Result of FASTA (omim) for
pF1KB9636
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9636, 272 aa
1>>>pF1KB9636 272 - 272 aa - 272 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.8043+/-0.000293; mu= 10.5251+/- 0.018
mean_var=142.6809+/-29.640, 0's: 0 Z-trim(122.1): 36 B-trim: 1308 in 1/57
Lambda= 0.107372
statistics sampled from 39657 (39694) to 39657 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.465), width: 16
Scan time: 8.270
The best scores are: opt bits E(85289)
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 1827 293.6 2.6e-79
NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323) 613 105.6 1.2e-22
XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323) 613 105.6 1.2e-22
NP_689627 (OMIM: 613483) class E basic helix-loop- ( 381) 379 69.4 1.1e-11
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 335 62.4 9.1e-10
NP_620450 (OMIM: 606385) oligodendrocyte transcrip ( 271) 310 58.6 1.4e-08
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 225 45.3 0.00011
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 225 45.3 0.00011
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 224 45.3 0.00015
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 212 43.5 0.00062
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 206 42.6 0.0012
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 198 41.1 0.0019
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 201 41.8 0.0023
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 200 41.7 0.0024
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 195 40.7 0.003
>>NP_786923 (OMIM: 609323) oligodendrocyte transcription (272 aa)
initn: 1827 init1: 1827 opt: 1827 Z-score: 1544.7 bits: 293.6 E(85289): 2.6e-79
Smith-Waterman score: 1827; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272)
10 20 30 40 50 60
pF1KB9 MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHQESRLNSVSSTQGDMMQKMPGESLSRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_786 MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHQESRLNSVSSTQGDMMQKMPGESLSRAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AKAAGESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_786 AKAAGESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 LSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANSVHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_786 LSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANSVHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 VHPILGGALSSGNASSPLSAASLPAIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_786 VHPILGGALSSGNASSPLSAASLPAIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCP
190 200 210 220 230 240
250 260 270
pF1KB9 CTICQMPPPPHLSALSTANMARLSAESKDLLK
::::::::::::::::::::::::::::::::
NP_786 CTICQMPPPPHLSALSTANMARLSAESKDLLK
250 260 270
>>NP_005797 (OMIM: 606386) oligodendrocyte transcription (323 aa)
initn: 924 init1: 554 opt: 613 Z-score: 527.4 bits: 105.6 E(85289): 1.2e-22
Smith-Waterman score: 912; 50.2% identity (70.9% similar) in 323 aa overlap (1-268:1-323)
10 20 30 40 50
pF1KB9 MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHQESRLNSVSSTQGDMMQKM---------
:.::.: :::: :::. :...: . . . . ::: .: ..
NP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
10 20 30 40 50 60
60 70 80 90
pF1KB9 -----PGESLSRAGAKA-----------AGESSKYKIKKQLSEQDLQQLRLKINGRERKR
::..:. .: :. :. :: : :::..: .:::::::::.:::::
NP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 MHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGH
:::::.:::::::::::::::::::::::::::::::::::::.:::::::::.::::::
NP_005 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
130 140 150 160 170 180
160 170 180 190 200
pF1KB9 HSAFH---CGTVGHSA------GHPAHAANSVH-PV--HPIL---GGALSSGNASSPLSA
:..:: :: ..::: .::: ::...: :. :::: ..: ... :.. .:.
NP_005 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
190 200 210 220 230 240
210 220 230 240
pF1KB9 ASLP-----AIGTIRPPHSLLKAPSTPPALQLGSG---------FQHWAGLPCPCTICQM
:::: ..:.:::::.:::.::. : ::.: ::::.:.::::..::.
NP_005 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
250 260 270 280 290 300
250 260 270
pF1KB9 PPPPH-LSALSTANMARLSAESKDLLK
::: : .::...... ::....:
NP_005 PPPHHHVSAMGAGSLPRLTSDAK
310 320
>>XP_005260965 (OMIM: 606386) PREDICTED: oligodendrocyte (323 aa)
initn: 924 init1: 554 opt: 613 Z-score: 527.4 bits: 105.6 E(85289): 1.2e-22
Smith-Waterman score: 912; 50.2% identity (70.9% similar) in 323 aa overlap (1-268:1-323)
10 20 30 40 50
pF1KB9 MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHQESRLNSVSSTQGDMMQKM---------
:.::.: :::: :::. :...: . . . . ::: .: ..
XP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
10 20 30 40 50 60
60 70 80 90
pF1KB9 -----PGESLSRAGAKA-----------AGESSKYKIKKQLSEQDLQQLRLKINGRERKR
::..:. .: :. :. :: : :::..: .:::::::::.:::::
XP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 MHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGH
:::::.:::::::::::::::::::::::::::::::::::::.:::::::::.::::::
XP_005 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
130 140 150 160 170 180
160 170 180 190 200
pF1KB9 HSAFH---CGTVGHSA------GHPAHAANSVH-PV--HPIL---GGALSSGNASSPLSA
:..:: :: ..::: .::: ::...: :. :::: ..: ... :.. .:.
XP_005 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
190 200 210 220 230 240
210 220 230 240
pF1KB9 ASLP-----AIGTIRPPHSLLKAPSTPPALQLGSG---------FQHWAGLPCPCTICQM
:::: ..:.:::::.:::.::. : ::.: ::::.:.::::..::.
XP_005 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
250 260 270 280 290 300
250 260 270
pF1KB9 PPPPH-LSALSTANMARLSAESKDLLK
::: : .::...... ::....:
XP_005 PPPHHHVSAMGAGSLPRLTSDAK
310 320
>>NP_689627 (OMIM: 613483) class E basic helix-loop-heli (381 aa)
initn: 391 init1: 327 opt: 379 Z-score: 330.6 bits: 69.4 E(85289): 1.1e-11
Smith-Waterman score: 379; 50.3% identity (73.2% similar) in 153 aa overlap (53-205:217-356)
30 40 50 60 70 80
pF1KB9 RDHHHRHHHHQESRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQ
: : : .:..... ::. : .: :: .
NP_689 AHLHGGASVPPGGLGGGGGGGSSSGSSGGGGGSGSGSGGSSSSSSSSSKKSK---EQ--K
190 200 210 220 230 240
90 100 110 120 130 140
pF1KB9 QLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLE
:::.::.:::.:::::: :.: :: :.::::.:::::::::::::::.::::: ...::
NP_689 ALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALE
250 260 270 280 290 300
150 160 170 180 190 200
pF1KB9 EMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAAS
::.:::. . :. :. ... ::. : :: .:: ::. .. :. :.::.
NP_689 EMRRLVAYLNQGQ--AISAASLPSSAAAAAAAAA----LHPALGAYEQA--AGYPFSAGL
310 320 330 340 350
210 220 230 240 250 260
pF1KB9 LPAIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMAR
::
NP_689 PPAASCPEKCALFNSVSSSLCKQCTEKP
360 370 380
>>NP_542173 (OMIM: 609331) class E basic helix-loop-heli (241 aa)
initn: 369 init1: 327 opt: 335 Z-score: 296.4 bits: 62.4 E(85289): 9.1e-10
Smith-Waterman score: 335; 60.4% identity (83.5% similar) in 91 aa overlap (65-155:100-188)
40 50 60 70 80 90
pF1KB9 SRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERK
: .: ... :: ..:::.::.:::.
NP_542 APRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQ--RSLRLSINARERR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 RMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGG
:::::: :.:::: :.::::.:::::::::::::::.::::: ...:.::.:::. . :
NP_542 RMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQG
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 HHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAASLPAIGTIRPPHS
.
NP_542 QGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEKP
190 200 210 220 230 240
>>NP_620450 (OMIM: 606385) oligodendrocyte transcription (271 aa)
initn: 316 init1: 158 opt: 310 Z-score: 274.8 bits: 58.6 E(85289): 1.4e-08
Smith-Waterman score: 349; 42.7% identity (59.0% similar) in 227 aa overlap (52-268:82-271)
30 40 50 60 70 80
pF1KB9 LRDHHHRHHHHQESRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDL
:: . .::. .: :.. : :..
NP_620 TSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPG---SGAHPGG-SARPDAK----EEQQ
60 70 80 90 100
90 100 110 120 130
pF1KB9 QQLRLKINGRERKRMHDLNLAMDGLREV-MPY--AH--GPSVRKLSKIATLLLARNYILM
:::: :::.::::::.:::::::.:::: .:: :: : :::::::::::::::::.
NP_620 QQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILL
110 120 130 140 150 160
140 150 160 170 180 190
pF1KB9 LTSSLEEMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASS
: :::.:..: .:: :. .: . :: : :: : :..: . .: .
NP_620 LGSSLQELRRALGE--GAGPAAPRLLL----AGLPLLAAA---P-----GSVLLAPGAVG
170 180 190 200
200 210 220 230 240 250
pF1KB9 PLSAASLPAIGTIRPPHSLLKAPSTPPALQL---GSGFQHWAGLP--CPCTICQMPPPPH
: .: .:: . : : . :: :. :.: :: : : :..:..: :
NP_620 PPDA--------LRPAKYLSLALDEPPCGQFALPGGG----AGGPGLCTCAVCKFP---H
210 220 230 240 250
260 270
pF1KB9 LSALSTANMARLSAESKDLLK
: : . : . ::
NP_620 LVPASLGLAAVQAQFSK
260 270
>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa)
initn: 224 init1: 98 opt: 225 Z-score: 204.9 bits: 45.3 E(85289): 0.00011
Smith-Waterman score: 225; 40.2% identity (63.0% similar) in 127 aa overlap (65-190:66-183)
40 50 60 70 80 90
pF1KB9 SRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERK
: :. : . ::.: .. : : : :::.
XP_016 PPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSR-RKKANDRERN
40 50 60 70 80 90
100 110 120 130 140 150
pF1KB9 RMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGE-IYG
:::.:: :.:.:: :.: :. ::.:: :: .:.::: ::..: :.. . .:.
XP_016 RMHNLNSALDALRGVLPTF--PDDAKLTKIETLRFAHNYIWALTQTL----RIADHSLYA
100 110 120 130 140
160 170 180 190 200 210
pF1KB9 GHHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAASLPAIGTIRPPH
. : ::: .: .: :. .. :: .:.::
XP_016 LEPPAPHCGELGSPGGSPGDWGSLYSPVSQ--AGSLSPAASLEERPGLLGATFSACLSPG
150 160 170 180 190 200
220 230 240 250 260 270
pF1KB9 SLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSAESKDLLK
XP_016 SLAFSDFL
210
>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa)
initn: 224 init1: 98 opt: 225 Z-score: 204.9 bits: 45.3 E(85289): 0.00011
Smith-Waterman score: 225; 40.2% identity (63.0% similar) in 127 aa overlap (65-190:66-183)
40 50 60 70 80 90
pF1KB9 SRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERK
: :. : . ::.: .. : : : :::.
NP_066 PPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSR-RKKANDRERN
40 50 60 70 80 90
100 110 120 130 140 150
pF1KB9 RMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGE-IYG
:::.:: :.:.:: :.: :. ::.:: :: .:.::: ::..: :.. . .:.
NP_066 RMHNLNSALDALRGVLPTF--PDDAKLTKIETLRFAHNYIWALTQTL----RIADHSLYA
100 110 120 130 140
160 170 180 190 200 210
pF1KB9 GHHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAASLPAIGTIRPPH
. : ::: .: .: :. .. :: .:.::
NP_066 LEPPAPHCGELGSPGGSPGDWGSLYSPVSQ--AGSLSPAASLEERPGLLGATFSACLSPG
150 160 170 180 190 200
220 230 240 250 260 270
pF1KB9 SLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSAESKDLLK
NP_066 SLAFSDFL
210
>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa)
initn: 242 init1: 132 opt: 224 Z-score: 202.7 bits: 45.3 E(85289): 0.00015
Smith-Waterman score: 242; 34.0% identity (54.6% similar) in 194 aa overlap (57-250:91-256)
30 40 50 60 70 80
pF1KB9 HRHHHHQESRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRL
::: : . : .. ... . . ::
NP_076 QGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTR-----RL
70 80 90 100 110
90 100 110 120 130 140
pF1KB9 KINGRERKRMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKR
: :.:::.:::.:: :.:.::::.: : ::.:: :: .:.::: :: .:. .
NP_076 KANNRERNRMHNLNAALDALREVLPTF--PEDAKLTKIETLRFAHNYIWALTETLR-LAD
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB9 LVGEIYGGHHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAASLPAI
: :: .:. .: : : : :: : : ... : :. .: :..:
NP_076 HCGGGGGGLPGALFSEAVLLSPGG-ASAALSSSGDSPSPASTWSCTNSPAPSSSVS----
180 190 200 210 220
210 220 230 240 250 260
pF1KB9 GTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSAE
.. :.: .:..: :: ...: .::::
NP_076 SNSTSPYSCTLSPASPA----GSDMDYW-----------QPPPPDKHRYAPHLPIARDCI
230 240 250 260 270
270
pF1KB9 SKDLLK
>>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa)
initn: 189 init1: 120 opt: 212 Z-score: 191.6 bits: 43.5 E(85289): 0.00062
Smith-Waterman score: 212; 33.0% identity (52.5% similar) in 221 aa overlap (65-272:64-275)
40 50 60 70 80
pF1KB9 SRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYK--IKKQLSEQDLQQLR---LKIN
::. : . ::.... :...: .: :
NP_067 EESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKAN
40 50 60 70 80 90
90 100 110 120 130 140
pF1KB9 GRERKRMHDLNLAMDGLREVMP-YAHGPSVRKLSKIATLLLARNYILMLTSSLE-----E
.::: ::: :: :.:.::.::: :. ...::::: :: :::::: :. :: :
NP_067 ARERTRMHGLNDALDNLRRVMPCYS---KTQKLSKIETLRLARNYIWALSEVLETGQTPE
100 110 120 130 140 150
150 160 170 180 190 200
pF1KB9 MKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANSVHPVH-PILGGALSSGNASSPLSAAS
: .: . : . ..: : . : . :: .:.: : . .
NP_067 GKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLP
160 170 180 190 200 210
210 220 230 240 250 260
pF1KB9 LPAIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLP-CPCTICQMPPPPHLSALSTANMA
: : .. : : :.. .: .: .: :: : . : : :: ..:..
NP_067 SPPYGHMET-HLLHLKPQVFKSLGESSFGSH---LPDCSTPPYEGPLTPPLSI--SGNFS
220 230 240 250 260
270
pF1KB9 RLSAESKDLLK
. : :: :
NP_067 LKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQAGTPRYDVPIDMSYDSYPHHGIGTQ
270 280 290 300 310 320
272 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:53:54 2016 done: Fri Nov 4 17:53:55 2016
Total Scan time: 8.270 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]