Result of FASTA (omim) for
pF1KB9770
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9770, 462 aa
1>>>pF1KB9770 462 - 462 aa - 462 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2421+/-0.000412; mu= -0.0399+/- 0.026
mean_var=215.8311+/-44.547, 0's: 0 Z-trim(118.6): 403 B-trim: 1730 in 1/55
Lambda= 0.087301
statistics sampled from 31238 (31648) to 31238 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.371), width: 16
Scan time: 8.980
The best scores are: opt bits E(85289)
NP_002948 (OMIM: 180245) retinoic acid receptor RX ( 462) 3123 406.2 9.8e-113
NP_001278849 (OMIM: 180245) retinoic acid receptor ( 435) 2946 383.9 4.8e-106
NP_001278850 (OMIM: 180245) retinoic acid receptor ( 365) 2464 323.1 7.9e-88
NP_008848 (OMIM: 180247) retinoic acid receptor RX ( 463) 2162 285.1 2.7e-76
NP_068811 (OMIM: 180246) retinoic acid receptor RX ( 533) 2137 282.0 2.7e-75
NP_001257330 (OMIM: 180246) retinoic acid receptor ( 537) 2119 279.8 1.3e-74
XP_016866665 (OMIM: 180246) PREDICTED: retinoic ac ( 414) 2076 274.3 4.5e-73
XP_005249335 (OMIM: 180246) PREDICTED: retinoic ac ( 441) 1998 264.5 4.3e-70
NP_001243500 (OMIM: 180247) retinoic acid receptor ( 340) 1983 262.5 1.3e-69
NP_001243499 (OMIM: 180247) retinoic acid receptor ( 340) 1983 262.5 1.3e-69
NP_001278918 (OMIM: 180246) retinoic acid receptor ( 347) 1933 256.2 1e-67
XP_011513098 (OMIM: 180246) PREDICTED: retinoic ac ( 420) 1933 256.3 1.2e-67
NP_066285 (OMIM: 107773,615779) COUP transcription ( 414) 1001 138.9 2.6e-32
NP_005645 (OMIM: 132890,615722) COUP transcription ( 423) 972 135.2 3.3e-31
XP_016868865 (OMIM: 605966) PREDICTED: hepatocyte ( 408) 916 128.2 4.2e-29
NP_001317490 (OMIM: 605966) hepatocyte nuclear fac ( 408) 916 128.2 4.2e-29
XP_016868863 (OMIM: 605966) PREDICTED: hepatocyte ( 408) 916 128.2 4.2e-29
XP_016868864 (OMIM: 605966) PREDICTED: hepatocyte ( 408) 916 128.2 4.2e-29
XP_016868862 (OMIM: 605966) PREDICTED: hepatocyte ( 408) 916 128.2 4.2e-29
NP_004124 (OMIM: 605966) hepatocyte nuclear factor ( 445) 916 128.2 4.5e-29
NP_001274111 (OMIM: 125850,125853,600281,616026) h ( 439) 907 127.1 9.8e-29
NP_001025174 (OMIM: 125850,125853,600281,616026) h ( 442) 907 127.1 9.9e-29
NP_001274112 (OMIM: 125850,125853,600281,616026) h ( 449) 907 127.1 1e-28
NP_787110 (OMIM: 125850,125853,600281,616026) hepa ( 452) 907 127.1 1e-28
NP_849180 (OMIM: 125850,125853,600281,616026) hepa ( 464) 907 127.1 1e-28
NP_001245284 (OMIM: 125850,125853,600281,616026) h ( 467) 907 127.1 1e-28
NP_000448 (OMIM: 125850,125853,600281,616026) hepa ( 474) 907 127.1 1e-28
XP_005260464 (OMIM: 125850,125853,600281,616026) P ( 513) 907 127.1 1.1e-28
NP_001274113 (OMIM: 125850,125853,600281,616026) h ( 392) 902 126.4 1.4e-28
NP_001025175 (OMIM: 125850,125853,600281,616026) h ( 395) 902 126.4 1.4e-28
NP_849181 (OMIM: 125850,125853,600281,616026) hepa ( 417) 902 126.4 1.5e-28
XP_016856128 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
XP_016856127 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
NP_001230440 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
XP_016856129 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
XP_016856132 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
XP_016856138 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
XP_016856134 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
XP_016856136 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
NP_001127757 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
NP_001230442 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
XP_016856133 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
NP_001230443 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
XP_016856135 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
NP_001230439 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
XP_016856131 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
NP_001230441 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
NP_001230448 (OMIM: 602969) estrogen-related recep ( 435) 743 106.4 1.6e-22
NP_996318 (OMIM: 602969) estrogen-related receptor ( 435) 743 106.4 1.6e-22
XP_016856130 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 743 106.4 1.6e-22
>>NP_002948 (OMIM: 180245) retinoic acid receptor RXR-al (462 aa)
initn: 3123 init1: 3123 opt: 3123 Z-score: 2144.9 bits: 406.2 E(85289): 9.8e-113
Smith-Waterman score: 3123; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462)
10 20 30 40 50 60
pF1KB9 MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
370 380 390 400 410 420
430 440 450 460
pF1KB9 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
::::::::::::::::::::::::::::::::::::::::::
NP_002 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
430 440 450 460
>>NP_001278849 (OMIM: 180245) retinoic acid receptor RXR (435 aa)
initn: 2946 init1: 2946 opt: 2946 Z-score: 2024.8 bits: 383.9 E(85289): 4.8e-106
Smith-Waterman score: 2946; 100.0% identity (100.0% similar) in 435 aa overlap (28-462:1-435)
10 20 30 40 50 60
pF1KB9 MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
:::::::::::::::::::::::::::::::::
NP_001 MAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
10 20 30
70 80 90 100 110 120
pF1KB9 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB9 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB9 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB9 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB9 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB9 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
340 350 360 370 380 390
430 440 450 460
pF1KB9 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
::::::::::::::::::::::::::::::::::::::::::
NP_001 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
400 410 420 430
>>NP_001278850 (OMIM: 180245) retinoic acid receptor RXR (365 aa)
initn: 2464 init1: 2464 opt: 2464 Z-score: 1697.8 bits: 323.1 E(85289): 7.9e-88
Smith-Waterman score: 2464; 100.0% identity (100.0% similar) in 365 aa overlap (98-462:1-365)
70 80 90 100 110 120
pF1KB9 ISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNM
::::::::::::::::::::::::::::::
NP_001 MNPVSSSEDIKPPLGLNGVLKVPAHPSGNM
10 20 30
130 140 150 160 170 180
pF1KB9 ASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRC
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB9 QYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTE
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB9 TYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNE
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB9 LLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTEL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB9 GCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRS
280 290 300 310 320 330
430 440 450 460
pF1KB9 IGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
:::::::::::::::::::::::::::::::::::
NP_001 IGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
340 350 360
>>NP_008848 (OMIM: 180247) retinoic acid receptor RXR-ga (463 aa)
initn: 2139 init1: 1217 opt: 2162 Z-score: 1490.8 bits: 285.1 E(85289): 2.7e-76
Smith-Waterman score: 2162; 73.8% identity (87.1% similar) in 451 aa overlap (21-462:18-463)
10 20 30 40 50
pF1KB9 MDTKHFLPLDFSTQVNSSLTSPTGRGSMA-APSLHPSLGPGIGS-PGQLHSPIS---TLS
:: :: . .:: : : . : :. .:.: :::
NP_008 MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLS
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 ---SPINGMGPPFSVISSPMGPHSMSVPTTPTLGF-STGSPQLSSPMNPVSSSEDIKPPL
.:.:..: :. ::.: ::: : .. . : ... . : ::. .: :::::::::
NP_008 AVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNV-VNSVSSSEDIKPLP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 GLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTC
:: :. .. .:: . .:..:::::::::::::::::::::::::::::::.:::: :::
NP_008 GLPGIGNM-NYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 RDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMP
:::::::::::::::::::::::::.::::::::::::::...: :.:.: ..:..::::
NP_008 RDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB9 VERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSE
::::::::::::::::.: . :: .: ::::::::.::::::::::::::::::::.
NP_008 VERILEAELAVEPKTESYGDMNM---ENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB9 LPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLT
: :.::::::::::::::::::::::..:.:::::::::::::.::::::::.:::::::
NP_008 LTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLT
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB9 ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQ
::::::.::::::.::::::::::::::.::::::.:::.:::::::.:::: :.:::::
NP_008 ELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQ
360 370 380 390 400 410
420 430 440 450 460
pF1KB9 PGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
:::::::::::::::::::::::::::::::::::::::::::::.: :.:
NP_008 PGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
420 430 440 450 460
>>NP_068811 (OMIM: 180246) retinoic acid receptor RXR-be (533 aa)
initn: 2092 init1: 1281 opt: 2137 Z-score: 1472.9 bits: 282.0 E(85289): 2.7e-75
Smith-Waterman score: 2137; 72.0% identity (84.6% similar) in 461 aa overlap (12-461:80-532)
10 20 30
pF1KB9 MDTKHFLPLDFSTQVNSSLTSPTGRG----SMAAPSLHPSL
: . .:: .: .: : .: : ::
NP_068 AAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPST
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB9 GPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSP
.:..:. : : . : .: :: :::: :: .. :. : .. ..:::..:
NP_068 APSLGGSGA--PPPPPMPPP--PLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINST
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB9 MN-PVSSS---EDIKPP-LGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSC
.. : ..: ::.::: ::. : :. : :.: :. :..::::::::::::::::::
NP_068 VSLPGGGSGPPEDVKPPVLGVRG-LHCPPPPGGPGAG--KRLCAICGDRSSGKHYGVYSC
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB9 EGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRG
::::::::::.::::::.::::::: .:::::::::::::::::: ::::::::::::::
NP_068 EGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRG
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB9 KDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEA--NMGLNPSSPNDPVTNICQ
::.. .. :....: :.:::.:::::::::: :.. ::. . : . ::::::::::::
NP_068 KDKD-GDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQ
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB9 AADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL
:::::::::::::::::::: ::::::::::::::::::::::::::: :.:::::::::
NP_068 AADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL
350 360 370 380 390 400
340 350 360 370 380 390
pF1KB9 HVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVE
::::::::::::::::::::::::::::::.::::::::::::.:::::.::::::.:::
NP_068 HVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVE
410 420 430 440 450 460
400 410 420 430 440 450
pF1KB9 ALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF
.::::::::::.:::.::::: ::::::::::::::::::::::::::::::::::::::
NP_068 VLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF
470 480 490 500 510 520
460
pF1KB9 LMEMLEAPHQMT
::::::::::.
NP_068 LMEMLEAPHQLA
530
>>NP_001257330 (OMIM: 180246) retinoic acid receptor RXR (537 aa)
initn: 2099 init1: 707 opt: 2119 Z-score: 1460.6 bits: 279.8 E(85289): 1.3e-74
Smith-Waterman score: 2119; 71.4% identity (83.9% similar) in 465 aa overlap (12-461:80-536)
10 20 30
pF1KB9 MDTKHFLPLDFSTQVNSSLTSPTGRG----SMAAPSLHPSL
: . .:: .: .: : .: : ::
NP_001 AAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPST
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB9 GPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSP
.:..:. : : . : .: :: :::: :: .. :. : .. ..:::..:
NP_001 APSLGGSGA--PPPPPMPPP--PLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINST
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB9 MN-PVSSS---EDIKPP-LGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSC
.. : ..: ::.::: ::. : :. : :.: :. :..::::::::::::::::::
NP_001 VSLPGGGSGPPEDVKPPVLGVRG-LHCPPPPGGPGAG--KRLCAICGDRSSGKHYGVYSC
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB9 EGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRG
::::::::::.::::::.::::::: .:::::::::::::::::: ::::::::::::::
NP_001 EGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRG
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB9 KDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEA--NMGLNPSSPNDPVTNICQ
::.. .. :....: :.:::.:::::::::: :.. ::. . : . ::::::::::::
NP_001 KDKD-GDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQ
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB9 AADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL
:::::::::::::::::::: ::::::::::::::::::::::::::: :.:::::::::
NP_001 AADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL
350 360 370 380 390 400
340 350 360 370 380
pF1KB9 HVHRNSAHSAGVGAIFDR----VLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP
:::::::::::::::::: ::::::::::::.::::::::::::.:::::.::::::
NP_001 HVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNP
410 420 430 440 450 460
390 400 410 420 430 440
pF1KB9 AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP
.:::.::::::::::.:::.::::: ::::::::::::::::::::::::::::::::::
NP_001 SEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP
470 480 490 500 510 520
450 460
pF1KB9 IDTFLMEMLEAPHQMT
::::::::::::::.
NP_001 IDTFLMEMLEAPHQLA
530
>>XP_016866665 (OMIM: 180246) PREDICTED: retinoic acid r (414 aa)
initn: 2104 init1: 707 opt: 2076 Z-score: 1432.9 bits: 274.3 E(85289): 4.5e-73
Smith-Waterman score: 2076; 76.4% identity (88.0% similar) in 416 aa overlap (57-461:2-413)
30 40 50 60 70 80
pF1KB9 SMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLG
: .: :: :::: :: .. :. : ..
XP_016 MPPPPLGSPFPVISSSMGSPGLPPPAPPGFS
10 20 30
90 100 110 120 130 140
pF1KB9 FSTGSPQLSSPMN-PVSSS---EDIKPP-LGLNGVLKVPAHPSGNMASFTKHICAICGDR
..:::..: .. : ..: ::.::: ::. : :. : :.: :. :..:::::::
XP_016 GPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRG-LHCPPPPGGPGAG--KRLCAICGDR
40 50 60 70 80
150 160 170 180 190 200
pF1KB9 SSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMK
:::::::::::::::::::::.::::::.::::::: .:::::::::::::::::: :::
XP_016 SSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMK
90 100 110 120 130 140
210 220 230 240 250
pF1KB9 REAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEA--NMGLNPS
:::::::::::::.. .. :....: :.:::.:::::::::: :.. ::. . : . :
XP_016 REAVQEERQRGKDKD-GDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGS
150 160 170 180 190 200
260 270 280 290 300 310
pF1KB9 SPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIA
::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 SPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSID
210 220 230 240 250 260
320 330 340 350 360 370
pF1KB9 VKDGILLATGLHVHRNSAHSAGVGAIFDR----VLTELVSKMRDMQMDKTELGCLRAIVL
:.::::::::::::::::::::::::::: ::::::::::::.::::::::::::.:
XP_016 VRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIIL
270 280 290 300 310 320
380 390 400 410 420 430
pF1KB9 FNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEH
::::.::::::.:::.::::::::::.:::.::::: :::::::::::::::::::::::
XP_016 FNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEH
330 340 350 360 370 380
440 450 460
pF1KB9 LFFFKLIGDTPIDTFLMEMLEAPHQMT
:::::::::::::::::::::::::.
XP_016 LFFFKLIGDTPIDTFLMEMLEAPHQLA
390 400 410
>>XP_005249335 (OMIM: 180246) PREDICTED: retinoic acid r (441 aa)
initn: 1989 init1: 707 opt: 1998 Z-score: 1379.4 bits: 264.5 E(85289): 4.3e-70
Smith-Waterman score: 1998; 77.1% identity (87.7% similar) in 398 aa overlap (74-461:47-440)
50 60 70 80 90 100
pF1KB9 PGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTG---SPQLSSPMNP
:.: : :..:. . .: : .
XP_005 VGSRPGGGGDGPGWIPQRRRRRRWQAENNKPRSRSQGRLDGTGWATAGGINSTVSLPGGG
20 30 40 50 60 70
110 120 130 140 150
pF1KB9 VSSSEDIKPP-LGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFF
. ::.::: ::. : :. : :.: :. :..:::::::::::::::::::::::::
XP_005 SGPPEDVKPPVLGVRG-LHCPPPPGGPGAG--KRLCAICGDRSSGKHYGVYSCEGCKGFF
80 90 100 110 120 130
160 170 180 190 200 210
pF1KB9 KRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENE
:::.::::::.::::::: .:::::::::::::::::: ::::::::::::::::.. ..
XP_005 KRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKD-GD
140 150 160 170 180 190
220 230 240 250 260 270
pF1KB9 VESTSSANEDMPVERILEAELAVEPKTETYVEA--NMGLNPSSPNDPVTNICQAADKQLF
:....: :.:::.:::::::::: :.. ::. . : . :::::::::::::::::::
XP_005 GEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLF
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB9 TLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSA
::::::::::::: ::::::::::::::::::::::::::: :.::::::::::::::::
XP_005 TLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSA
260 270 280 290 300 310
340 350 360 370 380 390
pF1KB9 HSAGVGAIFDR----VLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALR
::::::::::: ::::::::::::.::::::::::::.:::::.::::::.:::.::
XP_005 HSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLR
320 330 340 350 360 370
400 410 420 430 440 450
pF1KB9 EKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLME
::::::::.:::.::::: :::::::::::::::::::::::::::::::::::::::::
XP_005 EKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLME
380 390 400 410 420 430
460
pF1KB9 MLEAPHQMT
:::::::.
XP_005 MLEAPHQLA
440
>>NP_001243500 (OMIM: 180247) retinoic acid receptor RXR (340 aa)
initn: 1985 init1: 1217 opt: 1983 Z-score: 1370.9 bits: 262.5 E(85289): 1.3e-69
Smith-Waterman score: 1983; 85.0% identity (95.6% similar) in 341 aa overlap (122-462:3-340)
100 110 120 130 140 150
pF1KB9 PQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYS
.:: . .:..::::::::::::::::::::
NP_001 MNYPSTSPGSLVKHICAICGDRSSGKHYGVYS
10 20 30
160 170 180 190 200 210
pF1KB9 CEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQR
:::::::::::.:::: ::::::::::::::::::::::::::::.::::::::::::::
NP_001 CEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB9 GKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQA
...: :.:.: ..:..::::::::::::::::::::.: . :: .: ::::::::.:
NP_001 SRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNM---ENSTNDPVTNICHA
100 110 120 130 140
280 290 300 310 320 330
pF1KB9 ADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLH
:::::::::::::::::::.: :.::::::::::::::::::::::..:.::::::::::
NP_001 ADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLH
150 160 170 180 190 200
340 350 360 370 380 390
pF1KB9 VHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEA
:::.::::::::.:::::::::::::.::::::.::::::::::::::.::::::.:::.
NP_001 VHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVET
210 220 230 240 250 260
400 410 420 430 440 450
pF1KB9 LREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL
:::::::.:::: :.:::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL
270 280 290 300 310 320
460
pF1KB9 MEMLEAPHQMT
:::::.: :.:
NP_001 MEMLETPLQIT
330 340
>>NP_001243499 (OMIM: 180247) retinoic acid receptor RXR (340 aa)
initn: 1985 init1: 1217 opt: 1983 Z-score: 1370.9 bits: 262.5 E(85289): 1.3e-69
Smith-Waterman score: 1983; 85.0% identity (95.6% similar) in 341 aa overlap (122-462:3-340)
100 110 120 130 140 150
pF1KB9 PQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYS
.:: . .:..::::::::::::::::::::
NP_001 MNYPSTSPGSLVKHICAICGDRSSGKHYGVYS
10 20 30
160 170 180 190 200 210
pF1KB9 CEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQR
:::::::::::.:::: ::::::::::::::::::::::::::::.::::::::::::::
NP_001 CEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB9 GKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQA
...: :.:.: ..:..::::::::::::::::::::.: . :: .: ::::::::.:
NP_001 SRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNM---ENSTNDPVTNICHA
100 110 120 130 140
280 290 300 310 320 330
pF1KB9 ADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLH
:::::::::::::::::::.: :.::::::::::::::::::::::..:.::::::::::
NP_001 ADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLH
150 160 170 180 190 200
340 350 360 370 380 390
pF1KB9 VHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEA
:::.::::::::.:::::::::::::.::::::.::::::::::::::.::::::.:::.
NP_001 VHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVET
210 220 230 240 250 260
400 410 420 430 440 450
pF1KB9 LREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL
:::::::.:::: :.:::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL
270 280 290 300 310 320
460
pF1KB9 MEMLEAPHQMT
:::::.: :.:
NP_001 MEMLETPLQIT
330 340
462 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 18:47:55 2016 done: Fri Nov 4 18:47:56 2016
Total Scan time: 8.980 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]