Result of FASTA (omim) for
pF1KB9640
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9640, 361 aa
1>>>pF1KB9640 361 - 361 aa - 361 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1982+/-0.00034; mu= 9.8585+/- 0.021
mean_var=177.1030+/-36.911, 0's: 0 Z-trim(120.8): 59 B-trim: 1922 in 1/53
Lambda= 0.096374
statistics sampled from 36476 (36547) to 36476 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.429), width: 16
Scan time: 8.690
The best scores are: opt bits E(85289)
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 2475 355.9 8.1e-98
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 1078 161.8 2.8e-39
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 1069 160.6 7.2e-39
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 983 148.6 2.6e-35
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 692 108.3 5.3e-23
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 692 108.3 5.7e-23
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 692 108.3 5.7e-23
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 692 108.3 5.8e-23
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 692 108.3 5.8e-23
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 686 107.5 9.7e-23
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 666 104.4 4.2e-22
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 666 104.4 4.5e-22
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 666 104.4 4.5e-22
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 666 104.4 4.5e-22
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 666 104.5 4.8e-22
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 666 104.5 4.8e-22
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 666 104.5 4.8e-22
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 666 104.5 4.8e-22
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 638 100.5 6.2e-21
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 629 99.1 1.2e-20
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 629 99.2 1.5e-20
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 609 96.4 8.8e-20
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 609 96.4 9.3e-20
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 518 83.9 7.2e-16
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 518 83.9 7.3e-16
NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 498 80.7 2.9e-15
NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 498 80.7 2.9e-15
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 496 80.7 5.2e-15
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 428 71.6 5.8e-12
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 421 70.4 9e-12
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 421 70.4 9.2e-12
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 421 70.5 1.1e-11
XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602) 421 70.5 1.1e-11
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 412 69.1 1.9e-11
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 412 69.2 2.1e-11
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 412 69.2 2.2e-11
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 412 69.3 2.5e-11
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 412 69.3 2.6e-11
XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 412 69.4 2.9e-11
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 409 68.8 3e-11
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 409 68.8 3.2e-11
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 409 68.9 3.4e-11
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 409 68.9 3.5e-11
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 409 68.9 3.8e-11
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 409 68.9 3.8e-11
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 409 68.9 3.8e-11
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 409 68.9 3.8e-11
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 409 68.9 3.8e-11
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 409 68.9 3.8e-11
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 409 69.0 3.9e-11
>>NP_000298 (OMIM: 300039,304400) POU domain, class 3, t (361 aa)
initn: 2475 init1: 2475 opt: 2475 Z-score: 1877.1 bits: 355.9 E(85289): 8.1e-98
Smith-Waterman score: 2475; 100.0% identity (100.0% similar) in 361 aa overlap (1-361:1-361)
10 20 30 40 50 60
pF1KB9 MATAASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MATAASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 NPSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NPSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 QDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 SFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 PKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHD
310 320 330 340 350 360
pF1KB9 L
:
NP_000 L
>>NP_005595 (OMIM: 600494) POU domain, class 3, transcri (443 aa)
initn: 1291 init1: 1024 opt: 1078 Z-score: 826.3 bits: 161.8 E(85289): 2.8e-39
Smith-Waterman score: 1193; 56.3% identity (66.3% similar) in 398 aa overlap (48-359:50-435)
20 30 40 50 60
pF1KB9 VHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGH--HWVTSLS-------------
::::::.: .:.:.::
NP_005 HAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGG
20 30 40 50 60 70
70 80 90
pF1KB9 ---------DGGPWSSTLATSPLDQQDVKP-------GREDLQL---GAIIHH-------
::.::: :::: : :.:: :: : .: ::. ..
NP_005 GGGGGGGGGDGSPWS----TSPLGQPDIKPSVVVQQGGRGD-ELHGPGALQQQHQQQQQQ
80 90 100 110 120 130
100 110 120 130
pF1KB9 ---------------RSPHVAHHSP-HTNHPNAWGASPAPN---PSITSSGQPLNVYSQP
: ::..::. : :.:: .. : ::. .:. : .::::
NP_005 QQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGL-LYSQP
140 150 160 170 180 190
140 150 160 170
pF1KB9 GFTVSGMLEHGGLTPPPAAASAQSL------------------HPVLREPPDH------G
.:::.::: :: ::. ..: :: . :: :
NP_005 SFTVNGMLGAGG---QPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPG
200 210 220 230 240 250
180 190 200 210 220 230
pF1KB9 ELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTIC
. :.:: . ::::.:::::.::::::::::::::::::::::::::::::::::::::::
NP_005 HPGAHH-DPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTIC
260 270 280 290 300
240 250 260 270 280 290
pF1KB9 RFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVL
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::.:
NP_005 RFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGAL
310 320 330 340 350 360
300 310 320 330 340 350
pF1KB9 ETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQP--HEVYSHT
:.::::::::.::::.::::::::::::::::::::::::::::::: : ..::. .
NP_005 ESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGS
370 380 390 400 410 420
360
pF1KB9 VKTDTSCHDL
:: :
NP_005 --RDTPPHHGVQTPVQ
430 440
>>NP_006227 (OMIM: 602480) POU domain, class 3, transcri (500 aa)
initn: 1239 init1: 1021 opt: 1069 Z-score: 818.9 bits: 160.6 E(85289): 7.2e-39
Smith-Waterman score: 1182; 60.1% identity (70.6% similar) in 361 aa overlap (64-356:131-488)
40 50 60 70 80 90
pF1KB9 PQKLLQSDYLQGVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQ-QDVK--PGREDLQL
:.: . : : ::: ::.::.
NP_006 LPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHA
110 120 130 140 150 160
100 110 120 130
pF1KB9 GAIIHHRSP-HVAHHSP--HTNHPNAWGASPAPN------------PSITSSGQPLN---
:. .:::.: :.. : : .::..:::. : ::.... ::
NP_006 GTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSL
170 180 190 200 210 220
140 150 160
pF1KB9 VYSQPG-FTVSGMLEHGGLTPPP------AAASAQSL-HPVL------------------
.::::: :::.::: . : : :...:::: :: :
NP_006 LYSQPGGFTVNGML---SAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHH
230 240 250 260 270
170 180 190 200
pF1KB9 -----------REPPDHGELGSH-----HCQD-HSDEETPTSDELEQFAKQFKQRRIKLG
. :: :: :. . .: ::::.:::::.::::::::::::::::
NP_006 AHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLG
280 290 300 310 320 330
210 220 230 240 250 260
pF1KB9 FTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSI
340 350 360 370 380 390
270 280 290 300 310 320
pF1KB9 DKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNR
::::::::::::::::::::::.::.::::::::.::::..:::::::::::::::::::
NP_006 DKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNR
400 410 420 430 440 450
330 340 350 360
pF1KB9 RQKEKRMTPPGDQQ--PHEVYSH--TVKTDTSCHDL
::::::::::: :: : .:::. ::..::
NP_006 RQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ
460 470 480 490 500
>>NP_002690 (OMIM: 602479) POU domain, class 3, transcri (451 aa)
initn: 1035 init1: 963 opt: 983 Z-score: 754.8 bits: 148.6 E(85289): 2.6e-35
Smith-Waterman score: 1064; 51.6% identity (68.4% similar) in 376 aa overlap (25-349:40-413)
10 20 30 40 50
pF1KB9 MATAASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLG
.. :. .:. :::.. ..: :. . :::.:
NP_002 RGPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQKLMHHEWL-GA-GAGHPVG
10 20 30 40 50 60
60 70 80 90 100
pF1KB9 --H-HWV-TSLSDGGPWSSTLATSPLDQQDVKPGREDLQLGA------IIHHRSPHV--A
: .:. :. . :: :.. :: : :. ..:. . :. :
NP_002 LAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADDGGGGGGFHARLVHQGAAHAGAA
70 80 90 100 110 120
110 120 130 140 150
pF1KB9 HHSPHTNHPNAWGASPAPNPSITSSGQPLNVYSQPGFT------VSGMLEHGGLTPPPAA
. : : . . ::.:. : . :::..:.: .. ..::: :: :.
NP_002 WAQGSTAHHLGPAMSPSPGASGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGL
130 140 150 160 170 180
160 170 180
pF1KB9 ASA--QSLHPVLREPPDHGELGSH-HCQ---------------------------DHSDE
: .. : . :: .::.: : . .::::
NP_002 HHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVGEHSDE
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB9 ETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMC
..:.::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMC
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB9 KLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQ
::::::::::::.:::.::::..::::::::::::::::::.:::.::.::::::::.:.
NP_002 KLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAH
310 320 330 340 350 360
310 320 330 340 350 360
pF1KB9 EISSLADSLQLEKEVVRVWFCNRRQKEKRMTPP-GDQQP--HEVYSHTVKTDTSCHDL
::..:::::::::::::::::::::::::::: : .: .::.
NP_002 EITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPP
370 380 390 400 410 420
NP_002 SAPPPPPPAALHHHHHHTLPGSVQ
430 440 450
>>XP_011507957 (OMIM: 164175) PREDICTED: POU domain, cla (671 aa)
initn: 682 init1: 383 opt: 692 Z-score: 534.0 bits: 108.3 E(85289): 5.3e-23
Smith-Waterman score: 698; 42.6% identity (66.4% similar) in 324 aa overlap (35-339:146-466)
10 20 30 40 50 60
pF1KB9 ASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDG
: :::. :. . : . : .
XP_011 QPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAA
120 130 140 150 160 170
70 80 90 100 110
pF1KB9 GPWSSTLATSPLDQQDV-KPGR--EDLQLGAIIHHRSPHVAHH---SPHTN-HPNAWGAS
: :. :..:. : . .: . .::: ..... .. . : :: .: . :
XP_011 GATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIIS
180 190 200 210 220 230
120 130 140 150 160 170
pF1KB9 PAPNPSITSSGQPLNVYSQ-PGFTVSGMLEHGG---LTPPPAAASAQ-SLHPVLREPPDH
.:. . . : :. .: : . ...:. :: ::. . . :. : ..
XP_011 QTPQGQ-QGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQ
240 250 260 270 280 290
180 190 200 210 220 230
pF1KB9 GELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI
. .. . : :: .::::::: ::::::::::::.:::::.: :::: ::::::
XP_011 ST--PKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
300 310 320 330 340 350
240 250 260 270 280
pF1KB9 CRFEALQLSFKNMCKLKPLLNKWLEEA-----DSSTGSPTSIDKIAAQG--RKRKKRTSI
:::::.:::::::::::::.:::..: ::: .::..... . .: :.:::::::
XP_011 SRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSI
360 370 380 390 400 410
290 300 310 320 330 340
pF1KB9 EVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPH
:.... .:: ::. ::...::. .::.:..::::.:::::::::::::..::
XP_011 ETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTS
420 430 440 450 460 470
350 360
pF1KB9 EVYSHTVKTDTSCHDL
XP_011 SSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTA
480 490 500 510 520 530
>>XP_011507956 (OMIM: 164175) PREDICTED: POU domain, cla (743 aa)
initn: 682 init1: 383 opt: 692 Z-score: 533.4 bits: 108.3 E(85289): 5.7e-23
Smith-Waterman score: 698; 42.6% identity (66.4% similar) in 324 aa overlap (35-339:120-440)
10 20 30 40 50 60
pF1KB9 ASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDG
: :::. :. . : . : .
XP_011 QPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAA
90 100 110 120 130 140
70 80 90 100 110
pF1KB9 GPWSSTLATSPLDQQDV-KPGR--EDLQLGAIIHHRSPHVAHH---SPHTN-HPNAWGAS
: :. :..:. : . .: . .::: ..... .. . : :: .: . :
XP_011 GATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIIS
150 160 170 180 190 200
120 130 140 150 160 170
pF1KB9 PAPNPSITSSGQPLNVYSQ-PGFTVSGMLEHGG---LTPPPAAASAQ-SLHPVLREPPDH
.:. . . : :. .: : . ...:. :: ::. . . :. : ..
XP_011 QTPQGQ-QGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQ
210 220 230 240 250 260
180 190 200 210 220 230
pF1KB9 GELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI
. .. . : :: .::::::: ::::::::::::.:::::.: :::: ::::::
XP_011 ST--PKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
270 280 290 300 310 320
240 250 260 270 280
pF1KB9 CRFEALQLSFKNMCKLKPLLNKWLEEA-----DSSTGSPTSIDKIAAQG--RKRKKRTSI
:::::.:::::::::::::.:::..: ::: .::..... . .: :.:::::::
XP_011 SRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSI
330 340 350 360 370 380
290 300 310 320 330 340
pF1KB9 EVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPH
:.... .:: ::. ::...::. .::.:..::::.:::::::::::::..::
XP_011 ETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTS
390 400 410 420 430 440
350 360
pF1KB9 EVYSHTVKTDTSCHDL
XP_011 SSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTA
450 460 470 480 490 500
>>NP_001185712 (OMIM: 164175) POU domain, class 2, trans (755 aa)
initn: 682 init1: 383 opt: 692 Z-score: 533.3 bits: 108.3 E(85289): 5.7e-23
Smith-Waterman score: 698; 42.6% identity (66.4% similar) in 324 aa overlap (35-339:132-452)
10 20 30 40 50 60
pF1KB9 ASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDG
: :::. :. . : . : .
NP_001 QPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAA
110 120 130 140 150 160
70 80 90 100 110
pF1KB9 GPWSSTLATSPLDQQDV-KPGR--EDLQLGAIIHHRSPHVAHH---SPHTN-HPNAWGAS
: :. :..:. : . .: . .::: ..... .. . : :: .: . :
NP_001 GATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIIS
170 180 190 200 210 220
120 130 140 150 160 170
pF1KB9 PAPNPSITSSGQPLNVYSQ-PGFTVSGMLEHGG---LTPPPAAASAQ-SLHPVLREPPDH
.:. . . : :. .: : . ...:. :: ::. . . :. : ..
NP_001 QTPQGQ-QGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQ
230 240 250 260 270 280
180 190 200 210 220 230
pF1KB9 GELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI
. .. . : :: .::::::: ::::::::::::.:::::.: :::: ::::::
NP_001 ST--PKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
290 300 310 320 330
240 250 260 270 280
pF1KB9 CRFEALQLSFKNMCKLKPLLNKWLEEA-----DSSTGSPTSIDKIAAQG--RKRKKRTSI
:::::.:::::::::::::.:::..: ::: .::..... . .: :.:::::::
NP_001 SRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSI
340 350 360 370 380 390
290 300 310 320 330 340
pF1KB9 EVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPH
:.... .:: ::. ::...::. .::.:..::::.:::::::::::::..::
NP_001 ETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTS
400 410 420 430 440 450
350 360
pF1KB9 EVYSHTVKTDTSCHDL
NP_001 SSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTA
460 470 480 490 500 510
>>NP_002688 (OMIM: 164175) POU domain, class 2, transcri (766 aa)
initn: 682 init1: 383 opt: 692 Z-score: 533.3 bits: 108.3 E(85289): 5.8e-23
Smith-Waterman score: 698; 42.6% identity (66.4% similar) in 324 aa overlap (35-339:143-463)
10 20 30 40 50 60
pF1KB9 ASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDG
: :::. :. . : . : .
NP_002 QPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAA
120 130 140 150 160 170
70 80 90 100 110
pF1KB9 GPWSSTLATSPLDQQDV-KPGR--EDLQLGAIIHHRSPHVAHH---SPHTN-HPNAWGAS
: :. :..:. : . .: . .::: ..... .. . : :: .: . :
NP_002 GATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIIS
180 190 200 210 220 230
120 130 140 150 160 170
pF1KB9 PAPNPSITSSGQPLNVYSQ-PGFTVSGMLEHGG---LTPPPAAASAQ-SLHPVLREPPDH
.:. . . : :. .: : . ...:. :: ::. . . :. : ..
NP_002 QTPQGQ-QGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQ
240 250 260 270 280 290
180 190 200 210 220 230
pF1KB9 GELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI
. .. . : :: .::::::: ::::::::::::.:::::.: :::: ::::::
NP_002 ST--PKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
300 310 320 330 340
240 250 260 270 280
pF1KB9 CRFEALQLSFKNMCKLKPLLNKWLEEA-----DSSTGSPTSIDKIAAQG--RKRKKRTSI
:::::.:::::::::::::.:::..: ::: .::..... . .: :.:::::::
NP_002 SRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSI
350 360 370 380 390 400
290 300 310 320 330 340
pF1KB9 EVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPH
:.... .:: ::. ::...::. .::.:..::::.:::::::::::::..::
NP_002 ETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTS
410 420 430 440 450 460
350 360
pF1KB9 EVYSHTVKTDTSCHDL
NP_002 SSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTA
470 480 490 500 510 520
>>XP_011507955 (OMIM: 164175) PREDICTED: POU domain, cla (769 aa)
initn: 682 init1: 383 opt: 692 Z-score: 533.2 bits: 108.3 E(85289): 5.8e-23
Smith-Waterman score: 698; 42.6% identity (66.4% similar) in 324 aa overlap (35-339:146-466)
10 20 30 40 50 60
pF1KB9 ASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDG
: :::. :. . : . : .
XP_011 QPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAA
120 130 140 150 160 170
70 80 90 100 110
pF1KB9 GPWSSTLATSPLDQQDV-KPGR--EDLQLGAIIHHRSPHVAHH---SPHTN-HPNAWGAS
: :. :..:. : . .: . .::: ..... .. . : :: .: . :
XP_011 GATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIIS
180 190 200 210 220 230
120 130 140 150 160 170
pF1KB9 PAPNPSITSSGQPLNVYSQ-PGFTVSGMLEHGG---LTPPPAAASAQ-SLHPVLREPPDH
.:. . . : :. .: : . ...:. :: ::. . . :. : ..
XP_011 QTPQGQ-QGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQ
240 250 260 270 280 290
180 190 200 210 220 230
pF1KB9 GELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI
. .. . : :: .::::::: ::::::::::::.:::::.: :::: ::::::
XP_011 ST--PKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
300 310 320 330 340 350
240 250 260 270 280
pF1KB9 CRFEALQLSFKNMCKLKPLLNKWLEEA-----DSSTGSPTSIDKIAAQG--RKRKKRTSI
:::::.:::::::::::::.:::..: ::: .::..... . .: :.:::::::
XP_011 SRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSI
360 370 380 390 400 410
290 300 310 320 330 340
pF1KB9 EVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPH
:.... .:: ::. ::...::. .::.:..::::.:::::::::::::..::
XP_011 ETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTS
420 430 440 450 460 470
350 360
pF1KB9 EVYSHTVKTDTSCHDL
XP_011 SSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTA
480 490 500 510 520 530
>>NP_001185715 (OMIM: 164175) POU domain, class 2, trans (703 aa)
initn: 682 init1: 383 opt: 686 Z-score: 529.2 bits: 107.5 E(85289): 9.7e-23
Smith-Waterman score: 686; 45.9% identity (69.0% similar) in 281 aa overlap (73-339:133-400)
50 60 70 80 90 100
pF1KB9 LQGVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQ-QDVKPGREDLQLGAIIHHRSPHV
:. :.: :... .:: ...:
NP_001 DSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGDLQQLQQLQQQNLNLQQFVLVH------
110 120 130 140 150
110 120 130 140 150
pF1KB9 AHHSPHTN-HPNAWGASPAPNPSITSSGQPLNVYSQ-PGFTVSGMLEHGG---LTPPPAA
: :: .: . : .:. . . : :. .: : . ...:. :: ::.
NP_001 ----PTTNLQPAQFIISQTPQGQ-QGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPAT
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB9 ASAQ-SLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADV
. . :. : ... .. . : :: .::::::: ::::::::::::.::
NP_001 PTRTIAATPIQTLPQSQST--PKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDV
220 230 240 250 260
220 230 240 250 260 270
pF1KB9 GLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEA-----DSSTGSPTSID
:::.: :::: :::::: :::::.:::::::::::::.:::..: ::: .::....
NP_001 GLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALN
270 280 290 300 310 320
280 290 300 310 320
pF1KB9 KIAAQG--RKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCN
. . .: :.::::::::.... .:: ::. ::...::. .::.:..::::.::::::
NP_001 SPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCN
330 340 350 360 370 380
330 340 350 360
pF1KB9 RRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHDL
:::::::..::
NP_001 RRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAV
390 400 410 420 430 440
361 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:55:08 2016 done: Fri Nov 4 17:55:09 2016
Total Scan time: 8.690 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]