNPYHYQRVETPVL
10 20 30
180 190 200 210 220 230
pF1KB9 PPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQ
::::::::::: .:.::::::.:::::::::::::::::: :::::::::.::::::::.
CCDS53 PPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSN-IPETPPPGYLSEDGETSDH
40 50 60 70 80
240 250 260 270 280 290
pF1KB9 QLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQP
:.:.:::.::: .:::. .::....:::::::: ::::::::.:::::::::::::::::
CCDS53 QMNHSMDAGSP-NLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQP
90 100 110 120 130 140
300 310 320 330 340 350
pF1KB9 SLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAI
:.::::::::::::::::::::::::::.::.::::::::::::::::::::::::::::
CCDS53 SMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAI
150 160 170 180 190 200
360 370 380 390 400 410
pF1KB9 FVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 FVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIR
210 220 230 240 250 260
420 430 440 450 460
pF1KB9 MSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
:::::::::::::::::::::::::::::::::::::::::::::.::::.:
CCDS53 MSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
270 280 290 300 310 320
>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 (430 aa)
initn: 1695 init1: 901 opt: 1625 Z-score: 1591.3 bits: 303.6 E(32554): 2.6e-82
Smith-Waterman score: 1804; 59.3% identity (75.1% similar) in 477 aa overlap (1-467:7-430)
10 20 30 40 50
pF1KB9 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKK
.::.. :: :.:::::::: :. .:::: :::: ::::::::
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDSLVKKLKK
10 20 30 40
60 70 80 90 100 110
pF1KB9 T-GRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDG
: .::::.:.. . .:::::: :::::
CCDS93 KKGAMDELERALSCPGQPSKCVTIP------------------------------RSLDG
50 60 70
120 130 140 150 160 170
pF1KB9 RLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETP
:::::::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::::
CCDS93 RLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETP
80 90 100 110 120 130
180 190 200 210 220
pF1KB9 VLPPVLVPRHTEILTELPPLDDYT----HS---IPENTNFPAGIE-PQSNYIPETPPPGY
::::::::::.: .: : . :: .:.:...: ... : . .: .: ..
CCDS93 VLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAF
140 150 160 170 180 190
230 240 250 260 270 280
pF1KB9 ISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQR
:.. :. . . :::.: : :: .:: :..:: : :: :::.::::::.:
CCDS93 -SQSPCTA----SYPHSPGSPSE--PE--SPYQHS-DFRPVCYEEPQHWCSVAYYELNNR
200 210 220 230 240
290 300 310 320 330 340
pF1KB9 VGETFHASQPSLTVDGFTDPSNSE-RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGE
:::::.::. :. .::::::::.. :::::::::::::.:.: ::::::.::.:::.:::
CCDS93 VGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGE
250 260 270 280 290 300
350 360 370 380 390 400
pF1KB9 VFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEA
:.:::.:::.::::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.
CCDS93 VYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEV
310 320 330 340 350 360
410 420 430 440 450 460
pF1KB9 VYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCS
::.::.::::::::::::::::.:: :::::::::.::.:::::::::::::::: :
CCDS93 VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPIS
370 380 390 400 410 420
pF1KB9 SMS
:.:
CCDS93 SVS
430
>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 (230 aa)
initn: 1494 init1: 1454 opt: 1496 Z-score: 1469.6 bits: 280.2 E(32554): 1.5e-75
Smith-Waterman score: 1496; 91.8% identity (98.7% similar) in 231 aa overlap (237-467:1-230)
210 220 230 240 250 260
pF1KB9 PAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPV
.:.:::.::: .:::. .::....::::::
CCDS53 MNHSMDAGSP-NLSPNPMSPAHNNLDLQPV
10 20
270 280 290 300 310 320
pF1KB9 TYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVE
:: ::::::::.::::::::::::::::::.::::::::::::::::::::::::::.::
CCDS53 TYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVE
30 40 50 60 70 80
330 340 350 360 370 380
pF1KB9 MTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFN
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 LTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFN
90 100 110 120 130 140
390 400 410 420 430 440
pF1KB9 NQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 NQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPL
150 160 170 180 190 200
450 460
pF1KB9 QWLDKVLTQMGSPSVRCSSMS
::::::::::::::.::::.:
CCDS53 QWLDKVLTQMGSPSIRCSSVS
210 220 230
>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 (465 aa)
initn: 1494 init1: 902 opt: 1402 Z-score: 1373.3 bits: 263.4 E(32554): 3.6e-70
Smith-Waterman score: 1794; 56.6% identity (71.9% similar) in 509 aa overlap (1-467:4-465)
10 20 30 40 50
pF1KB9 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-G
:.:.. :: :.:::::::: :. .:::: :::: .::::::: :
CCDS75 MTSMASLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKG
10 20 30 40
60 70 80 90 100 110
pF1KB9 RLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQ
..:::::... . .:::::: ::::::::
CCDS75 AMEELEKALSSPGQPSKCVTIP------------------------------RSLDGRLQ
50 60 70
120 130 140 150 160 170
pF1KB9 VSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLP
::::::::::::::.::::::.:::::: .. ::. :. :. :::.:::::.:::.::::
CCDS75 VSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLP
80 90 100 110 120 130
180 190 200 210
pF1KB9 PVLVPRHTE------ILTELPPLDDYTHSIPENTNFPAG----------IEPQSNYIP--
:::::::.: .:... :. .:.:..:: . . :.: : :
CCDS75 PVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSP
140 150 160 170 180 190
220 230 240 250
pF1KB9 ----------------------ETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSP
.::::.:. : . . :. .: :::.. .. : . :
CCDS75 ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMG-QDNSQPMDTSN--NMIPQIM-P
200 210 220 230 240 250
260 270 280 290 300 310
pF1KB9 VNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGL
: :.:::.: :: ::::.:::::.::::.::::. :. :::::::::.. ::::::
CCDS75 SISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGL
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB9 LSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
:::::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::.::::
CCDS75 LSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCK
320 330 340 350 360 370
380 390 400 410 420 430
pF1KB9 IPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTP
:: .:.:::::::::: :::::::.::::::.::.::::::::::::::::.:: :::::
CCDS75 IPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTP
380 390 400 410 420 430
440 450 460
pF1KB9 CWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
::::.::.:::::::::::::::: ::.:
CCDS75 CWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
440 450 460
>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 (467 aa)
initn: 1676 init1: 894 opt: 1320 Z-score: 1293.3 bits: 248.6 E(32554): 1e-65
Smith-Waterman score: 1754; 56.7% identity (72.0% similar) in 504 aa overlap (1-467:7-467)
10 20 30 40 50
pF1KB9 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKK
.::.. :: :.:::::::: :. .:::: :::: ::::::::
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDSLVKKLKK
10 20 30 40
60 70 80 90 100 110
pF1KB9 T-GRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDG
: .::::.:.. . .:::::: :::::
CCDS45 KKGAMDELERALSCPGQPSKCVTIP------------------------------RSLDG
50 60 70
120 130 140 150 160 170
pF1KB9 RLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETP
:::::::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::::
CCDS45 RLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETP
80 90 100 110 120 130
180 190 200 210 220
pF1KB9 VLPPVLVPRHTEILTELPPLDDYT----HS---IPENTNFPAGIE-PQSNYIPETPP---
::::::::::.: .: : . :: .:.:...: ... : . .: .:
CCDS45 VLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAF
140 150 160 170 180 190
230 240 250 260
pF1KB9 ---P---GYISEDGETSDQQ--LNQSMDTGS-P---AELSPT-TLSPVN-----HSL---
: .: : :. . ..:.:: : .: : : . .::. : .
CCDS45 SQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSI
200 210 220 230 240 250
270 280 290 300 310
pF1KB9 ---DLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLS
:..:: : :: :::.::::::.::::::.::. :. .::::::::.. ::::::::
CCDS45 PNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLS
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB9 NVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIP
:::::.:.: ::::::.::.:::.::::.:::.:::.::::: ::: ..:.:::::::::
CCDS45 NVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIP
320 330 340 350 360 370
380 390 400 410 420 430
pF1KB9 PGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCW
::.::.:::: :: ::::::..:::.::.::.::::::::::::::::.:: :::::::
CCDS45 SGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCW
380 390 400 410 420 430
440 450 460
pF1KB9 IELHLNGPLQWLDKVLTQMGSPSVRCSSMS
::.::.:::::::::::::::: ::.:
CCDS45 IEIHLHGPLQWLDKVLTQMGSPHNPISSVS
440 450 460
>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 (465 aa)
initn: 1665 init1: 908 opt: 1297 Z-score: 1270.9 bits: 244.5 E(32554): 1.8e-64
Smith-Waterman score: 1773; 56.0% identity (72.2% similar) in 507 aa overlap (1-467:3-465)
10 20 30 40 50
pF1KB9 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GR
..:.. :: :.:::::::: :. .:::: :::: .::::::: :
CCDS37 MNVTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGA
10 20 30 40
60 70 80 90 100 110
pF1KB9 LDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQV
..:::::.. . ..::::: :::::::::
CCDS37 MEELEKALSCPGQPSNCVTIP------------------------------RSLDGRLQV
50 60 70
120 130 140 150 160 170
pF1KB9 SHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPP
:::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::.:::::
CCDS37 SHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPP
80 90 100 110 120 130
180 190 200 210 220 230
pF1KB9 VLVPRHTE------ILTELPPLDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDG
::::::.: .:... : . .: :..:: ... :.:. .:..: .: . :
CCDS37 VLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPG
140 150 160 170 180 190
240 250
pF1KB9 ETSDQQLNQ--SMDTGSPAELS-----PTTLSP------------------------VNH
.:. .. : : ::: .. :. : : .:.
CCDS37 SSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINR
200 210 220 230 240 250
260 270 280 290 300 310
pF1KB9 SLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLSN
. :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. :::::::::
CCDS37 G-DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSN
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB9 VNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP
::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::.::::::
CCDS37 VNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPS
320 330 340 350 360 370
380 390 400 410 420 430
pF1KB9 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI
::.:::::::::: :::::::.:::.::.::.::::::::::::::::.:: ::::::::
CCDS37 GCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWI
380 390 400 410 420 430
440 450 460
pF1KB9 ELHLNGPLQWLDKVLTQMGSPSVRCSSMS
:.::.:::::::::::::::: ::.:
CCDS37 EIHLHGPLQWLDKVLTQMGSPHNPISSVS
440 450 460
>>CCDS10221.1 SMAD6 gene_id:4091|Hs108|chr15 (496 aa)
initn: 603 init1: 145 opt: 396 Z-score: 391.6 bits: 81.9 E(32554): 1.7e-15
Smith-Waterman score: 473; 30.3% identity (56.8% similar) in 333 aa overlap (115-445:213-495)
90 100 110 120 130 140
pF1KB9 WGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELK
:... . . :... ::.:::::. :::
CCDS10 LKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELK
190 200 210 220 230 240
150 160 170 180 190 200
pF1KB9 AIENCEYAFNLKKD--EVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPE
. .: ..: : :: ::::..:. : :: :: :..
CCDS10 PLCGC-HSFAAAADGPTVCCNPYHFSRLCGPESPP-------------PP---YSR----
250 260 270 280
210 220 230 240 250 260
pF1KB9 NTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLD
. :...: : . .: .. . ..:. : .:.:.: ...::
CCDS10 -------LSPRDEYKPLDLSDSTLS----YTETEATNSLIT-APGEFSDASMSP------
290 300 310 320
270 280 290 300 310 320
pF1KB9 LQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRN
..:. :::.::.: :::. . . . .... : : .. :::: :. .:.
CCDS10 ----DATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRS
330 340 350 360 370
330 340 350 360 370 380
pF1KB9 ATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNL
.:. :: .:: :. : :.: .. :::.::. . : . .: :.::: ..
CCDS10 ESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSI
380 390 400 410 420 430
390 400 410 420 430 440
pF1KB9 KIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHL
:.:. : ..: .. .. :. . ..:.::.:::: : :: .:: :::.:. :
CCDS10 KVFDF-ERSGLQHAPEPDAADGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILL
440 450 460 470 480 490
450 460
pF1KB9 NGPLQWLDKVLTQMGSPSVRCSSMS
:.:
CCDS10 NNPR
467 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:01:01 2016 done: Fri Nov 4 20:01:02 2016
Total Scan time: 3.370 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]