FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9819, 310 aa 1>>>pF1KB9819 310 - 310 aa - 310 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1949+/-0.000287; mu= 10.3204+/- 0.018 mean_var=171.2327+/-35.233, 0's: 0 Z-trim(123.9): 4 B-trim: 1405 in 1/56 Lambda= 0.098012 statistics sampled from 44578 (44582) to 44578 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.815), E-opt: 0.2 (0.523), width: 16 Scan time: 7.580 The best scores are: opt bits E(85289) NP_777571 (OMIM: 609483) protein FAM84B [Homo sapi ( 310) 2148 314.8 1.5e-85 XP_016868596 (OMIM: 609483) PREDICTED: protein FAM ( 310) 2148 314.8 1.5e-85 XP_016868597 (OMIM: 609483) PREDICTED: protein FAM ( 292) 1669 247.0 3.4e-65 NP_660158 (OMIM: 611234) protein FAM84A [Homo sapi ( 292) 627 99.7 7.7e-21 >>NP_777571 (OMIM: 609483) protein FAM84B [Homo sapiens] (310 aa) initn: 2148 init1: 2148 opt: 2148 Z-score: 1657.1 bits: 314.8 E(85289): 1.5e-85 Smith-Waterman score: 2148; 100.0% identity (100.0% similar) in 310 aa overlap (1-310:1-310) 10 20 30 40 50 60 pF1KB9 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQGPDGGGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQGPDGGGLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DGGDGPPPPQPQPYDPRLHEVECSVFYRDECIYQKSFAPGSAALSTYTPENLLNKCKPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 DGGDGPPPPQPQPYDPRLHEVECSVFYRDECIYQKSFAPGSAALSTYTPENLLNKCKPGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQGRRGRVVNDLYRYKPLSSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 LVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQGRRGRVVNDLYRYKPLSSSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 VVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGGELRIGKQPYRLQIQLSAQRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 VVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGGELRIGKQPYRLQIQLSAQRSH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 TLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPAEPEEGDSNVARTTPPPGRPPAPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 TLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPAEPEEGDSNVARTTPPPGRPPAPSS 250 260 270 280 290 300 310 pF1KB9 EEEDGEAVAH :::::::::: NP_777 EEEDGEAVAH 310 >>XP_016868596 (OMIM: 609483) PREDICTED: protein FAM84B (310 aa) initn: 2148 init1: 2148 opt: 2148 Z-score: 1657.1 bits: 314.8 E(85289): 1.5e-85 Smith-Waterman score: 2148; 100.0% identity (100.0% similar) in 310 aa overlap (1-310:1-310) 10 20 30 40 50 60 pF1KB9 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQGPDGGGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQGPDGGGLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DGGDGPPPPQPQPYDPRLHEVECSVFYRDECIYQKSFAPGSAALSTYTPENLLNKCKPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGGDGPPPPQPQPYDPRLHEVECSVFYRDECIYQKSFAPGSAALSTYTPENLLNKCKPGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQGRRGRVVNDLYRYKPLSSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQGRRGRVVNDLYRYKPLSSSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 VVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGGELRIGKQPYRLQIQLSAQRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGGELRIGKQPYRLQIQLSAQRSH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 TLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPAEPEEGDSNVARTTPPPGRPPAPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPAEPEEGDSNVARTTPPPGRPPAPSS 250 260 270 280 290 300 310 pF1KB9 EEEDGEAVAH :::::::::: XP_016 EEEDGEAVAH 310 >>XP_016868597 (OMIM: 609483) PREDICTED: protein FAM84B (292 aa) initn: 1669 init1: 1669 opt: 1669 Z-score: 1291.4 bits: 247.0 E(85289): 3.4e-65 Smith-Waterman score: 1950; 94.2% identity (94.2% similar) in 310 aa overlap (1-310:1-292) 10 20 30 40 50 60 pF1KB9 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQGPDGGGLP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQ-------- 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DGGDGPPPPQPQPYDPRLHEVECSVFYRDECIYQKSFAPGSAALSTYTPENLLNKCKPGD :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ----------PQPYDPRLHEVECSVFYRDECIYQKSFAPGSAALSTYTPENLLNKCKPGD 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 LVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQGRRGRVVNDLYRYKPLSSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQGRRGRVVNDLYRYKPLSSSA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 VVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGGELRIGKQPYRLQIQLSAQRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGGELRIGKQPYRLQIQLSAQRSH 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 TLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPAEPEEGDSNVARTTPPPGRPPAPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPAEPEEGDSNVARTTPPPGRPPAPSS 230 240 250 260 270 280 310 pF1KB9 EEEDGEAVAH :::::::::: XP_016 EEEDGEAVAH 290 >>NP_660158 (OMIM: 611234) protein FAM84A [Homo sapiens] (292 aa) initn: 636 init1: 408 opt: 627 Z-score: 495.1 bits: 99.7 E(85289): 7.7e-21 Smith-Waterman score: 812; 46.1% identity (68.1% similar) in 295 aa overlap (1-270:1-285) 10 20 30 40 50 60 pF1KB9 MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDEDVEPQPPPQGPDGGGLP ::::....:::.:.:.::.::.:...:. :.::.:.::.:.::.. . : : NP_660 MGNQLDRITHLNYSELPTGDPSGIEKDEL-RVGVAYFFSDDEEDLDER---------GQP 10 20 30 40 50 70 80 90 100 pF1KB9 D--GGDGPPPPQPQPYDPRLH-----------EVECSVFYRDECIYQK-SFAPGSAALST : : .:: : : .: : :.. :.: .:::..: : .: .: ::. NP_660 DKFGVKAPPGCTPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSV 60 70 80 90 100 110 110 120 130 140 150 pF1KB9 YTPENLLNKCKPGDLVEFV-------SQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDAS :. : :.::::.:.. : ::::::::. :..:::. :. .. : .:. NP_660 YAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLHQGEIRQDSLYEAG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 QGRRGRVVNDLYRYKPLSSSAVVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIGG . :::::. :::.:: . ::.:: .:.: : .:. : ::::::::::.:::::: :: NP_660 AANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGG 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB9 ELRIGKQP----YRLQIQLSAQRSHTLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHP :. : :: : :...:. .. :: .:.:::::: :::: : :: :::::: NP_660 EVPAGTQPPQQQYYLKVHLGENKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDD 240 250 260 270 280 290 280 290 300 310 pF1KB9 AEPEEGDSNVARTTPPPGRPPAPSSEEEDGEAVAH NP_660 KE 310 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:26:29 2016 done: Fri Nov 4 19:26:30 2016 Total Scan time: 7.580 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]